{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T16:20:06Z","timestamp":1790612406052,"version":"4.1.0"},"reference-count":83,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,6,4]],"date-time":"2025-06-04T00:00:00Z","timestamp":1748995200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004233","name":"Universitat Polit\u00e8cnica de Val\u00e8ncia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004233","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010661","name":"Horizon 2020 Framework Programme","doi-asserted-by":"publisher","award":["101016496"],"award-info":[{"award-number":["101016496"]}],"id":[{"id":"10.13039\/100010661","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010661","name":"Horizon 2020 Framework Programme","doi-asserted-by":"publisher","award":["MICIU\/AEI\/10.13039\/501100011033"],"award-info":[{"award-number":["MICIU\/AEI\/10.13039\/501100011033"]}],"id":[{"id":"10.13039\/100010661","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010661","name":"Horizon 2020 Framework Programme","doi-asserted-by":"publisher","award":["PID2022-140553OB-C41"],"award-info":[{"award-number":["PID2022-140553OB-C41"]}],"id":[{"id":"10.13039\/100010661","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Computer Methods and Programs in Biomedicine"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1016\/j.cmpb.2025.108896","type":"journal-article","created":{"date-parts":[[2025,6,4]],"date-time":"2025-06-04T11:09:56Z","timestamp":1749035396000},"page":"108896","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Integration of electrophysiological and mechanical biomarkers in cardiac risk assessment models"],"prefix":"10.1016","volume":"269","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2354-6180","authenticated-orcid":false,"given":"Lucia","family":"Priego","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8069-2486","authenticated-orcid":false,"given":"Maria Teresa","family":"Mora","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordi","family":"Llopis-Lorente","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3766-2393","authenticated-orcid":false,"given":"Henrik","family":"Finsberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6247-9940","authenticated-orcid":false,"given":"Cecile","family":"Daversin-Catty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilsbeth","family":"Van Herck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel","family":"Wall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hermenegild","family":"Arevalo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco Javier","family":"Saiz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9166-6112","authenticated-orcid":false,"given":"Beatriz","family":"Trenor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.cmpb.2025.108896_bib0001","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1002\/psp4.12423","article-title":"Quantitative systems pharmacology models for a new international cardiac safety regulatory paradigm: an overview of the comprehensive In vitro proarrhythmia assay In Silico modeling approach","volume":"8","author":"Li","year":"2019","journal-title":"CPT Pharmacomet. Syst. Pharmacol."},{"issue":"2","key":"10.1016\/j.cmpb.2025.108896_bib0002","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1002\/cpt.1184","article-title":"Assessment of an In silico mechanistic model for proarrhythmia risk prediction under the CiPA initiative","volume":"105","author":"Li","year":"2019","journal-title":"Clin. Pharmacol. Ther."},{"issue":"1","key":"10.1016\/j.cmpb.2025.108896_bib0003","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1093\/cvr\/cvr044","article-title":"Simulation of multiple ion channel block provides improved early prediction of compounds\u2019 clinical torsadogenic risk","volume":"91","author":"Mirams","year":"2011","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.cmpb.2025.108896_bib0004","doi-asserted-by":"crossref","first-page":"668","DOI":"10.3389\/fphys.2017.00668","article-title":"Human In Silico drug trials demonstrate higher accuracy than animal models in predicting clinical pro-arrhythmic cardiotoxicity","volume":"8","author":"Passini","year":"2017","journal-title":"Front. Physiol."},{"key":"10.1016\/j.cmpb.2025.108896_bib0005","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.pbiomolbio.2020.06.007","article-title":"In-silico human electro-mechanical ventricular modelling and simulation for drug-induced pro-arrhythmia and inotropic risk assessment","volume":"159","author":"Margara","year":"2021","journal-title":"Prog. Biophys. Mol. Biol."},{"issue":"19","key":"10.1016\/j.cmpb.2025.108896_bib0006","doi-asserted-by":"crossref","first-page":"3819","DOI":"10.1111\/bph.14786","article-title":"Drug-induced shortening of the electromechanical window is an effective biomarker for in silico prediction of clinical risk of arrhythmias","volume":"176","author":"Passini","year":"2019","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.cmpb.2025.108896_bib0007","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.vascn.2015.05.009","article-title":"Predictivity of in vitro non-clinical cardiac contractility assays for inotropic effects in humans \u2014 A literature search","volume":"75","author":"Wallis","year":"2015","journal-title":"J. Pharmacol. Toxicol. Methods"},{"issue":"6","key":"10.1016\/j.cmpb.2025.108896_bib0008","article-title":"Guideline for the prevention, detection, evaluation, and management of high blood pressure in adults: A report of the American College of Cardiology\/American Heart Association Task Force on Clinical Practice Guidelines","volume":"71","author":"Whelton","year":"2018","journal-title":"Hypertension"},{"issue":"Suppl. 1","key":"10.1016\/j.cmpb.2025.108896_bib0009","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1159\/000047278","article-title":"Calcium channel blockers in heart failure","volume":"89","author":"Elkayam","year":"1998","journal-title":"Cardiology"},{"issue":"1","key":"10.1016\/j.cmpb.2025.108896_bib0010","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1161\/01.CIR.83.1.52","article-title":"Diltiazem increases late-onset congestive heart failure in postinfarction patients with early reduction in ejection fraction. The Adverse Experience Committee; and the Multicenter Diltiazem Postinfarction Research Group","volume":"83","author":"Goldstein","year":"1991","journal-title":"Circulation"},{"key":"10.1016\/j.cmpb.2025.108896_bib0011","doi-asserted-by":"crossref","DOI":"10.1016\/j.cmpb.2022.106934","article-title":"Considering population variability of electrophysiological models improves the in silico assessment of drug-induced torsadogenic risk","volume":"221","author":"Llopis-Lorente","year":"2022","journal-title":"Comput. Methods Programs Biomed."},{"key":"10.1016\/j.cmpb.2025.108896_bib0012","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2024.1374355","article-title":"Evaluation of cardiac pro-arrhythmic risks using the artificial neural network with ToR\u2013ORd in silico model output","volume":"15","author":"Mahardika T","year":"2024","journal-title":"Front. Physiol."},{"key":"10.1016\/j.cmpb.2025.108896_bib0013","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.48890","article-title":"Development, calibration, and validation of a novel human ventricular myocyte model in health, disease, and drug block","volume":"8","author":"Tomek","year":"2019","journal-title":"eLife"},{"key":"10.1016\/j.cmpb.2025.108896_bib0014","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.yjmcc.2017.03.008","article-title":"A model of cardiac contraction based on novel measurements of tension development in human cardiomyocytes","volume":"106","author":"Land","year":"2017","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.cmpb.2025.108896_bib0015","doi-asserted-by":"crossref","DOI":"10.1016\/j.cmpb.2023.107350","article-title":"Insights from an electro-mechanical heart failure cell model: role of SERCA enhancement on arrhythmogenesis and myocyte contraction","volume":"230","author":"Mora","year":"2023","journal-title":"Comput. Methods Programs Biomed."},{"key":"10.1016\/j.cmpb.2025.108896_bib0016","doi-asserted-by":"crossref","first-page":"278","DOI":"10.3389\/fphys.2017.00278","article-title":"The electrogenic Na+\/K+ pump is a key determinant of repolarization abnormality susceptibility in Human ventricular cardiomyocytes: A population-based simulation study","volume":"8","author":"Britton","year":"2017","journal-title":"Front. Physiol."},{"issue":"1","key":"10.1016\/j.cmpb.2025.108896_bib0017","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.yjmcc.2009.09.019","article-title":"A novel computational model of the human ventricular action potential and Ca transient","volume":"48","author":"Grandi","year":"2010","journal-title":"J. Mol. Cell. Cardiol."},{"issue":"4","key":"10.1016\/j.cmpb.2025.108896_bib0018","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1161\/01.CIR.0000023042.50192.F4","article-title":"Rate dependence of [Na+]i and contractility in nonfailing and failing Human myocardium","volume":"106","author":"Pieske","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.cmpb.2025.108896_bib0019","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.vascn.2016.06.002","article-title":"The Comprehensive in Vitro Proarrhythmia Assay (CiPA) initiative \u2014 Update on progress","volume":"81","author":"Colatsky","year":"2016","journal-title":"J. Pharmacol. Toxicol. Methods"},{"issue":"23","key":"10.1016\/j.cmpb.2025.108896_bib0020","doi-asserted-by":"crossref","DOI":"10.3390\/ijms232314651","article-title":"Antiarrhythmic and inotropic effects of selective Na+\/Ca2+ exchanger inhibition: what can we learn from the pharmacological studies?","volume":"23","author":"Nagy","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.cmpb.2025.108896_bib0021","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-022-26889-2","article-title":"Mechanism based therapies enable personalised treatment of hypertrophic cardiomyopathy","volume":"12","author":"Margara","year":"2022","journal-title":"Sci. Rep."},{"key":"10.1016\/j.cmpb.2025.108896_bib0022","article-title":"Efficacy and safety of Mavacamten for symptomatic hypertrophic cardiomyopathy \u2013 an updated Meta-analysis of randomized controlled trials","volume":"53","author":"Ullah","year":"2024","journal-title":"IJC Heart Vasc"},{"key":"10.1016\/j.cmpb.2025.108896_bib0023","doi-asserted-by":"crossref","unstructured":"L. Myklebust, H. Arevalo, C. Daversin-Catty, S. Wall, H. Finsberg, Impact of Segregation Scheme on Performance of a Strongly Coupled, Electromechanical Solver\u2019, 2025, SSRN, doi:10.2139\/ssrn.5128775.","DOI":"10.2139\/ssrn.5128775"},{"key":"10.1016\/j.cmpb.2025.108896_bib0024","series-title":"en Lecture Notes in Computational Science and Engineering","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/978-3-642-23099-8_1","article-title":"A FEniCS tutorial, en Automated Solution of Differential equations by the Finite element Method","author":"Langtangen","year":"2012"},{"key":"10.1016\/j.cmpb.2025.108896_bib0025","article-title":"Impact of segregation scheme on performance of a strongly coupled electromechanical solver","author":"Myklebust","year":"2025","journal-title":"SSRN"},{"issue":"02","key":"10.1016\/j.cmpb.2025.108896_bib0026","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1142\/S0219720005001004","article-title":"Minimum redundancy feature selection from microarray gene expression data","volume":"03","author":"Ding","year":"2005","journal-title":"J. Bioinform. Comput. Biol."},{"key":"10.1016\/j.cmpb.2025.108896_bib0027","doi-asserted-by":"crossref","first-page":"144","DOI":"10.22159\/ajpcr.2022.v15i8.44858","article-title":"Study of clinical and echocardiographic profile in patients of dilated cardiomyopathy","author":"Behera","year":"2022","journal-title":"Asian J. Pharm. Clin. Res."},{"issue":"1","key":"10.1016\/j.cmpb.2025.108896_bib0028","first-page":"5","article-title":"The relative impact of circumferential and longitudinal shortening on left ventricular ejection fraction and stroke volume","volume":"17","author":"Maciver","year":"2012","journal-title":"Exp. Clin. Cardiol."},{"issue":"8","key":"10.1016\/j.cmpb.2025.108896_bib0029","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1016\/j.jacc.2017.06.046","article-title":"Geometry as a confounder when assessing ventricular systolic function","volume":"70","author":"Stokke","year":"2017","journal-title":"J. Am. Coll. Cardiol."},{"issue":"8","key":"10.1016\/j.cmpb.2025.108896_bib0030","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1111\/j.1540-8167.2009.01476.x","article-title":"Ibutilide-induced changes in the temporal lability of ventricular repolarization in patients with and without structural heart disease","volume":"20","author":"Cheng","year":"2009","journal-title":"J. Cardiovasc. Electrophysiol."},{"issue":"6","key":"10.1016\/j.cmpb.2025.108896_bib0031","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1097\/00045391-200211000-00013","article-title":"Ibutilide-induced long QT syndrome and Torsade de Pointes","volume":"9","author":"Gowda","year":"2002","journal-title":"Am. J. Ther."},{"key":"10.1016\/j.cmpb.2025.108896_bib0032","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.pbiomolbio.2020.06.007","article-title":"In-silico human electro-mechanical ventricular modelling and simulation for drug-induced pro-arrhythmia and inotropic risk assessment","volume":"159","author":"Margara","year":"2021","journal-title":"Prog. Biophys. Mol. Biol."},{"key":"10.1016\/j.cmpb.2025.108896_bib0033","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.3389\/fphys.2017.01073","article-title":"Adult Human primary cardiomyocyte-based model for the simultaneous prediction of drug-induced inotropic and pro-arrhythmia risk","volume":"8","author":"Nguyen","year":"2017","journal-title":"Front. Physiol."},{"key":"10.1016\/j.cmpb.2025.108896_bib0034","unstructured":"R.L. Woosley, C.W. Heise, T. Gallo, R.D. Woosley, J. Lambson, and K.A. Romero, \u2018QTdrugs List\u2019. Accessed: Nov. 07, 2024. [Online]. Available: https:\/\/crediblemeds.org\/."},{"issue":"1","key":"10.1016\/j.cmpb.2025.108896_bib0035","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1186\/s12938-018-0508-2","article-title":"The effect of myocardial action potential duration on cardiac pumping efficacy: a computational study","volume":"17","author":"Jeong","year":"2018","journal-title":"Biomed. Eng. OnLine"},{"key":"10.1016\/j.cmpb.2025.108896_bib0036","unstructured":"\u2018American Society of Echocardiography\u2019. Accessed: Nov. 07, 2024. [Online]. Available: https:\/\/www.asecho.org\/."},{"key":"10.1016\/j.cmpb.2025.108896_bib0037","unstructured":"\u2018European Association of Cardiovascular Imaging (EACVI)\u2019. Accessed: Nov. 07, 2024. [Online]. Available: https:\/\/www.escardio.org\/Sub-specialty-communities\/European-Association-of-Cardiovascular-Imaging-(EACVI)."},{"issue":"2","key":"10.1016\/j.cmpb.2025.108896_bib0038","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1378\/chest.104.2.618","article-title":"Left ventricular systolic dysfunction precipitated by verapamil in cardiac amyloidosis","volume":"104","author":"Pollak","year":"1993","journal-title":"Chest"},{"issue":"4","key":"10.1016\/j.cmpb.2025.108896_bib0039","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1002\/cpt.367","article-title":"Improved prediction of drug-induced torsades de pointes through simulations of dynamics and machine learning algorithms","volume":"100","author":"Lancaster","year":"2016","journal-title":"Clin. Pharmacol. Ther."},{"issue":"2","key":"10.1016\/j.cmpb.2025.108896_bib0040","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCEP.116.004628","article-title":"Improving the In silico assessment of proarrhythmia risk by combining hERG (Human Ether-\u00e0-go-go-Related Gene) channel\u2013Drug binding kinetics and multichannel pharmacology","volume":"10","author":"Li","year":"2017","journal-title":"Circ. Arrhythm. Electrophysiol."},{"issue":"10","key":"10.1016\/j.cmpb.2025.108896_bib0041","doi-asserted-by":"crossref","first-page":"5172","DOI":"10.1021\/acs.jcim.0c00201","article-title":"Silico classifiers for the assessment of drug proarrhythmicity","volume":"60","author":"Llopis-Lorente","year":"2020","journal-title":"J. Chem. Inf. Model"},{"key":"10.1016\/j.cmpb.2025.108896_bib0042","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2022.1080190","article-title":"qInward variability-based in-silico proarrhythmic risk assessment of drugs using deep learning model","volume":"13","author":"Jeong","year":"2022","journal-title":"Front. Physiol."},{"key":"10.1016\/j.cmpb.2025.108896_bib0043","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2021.761691","article-title":"Assessment of drug proarrhythmicity using artificial neural networks with in silico deterministic model outputs","volume":"12","author":"Yoo","year":"2021","journal-title":"Front. Physiol."},{"key":"10.1016\/j.cmpb.2025.108896_bib0044","series-title":"Electromechanical modelling and simulation of hiPSC-derived cardiac cell cultures, DuEPublico: Duisburg-Essen Publications online","author":"Jung","year":"2021"},{"issue":"5","key":"10.1016\/j.cmpb.2025.108896_bib0045","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1016\/S0735-1097(99)00006-6","article-title":"Drug-induced heart failure","volume":"33","author":"Feenstra","year":"1999","journal-title":"J. Am. Coll. Cardiol."},{"issue":"6","key":"10.1016\/j.cmpb.2025.108896_bib0046","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1016\/0002-9149(80)90367-7","article-title":"Effects of nifedipine on electrical activity of cardiac cells","volume":"46","author":"Dangman","year":"1980","journal-title":"Am. J. Cardiol."},{"issue":"3","key":"10.1016\/j.cmpb.2025.108896_bib0047","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1161\/01.RES.52.3.302","article-title":"Reflex chronotropic and inotropic effects of calcium channel-blocking agents in conscious dogs. Diltiazem, verapamil, and nifedipine compared","volume":"52","author":"Nakaya","year":"1983","journal-title":"Circ. Res."},{"issue":"1","key":"10.1016\/j.cmpb.2025.108896_bib0048","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-022-26889-2","article-title":"Mechanism based therapies enable personalised treatment of hypertrophic cardiomyopathy","volume":"12","author":"Margara","year":"2022","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.cmpb.2025.108896_bib0049","doi-asserted-by":"crossref","first-page":"7692","DOI":"10.1038\/s41598-020-64657-2","article-title":"Multiparametric mechanistic profiling of inotropic drugs in adult Human primary cardiomyocytes","volume":"10","author":"Abi-Gerges","year":"2020","journal-title":"Sci. Rep."},{"issue":"6","key":"10.1016\/j.cmpb.2025.108896_bib0050","doi-asserted-by":"crossref","DOI":"10.1161\/CIR.0000000000000426","article-title":"Drugs that may cause or exacerbate Heart failure: A scientific statement from the American Heart Association","volume":"134","author":"Page","year":"2016","journal-title":"Circulation"},{"issue":"3","key":"10.1016\/j.cmpb.2025.108896_bib0051","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/j.jacbts.2023.07.013","article-title":"Assessing cardiac contractility from single molecules to whole hearts","volume":"9","author":"Garg","year":"2024","journal-title":"JACC Basic Transl. Sci."},{"issue":"5","key":"10.1016\/j.cmpb.2025.108896_bib0052","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1016\/S0735-1097(99)00006-6","article-title":"Drug-induced heart failure","volume":"33","author":"Feenstra","year":"1999","journal-title":"J. Am. Coll. Cardiol."},{"issue":"5","key":"10.1016\/j.cmpb.2025.108896_bib0053","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1007\/BF00878548","article-title":"Vascular selective calcium entry blockers in the treatment of cardiovascular disorders: focus on felodipine","volume":"9","author":"Little","year":"1995","journal-title":"Cardiovasc. Drugs Ther."},{"issue":"2-3","key":"10.1016\/j.cmpb.2025.108896_bib0054","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/S0014-2999(99)00528-2","article-title":"Cardiac inotropic vs. chronotropic selectivity of isradipine, nifedipine and clevidipine, a new ultrashort-acting dihydropyridine","volume":"380","author":"Segawa","year":"1999","journal-title":"Eur. J. Pharmacol."},{"issue":"3","key":"10.1016\/j.cmpb.2025.108896_bib0055","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1111\/j.2042-7158.1985.tb05047.x","article-title":"Metronidazole-induced myocardial depression: chemical and pharmacological studies on the role of calcium in-vitro","volume":"37","author":"Essien","year":"1985","journal-title":"J. Pharm. Pharmacol."},{"issue":"3","key":"10.1016\/j.cmpb.2025.108896_bib0056","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1124\/jpet.103.062182","article-title":"Cardiac ion channel effects of tolterodine","volume":"308","author":"Kang","year":"2004","journal-title":"J. Pharmacol. Exp. Ther."},{"issue":"8","key":"10.1016\/j.cmpb.2025.108896_bib0057","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1038\/s44161-024-00505-0","article-title":"Aficamten is a small-molecule cardiac myosin inhibitor designed to treat hypertrophic cardiomyopathy","volume":"3","author":"Hartman","year":"2024","journal-title":"Nat. Cardiovasc. Res."},{"key":"10.1016\/j.cmpb.2025.108896_bib0058","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2018\/4737489","article-title":"Influence of amiodarone and Dronedarone on the force-interval dependence of rat myocardium","volume":"2018","author":"Kondratieva","year":"2018","journal-title":"BioMed Res. Int."},{"issue":"3","key":"10.1016\/j.cmpb.2025.108896_bib0059","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1093\/cvr\/24.3.182","article-title":"Negative inotropic effects of amiodarone on isolated guinea pig papillary muscle","volume":"24","author":"Aomine","year":"1990","journal-title":"Cardiovasc. Res."},{"issue":"10253","key":"10.1016\/j.cmpb.2025.108896_bib0060","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/S0140-6736(20)31792-X","article-title":"Mavacamten for treatment of symptomatic obstructive hypertrophic cardiomyopathy (EXPLORER-HCM): a randomised, double-blind, placebo-controlled, phase 3 trial","volume":"396","author":"Olivotto","year":"2020","journal-title":"The Lancet"},{"issue":"10","key":"10.1016\/j.cmpb.2025.108896_bib0061","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1161\/CIRCULATIONAHA.121.056324","article-title":"Myosin modulation in hypertrophic cardiomyopathy and systolic heart failure: getting inside the engine","volume":"144","author":"Daniels","year":"2021","journal-title":"Circulation"},{"issue":"7","key":"10.1016\/j.cmpb.2025.108896_bib0062","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1016\/j.jchf.2023.04.018","article-title":"Cardiac myosin inhibitors for managing obstructive hypertrophic cardiomyopathy","volume":"11","author":"Ostrominski","year":"2023","journal-title":"JACC Heart Fail"},{"issue":"5","key":"10.1016\/j.cmpb.2025.108896_bib0063","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2021.101297","article-title":"Cardiac myosin contraction and mechanotransduction in health and disease","volume":"297","author":"Barrick","year":"2021","journal-title":"J. Biol. Chem."},{"issue":"8","key":"10.1016\/j.cmpb.2025.108896_bib0064","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1038\/s44161-024-00503-2","article-title":"Aficamten reduces cardiac contractility by modifying the actomyosin interaction","volume":"3","author":"Moussavi-Harami","year":"2024","journal-title":"Nat. Cardiovasc. Res."},{"issue":"5","key":"10.1016\/j.cmpb.2025.108896_bib0065","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1007\/s00424-012-1147-2","article-title":"Properties of blebbistatin for cardiac optical mapping and other imaging applications","volume":"464","author":"Swift","year":"2012","journal-title":"Pfl\u00fcg. Arch. - Eur. J. Physiol."},{"issue":"4","key":"10.1016\/j.cmpb.2025.108896_bib0066","doi-asserted-by":"crossref","first-page":"1862","DOI":"10.1002\/ehf2.12752","article-title":"Potentially harmful drug prescription in elderly patients with heart failure with reduced ejection fraction","volume":"7","author":"Alvarez","year":"2020","journal-title":"ESC Heart Fail"},{"issue":"6","key":"10.1016\/j.cmpb.2025.108896_bib0067","doi-asserted-by":"crossref","first-page":"e32","DOI":"10.1161\/CIR.0000000000000426","article-title":"Drugs that may cause or exacerbate heart failure","volume":"134","author":"Page","year":"2016","journal-title":"Circulation"},{"issue":"11","key":"10.1016\/j.cmpb.2025.108896_bib0068","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1016\/j.amjmed.2021.06.013","article-title":"Trends in calcium channel blocker use in patients with heart failure with reduced ejection fraction and comorbid atrial fibrillation","volume":"134","author":"Cholack","year":"2021","journal-title":"Am. J. Med."},{"key":"10.1016\/j.cmpb.2025.108896_bib0069","unstructured":"\u2018S 7 B The nonclinical Evaluation of the Potential for delayed Ventricular Repolarization (QT Interval Prolongation) by Human Pharmaceuticals\u2019, [Online]. Available: https:\/\/www.ema.europa.eu\/en\/ich-s7b-non-clinical-evaluation-potential-delayed-ventricular-repolarization-qt-interval-prolongation-human-pharmaceuticals-scientific-guideline."},{"key":"10.1016\/j.cmpb.2025.108896_bib0070","unstructured":"\u2018S 7 A Safety Pharmacology Studies for Human Pharmaceuticals\u2019. [Online]. Available: https:\/\/www.ema.europa.eu\/en\/ich-s7a-safety-pharmacology-studies-human-pharmaceuticals-scientific-guideline."},{"issue":"6","key":"10.1016\/j.cmpb.2025.108896_bib0071","doi-asserted-by":"crossref","DOI":"10.1088\/2057-1976\/ad7268","article-title":"Automatic motion estimation with applications to hiPSC-CMs","volume":"10","author":"Finsberg","year":"2024","journal-title":"Biomed. Phys. Eng. Express"},{"key":"10.1016\/j.cmpb.2025.108896_bib0072","doi-asserted-by":"crossref","first-page":"917","DOI":"10.3389\/fphys.2017.00917","article-title":"Uncertainty quantification reveals the importance of data variability and experimental design considerations for in Silico proarrhythmia risk assessment","volume":"8","author":"Chang","year":"2017","journal-title":"Front. Physiol."},{"issue":"3","key":"10.1016\/j.cmpb.2025.108896_bib0073","doi-asserted-by":"crossref","first-page":"1779","DOI":"10.1021\/acs.jcim.9b01085","article-title":"When does the IC50 accurately assess the blocking potency of a drug?","volume":"60","author":"Gomis-Tena","year":"2020","journal-title":"J. Chem. Inf. Model."},{"issue":"2","key":"10.1016\/j.cmpb.2025.108896_bib0074","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1002\/pst.426","article-title":"Guidelines for accurate EC50\/IC50 estimation","volume":"10","author":"Sebaugh","year":"2011","journal-title":"Pharm. Stat."},{"issue":"20","key":"10.1016\/j.cmpb.2025.108896_bib0075","doi-asserted-by":"crossref","first-page":"17931","DOI":"10.1021\/acs.jmedchem.4c02052","article-title":"Dose\u2013Response curves and the determination of IC50 and EC50 values","volume":"67","author":"Srinivasan","year":"2024","journal-title":"J. Med. Chem."},{"issue":"4","key":"10.1016\/j.cmpb.2025.108896_bib0076","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1021\/acs.jcim.7b00440","article-title":"In Silico QT and APD prolongation assay for early screening of drug-induced proarrhythmic risk","volume":"58","author":"Romero","year":"2018","journal-title":"J. Chem. Inf. Model."},{"issue":"5","key":"10.1016\/j.cmpb.2025.108896_bib0077","doi-asserted-by":"crossref","DOI":"10.1172\/JCI148557","article-title":"Myosin modulators: emerging approaches for the treatment of cardiomyopathies and heart failure","volume":"132","author":"Day","year":"2022","journal-title":"J. Clin. Invest."},{"issue":"3","key":"10.1016\/j.cmpb.2025.108896_bib0078","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1113\/jphysiol.2006.111252","article-title":"The inotropic effect of cardioactive glycosides in ventricular myocytes requires Na+ \u2013Ca2+ exchanger function","volume":"575","author":"Altamirano","year":"2006","journal-title":"J. Physiol."},{"issue":"2","key":"10.1016\/j.cmpb.2025.108896_bib0079","first-page":"62","article-title":"Negative inotropic effect of inhalation anaesthetics and the compensation of this effect by cardiac glycosides]","volume":"22","author":"Benthe","year":"1973","journal-title":"Anaesthesist"},{"issue":"4","key":"10.1016\/j.cmpb.2025.108896_bib0080","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1002\/med.21476","article-title":"Comprehensive review of cardiovascular toxicity of drugs and related agents","volume":"38","author":"Mlad\u011bnka","year":"2018","journal-title":"Med. Res. Rev."},{"key":"10.1016\/j.cmpb.2025.108896_bib0081","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2025.1500668","article-title":"In silico predictions of drug-induced changes in human cardiac contractility align with experimental recordings","volume":"16","author":"Trovato","year":"2025","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.cmpb.2025.108896_bib0082","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.yjmcc.2016.10.018","article-title":"Sarcoplasmic reticulum Ca 2+, Mg 2+, K +, and Cl \u2212 concentrations adjust quickly as heart rate changes","volume":"103","author":"Berti","year":"2017","journal-title":"J. Mol. Cell. Cardiol."},{"issue":"2","key":"10.1016\/j.cmpb.2025.108896_bib0083","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1002\/cpt.2240","article-title":"Sex-specific classification of drug-induced Torsade de pointes susceptibility using cardiac simulations and machine learning","volume":"110","author":"Fogli Iseppe","year":"2021","journal-title":"Clin. Pharmacol. Ther."}],"container-title":["Computer Methods and Programs in Biomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S016926072500313X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S016926072500313X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T13:40:47Z","timestamp":1778766047000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S016926072500313X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":83,"alternative-id":["S016926072500313X"],"URL":"https:\/\/doi.org\/10.1016\/j.cmpb.2025.108896","relation":{},"ISSN":["0169-2607"],"issn-type":[{"value":"0169-2607","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Integration of electrophysiological and mechanical biomarkers in cardiac risk assessment models","name":"articletitle","label":"Article Title"},{"value":"Computer Methods and Programs in Biomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cmpb.2025.108896","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"108896"}}