{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T06:50:24Z","timestamp":1788591024707,"version":"build-2803163510"},"reference-count":55,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,8,5]],"date-time":"2025-08-05T00:00:00Z","timestamp":1754352000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010661","name":"Horizon 2020 Framework Programme","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010661","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004462","name":"National Research Council","doi-asserted-by":"publisher","award":["826121"],"award-info":[{"award-number":["826121"]}],"id":[{"id":"10.13039\/501100004462","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Computer Methods and Programs in Biomedicine"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1016\/j.cmpb.2025.108917","type":"journal-article","created":{"date-parts":[[2025,6,25]],"date-time":"2025-06-25T02:41:15Z","timestamp":1750819275000},"page":"108917","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Mimicking cancer therapy in an agent-based model: The case of hepatoblastoma"],"prefix":"10.1016","volume":"269","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0228-1806","authenticated-orcid":false,"given":"Alessandro","family":"Ravoni","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0023-7943","authenticated-orcid":false,"given":"Enrico","family":"Mastrostefano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8581-2803","authenticated-orcid":false,"given":"Roland","family":"Kappler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4690-4027","authenticated-orcid":false,"given":"Carolina","family":"Armengol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1442-3552","authenticated-orcid":false,"given":"Filippo","family":"Castiglione","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7601-321X","authenticated-orcid":false,"given":"Christine","family":"Nardini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cmpb.2025.108917_b1","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1053\/j.semdp.2016.12.015","article-title":"Hepatoblastoma","volume":"34","author":"Sharma","year":"2017","journal-title":"Semin. Diagn. Pathol."},{"key":"10.1016\/j.cmpb.2025.108917_b2","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1634\/theoncologist.5-6-445","article-title":"Childhood cancers: Hepatoblastoma","volume":"5","author":"Herzog","year":"2000","journal-title":"Oncol."},{"key":"10.1016\/j.cmpb.2025.108917_b3","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1016\/j.jhep.2024.01.003","article-title":"A novel treatment strategy utilizing panobinostat for high-risk and treatment-refractory hepatoblastoma","volume":"80","author":"Espinoza","year":"2024","journal-title":"J. Hepatol."},{"key":"10.1016\/j.cmpb.2025.108917_b4","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1007\/s11912-022-01230-2","article-title":"Current approaches in hepatoblastoma-new biological insights to inform therapy","volume":"24","author":"Wu","year":"2022","journal-title":"Curr. Oncol. Rep."},{"key":"10.1016\/j.cmpb.2025.108917_b5","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1016\/S1470-2045(13)70272-9","article-title":"Dose-dense cisplatin-based chemotherapy and surgery for children with high-risk hepatoblastoma (SIOPEL-4): a prospective, single-arm, feasibility study","volume":"14","author":"Zsiros","year":"2013","journal-title":"Lancet Oncol."},{"key":"10.1016\/j.cmpb.2025.108917_b6","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/S0010-4825(01)00011-7","article-title":"Design and implementation of an immune system simulator","volume":"31","author":"Bernaschi","year":"2001","journal-title":"Comput. Biol. Med."},{"key":"10.1016\/j.cmpb.2025.108917_b7","series-title":"Immune System Modelling and Simulation","author":"Castiglione","year":"2020"},{"issue":"2009","key":"10.1016\/j.cmpb.2025.108917_b8","first-page":"159","article-title":"Agent-based models in translational systems biology","volume":"1","author":"An","year":"2009","journal-title":"Wiley Interdiscip. Rev.: Syst. Biol. Med."},{"key":"10.1016\/j.cmpb.2025.108917_b9","doi-asserted-by":"crossref","DOI":"10.1016\/j.cmpb.2024.108046","article-title":"A simple agent-based hybrid model to simulate the biophysics of glioblastoma multiforme cells and the concomitant evolution of the oxygen field","volume":"246","author":"Saucedo-Mora","year":"2024","journal-title":"Comput. Methods Programs Biomed."},{"key":"10.1016\/j.cmpb.2025.108917_b10","doi-asserted-by":"crossref","DOI":"10.1016\/j.cmpb.2024.108331","article-title":"An agent-based method to estimate 3D cell migration trajectories from 2D measurements: Quantifying and comparing T vs CAR-T 3D cell migration","volume":"255","author":"Camacho-Gomez","year":"2024","journal-title":"Comput. Methods Programs Biomed."},{"key":"10.1016\/j.cmpb.2025.108917_b11","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1016\/j.jtbi.2005.04.024","article-title":"Computational modeling of the immune response to tumor antigens","volume":"237","author":"Castiglione","year":"2005","journal-title":"J. Theor. Biol."},{"key":"10.1016\/j.cmpb.2025.108917_b12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jtbi.2012.05.015","article-title":"Modelling the effects of cell-cycle heterogeneity on the response of a solid tumour to chemotherapy: Biological insights from a hybrid multiscale cellular automaton model","volume":"308","author":"Powathil","year":"2012","journal-title":"J. Theor. Biol."},{"key":"10.1016\/j.cmpb.2025.108917_b13","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1111\/cpr.13187","article-title":"A multiscale cell-based model of tumor growth for chemotherapy assessment and tumor-targeted therapy through a 3D computational approach","volume":"55","author":"Jafari Nivlouei","year":"2022","journal-title":"Cell Prolif."},{"key":"10.1016\/j.cmpb.2025.108917_b14","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1186\/1471-2105-11-S7-S13","article-title":"Modeling the competition between lung metastases and the immune system using agents","volume":"11","author":"Pennisi","year":"2010","journal-title":"BMC Bioinform."},{"key":"10.1016\/j.cmpb.2025.108917_b15","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1002\/j.1538-7305.1950.tb00463.x","article-title":"Error detecting and error correcting codes","volume":"29","author":"Hamming","year":"1950","journal-title":"Bell Syst. Tech. J."},{"key":"10.1016\/j.cmpb.2025.108917_b16","doi-asserted-by":"crossref","first-page":"505","DOI":"10.4161\/cc.8.3.7608","article-title":"Does the cell number 10-9 still really fit one gram of tumor tissue?","volume":"8","author":"Del Monte","year":"2009","journal-title":"Cell Cycle"},{"key":"10.1016\/j.cmpb.2025.108917_b17","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1051\/mmnp\/20127312","article-title":"Mathematical and computational models in tumor immunology","volume":"7","author":"Pappalardo","year":"2012","journal-title":"Math. Model. Nat. Phenom."},{"key":"10.1016\/j.cmpb.2025.108917_b18","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2021-002694","article-title":"Identification and validation of viral antigens sharing sequence and structural homology with tumor-associated antigens (TAAs)","volume":"9","author":"Ragone","year":"2021","journal-title":"J. ImmunoTherapy Cancer"},{"key":"10.1016\/j.cmpb.2025.108917_b19","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1111\/imm.13114","article-title":"Cancer immune escape: MHC expression in primary tumours versus metastases","volume":"158","author":"Garrido","year":"2019","journal-title":"Immunol."},{"key":"10.1016\/j.cmpb.2025.108917_b20","first-page":"33","article-title":"A short introduction to pharmacokinetics","volume":"6","author":"Urso","year":"2002","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"10.1016\/j.cmpb.2025.108917_b21","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1002\/pst.426","article-title":"Guidelines for accurate EC50\/IC50 estimation","volume":"10","author":"Sebaugh","year":"2011","journal-title":"Pharm. Stat."},{"key":"10.1016\/j.cmpb.2025.108917_b22","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.ccr.2008.11.002","article-title":"Hepatic stem-like phenotype and interplay of Wnt \/ \u03b2 -catenin and Myc signaling in aggressive childhood liver cancer","volume":"14","author":"Cairo","year":"2008","journal-title":"Cancer Cell."},{"key":"10.1016\/j.cmpb.2025.108917_b23","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1097\/HEP.0000000000000601","article-title":"Computational drug prediction in hepatoblastoma by integrating pan-cancer transcriptomics with pharmacological response","volume":"80","author":"Failli","year":"2023","journal-title":"Hepatol."},{"key":"10.1016\/j.cmpb.2025.108917_b24","article-title":"Bridging molecular basis, prognosis, and treatment of pediatric liver tumors","volume":"7","author":"Armengol","year":"2021","journal-title":"Hr"},{"key":"10.1016\/j.cmpb.2025.108917_b25","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.ejca.2020.09.026","article-title":"A combined clinical and biological risk classification improves prediction of outcome in hepatoblastoma patients","volume":"141","author":"Cairo","year":"2020","journal-title":"Eur. J. Cancer"},{"key":"10.1016\/j.cmpb.2025.108917_b26","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/j.jhep.2020.03.025","article-title":"Epigenetic footprint enables molecular risk stratification of hepatoblastoma with clinical implications","volume":"73","author":"Carrillo-Reixach","year":"2020","journal-title":"J. Hepatol."},{"key":"10.1016\/j.cmpb.2025.108917_b27","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1097\/MOP.0000000000000042","article-title":"Hepatoblastoma state of the art","volume":"26","author":"Meyers","year":"2014","journal-title":"Curr. Opin. Pediatr."},{"key":"10.1016\/j.cmpb.2025.108917_b28","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1111\/hpb.12157","article-title":"Three-dimensional volumetry in 107 normal livers reveals clinically relevant inter-segment variation in size","volume":"16","author":"Mise","year":"2014","journal-title":"HPB"},{"key":"10.1016\/j.cmpb.2025.108917_b29","doi-asserted-by":"crossref","first-page":"326","DOI":"10.4253\/wjge.v10.i11.326","article-title":"Stepwise evaluation of liver sectors and liver segments by endoscopic ultrasound","volume":"10","author":"Sharma","year":"2018","journal-title":"World J. Gastrointest. Endosc."},{"key":"10.1016\/j.cmpb.2025.108917_b30","doi-asserted-by":"crossref","first-page":"1823","DOI":"10.1016\/S0959-8049(97)00341-9","article-title":"Cisplatin pharmacokinetics in children with cancer","volume":"33","author":"Peng","year":"1997","journal-title":"Eur. J. Cancer"},{"key":"10.1016\/j.cmpb.2025.108917_b31","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1186\/s13046-024-03221-6","article-title":"Drug prioritization identifies panobinostat as a tailored treatment element for patients with metastatic hepatoblastoma","volume":"43","author":"Demir","year":"2024","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"10.1016\/j.cmpb.2025.108917_b32","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1091\/mbc.E19-09-0515","article-title":"The effects of proliferation status and cell cycle phase on the responses of single cells to chemotherapy","volume":"31","author":"Granada","year":"2020","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.cmpb.2025.108917_b33","doi-asserted-by":"crossref","first-page":"5384","DOI":"10.1158\/1078-0432.CCR-14-1298","article-title":"Cisplatin-induced antitumor immunomodulation: A review of preclinical and clinical evidence","volume":"20","author":"Biasi","year":"2014","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.cmpb.2025.108917_b34","doi-asserted-by":"crossref","first-page":"1662","DOI":"10.1056\/NEJMoa0810613","article-title":"Cisplatin versus cisplatin plus doxorubicin for standard-risk hepatoblastoma","volume":"361","author":"Perilongo","year":"2009","journal-title":"New Engl. J. Med."},{"key":"10.1016\/j.cmpb.2025.108917_b35","doi-asserted-by":"crossref","DOI":"10.1186\/s12885-021-08893-3","article-title":"Development and validation of genomic and epigenomic signatures associated with tumor immune microenvironment in hepatoblastoma","volume":"21","author":"Zhang","year":"2021","journal-title":"BMC Cancer"},{"key":"10.1016\/j.cmpb.2025.108917_b36","doi-asserted-by":"crossref","DOI":"10.1080\/2162402X.2019.1583547","article-title":"APC germline hepatoblastomas demonstrate cisplatin-induced intratumor tertiary lymphoid structures","volume":"8","author":"Morcrette","year":"2019","journal-title":"OncoImmunology"},{"key":"10.1016\/j.cmpb.2025.108917_b37","doi-asserted-by":"crossref","DOI":"10.2217\/hep-2019-0007","article-title":"The role of the innate immune system in the development and treatment of hepatocellular carcinoma","volume":"7","author":"Roderburg","year":"2020","journal-title":"Hepatic Oncol."},{"key":"10.1016\/j.cmpb.2025.108917_b38","series-title":"Standard Liver Volume-Predicting Formulae Derived from Normal Liver Volume in Children under 18 Years of Age","author":"Yang","year":"2021"},{"key":"10.1016\/j.cmpb.2025.108917_b39","doi-asserted-by":"crossref","first-page":"23","DOI":"10.4274\/Mirt.138","article-title":"Limits of tumor detectability in nuclear medicine and PET","volume":"21","author":"Erdi","year":"2012","journal-title":"Mol. Imaging Radionucl. Ther."},{"key":"10.1016\/j.cmpb.2025.108917_b40","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pcbi.1003800","article-title":"Classical mathematical models for description and prediction of experimental tumor growth","volume":"10","author":"Benzekry","year":"2014","journal-title":"PLoS Comput. Biol."},{"key":"10.1016\/j.cmpb.2025.108917_b41","doi-asserted-by":"crossref","first-page":"2013","DOI":"10.1002\/1097-0142(19930315)71:6<2013::AID-CNCR2820710615>3.0.CO;2-V","article-title":"Decelerating growth and human breast cancer","volume":"71","author":"Spratt","year":"1993","journal-title":"Cancer"},{"key":"10.1016\/j.cmpb.2025.108917_b42","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/0022-3468(75)90095-0","article-title":"Liver tumors in children in the particular reference to hepatoblastoma and hepatocellular carcinoma: American Academy of pediatrics surgical section survey \u2014 1974","volume":"10","author":"Exelby","year":"1975","journal-title":"J. Pediatr. Surg."},{"key":"10.1016\/j.cmpb.2025.108917_b43","doi-asserted-by":"crossref","first-page":"201","DOI":"10.4103\/0971-9261.142001","article-title":"The treatment of hepatoblastoma: Its evolution and the current status as per the SIOPEL trials","volume":"19","author":"Aronson","year":"2014","journal-title":"J. Indian Assoc. Pediatr. Surg."},{"key":"10.1016\/j.cmpb.2025.108917_b44","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1007\/s10147-018-1285-4","article-title":"Rapid decrease of serum alpha-fetoprotein and tumor volume predicts outcome in children with hepatoblastoma treated with neoadjuvant chemotherapy","volume":"23","author":"Nguyen","year":"2018","journal-title":"Int. J. Clin. Oncol."},{"key":"10.1016\/j.cmpb.2025.108917_b45","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1002\/jgm.1452","article-title":"Differential antitumor effect of interleukin-12 family cytokines on orthotopic hepatocellular carcinoma","volume":"12","author":"Lo","year":"2010","journal-title":"J. Gene Med."},{"key":"10.1016\/j.cmpb.2025.108917_b46","doi-asserted-by":"crossref","first-page":"4345","DOI":"10.3748\/wjg.v13.i32.4345","article-title":"Role of serum interleukin-18 as a prognostic factor in patients with hepatocellular carcinoma","volume":"13","author":"Tangkijvanich","year":"2007","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.cmpb.2025.108917_b47","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.31557\/APJCP.2021.22.4.1105","article-title":"IL-4, IL-17 and CD163 immunoexpression and IL-6 gene polymorphism in chronic hepatitis c patients and associated hepatocellular carcinoma","volume":"22","author":"Aboushousha","year":"2021","journal-title":"Asian Pac. J. Cancer Prev."},{"key":"10.1016\/j.cmpb.2025.108917_b48","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1053\/jhep.2000.9409","article-title":"Interferon beta prevents recurrence of hepatocellular carcinoma after complete resection or ablation of the primary tumor\u2014A prospective randomized study of hepatitis c virus\u2013related liver cancer","volume":"32","author":"Ikeda","year":"2000","journal-title":"Hepatol."},{"key":"10.1016\/j.cmpb.2025.108917_b49","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1002\/hep.29672","article-title":"New insights into diagnosis and therapeutic options for proliferative hepatoblastoma","volume":"68","author":"Hooks","year":"2018","journal-title":"Hepatol."},{"key":"10.1016\/j.cmpb.2025.108917_b50","series-title":"Introduction To Probability Models","isbn-type":"print","author":"Ross","year":"2010","ISBN":"https:\/\/id.crossref.org\/isbn\/9780123756862"},{"issue":"7","key":"10.1016\/j.cmpb.2025.108917_b51","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1111\/eva.13571","article-title":"The paradox of cooperation among selfish cancer cells","volume":"16","author":"Capp","year":"2023","journal-title":"Evol. Appl."},{"key":"10.1016\/j.cmpb.2025.108917_b52","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1038\/bjc.1965.32","article-title":"Dynamics of tumour growth: Comparison of growth rates and extrapolation of growth curve to one cell","volume":"19","author":"Laird","year":"1965","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.cmpb.2025.108917_b53","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.xphs.2023.10.022","article-title":"Physiologically-based modeling and interspecies prediction of cisplatin pharmacokinetics","volume":"113","author":"X","year":"2024","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.cmpb.2025.108917_b54","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1080\/14737140.2018.1527689","article-title":"Mathematical models of tumor cell proliferation: A review of the literature","volume":"18","author":"Jarrett","year":"2018","journal-title":"Expert. Rev. Anticancer. Ther."},{"key":"10.1016\/j.cmpb.2025.108917_b55","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S0951-8320(03)00058-9","article-title":"Latin hypercube sampling and the propagation of uncertainty in analyses of complex systems","volume":"81","author":"Helton","year":"2003","journal-title":"Reliab. Eng. Syst. Saf."}],"container-title":["Computer Methods and Programs in Biomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0169260725003347?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0169260725003347?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T13:40:56Z","timestamp":1778766056000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0169260725003347"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":55,"alternative-id":["S0169260725003347"],"URL":"https:\/\/doi.org\/10.1016\/j.cmpb.2025.108917","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2025.02.07.25321671","asserted-by":"object"}]},"ISSN":["0169-2607"],"issn-type":[{"value":"0169-2607","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mimicking cancer therapy in an agent-based model: The case of hepatoblastoma","name":"articletitle","label":"Article Title"},{"value":"Computer Methods and Programs in Biomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cmpb.2025.108917","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"108917"}}