{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T06:15:47Z","timestamp":1790403347927,"version":"4.1.0"},"reference-count":86,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["RGPIN-2017-05349"],"award-info":[{"award-number":["RGPIN-2017-05349"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Computer Methods and Programs in Biomedicine"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.cmpb.2025.109071","type":"journal-article","created":{"date-parts":[[2025,9,6]],"date-time":"2025-09-06T22:20:28Z","timestamp":1757197228000},"page":"109071","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Precision CT-based Aortic Valve Reconstruction: Minimal Variation Geometry Invariant Parametric Reconstruction Approach for Aortic Stenosis and Bicuspid Valves"],"prefix":"10.1016","volume":"273","author":[{"given":"Mohamed","family":"Abdelkhalek","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zahra","family":"Keshavarz-Motamed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"12","key":"10.1016\/j.cmpb.2025.109071_bib0001","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1038\/s41569-021-00570-z","article-title":"Global epidemiology of valvular heart disease","volume":"18","author":"Coffey","year":"2021","journal-title":"Nat Rev Cardiol"},{"issue":"1","key":"10.1016\/j.cmpb.2025.109071_bib0002","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/nrdp.2016.6","article-title":"Calcific aortic stenosis","volume":"2","author":"Lindman","year":"2016","journal-title":"Nature Reviews Disease Primers"},{"key":"10.1016\/j.cmpb.2025.109071_bib0003","series-title":"Clinical and Surgical Aspects of Congenital Heart Diseases : Text and Study Guide","first-page":"121","article-title":"Bicuspid Aortic Valve","author":"Khan","year":"2023"},{"issue":"11","key":"10.1016\/j.cmpb.2025.109071_bib0004","doi-asserted-by":"crossref","first-page":"1632","DOI":"10.1016\/j.amjcard.2012.01.390","article-title":"Frequency of Congenitally Bicuspid Aortic Valves in Patients \u226580 Years of Age Undergoing Aortic Valve Replacement for Aortic Stenosis (With or Without Aortic Regurgitation) and Implications for Transcatheter Aortic Valve Implantation","volume":"109","author":"Roberts","year":"2012","journal-title":"The American Journal of Cardiology"},{"issue":"5","key":"10.1016\/j.cmpb.2025.109071_bib0005","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.119.015063","article-title":"Mixed Valvular Disease Following Transcatheter Aortic Valve Replacement: Quantification and Systematic Differentiation Using Clinical Measurements and Image-Based Patient-Specific In Silico Modeling","volume":"9","author":"Keshavarz-Motamed","year":"2020","journal-title":"Journal of the American Heart Association"},{"key":"10.1016\/j.cmpb.2025.109071_bib0006","article-title":"A Decade of Revolutions in Calcific Aortic Stenosis","volume":"38","author":"Clavel","year":"2020","journal-title":"W.B. Saunders"},{"issue":"9","key":"10.1016\/j.cmpb.2025.109071_bib0007","first-page":"1224","article-title":"Patterns and Structure of Calcification in Aortic Stenosis","volume":"16","author":"Abdelkhalek","year":"2023","journal-title":"JACC: Cardiovascular Imaging"},{"issue":"1","key":"10.1016\/j.cmpb.2025.109071_bib0008","article-title":"A Doppler-exclusive non-invasive computational diagnostic framework for personalized transcatheter aortic valve replacement","volume":"13","author":"Bahadormanesh","year":"2023","journal-title":"Sci Rep"},{"issue":"1","key":"10.1016\/j.cmpb.2025.109071_bib0009","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jcct.2018.11.008","article-title":"Computed tomography imaging in the context of transcatheter aortic valve implantation (TAVI) \/transcatheter aortic valve replacement (TAVR): An expert consensus document of the Society of Cardiovascular Computed Tomography","volume":"13","author":"Blanke","year":"2019","journal-title":"Journal of Cardiovascular Computed Tomography"},{"key":"10.1016\/j.cmpb.2025.109071_bib0010","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/s12410-016-9383-z","article-title":"The Role of Imaging in Aortic Valve Disease","volume":"9","author":"Everett","year":"2016","journal-title":"Curr Cardiovasc Imaging Rep"},{"issue":"4","key":"10.1016\/j.cmpb.2025.109071_bib0011","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/j.echo.2017.02.009","article-title":"Recommendations on the Echocardiographic Assessment of Aortic Valve Stenosis: A Focused Update from the European Association of Cardiovascular Imaging and the American Society of Echocardiography","volume":"30","author":"Baumgartner","year":"2017","journal-title":"Journal of the American Society of Echocardiography"},{"issue":"1","key":"10.1016\/j.cmpb.2025.109071_bib0012","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.crad.2020.04.007","article-title":"Imaging aortic valve calcification: significance, approach and implications","volume":"76","author":"Fletcher","year":"2021","journal-title":"Clinical Radiology"},{"key":"10.1016\/j.cmpb.2025.109071_bib0013","volume":"7","author":"Wang","year":"2018"},{"key":"10.1016\/j.cmpb.2025.109071_bib0014","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1109\/RBME.2022.3142058","article-title":"Hemodynamic Modeling, Medical Imaging, and Machine Learning and Their Applications to Cardiovascular Interventions","volume":"16","author":"Kadem","year":"2023","journal-title":"IEEE Reviews in Biomedical Engineering"},{"key":"10.1016\/j.cmpb.2025.109071_bib0015","article-title":"Regional assessment of aortic valve calcification using topographic maps in contrast-enhanced CT: in-vivo sex and severity-based differences in calcific presentation","author":"Abdelkhalek","year":"2023","journal-title":"Quantitative Imaging in Medicine and Surgery"},{"key":"10.1016\/j.cmpb.2025.109071_bib0016","volume":"12","author":"Pawade","year":"2019"},{"issue":"3","key":"10.1016\/j.cmpb.2025.109071_bib0017","article-title":"Computed Tomography Aortic Valve Calcium Scoring in Patients with Aortic Stenosis","volume":"11","author":"Pawade","year":"2018","journal-title":"Circulation: Cardiovascular Imaging"},{"key":"10.1016\/j.cmpb.2025.109071_bib0018","series-title":"The ITK Software Guide Book2: Design and Functionality - Volume 2","author":"Johnson","year":"2015"},{"key":"10.1016\/j.cmpb.2025.109071_bib0019","series-title":"2007 Joint Meeting of the 6th International Symposium on Noninvasive Functional Source Imaging of the Brain and Heart and the International Conference on Functional Biomedical Imaging","first-page":"140","article-title":"Medical Image Segmentation: Methods and Software","author":"Withey","year":"2007"},{"key":"10.1016\/j.cmpb.2025.109071_bib0020","series-title":"Practical Signal and Image Processing in Clinical Cardiology","year":"2010"},{"issue":"3","key":"10.1016\/j.cmpb.2025.109071_bib0021","doi-asserted-by":"crossref","DOI":"10.1016\/j.jtcvs.2018.03.157","article-title":"Aortic root dynamism, geometry, and function after the remodeling operation: Clinical relevance","volume":"156","author":"Yacoub","year":"2018","journal-title":"The Journal of Thoracic and Cardiovascular Surgery"},{"issue":"3","key":"10.1016\/j.cmpb.2025.109071_bib0022","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.jcct.2021.11.014","article-title":"Patient-specific computer simulation to predict long-term outcomes after transcatheter aortic valve replacement","volume":"16","author":"Dowling","year":"2022","journal-title":"Journal of Cardiovascular Computed Tomography"},{"key":"10.1016\/j.cmpb.2025.109071_bib0023","article-title":"Towards a non-invasive computational diagnostic framework for personalized cardiology of transcatheter aortic valve replacement in interactions with complex valvular, ventricular and vascular disease","volume":"202\u2013203","author":"Khodaei","year":"2021","journal-title":"International Journal of Mechanical Sciences"},{"key":"10.1016\/j.cmpb.2025.109071_bib0024","doi-asserted-by":"crossref","DOI":"10.1016\/j.cmpb.2022.106647","article-title":"Development of an automatic modeling method for patient-specific aortic graft reconstruction guide in thoracoabdominal aortic repair","volume":"215","author":"Kim","year":"2022","journal-title":"Computer Methods and Programs in Biomedicine"},{"key":"10.1016\/j.cmpb.2025.109071_bib0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.compbiomed.2022.105440","article-title":"Design of an aortic polymeric valve with asymmetric leaflets and evaluation of its performance by finite element method","volume":"145","author":"Sarrafzadeh-Ghadimi","year":"2022","journal-title":"Computers in Biology and Medicine"},{"key":"10.1016\/j.cmpb.2025.109071_bib0026","doi-asserted-by":"crossref","DOI":"10.1016\/j.media.2023.102795","article-title":"An ultrasound-exclusive non-invasive computational diagnostic framework for personalized cardiology of aortic valve stenosis","volume":"87","author":"Bahadormanesh","year":"2023","journal-title":"Medical Image Analysis"},{"issue":"5","key":"10.1016\/j.cmpb.2025.109071_bib0027","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/j.jacc.2015.05.066","article-title":"Calcification in Aortic Stenosis: The Skeleton Key","volume":"66","author":"Pawade","year":"2015","journal-title":"Journal of the American College of Cardiology"},{"key":"10.1016\/j.cmpb.2025.109071_bib0028","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/9843275","article-title":"Automatic Detection of the Aortic Annular Plane and Coronary Ostia from Multidetector Computed Tomography","volume":"2020","author":"Astudillo","year":"2020","journal-title":"J Interv Cardiol"},{"issue":"1","key":"10.1016\/j.cmpb.2025.109071_bib0029","first-page":"99","article-title":"Automated Quantitative 3-Dimensional Modeling of the Aortic Valve and Root by 3-Dimensional Transesophageal Echocardiography in Normals, Aortic Regurgitation, and Aortic Stenosis","volume":"6","author":"Calleja","year":"2013","journal-title":"Circulation: Cardiovascular Imaging"},{"issue":"Suppl 2","key":"10.1016\/j.cmpb.2025.109071_bib0030","doi-asserted-by":"crossref","first-page":"s21","DOI":"10.1136\/heartjnl-2018-313514","article-title":"Patient-specific computer simulation for transcatheter cardiac interventions: what a clinician needs to know","volume":"105","author":"de Jaegere","year":"2019","journal-title":"Heart"},{"key":"10.1016\/j.cmpb.2025.109071_bib0031","doi-asserted-by":"crossref","DOI":"10.1016\/j.shj.2023.100180","article-title":"Early Detection of Risk of Neo-Sinus Blood Stasis Post-Transcatheter Aortic Valve Replacement Using Personalized Hemodynamic Analysis","author":"Khodaei","year":"2023","journal-title":"Structural Heart"},{"issue":"5","key":"10.1016\/j.cmpb.2025.109071_bib0032","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1007\/s12265-019-09877-2","article-title":"The Impact of Size and Position of a Mechanical Expandable Transcatheter Aortic Valve: Novel Insights Through Computational Modelling and Simulation","volume":"12","author":"Rocatello","year":"2019","journal-title":"J. of Cardiovasc. Trans. Res."},{"issue":"4","key":"10.1016\/j.cmpb.2025.109071_bib0033","doi-asserted-by":"crossref","first-page":"e3435","DOI":"10.1002\/cnm.3435","article-title":"Polygonal surface processing and mesh generation tools for the numerical simulation of the cardiac function","volume":"37","author":"Fedele","year":"2021","journal-title":"Int J Numer Method Biomed Eng"},{"key":"10.1016\/j.cmpb.2025.109071_bib0034","series-title":"Deformation Models: Tracking, Animation and Applications","first-page":"3","article-title":"Deformable Objects Representation","author":"Palmer","year":"2013"},{"issue":"12","key":"10.1016\/j.cmpb.2025.109071_bib0035","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1016\/S0965-9978(00)00060-0","article-title":"3D image acquisition and NURBS based geometry modelling of natural objects","volume":"31","author":"Moustakides","year":"2000","journal-title":"Advances in Engineering Software"},{"key":"10.1016\/j.cmpb.2025.109071_bib0036","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2023.104794","article-title":"Development and validation of a deep learning-based fully automated algorithm for pre-TAVR CT assessment of the aortic valvular complex and detection of anatomical risk factors: a retrospective, multicentre study","volume":"96","author":"Wang","year":"2023","journal-title":"eBioMedicine"},{"issue":"4","key":"10.1016\/j.cmpb.2025.109071_bib0037","doi-asserted-by":"crossref","first-page":"e2938","DOI":"10.1002\/cnm.2938","article-title":"A framework for designing patient-specific bioprosthetic heart valves using immersogeometric fluid\u2013structure interaction analysis","volume":"34","author":"Xu","year":"2018","journal-title":"International Journal for Numerical Methods in Biomedical Engineering"},{"key":"10.1016\/j.cmpb.2025.109071_bib0038","doi-asserted-by":"crossref","DOI":"10.1016\/j.compmedimag.2023.102289","article-title":"CardioVision: A fully automated deep learning package for medical image segmentation and reconstruction generating digital twins for patients with aortic stenosis","volume":"109","author":"Rouhollahi","year":"2023","journal-title":"Computerized Medical Imaging and Graphics"},{"key":"10.1016\/j.cmpb.2025.109071_bib0039","doi-asserted-by":"crossref","DOI":"10.1016\/j.compbiomed.2023.107147","article-title":"A CT-based deep learning system for automatic assessment of aortic root morphology for TAVI planning","volume":"163","author":"Saitta","year":"2023","journal-title":"Computers in Biology and Medicine"},{"issue":"6","key":"10.1016\/j.cmpb.2025.109071_bib0040","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1080\/24748706.2021.1991604","article-title":"Patient-Specific Computer Simulation to Optimize Transcatheter Heart Valve Sizing and Positioning in Bicuspid Aortic Valve","volume":"5","author":"Dowling","year":"2021","journal-title":"Structural Heart"},{"issue":"2","key":"10.1016\/j.cmpb.2025.109071_bib0041","doi-asserted-by":"crossref","first-page":"qyad027","DOI":"10.1093\/ehjimp\/qyad027","article-title":"Incremental prognostic value of intensity-weighted regional calcification scoring using contrast CT imaging in TAVR","volume":"1","author":"Abdelkhalek","year":"2023","journal-title":"European Heart Journal - Imaging Methods and Practice"},{"issue":"5","key":"10.1016\/j.cmpb.2025.109071_bib0042","first-page":"e72","article-title":"2020 ACC\/AHA Guideline for the Management of Patients With Valvular Heart Disease: A Report of the American College of Cardiology\/American Heart Association Joint Committee on Clinical Practice Guidelines","volume":"143","author":"Otto","year":"2021","journal-title":"Circulation"},{"issue":"6","key":"10.1016\/j.cmpb.2025.109071_bib0043","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1007\/s13239-022-00620-8","article-title":"Validating In Silico and In Vitro Patient-Specific Structural and Flow Models with Transcatheter Bicuspid Aortic Valve Replacement Procedure","volume":"13","author":"Anam","year":"2022","journal-title":"Cardiovasc Eng Tech"},{"key":"10.1016\/j.cmpb.2025.109071_bib0044","doi-asserted-by":"crossref","DOI":"10.1016\/j.cmpb.2024.108469","article-title":"Thrombogenic Risk Assessment of Transcatheter Prosthetic Heart Valves Using a Fluid-Structure Interaction Approach","volume":"257","author":"Baylous","year":"2024","journal-title":"Computer Methods and Programs in Biomedicine"},{"key":"10.1016\/j.cmpb.2025.109071_bib0045","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.jbiomech.2018.02.017","article-title":"Population-specific material properties of the implantation site for transcatheter aortic valve replacement finite element simulations","volume":"71","author":"Bosi","year":"2018","journal-title":"Journal of Biomechanics"},{"issue":"5","key":"10.1016\/j.cmpb.2025.109071_bib0046","doi-asserted-by":"crossref","first-page":"1725","DOI":"10.1007\/s10237-020-01304-9","article-title":"Numerical evaluation of transcatheter aortic valve performance during heart beating and its post-deployment fluid\u2013structure interaction analysis","volume":"19","author":"Ghosh","year":"2020","journal-title":"Biomech Model Mechanobiol"},{"issue":"2","key":"10.1016\/j.cmpb.2025.109071_bib0047","doi-asserted-by":"crossref","DOI":"10.3390\/bioengineering10020188","article-title":"Mild Paravalvular Leak May Pose an Increased Thrombogenic Risk in Transcatheter Aortic Valve Replacement (TAVR) Patients-Insights from Patient Specific In Vitro and In Silico Studies","volume":"10","author":"Kovarovic","year":"2023","journal-title":"Bioengineering"},{"issue":"17","key":"10.1016\/j.cmpb.2025.109071_bib0048","doi-asserted-by":"crossref","first-page":"1598","DOI":"10.1161\/CIRCULATIONAHA.117.029479","article-title":"The Fluid Mechanics of Transcatheter Heart Valve Leaflet Thrombosis in the Neosinus","volume":"136","author":"Midha","year":"2017","journal-title":"Circulation"},{"key":"10.1016\/j.cmpb.2025.109071_bib0049","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.softx.2018.12.005","article-title":"NURBS-Python: An open-source object-oriented NURBS modeling framework in Python","volume":"9","author":"Bingol","year":"2019","journal-title":"SoftwareX"},{"key":"10.1016\/j.cmpb.2025.109071_bib0050","series-title":"European Synchrotron Radiation Facility","article-title":"Complete heart from the body donor LADAF-2020-27","author":"Tafforeau","year":"2021"},{"issue":"12","key":"10.1016\/j.cmpb.2025.109071_bib0051","doi-asserted-by":"crossref","DOI":"10.1038\/s41592-021-01317-x","article-title":"Imaging intact human organs with local resolution of cellular structures using hierarchical phase-contrast tomography","volume":"18","author":"Walsh","year":"2021","journal-title":"Nat Methods"},{"key":"10.1016\/j.cmpb.2025.109071_bib0052","article-title":"Data From Phantom FDA","author":"Gavrielides","year":"2015","journal-title":"The Cancer Imaging Archive"},{"issue":"14","key":"10.1016\/j.cmpb.2025.109071_bib0053","doi-asserted-by":"crossref","first-page":"15244","DOI":"10.1364\/OE.18.015244","article-title":"A resource for the assessment of lung nodule size estimation methods: database of thoracic CT scans of an anthropomorphic phantom","volume":"18","author":"Gavrielides","year":"2010","journal-title":"Opt. Express"},{"key":"10.1016\/j.cmpb.2025.109071_bib0054","doi-asserted-by":"crossref","DOI":"10.1016\/j.parco.2021.102809","article-title":"NVIDIA IndeX accelerated computing for visualizing Cholla\u2019s galactic winds","volume":"107","author":"Schneider","year":"2021","journal-title":"Parallel Computing"},{"key":"10.1016\/j.cmpb.2025.109071_bib0055","series-title":"The visualization toolkit: an object-oriented approach to 3D graphics ; [visualize data in 3D - medical, engineering or scientific ; build your own applications with C++, Tcl, Java or Python ; includes source code for VTK (supports Unix, Windows and Mac)","author":"Schroeder","year":"2006"},{"issue":"3","key":"10.1016\/j.cmpb.2025.109071_bib0056","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.medengphy.2015.01.003","article-title":"Non-invasive determination of transcatheter pressure gradient in stenotic aortic valves: An analytical model","volume":"37","author":"Keshavarz-Motamed","year":"2015","journal-title":"Medical Engineering & Physics"},{"key":"10.1016\/j.cmpb.2025.109071_bib0057","series-title":"The NURBS Book","first-page":"81","article-title":"B-spline Curves and Surfaces","author":"Piegl","year":"1995"},{"key":"10.1016\/j.cmpb.2025.109071_bib0058","series-title":"The NURBS Book","first-page":"361","article-title":"Curve and Surface Fitting","author":"Piegl","year":"1995"},{"key":"10.1016\/j.cmpb.2025.109071_bib0059","series-title":"MultivariateCalculusand Geometry","first-page":"83","article-title":"Geometry of Curves in R3","author":"Dineen","year":"2014"},{"issue":"3","key":"10.1016\/j.cmpb.2025.109071_bib0060","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1007\/s10554-015-0793-9","article-title":"Automatic aortic root landmark detection in CTA images for preprocedural planning of transcatheter aortic valve implantation","volume":"32","author":"Elattar","year":"2016","journal-title":"Int J Cardiovasc Imaging"},{"key":"10.1016\/j.cmpb.2025.109071_bib0061","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.jbiomech.2017.10.014","article-title":"A strain-based finite element model for calcification progression in aortic valves","volume":"65","author":"Arzani","year":"2017","journal-title":"Journal of Biomechanics"},{"issue":"12","key":"10.1016\/j.cmpb.2025.109071_bib0062","doi-asserted-by":"crossref","first-page":"2520","DOI":"10.1016\/j.jbiomech.2016.03.036","article-title":"Impact of different aortic valve calcification patterns on the outcome of transcatheter aortic valve implantation: A finite element study","volume":"49","author":"Sturla","year":"2016","journal-title":"Journal of Biomechanics"},{"issue":"4","key":"10.1016\/j.cmpb.2025.109071_bib0063","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1016\/0735-1097(90)90282-T","article-title":"Quantification of coronary artery calcium using ultrafast computed tomography","volume":"15","author":"Agatston","year":"1990","journal-title":"Journal of the American College of Cardiology"},{"key":"10.1016\/j.cmpb.2025.109071_bib0064","doi-asserted-by":"crossref","DOI":"10.1136\/heartjnl-2020-318556","article-title":"Contrast-enhanced computed tomography assessment of aortic stenosis","author":"Cartlidge","year":"2021","journal-title":"Heart"},{"issue":"7","key":"10.1016\/j.cmpb.2025.109071_bib0065","doi-asserted-by":"crossref","first-page":"2064","DOI":"10.1148\/rg.2016160079","article-title":"Artifacts at Cardiac CT: Physics and Solutions","volume":"36","author":"Kalisz","year":"2016","journal-title":"RadioGraphics"},{"key":"10.1016\/j.cmpb.2025.109071_bib0066","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2018.00363","article-title":"3D Fluid-Structure Interaction Simulation of Aortic Valves Using a Unified Continuum ALE FEM Model","volume":"9","author":"Sp\u00fchler","year":"2018","journal-title":"Frontiers in Physiology"},{"key":"10.1016\/j.cmpb.2025.109071_bib0067","series-title":"Practical 3D Echocardiography","first-page":"129","article-title":"3DE Anatomy of Normal Aortic Valve and Root. Image Display and Anatomic Correlations","author":"Faletra","year":"2022"},{"key":"10.1016\/j.cmpb.2025.109071_bib0068","doi-asserted-by":"crossref","unstructured":"F. Indorato, S. G. Cosentino, and G. Bartoloni, \u201cAnatomy of the Aortic Valve,\u201d in Percutaneous Treatment of Left Side Cardiac Valves: A Practical Guide for the Interventional Cardiologist, C. Tamburino, M. Barbanti, and D. Capodanno, Eds., Cham: Springer International Publishing, 2018, pp. 239\u2013244. doi: 10.1007\/978-3-319-59620-4_13.","DOI":"10.1007\/978-3-319-59620-4_13"},{"issue":"1","key":"10.1016\/j.cmpb.2025.109071_bib0069","doi-asserted-by":"crossref","first-page":"i3","DOI":"10.1093\/ejechocard\/jen243","article-title":"Structure and anatomy of the aortic root","volume":"10","author":"Ho","year":"2009","journal-title":"European Journal of Echocardiography"},{"issue":"8","key":"10.1016\/j.cmpb.2025.109071_bib0070","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1093\/eurheartj\/ehv560","article-title":"Sex-related differences in calcific aortic stenosis: correlating clinical and echocardiographic characteristics and computed tomography aortic valve calcium score to excised aortic valve weight","volume":"37","author":"Thaden","year":"2016","journal-title":"European Heart Journal"},{"issue":"12","key":"10.1016\/j.cmpb.2025.109071_bib0071","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.1016\/j.medengphy.2013.07.015","article-title":"Impact of modeling fluid\u2013structure interaction in the computational analysis of aortic root biomechanics","volume":"35","author":"Sturla","year":"2013","journal-title":"Medical Engineering & Physics"},{"issue":"45","key":"10.1016\/j.cmpb.2025.109071_bib0072","doi-asserted-by":"crossref","first-page":"3351","DOI":"10.1093\/eurheartj\/ehx381","article-title":"Staging classification of aortic stenosis based on the extent of cardiac damage","volume":"38","author":"G\u00e9n\u00e9reux","year":"2017","journal-title":"European Heart Journal"},{"key":"10.1016\/j.cmpb.2025.109071_bib0073","volume":"72","author":"Greenland","year":"2018"},{"key":"10.1016\/j.cmpb.2025.109071_bib0074","volume":"10","author":"Nakahara","year":"2017"},{"issue":"5","key":"10.1016\/j.cmpb.2025.109071_bib0075","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1016\/j.media.2012.02.003","article-title":"Complete valvular heart apparatus model from 4D cardiac CT","volume":"16","author":"Grbic","year":"2012","journal-title":"Medical Image Analysis"},{"issue":"1","key":"10.1016\/j.cmpb.2025.109071_bib0076","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1109\/TMI.2012.2230015","article-title":"A High-Resolution Atlas and Statistical Model of the Human Heart From Multislice CT","volume":"32","author":"Hoogendoorn","year":"2013","journal-title":"IEEE Transactions on Medical Imaging"},{"issue":"6","key":"10.1016\/j.cmpb.2025.109071_bib0077","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1016\/j.media.2013.03.008","article-title":"Benchmarking framework for myocardial tracking and deformation algorithms: An open access database","volume":"17","author":"Tobon-Gomez","year":"2013","journal-title":"Medical Image Analysis"},{"issue":"22","key":"10.1016\/j.cmpb.2025.109071_bib0078","doi-asserted-by":"crossref","first-page":"1766","DOI":"10.1161\/CIRCULATIONAHA.116.023997","article-title":"Medical Treatment of Aortic Stenosis","volume":"134","author":"Marquis-Gravel","year":"2016","journal-title":"Circulation"},{"issue":"38","key":"10.1016\/j.cmpb.2025.109071_bib0079","doi-asserted-by":"crossref","first-page":"3143","DOI":"10.1093\/eurheartj\/ehz275","article-title":"Transcatheter aortic valve implantation vs. surgical aortic valve replacement for treatment of symptomatic severe aortic stenosis: an updated meta-analysis","volume":"40","author":"Siontis","year":"2019","journal-title":"European Heart Journal"},{"issue":"4","key":"10.1016\/j.cmpb.2025.109071_bib0080","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.jcct.2019.12.001","article-title":"Aortic valve calcification as a risk factor for major complications and reduced survival after transcatheter replacement","volume":"14","author":"Pollari","year":"2020","journal-title":"Journal of Cardiovascular Computed Tomography"},{"issue":"5","key":"10.1016\/j.cmpb.2025.109071_bib0081","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/j.jcct.2015.04.002","article-title":"The impact of calcium volume and distribution in aortic root injury related to balloon-expandable transcatheter aortic valve replacement","volume":"9","author":"Hansson","year":"2015","journal-title":"J Cardiovasc Comput Tomogr"},{"issue":"8","key":"10.1016\/j.cmpb.2025.109071_bib0082","first-page":"885","article-title":"Quantity and Location of Aortic Valve Complex Calcification Predicts Severity and Location of Paravalvular Regurgitation and Frequency of Post-Dilation After Balloon-Expandable Transcatheter Aortic Valve Replacement","volume":"7","author":"Khalique","year":"2014","journal-title":"JACC: Cardiovascular Interventions"},{"key":"10.1016\/j.cmpb.2025.109071_bib0083","first-page":"14","article-title":"Three-Dimensional Printing for Procedure Rehearsal\/Simulation\/Planning in Interventional Radiology","volume":"22","author":"Chang","year":"2019"},{"issue":"11","key":"10.1016\/j.cmpb.2025.109071_bib0084","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.123.029310","article-title":"Reducing Long-Term Mortality Post Transcatheter Aortic Valve Replacement Requires Systemic Differentiation of Patient-Specific Coronary Hemodynamics","volume":"12","author":"Khodaei","year":"2023","journal-title":"Journal of the American Heart Association"},{"issue":"1","key":"10.1016\/j.cmpb.2025.109071_bib0085","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-022-21104-8","article-title":"Long-term prognostic impact of paravalvular leakage on coronary artery disease requires patient-specific quantification of hemodynamics","volume":"12","author":"Khodaei","year":"2022","journal-title":"Sci Rep"},{"key":"10.1016\/j.cmpb.2025.109071_bib0086","unstructured":"M. Abdelkhalek and Z. Motamed, \u201cThe Virtual Transcatheter Aortic Valve Replacement (VTAVR) framework predicts optimal device landing zones tailored to patient- specific anatomy,\u201d NPJ: Biomedical Innovations. [Online]. Available: In Press."}],"container-title":["Computer Methods and Programs in Biomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0169260725004882?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0169260725004882?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T14:27:16Z","timestamp":1772980036000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0169260725004882"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":86,"alternative-id":["S0169260725004882"],"URL":"https:\/\/doi.org\/10.1016\/j.cmpb.2025.109071","relation":{},"ISSN":["0169-2607"],"issn-type":[{"value":"0169-2607","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Precision CT-based Aortic Valve Reconstruction: Minimal Variation Geometry Invariant Parametric Reconstruction Approach for Aortic Stenosis and Bicuspid Valves","name":"articletitle","label":"Article Title"},{"value":"Computer Methods and Programs in Biomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cmpb.2025.109071","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"109071"}}