{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T17:17:59Z","timestamp":1788369479326,"version":"build-2803163510"},"reference-count":26,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T00:00:00Z","timestamp":1786406400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Swiss National Science Foundation","doi-asserted-by":"publisher","award":["200021_207900\/1"],"award-info":[{"award-number":["200021_207900\/1"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Computer Methods and Programs in Biomedicine"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.cmpb.2026.109597","type":"journal-article","created":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T23:41:45Z","timestamp":1786491705000},"page":"109597","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["ETODA: Automatic three-dimensional error tolerance grid generation for dosage adaptation in precision medicine"],"prefix":"10.1016","volume":"286","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-2589-7082","authenticated-orcid":false,"given":"Lin","family":"Du","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6334-5565","authenticated-orcid":false,"given":"Myriam","family":"Briki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0639-5536","authenticated-orcid":false,"given":"Thierry","family":"Buclin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6419-9317","authenticated-orcid":false,"given":"Monia","family":"Guidi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0404-7917","authenticated-orcid":false,"given":"Sandro","family":"Carrara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4374-6104","authenticated-orcid":false,"given":"Yann","family":"Thoma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.cmpb.2026.109597_b1","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1038\/nrclinonc.2010.227","article-title":"Predictive, personalized, preventive, participatory (p4) cancer medicine","volume":"8","author":"Hood","year":"2011","journal-title":"Nat. Rev. Clin. Oncol."},{"issue":"9","key":"10.1016\/j.cmpb.2026.109597_b2","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1038\/nrg.2016.86","article-title":"Towards precision medicine","volume":"17","author":"Ashley","year":"2016","journal-title":"Nature Rev. Genet."},{"issue":"4","key":"10.1016\/j.cmpb.2026.109597_b3","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1056\/NEJMp1006304","article-title":"The path to personalized medicine","volume":"363","author":"Hamburg","year":"2010","journal-title":"N. Engl. J. Med."},{"issue":"9","key":"10.1016\/j.cmpb.2026.109597_b4","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1056\/NEJMp1500523","article-title":"A new initiative on precision medicine","volume":"372","author":"Collins","year":"2015","journal-title":"N. Engl. J. Med."},{"issue":"23","key":"10.1016\/j.cmpb.2026.109597_b5","doi-asserted-by":"crossref","first-page":"2229","DOI":"10.1056\/NEJMsb1503104","article-title":"Precision medicine\u2014personalized, problematic, and promising","volume":"372","author":"Jameson","year":"2015","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.cmpb.2026.109597_b6","doi-asserted-by":"crossref","first-page":"177","DOI":"10.3389\/fphar.2020.00177","article-title":"The steps to therapeutic drug monitoring: a structured approach illustrated with imatinib","volume":"11","author":"Buclin","year":"2020","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.cmpb.2026.109597_b7","series-title":"Clinical Pharmacokinetics and Pharmacodynamics: Concepts and Applications","author":"Rowland","year":"2011"},{"issue":"12","key":"10.1016\/j.cmpb.2026.109597_b8","first-page":"785","article-title":"Model-informed precision dosing at the bedside: Scientific challenges and opportunities","volume":"7","author":"Keizer","year":"2018","journal-title":"CPT: Pharmacometrics Syst. Pharmacol."},{"key":"10.1016\/j.cmpb.2026.109597_b9","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/0010-4809(72)90051-1","article-title":"Modelling of individual pharmacokinetics for computer-aided drug dosage","volume":"5","author":"Sheiner","year":"1972","journal-title":"Comput. Biomed. Res."},{"issue":"6","key":"10.1016\/j.cmpb.2026.109597_b10","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1007\/BF01060053","article-title":"Evaluation of methods for estimating population pharmacokinetic parameters. I. Michaelis-Menten model: routine clinical pharmacokinetic data","volume":"8","author":"Sheiner","year":"1980","journal-title":"J. Pharmacokinet. Biopharm."},{"key":"10.1016\/j.cmpb.2026.109597_b11","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1002\/jcph.1633","article-title":"Parametric approaches in population pharmacokinetics","volume":"62","author":"Guidi","year":"2022","journal-title":"J. Clin. Pharmacol."},{"key":"10.1016\/j.cmpb.2026.109597_b12","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1002\/jcph.1650","article-title":"Nonparametric methods in population pharmacokinetics","volume":"62","author":"Goutelle","year":"2022","journal-title":"J. Clin. Pharmacol."},{"issue":"1","key":"10.1016\/j.cmpb.2026.109597_b13","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1146\/annurev-pharmtox-033020-113257","article-title":"Model-informed precision dosing: background, requirements, validation, implementation, and forward trajectory of individualizing drug therapy","volume":"61","author":"Darwich","year":"2021","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"issue":"11","key":"10.1016\/j.cmpb.2026.109597_b14","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1016\/j.tibtech.2020.03.001","article-title":"On-site therapeutic drug monitoring","volume":"38","author":"Ates","year":"2020","journal-title":"Trends Biotechnol."},{"key":"10.1016\/j.cmpb.2026.109597_b15","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2024.1348112","article-title":"Emerging therapeutic drug monitoring technologies: Considerations and opportunities in precision medicine","volume":"15","author":"Liang","year":"2024","journal-title":"Front. Pharmacol."},{"issue":"4","key":"10.1016\/j.cmpb.2026.109597_b16","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1007\/BF01060893","article-title":"Some suggestions for measuring predictive performance","volume":"9","author":"Sheiner","year":"1981","journal-title":"J. Pharmacokinet. Biopharm."},{"issue":"11","key":"10.1016\/j.cmpb.2026.109597_b17","doi-asserted-by":"crossref","first-page":"1907","DOI":"10.1345\/aph.1E259","article-title":"Population pharmacokinetics ii: Estimation methods","volume":"38","author":"Ette","year":"2004","journal-title":"Ann. Pharmacother."},{"issue":"5","key":"10.1016\/j.cmpb.2026.109597_b18","doi-asserted-by":"crossref","first-page":"622","DOI":"10.2337\/diacare.10.5.622","article-title":"Evaluating clinical accuracy of systems for self-monitoring of blood glucose","volume":"10","author":"Clarke","year":"1987","journal-title":"Diabetes Care"},{"issue":"3","key":"10.1016\/j.cmpb.2026.109597_b19","doi-asserted-by":"crossref","first-page":"187","DOI":"10.2165\/11596990-000000000-00000","article-title":"Therapeutic drug monitoring of imatinib","volume":"51","author":"Gotta","year":"2012","journal-title":"Clin. Pharmacokinet."},{"issue":"6","key":"10.1016\/j.cmpb.2026.109597_b20","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1111\/jphp.13071","article-title":"A population pharmacokinetic model of vancomycin for dose individualization based on serum cystatin c as a marker of renal function","volume":"71","author":"t. Liu","year":"2019","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.cmpb.2026.109597_b21","doi-asserted-by":"crossref","DOI":"10.1016\/j.smhl.2025.100600","article-title":"Tucuxi-core: An open source generic and efficient computing engine for model-informed precision dosing","volume":"38","author":"Thoma","year":"2025","journal-title":"Smart Health"},{"key":"10.1016\/j.cmpb.2026.109597_b22","series-title":"Proceedings of the 8th ACM International Conference on Bioinformatics, Computational Biology, and Health Informatics, ACM-BCB\u201917","first-page":"223","article-title":"Tucuxi: An intelligent system for personalized medicine from individualization of treatments to research databases and back","author":"Dubovitskaya","year":"2017"},{"key":"10.1016\/j.cmpb.2026.109597_b23","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.ejca.2015.12.029","article-title":"Relationship between imatinib trough concentration and outcomes in the treatment of advanced gastrointestinal stromal tumours in a real-life setting","volume":"57","author":"Bouchet","year":"2016","journal-title":"Eur. J. Cancer"},{"key":"10.1016\/j.cmpb.2026.109597_b24","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/j.ejca.2021.08.033","article-title":"Therapeutic drug monitoring in oncology: International association of therapeutic drug monitoring and clinical toxicology consensus guidelines for imatinib therapy","volume":"157","author":"Clarke","year":"2021","journal-title":"Eur. J. Cancer"},{"issue":"3","key":"10.1016\/j.cmpb.2026.109597_b25","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1086\/600877","article-title":"Vancomycin therapeutic guidelines: a summary of consensus recommendations from the infectious diseases society of America, the American society of health-system pharmacists, and the society of infectious diseases pharmacists","volume":"49","author":"Rybak","year":"2009","journal-title":"Clin. Infect. Dis."},{"issue":"1","key":"10.1016\/j.cmpb.2026.109597_b26","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1097\/FTD.0000000000000944","article-title":"Optimal practice for vancomycin therapeutic drug monitoring: position statement from the anti-infectives committee of the international association of therapeutic drug monitoring and clinical toxicology","volume":"44","author":"Reuter","year":"2022","journal-title":"Ther. Drug Monit."}],"container-title":["Computer Methods and Programs in Biomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0169260726003469?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0169260726003469?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T17:01:26Z","timestamp":1788368486000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0169260726003469"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":26,"alternative-id":["S0169260726003469"],"URL":"https:\/\/doi.org\/10.1016\/j.cmpb.2026.109597","relation":{},"ISSN":["0169-2607"],"issn-type":[{"value":"0169-2607","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"ETODA: Automatic three-dimensional error tolerance grid generation for dosage adaptation in precision medicine","name":"articletitle","label":"Article Title"},{"value":"Computer Methods and Programs in Biomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cmpb.2026.109597","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"109597"}}