{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T11:10:37Z","timestamp":1789470637414,"version":"build-2803163510"},"reference-count":19,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100012542","name":"Sichuan Provincial Science and Technology Support Program","doi-asserted-by":"publisher","award":["2023NSFSC1683"],"award-info":[{"award-number":["2023NSFSC1683"]}],"id":[{"id":"10.13039\/100012542","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["12472310"],"award-info":[{"award-number":["12472310"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["62306192"],"award-info":[{"award-number":["62306192"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82300542"],"award-info":[{"award-number":["82300542"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82170375"],"award-info":[{"award-number":["82170375"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81970325"],"award-info":[{"award-number":["81970325"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["12072214"],"award-info":[{"award-number":["12072214"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004543","name":"China Scholarship Council","doi-asserted-by":"publisher","award":["CSCF 2020B04"],"award-info":[{"award-number":["CSCF 2020B04"]}],"id":[{"id":"10.13039\/501100004543","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004912","name":"Sichuan University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004912","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013365","name":"West China Hospital, Sichuan University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013365","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Computer Methods and Programs in Biomedicine"],"published-print":{"date-parts":[[2025,4]]},"DOI":"10.1016\/j.cmpb.2025.108602","type":"journal-article","created":{"date-parts":[[2025,1,14]],"date-time":"2025-01-14T11:31:58Z","timestamp":1736854318000},"page":"108602","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Analysis of the hemodynamic impact of coronary plaque morphology in mild coronary artery stenosis"],"prefix":"10.1016","volume":"261","author":[{"given":"Luyuan","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haoyao","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiming","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mao","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0597-3245","authenticated-orcid":false,"given":"Tinghui","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cmpb.2025.108602_bib0001","doi-asserted-by":"crossref","unstructured":"J. M\u00fcller-Nordhorn, S.N. Willich, Coronary Heart Disease, in: International Encyclopedia of Public Health, 2016: pp. 159\u2013167. https:\/\/doi.org\/10.1016\/B978-0-12-803678-5.00090-4.","DOI":"10.1016\/B978-0-12-803678-5.00090-4"},{"key":"10.1016\/j.cmpb.2025.108602_bib0002","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1186\/s12880-024-01213-8","article-title":"Diagnostic performance of coronary computed tomography angiography stenosis score for coronary stenosis","volume":"24","author":"Xiong","year":"2024","journal-title":"BMC. Med. ImAging"},{"key":"10.1016\/j.cmpb.2025.108602_bib0003","first-page":"2163","article-title":"Treatment of stable angina","volume":"12","author":"Perona","year":"2017","journal-title":"Medicine"},{"key":"10.1016\/j.cmpb.2025.108602_bib0004","first-page":"27","article-title":"Management of coronary artery disease and chronic stable angina","volume":"42","author":"Camero","year":"2017","journal-title":"U.S. Pharmacist"},{"key":"10.1016\/j.cmpb.2025.108602_bib0005","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1080\/08998280.2022.2083903","article-title":"Optimal cardiovascular medical therapy: current guidelines and new developments","volume":"35","author":"Reed","year":"2022","journal-title":"Baylor Univ. Med. Center Proc."},{"key":"10.1016\/j.cmpb.2025.108602_bib0006","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1093\/ehjci\/jet132","article-title":"Age-related risk of major adverse cardiac event risk and coronary artery disease extent and severity by coronary CT angiography: results from 15 187 patients from the international multisite CONFIRM study","volume":"15","author":"Nakazato","year":"2014","journal-title":"Eur. Heart J. Cardiovasc. Imag."},{"key":"10.1016\/j.cmpb.2025.108602_bib0007","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCIMAGING.117.007087","article-title":"Impact of coronary lesion geometry on fractional flow reserve: data from interventional cardiology research in-cooperation society-fractional flow reserve and intravascular ultrasound registry","volume":"11","author":"Kang","year":"2018","journal-title":"Circ. Cardiovas. Imag."},{"key":"10.1016\/j.cmpb.2025.108602_bib0008","first-page":"677","article-title":"Impact of longitudinal lesion geometry on location of plaque rupture and clinical presentations","volume":"10","author":"Lee","year":"2017","journal-title":"JACC"},{"key":"10.1016\/j.cmpb.2025.108602_bib0009","doi-asserted-by":"crossref","DOI":"10.1063\/5.0058765","article-title":"Effect of shape of the stenosis on the hemodynamics of a stenosed coronary artery","volume":"33","author":"Freidoonimehr","year":"2021","journal-title":"Phys. Fluids"},{"key":"10.1016\/j.cmpb.2025.108602_bib0010","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1007\/s10439-016-1762-8","article-title":"SimVascular: an open source pipeline for cardiovascular simulation","volume":"45","author":"Updegrove","year":"2017","journal-title":"Ann. Biomed. Eng."},{"key":"10.1016\/j.cmpb.2025.108602_bib0011","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1007\/s13239-020-00468-w","article-title":"Role of occlusion position in coronary artery fistulas with terminal aneurysms: a hemodynamic perspective","volume":"11","author":"Cao","year":"2020","journal-title":"Cardiovasc. Eng. Tech."},{"key":"10.1016\/j.cmpb.2025.108602_bib0012","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1080\/10255842.2019.1699540","article-title":"A computational fluid dynamics study pre- and post-fistula closure in a coronary artery fistula","volume":"23","author":"Cao","year":"2020","journal-title":"Comput. Methods Biomech. Biomed. Eng."},{"key":"10.1016\/j.cmpb.2025.108602_bib0013","doi-asserted-by":"crossref","first-page":"130","DOI":"10.17106\/jbr.37.130","article-title":"Disruptive effect of impinging jet flow environment on the integrity of endothelial monolayer","volume":"37","author":"Sawasaki","year":"2023","journal-title":"J. Biorheol."},{"key":"10.1016\/j.cmpb.2025.108602_bib0014","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1038\/nature03952","article-title":"A mechanosensory complex that mediates the endothelial cell response to fluid shear stress","volume":"437","author":"Tzima","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.cmpb.2025.108602_bib0015","doi-asserted-by":"crossref","first-page":"335","DOI":"10.4161\/19336918.2014.968498","article-title":"Mechanotransduction of shear stress occurs through changes in VE-cadherin and PECAM-1 tension: implications for cell migration","volume":"9","author":"Conway","year":"2015","journal-title":"Cell Adh. Migr."},{"key":"10.1016\/j.cmpb.2025.108602_bib0016","doi-asserted-by":"crossref","unstructured":"K.S. Sami, M. Ali, M.Q. Islam, Effects of swirling on non-Newtonian fluid flow through arterial stenosis, in: 2021. https:\/\/doi.org\/10.1063\/5.0037687.","DOI":"10.1063\/5.0037687"},{"key":"10.1016\/j.cmpb.2025.108602_bib0017","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2023.1083547","article-title":"Wall shear stress and its role in atherosclerosis","volume":"10","author":"Zhou","year":"2023","journal-title":"Front. Cardiovasc. Med."},{"key":"10.1016\/j.cmpb.2025.108602_bib0018","series-title":"PROCEEDING OF THE ASME SUMMER BIOENGINEERING CONFERENCE - 2007","first-page":"479","article-title":"Strain distribution over plaques in human coronary arteries relates to shear stress","author":"Gijsen","year":"2007"},{"key":"10.1016\/j.cmpb.2025.108602_bib0019","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/labinvest.3700215","article-title":"The role of shear stress in the pathogenesis of atherosclerosis","volume":"85","author":"Cunningham","year":"2005","journal-title":"Lab. Investig."}],"container-title":["Computer Methods and Programs in Biomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0169260725000197?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0169260725000197?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T02:17:27Z","timestamp":1777515447000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0169260725000197"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4]]},"references-count":19,"alternative-id":["S0169260725000197"],"URL":"https:\/\/doi.org\/10.1016\/j.cmpb.2025.108602","relation":{},"ISSN":["0169-2607"],"issn-type":[{"value":"0169-2607","type":"print"}],"subject":[],"published":{"date-parts":[[2025,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Analysis of the hemodynamic impact of coronary plaque morphology in mild coronary artery stenosis","name":"articletitle","label":"Article Title"},{"value":"Computer Methods and Programs in Biomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cmpb.2025.108602","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"108602"}}