{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T21:04:39Z","timestamp":1790802279645,"version":"4.1.0"},"reference-count":122,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Computer Methods and Programs in Biomedicine"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.cmpb.2026.109644","type":"journal-article","created":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T23:28:21Z","timestamp":1788910101000},"page":"109644","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Computational modeling of thrombosis after transcatheter aortic valve implantation: A systematic review of hemodynamic and mechanical risk metrics"],"prefix":"10.1016","volume":"287","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0579-0366","authenticated-orcid":false,"given":"Yulia","family":"Erina","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0466-175X","authenticated-orcid":false,"given":"Alex G.","family":"Kuchumov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cmpb.2026.109644_bib0001","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2018.00092","article-title":"Expanding tavi to low and intermediate risk patients","volume":"5","author":"Voigtl\u00a8ander","year":"2018","journal-title":"Front. Cardiovasc. Med."},{"issue":"1","key":"10.1016\/j.cmpb.2026.109644_bib0002","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1186\/s12872-024-03980-2","article-title":"The evolution of tavi performance over time: an overview of systematic reviews","volume":"24","author":"Angioletti","year":"2024","journal-title":"BMC Cardiovasc. Disord."},{"issue":"20","key":"10.1016\/j.cmpb.2026.109644_bib0003","article-title":"Intervention for symptomatic severe aortic stenosis","volume":"18","author":"Sayeed","year":"2020","journal-title":"E-J. Cardiol. Pract."},{"key":"10.1016\/j.cmpb.2026.109644_bib0004","doi-asserted-by":"crossref","DOI":"10.1093\/ejcts\/ezaf476","article-title":"Ten-year outcomes of transcatheter versus surgical aortic valve replacement: extended follow-up from the observant study","volume":"68","author":"Costa","year":"2026","journal-title":"Eur. J. CardioThorac. Surg."},{"issue":"18","key":"10.1016\/j.cmpb.2026.109644_bib0005","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.1056\/NEJMoa1814052","article-title":"Transcatheter aortic-valve replacement with a balloon-expandable valve in low-risk patients","volume":"380","author":"Mack","year":"2019","journal-title":"N. Engl. J. Med."},{"issue":"14","key":"10.1016\/j.cmpb.2026.109644_bib0006","first-page":"1667","article-title":"3-year outcomes from the evolut low risk tavr bicuspid study","volume":"17","author":"Zahr","year":"2024","journal-title":"JACC: Cardiovasc. Interv."},{"issue":"4","key":"10.1016\/j.cmpb.2026.109644_bib0007","first-page":"813","article-title":"Fontes-Carvalho R. valve thrombosis following transcatheter aortic valve replacement: state-of-the-art review","volume":"105","author":"Duarte","year":"2025","journal-title":"Catheter. Cardiovasc. Interv."},{"key":"10.1016\/j.cmpb.2026.109644_bib0008","doi-asserted-by":"crossref","DOI":"10.3390\/jcdd12020062","article-title":"Prothrombotic states in transcatheter heart valve leaflet thrombosis (PROSTHESIS): rationale and early results of the observational cohort study","volume":"12","author":"Grodecki","year":"2025","journal-title":"J. Cardiovasc. Dev. Dis."},{"issue":"5","key":"10.1016\/j.cmpb.2026.109644_bib0009","first-page":"1161","article-title":"Long-term impact of early subclinical leaflet thrombosis after transcatheter aortic valve implantation","volume":"105","author":"Iwata","year":"2025","journal-title":"Catheter. Cardiovasc. Interv."},{"key":"10.1016\/j.cmpb.2026.109644_bib0010","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2022.1001753","article-title":"Risk factors and clinical effects of subclinical leaflet thrombosis after transcatheter aortic valve replacement","volume":"9","author":"Bak","year":"2022","journal-title":"Front. Cardiovasc. Med."},{"issue":"10087","key":"10.1016\/j.cmpb.2026.109644_bib0011","doi-asserted-by":"crossref","first-page":"2383","DOI":"10.1016\/S0140-6736(17)30757-2","article-title":"Subclinical leaflet thrombosis in surgical and transcatheter bioprosthetic aortic valves: an observational study","volume":"389","author":"Chakravarty","year":"2017","journal-title":"Lancet"},{"key":"10.1016\/j.cmpb.2026.109644_bib0012","article-title":"Transcatheter aortic valve replacement in low-risk patients: an updated meta-analysis of randomized controlled trials","volume":"59","author":"Meeus","year":"2025","journal-title":"Int. J. Cardiol. Heart. Vasc."},{"issue":"4","key":"10.1016\/j.cmpb.2026.109644_bib0013","doi-asserted-by":"crossref","first-page":"e28","DOI":"10.1161\/ATVBAHA.118.310224","article-title":"Platelet signaling pathways and new inhibitors","volume":"38","author":"Grover","year":"2018","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"8","key":"10.1016\/j.cmpb.2026.109644_bib0014","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.disamonth.2012.04.004","article-title":"Brief overview of the coagulation cascade","volume":"58","author":"Johari","year":"2012","journal-title":"Disease-a-Month"},{"issue":"21","key":"10.1016\/j.cmpb.2026.109644_bib0015","doi-asserted-by":"crossref","DOI":"10.3390\/ijms232112772","article-title":"Platelets and their role in hemostasis and thrombosis\u2014from physiology to pathophysiology and therapeutic implications","volume":"23","author":"Scridon","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"5","key":"10.1016\/j.cmpb.2026.109644_bib0016","doi-asserted-by":"crossref","first-page":"606","DOI":"10.18097\/PBMC20156105606","article-title":"The molecular mechanisms of platelet activation in patients with cerebrovascular disease","volume":"61","author":"Sirotkina","year":"2015","journal-title":"Biomed. Khim."},{"key":"10.1016\/j.cmpb.2026.109644_bib0017","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/s12959-015-0048-y","article-title":"Contact pathway of coagulation and inflammation","volume":"13","author":"Wu","year":"2015","journal-title":"Thromb. J."},{"key":"10.1016\/j.cmpb.2026.109644_bib0018","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1007\/s44313-024-00040-8","article-title":"Back to basics: the coagulation pathway","volume":"59","author":"Park","year":"2024","journal-title":"Blood Res."},{"key":"10.1016\/j.cmpb.2026.109644_bib0019","article-title":"Analysis of microvascular thrombus mechanobiology with a novel particle-based model","volume":"130","author":"Masalceva","year":"2021","journal-title":"J. Biomech."},{"key":"10.1016\/j.cmpb.2026.109644_bib138","doi-asserted-by":"crossref","first-page":"141","DOI":"10.3389\/fcvm.2019.00141","article-title":"Shear-Dependent platelet aggregation: mechanisms and therapeutic opportunities","volume":"6","author":"Rana","year":"2019","journal-title":"Front. Cardiovasc. Med."},{"issue":"10","key":"10.1016\/j.cmpb.2026.109644_bib0020","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0272342","article-title":"Patientspecific approach to analysis of shear-induced platelet activation in haemodialysis arteriovenous fistula","volume":"17","author":"Yu. Salikhova","year":"2022","journal-title":"PLoS One"},{"issue":"4","key":"10.1016\/j.cmpb.2026.109644_bib0021","doi-asserted-by":"crossref","first-page":"146","DOI":"10.15593\/RJBiomech\/2024.4.15","article-title":"Non-stationary effects in the mathematical model of platelet thrombus growth","volume":"28","author":"Kalugina","year":"2024","journal-title":"Russ. J. Biomech."},{"issue":"2","key":"10.1016\/j.cmpb.2026.109644_bib0022","doi-asserted-by":"crossref","DOI":"10.3390\/jcm8020280","article-title":"Thromboembolic and bleeding complications in transcatheter aortic valve implantation: insights on mechanisms, prophylaxis and therapy","volume":"8","author":"Ranasinghe","year":"2019","journal-title":"J. Clin. Med."},{"issue":"1","key":"10.1016\/j.cmpb.2026.109644_bib0023","article-title":"Antithrombotic therapy after transcatheter aortic valve replacement","volume":"12","author":"Guedeney","year":"2019","journal-title":"Circ.: Cardiovasc. Interventions"},{"issue":"21","key":"10.1016\/j.cmpb.2026.109644_bib0024","doi-asserted-by":"crossref","first-page":"2015","DOI":"10.1056\/NEJMoa1509233","article-title":"Possible subclinical leaflet thrombosis in bioprosthetic aortic valves","volume":"373","author":"Makkar","year":"2015","journal-title":"N. Engl. J. Med."},{"issue":"7","key":"10.1016\/j.cmpb.2026.109644_bib0025","doi-asserted-by":"crossref","DOI":"10.31083\/j.rcm2507248","article-title":"Thrombosis of bioprosthetic aortic valve: is the entire arsenal deployed?","volume":"25","author":"Loardi","year":"2024","journal-title":"Rev. Cardiovasc. Med."},{"key":"10.1016\/j.cmpb.2026.109644_bib0026","doi-asserted-by":"crossref","DOI":"10.3390\/jcm10215046","article-title":"Vascular complications in TAVR: incidence, clinical impact, and management","volume":"10","author":"Mach","year":"2021","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.cmpb.2026.109644_bib0027","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.xjon.2022.01.017","article-title":"Flow dynamics of surgical and transcatheter aortic valves: past to present","volume":"9","author":"Hatoum","year":"2022","journal-title":"JTCVS. Open"},{"key":"10.1016\/j.cmpb.2026.109644_bib0028","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1134\/S1990747821040036","article-title":"Von willebrand factor in health and disease","volume":"15","author":"Avdonin","year":"2021","journal-title":"Biochem. (Mosc.) Suppl. A: Membr. Cell Biol."},{"issue":"5","key":"10.1016\/j.cmpb.2026.109644_bib0029","doi-asserted-by":"crossref","first-page":"2021","DOI":"10.1109\/TBME.2026.3658253","article-title":"The effect of von willebrand disease on platelet adhesion dynamics: correlating a multiscale platelet model to in vitro results","volume":"73","author":"Wang","year":"2026","journal-title":"IEEE Trans. Biomed. Eng."},{"key":"10.1016\/j.cmpb.2026.109644_bib0030","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.thromres.2018.07.028","article-title":"Von Willebrand factor and the aortic valve: concepts that are important in the transcatheter aortic valve replacement era","volume":"170","author":"Ibrahim","year":"2018","journal-title":"Thromb. Res."},{"issue":"184","key":"10.1016\/j.cmpb.2026.109644_bib0031","doi-asserted-by":"crossref","DOI":"10.1098\/rsif.2021.0599","article-title":"Transcatheter aortic valve thrombosis: a review of potential mechanisms","volume":"18","author":"Raghav","year":"2021","journal-title":"J. R. Soc., Interface"},{"issue":"17","key":"10.1016\/j.cmpb.2026.109644_bib0032","doi-asserted-by":"crossref","first-page":"1598","DOI":"10.1161\/CIRCULATIONAHA.117.029479","article-title":"The fluid mechanics of transcatheter heart valve leaflet thrombosis in the neosinus","volume":"136","author":"Midha","year":"2017","journal-title":"Circulation"},{"issue":"5","key":"10.1016\/j.cmpb.2026.109644_bib0033","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1007\/s13239-025-00792-z","article-title":"Role of neo-sinus on thrombogenicity of aortic valve prostheses: experimental proof-of-concept study","volume":"16","author":"Thoenissen","year":"2025","journal-title":"Cardiovasc. Eng. Technol."},{"key":"10.1016\/j.cmpb.2026.109644_bib0034","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2025.1663130","article-title":"Development of a standardized ovine aortic stenosis model: a pathomimetic platform for TAVI evaluation and durability testing","volume":"12","author":"Zhu","year":"2025","journal-title":"Front. Cardiovasc. Med."},{"issue":"1","key":"10.1016\/j.cmpb.2026.109644_bib0035","first-page":"79","article-title":"No antithrombotic therapy after transcatheter aortic valve replacement: insight from the OCEAN-TAVI registry","volume":"16","author":"Kobari","year":"2023","journal-title":"JACC: Cardiovasc. Interv."},{"issue":"8","key":"10.1016\/j.cmpb.2026.109644_bib0036","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1177\/0271678X20921974","article-title":"Microvascular platelet aggregation and thrombosis after subarachnoid hemorrhage: a review and synthesis","volume":"40","author":"Clarke","year":"2020","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.cmpb.2026.109644_bib139","doi-asserted-by":"crossref","first-page":"1942","DOI":"10.1136\/heartjnl-2017-311818","article-title":"Subclinical leaflet thrombosis after transcatheter aortic valve implantation","volume":"103","author":"Nakatani","year":"2017","journal-title":"Heart"},{"issue":"4","key":"10.1016\/j.cmpb.2026.109644_bib0037","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/ehjcr\/ytaa221","article-title":"Leaflet thrombosis after valve-in-valve transcatheter aortic valve implantation: a case series","volume":"4","author":"Aktuerk","year":"2020","journal-title":"Eur. Heart. J. Case Rep."},{"issue":"20","key":"10.1016\/j.cmpb.2026.109644_bib0038","doi-asserted-by":"crossref","DOI":"10.3390\/molecules29204883","article-title":"Overview of venous thromboembolism and emerging therapeutic technologies based on nanocarriers-mediated drug delivery systems","volume":"29","author":"Salavati","year":"2024","journal-title":"Molecules"},{"key":"10.1016\/j.cmpb.2026.109644_bib0039","series-title":"Drug Discovery and Evaluation","article-title":"Pharmacological assays in thrombosis and haemostasis","author":"Vogel","year":"2007"},{"key":"10.1016\/j.cmpb.2026.109644_bib0040","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2025.1622235","article-title":"Stent thrombosis: a contemporary guide to definitions, risk factors, and management","volume":"12","author":"Flowers","year":"2025","journal-title":"Front. Cardiovasc. Med."},{"issue":"2","key":"10.1016\/j.cmpb.2026.109644_bib0041","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1007\/s10439-025-03889-7","article-title":"Development of a polymeric TAVR device tailored to bicuspid aortic valve patients using in silico design optimization and evaluation","volume":"54","author":"Baylous","year":"2026","journal-title":"Ann. Biomed. Eng."},{"key":"10.1016\/j.cmpb.2026.109644_bib0042","doi-asserted-by":"crossref","first-page":"5570","DOI":"10.1134\/S0025654425605427","article-title":"Study of bending stiffness of transcatheter aortic valve stents","volume":"60","author":"Kuchumov","year":"2025","journal-title":"Mech. Solids"},{"issue":"1","key":"10.1016\/j.cmpb.2026.109644_bib0043","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1097\/MAT.0000000000002459","article-title":"Impact of device type and orientation on post-transcatheter aortic valve replacement complications in bicuspid aortic valve patients: a computational study","volume":"72","author":"Anam","year":"2026","journal-title":"ASAIO J."},{"issue":"1","key":"10.1016\/j.cmpb.2026.109644_bib0044","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1007\/s10439-022-03047-3","article-title":"Patient-specific immersed finite element-difference model of transcatheter aortic valve replacement","volume":"51","author":"Brown","year":"2023","journal-title":"Ann. Biomed. Eng."},{"issue":"6","key":"10.1016\/j.cmpb.2026.109644_bib0045","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1007\/s13239-022-00620-8","article-title":"Validating in silico and in vitro patient-specific structural and flow models with transcatheter bicuspid aortic valve replacement procedure","volume":"13","author":"Anam","year":"2022","journal-title":"Cardiovasc. Eng. Technol."},{"key":"10.1016\/j.cmpb.2026.109644_bib0046","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2023.1333138","article-title":"Computational study of the balloon dilation steps on transcatheter aortic valve replacement","volume":"11","author":"Li","year":"2023","journal-title":"Front. Bioeng. Biotechnol."},{"key":"10.1016\/j.cmpb.2026.109644_bib0047","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/1346308","article-title":"Complementary role of the computed biomodelling through finite element analysis and computed tomography for diagnosis of transcatheter heart valve thrombosis","volume":"2018","author":"Nappi","year":"2018","journal-title":"Biomed. Res. Int."},{"issue":"4","key":"10.1016\/j.cmpb.2026.109644_bib0048","doi-asserted-by":"crossref","DOI":"10.3390\/diagnostics10040183","article-title":"A finite element analysis study from 3d ct to predict transcatheter heart valve thrombosis","volume":"10","author":"Nappi","year":"2020","journal-title":"Diagnostics"},{"issue":"5","key":"10.1016\/j.cmpb.2026.109644_bib0049","doi-asserted-by":"crossref","DOI":"10.3390\/bioengineering8050052","article-title":"CoreValve vs. Sapien 3 transcatheter aortic valve replacement: a finite element analysis study","volume":"8","author":"Nappi","year":"2021","journal-title":"Bioengineering"},{"key":"10.1016\/j.cmpb.2026.109644_bib0050","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2024.1407215","article-title":"Computational study of transcatheter aortic valve replacement based on patient-specific models-rapid surgical planning for self-expanding valves","volume":"15","author":"Meng","year":"2024","journal-title":"Front. Physiol."},{"issue":"12, Part 2","key":"10.1016\/j.cmpb.2026.109644_bib0051","article-title":"Mechanics post-tavr for trileaflet vs bicuspid aortic valves: insights from computational simulation","volume":"4","author":"Yeats","year":"2025","journal-title":"JACC: Adv."},{"issue":"1","key":"10.1016\/j.cmpb.2026.109644_bib0052","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1038\/s44385-025-00035-9","article-title":"The virtual transcatheter aortic valve replacement (vtavr) framework predicts optimal device landing zones tailored to patient-specific anatomy","volume":"2","author":"Abdelkhalek","year":"2025","journal-title":"npj Biomed. Innov."},{"issue":"12","key":"10.1016\/j.cmpb.2026.109644_bib0053","doi-asserted-by":"crossref","first-page":"E292","DOI":"10.1111\/aor.12806","article-title":"Effect of balloon-expandable transcatheter aortic valve replacement positioning: a patient-specific numerical model","volume":"40","author":"Bianchi","year":"2016","journal-title":"Artif. Organs"},{"issue":"1","key":"10.1016\/j.cmpb.2026.109644_bib0054","article-title":"The impact of bicuspid valve morphology on the selection of transcatheter aortic valve implantation devices: an in silico study","volume":"3","author":"Grossi","year":"2025","journal-title":"Eur. Heart J. - Imaging Methods Pract."},{"issue":"11","key":"10.1016\/j.cmpb.2026.109644_bib0055","doi-asserted-by":"crossref","DOI":"10.1115\/1.4063000","article-title":"Simulating subject-specific aortic hemodynamic effects of valvular lesions in rheumatic heart disease","volume":"145","author":"Cebull","year":"2023","journal-title":"J. Biomech. Eng."},{"issue":"5","key":"10.1016\/j.cmpb.2026.109644_bib0056","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0251579","article-title":"Understanding tavr device expansion as it relates to morphology of the bicuspid aortic valve: a simulation study","volume":"16","author":"Kusner","year":"2021","journal-title":"PLoS One"},{"issue":"3","key":"10.1016\/j.cmpb.2026.109644_bib0057","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1016\/j.jtcvs.2019.04.091","article-title":"Modeling risk of coronary obstruction during transcatheter aortic valve replacement","volume":"159","author":"Heitkemper","year":"2020","journal-title":"J. Thorac. Cardiovasc. Surg."},{"issue":"6","key":"10.1016\/j.cmpb.2026.109644_bib0058","doi-asserted-by":"crossref","first-page":"1554","DOI":"10.1007\/s10439-024-03462-8","article-title":"Computational investigation of vessel injury due to catheter tracking during transcatheter aortic valve replacement","volume":"52","author":"Symes","year":"2024","journal-title":"Ann. Biomed. Eng."},{"issue":"8","key":"10.1016\/j.cmpb.2026.109644_bib0059","doi-asserted-by":"crossref","DOI":"10.1115\/1.4024275","article-title":"Fluid-structure interaction modeling of abdominal aortic aneurysms: the impact of patientspecific inflow conditions and fluid\/solid coupling","volume":"135","author":"Chandra","year":"2013","journal-title":"J. Biomech. Eng."},{"issue":"6","key":"10.1016\/j.cmpb.2026.109644_bib0060","doi-asserted-by":"crossref","first-page":"1889","DOI":"10.1007\/s10237-024-01874-y","article-title":"Computational analysis of heart valve growth and remodeling after the ross procedure","volume":"23","author":"Middendorp","year":"2024","journal-title":"Biomech. Model. Mechanobiol."},{"issue":"4","key":"10.1016\/j.cmpb.2026.109644_bib0061","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1007\/s13239-016-0285-7","article-title":"Fluid-structure interaction study of transcatheter aortic valve dynamics using smoothed particle hydrodynamics","volume":"7","author":"Mao","year":"2016","journal-title":"Cardiovasc. Eng. Technol."},{"issue":"3","key":"10.1016\/j.cmpb.2026.109644_bib0062","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1007\/s10237-022-01684-0","article-title":"Fluid-structure interaction modeling of compliant aortic valves using the lattice boltzmann cfd and fem methods","volume":"22","author":"Morany","year":"2023","journal-title":"Biomech. Model. Mechanobiol."},{"key":"10.1016\/j.cmpb.2026.109644_bib0063","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2020.593709","article-title":"Hemodynamic modeling of biological aortic valve replacement using preoperative data only","volume":"7","author":"Hellmeier","year":"2021","journal-title":"Front. Cardiovasc. Med."},{"issue":"6","key":"10.1016\/j.cmpb.2026.109644_bib0064","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2024.e27310","article-title":"A parametric study regarding structural design of a bioprosthetic aortic valve by 3d fluid-structure interaction simulations","volume":"10","author":"Kim","year":"2024","journal-title":"Heliyon"},{"issue":"6","key":"10.1016\/j.cmpb.2026.109644_bib0065","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1093\/icvts\/ivt379","article-title":"Apicoaortic conduit and cerebral perfusion in mixed aortic valve disease: a computational analysis","volume":"17","author":"Fragomeni","year":"2013","journal-title":"Interact. Cardiovasc. Thorac. Surg."},{"issue":"1","key":"10.1016\/j.cmpb.2026.109644_bib0066","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-019-49161-6","article-title":"Some effects of different constitutive laws on fsi simulation for the mitral valve","volume":"9","author":"Cai","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.cmpb.2026.109644_bib0067","doi-asserted-by":"crossref","DOI":"10.1016\/j.compbiomed.2025.111435","article-title":"Personalized computational hemodynamic analysis in transcatheter aortic valve: investigation of long-term degeneration","volume":"202","author":"Crugnola","year":"2026","journal-title":"Comput. Biol. Med."},{"key":"10.1016\/j.cmpb.2026.109644_bib0068","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2021.734224","article-title":"Detecting aortic valve anomaly from induced murmurs: insights from computational hemodynamic models","volume":"12","author":"Bailoor","year":"2021","journal-title":"Front. Physiol."},{"issue":"1","key":"10.1016\/j.cmpb.2026.109644_bib0069","doi-asserted-by":"crossref","first-page":"8033","DOI":"10.1038\/s41598-023-33511-6","article-title":"A doppler-exclusive non-invasive computational diagnostic framework for personalized transcatheter aortic valve replacement","volume":"13","author":"Bahadormanesh","year":"2023","journal-title":"Sci. Rep."},{"issue":"12","key":"10.1016\/j.cmpb.2026.109644_bib0070","doi-asserted-by":"crossref","DOI":"10.1002\/cnm.70119","article-title":"Coupling models of resistive valves to muscle mechanics in cardiac fluidstructure interaction simulations","volume":"41","author":"Bucelli","year":"2025","journal-title":"Int. J. Numer. Method. Biomed. Eng."},{"issue":"2","key":"10.1016\/j.cmpb.2026.109644_bib0071","doi-asserted-by":"crossref","DOI":"10.1098\/rsos.230905","article-title":"Analysis of fibrocalcific aortic valve stenosis: computational pre-and-post tavr haemodynamics behaviours","volume":"11","author":"Morany","year":"2024","journal-title":"R. Soc. Open. Sci."},{"issue":"5","key":"10.1016\/j.cmpb.2026.109644_bib0072","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines13051135","article-title":"In silico trials of prosthetic valves replicate methodologies for evaluating the fatigue life of artificial leaflets to expand beyond in vitro tests and conventional clinical trials","volume":"13","author":"Mao","year":"2025","journal-title":"Biomedicines"},{"issue":"5","key":"10.1016\/j.cmpb.2026.109644_bib0073","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1007\/s10439-020-02466-4","article-title":"Fluid-structure interaction models of bioprosthetic heart valve dynamics in an experimental pulse duplicator","volume":"48","author":"Lee","year":"2020","journal-title":"Ann. Biomed. Eng."},{"key":"10.1016\/j.cmpb.2026.109644_bib0074","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/9163085","article-title":"Fluid structure interaction on paravalvular leakage of transcatheter aortic valve implantation related to aortic stenosis: a patient-specific case","volume":"2020","author":"Basri","year":"2020","journal-title":"Comput. Math. Methods Med."},{"issue":"1","key":"10.1016\/j.cmpb.2026.109644_bib0075","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1007\/s10439-022-03039-3","article-title":"Designing a novel asymmetric transcatheter aortic valve for stenotic bicuspid aortic valves using patient-specific computational modeling","volume":"51","author":"Helbock","year":"2023","journal-title":"Ann. Biomed. Eng."},{"issue":"4","key":"10.1016\/j.cmpb.2026.109644_bib0076","doi-asserted-by":"crossref","DOI":"10.3390\/bioengineering12040339","article-title":"Hemodynamics of proximal coronary lesions in patients undergoing transcatheter aortic valve implantation: patient-specific in silico study","volume":"12","author":"Bellouche","year":"2025","journal-title":"Bioengineering"},{"issue":"2","key":"10.1016\/j.cmpb.2026.109644_bib0077","doi-asserted-by":"crossref","DOI":"10.1098\/rsos.211694","article-title":"Improving transcatheter aortic valve interventional predictability via fluid-structure interaction modelling using patient-specific anatomy","volume":"9","author":"Govindarajan","year":"2022","journal-title":"R. Soc. Open. Sci."},{"issue":"11","key":"10.1016\/j.cmpb.2026.109644_bib0078","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.123.029310","article-title":"Reducing long-term mortality post transcatheter aortic valve replacement requires systemic differentiation of patient-specific coronary hemodynamics","volume":"12","author":"Khodaei","year":"2023","journal-title":"J. Am. Heart. Assoc."},{"key":"10.1016\/j.cmpb.2026.109644_bib0079","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2025.1584509","article-title":"A fully coupled fluid-structure interaction model for patient-specific analysis of bioprosthetic aortic valve haemodynamics","volume":"13","author":"Yin","year":"2025","journal-title":"Front. Bioeng. Biotechnol."},{"key":"10.1016\/j.cmpb.2026.109644_bib0080","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2018.00363","article-title":"3d fluid-structure interaction simulation of aortic valves using a unified continuum ale fem model","volume":"9","author":"Spu\u00a8hler","year":"2018","journal-title":"Front. Physiol."},{"issue":"10","key":"10.1016\/j.cmpb.2026.109644_bib0081","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pcbi.1011479","article-title":"Wall shear stress and pressure patterns in aortic stenosis patients with and without aortic dilation captured by high-performance image-based computational fluid dynamics","volume":"19","author":"Zolfaghari","year":"2023","journal-title":"PLoS Comput. Biol."},{"key":"10.1016\/j.cmpb.2026.109644_bib0082","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2023.1136935","article-title":"Modelling blood flow in patients with heart valve disease using deep learning: a computationally efficient method to expand diagnostic capabilities in clinical routine","volume":"10","author":"Yevtushenko","year":"2023","journal-title":"Front. Cardiovasc. Med."},{"issue":"12","key":"10.1016\/j.cmpb.2026.109644_bib0083","doi-asserted-by":"crossref","first-page":"8620","DOI":"10.21037\/jtd-24-1650","article-title":"The biomechanical effect of the o-a angle on the aortic valve under left ventricular assist device support: a primary fluid-structure interaction study","volume":"16","author":"Wang","year":"2024","journal-title":"J. Thorac. Dis."},{"issue":"6","key":"10.1016\/j.cmpb.2026.109644_bib0084","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.1007\/s10237-023-01735-0","article-title":"Turbulent blood dynamics in the left heart in the presence of mitral regurgitation: a computational study based on multi-series cine-mri","volume":"22","author":"Bennati","year":"2023","journal-title":"Biomech. Model. Mechanobiol."},{"issue":"1","key":"10.1016\/j.cmpb.2026.109644_bib0085","doi-asserted-by":"crossref","DOI":"10.3390\/s25010011","article-title":"Algorithmic generation of parameterized geometric models of the aortic valve and left ventricle","volume":"25","author":"Pil","year":"2024","journal-title":"Sensors"},{"issue":"4","key":"10.1016\/j.cmpb.2026.109644_bib0086","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1007\/s13239-018-00391-1","article-title":"Validation and extension of a fluidstructure interaction model of the healthy aortic valve","volume":"9","author":"Tango","year":"2018","journal-title":"Cardiovasc. Eng. Technol."},{"issue":"2","key":"10.1016\/j.cmpb.2026.109644_bib0087","doi-asserted-by":"crossref","first-page":"448","DOI":"10.36660\/abc.20200926","article-title":"Computational fluid dynamics to assess the future risk of ascending aortic aneurysms","volume":"118","author":"Almeida","year":"2022","journal-title":"Arq. Bras. Cardiol."},{"issue":"4","key":"10.1016\/j.cmpb.2026.109644_bib0088","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1007\/s12650-025-01063-8","article-title":"Cfd-based estimation of the impact of transcatheter aortic valve implantation position on thrombosis risk","volume":"28","author":"Cheng","year":"2025","journal-title":"J. Vis."},{"key":"10.1016\/j.cmpb.2026.109644_bib0089","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1007\/s10237-018-1094-8","article-title":"Patient-specific simulation of transcatheter aortic valve replacement: impact of deployment options on paravalvular leakage","volume":"18","author":"Bianchi","year":"2019","journal-title":"Biomech. Model. Mechanobiol."},{"key":"10.1016\/j.cmpb.2026.109644_bib0090","article-title":"Fluid-structure interaction analysis on the influence of the aortic valve stent leaflet structure in hemodynamics","volume":"13","author":"Liu","year":"2022","journal-title":"Front. Physiol."},{"issue":"7","key":"10.1016\/j.cmpb.2026.109644_bib0091","doi-asserted-by":"crossref","first-page":"E141","DOI":"10.1111\/aor.13107","article-title":"Simulated transcatheter aortic valve flow: implications of elliptical deployment and under-expansion at the aortic annulus","volume":"42","author":"Sirois","year":"2018","journal-title":"Artif. Organs"},{"issue":"3","key":"10.1016\/j.cmpb.2026.109644_bib0092","doi-asserted-by":"crossref","DOI":"10.3390\/bioengineering7030090","article-title":"Hemodynamic performance of dysfunctional prosthetic heart valve with the concomitant presence of subaortic stenosis: in silico study","volume":"7","author":"Smadi","year":"2020","journal-title":"Bioengineering"},{"key":"10.1016\/j.cmpb.2026.109644_bib0093","doi-asserted-by":"crossref","DOI":"10.1016\/j.mechrescom.2020.103604","article-title":"Computational investigation of left ventricular hemodynamics following bioprosthetic aortic and mitral valve replacement","volume":"112","author":"Xu","year":"2021","journal-title":"Mech. Res. Commun."},{"issue":"1","key":"10.1016\/j.cmpb.2026.109644_bib0094","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1515\/cdbme-2023-1125","article-title":"In silico model to assess throm-\u00a8 bosis risk of TAVR with hemodynamic predictors using fluid structure interaction","volume":"9","author":"Borowski","year":"2023","journal-title":"Curr. Dir. Biomed. Eng."},{"issue":"5","key":"10.1016\/j.cmpb.2026.109644_bib0095","doi-asserted-by":"crossref","first-page":"1725","DOI":"10.1007\/s10237-020-01304-9","article-title":"Numerical evaluation of transcatheter aortic valve performance during heart beating and its post-deployment fluid-structure interaction analysis","volume":"19","author":"Ghosh","year":"2020","journal-title":"Biomech. Model. Mechanobiol."},{"issue":"2","key":"10.1016\/j.cmpb.2026.109644_bib0096","doi-asserted-by":"crossref","DOI":"10.3390\/bioengineering10020188","article-title":"Mild paravalvular leak may pose an increased thrombogenic risk in transcatheter aortic valve replacement (tavr) patients-insights from patient specific in vitro and in silico studies","volume":"10","author":"Kovarovic","year":"2023","journal-title":"Bioengineering"},{"key":"10.1016\/j.cmpb.2026.109644_bib0097","doi-asserted-by":"crossref","DOI":"10.1016\/j.cmpb.2024.108469","article-title":"Thrombogenic risk assessment of transcatheter prosthetic heart valves using a fluid-structure interaction approach","volume":"257","author":"Baylous","year":"2024","journal-title":"Comput. Methods Programs Biomed."},{"issue":"4","key":"10.1016\/j.cmpb.2026.109644_bib0098","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1007\/s12265-021-10191-z","article-title":"Assessment of paravalvular leak severity and thrombogenic potential in transcatheter bicuspid aortic valve replacements using patient-specific computational modeling","volume":"15","author":"Anam","year":"2022","journal-title":"J. Cardiovasc. Transl. Res."},{"issue":"4","key":"10.1016\/j.cmpb.2026.109644_bib0099","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1007\/s12265-025-10634-x","article-title":"Modeling the hemodynamic impact of y-incision aortic annular enlargements on aortic valve replacement and valve-in-valve procedures","volume":"18","author":"Bonini","year":"2025","journal-title":"J. Cardiovasc. Transl. Res."},{"issue":"12","key":"10.1016\/j.cmpb.2026.109644_bib0100","doi-asserted-by":"crossref","first-page":"3295","DOI":"10.1007\/s10439-024-03597-8","article-title":"Image-based computa-tional fluid dynamics to compare two repair techniques for mitral valve prolapse","volume":"52","author":"Bennati","year":"2024","journal-title":"Ann. Biomed. Eng."},{"key":"10.1016\/j.cmpb.2026.109644_bib0101","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2022.934305","article-title":"Patient-specific fluid simulation of transcatheter mitral valve replacement in mitral annulus calcification","volume":"9","author":"Hill","year":"2022","journal-title":"Front. Cardiovasc. Med."},{"issue":"1","key":"10.1016\/j.cmpb.2026.109644_bib0102","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/s13239-016-0284-8","article-title":"Pledget-armed sutures affect the haemodynamic performance of biologic aortic valve substitutes: a preliminary experimental and computational study","volume":"8","author":"Capelli","year":"2017","journal-title":"Cardiovasc. Eng. Technol."},{"issue":"1","key":"10.1016\/j.cmpb.2026.109644_bib0103","article-title":"On the three-dimensionality of flow in the neo-sinus and its implications for subclinical leaflet thrombosis","volume":"36","author":"Qiu","year":"2022","journal-title":"Interact. Cardiovasc. Thorac. Surg."},{"issue":"4","key":"10.1016\/j.cmpb.2026.109644_bib0104","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1007\/s10439-023-03419-3","article-title":"Effect of sinotubular junction size on TAVR leaflet thrombosis: a fluid\u2013structure interaction analysis","volume":"52","author":"Oks","year":"2024","journal-title":"Ann. Biomed. Eng."},{"key":"10.1016\/j.cmpb.2026.109644_bib0105","doi-asserted-by":"crossref","DOI":"10.1016\/j.compbiomed.2024.108828","article-title":"The relation between aortic morphology and transcatheter aortic heart valve thrombosis: particle tracing and platelet activation in larger aortic roots with and without neo-sinus","volume":"179","author":"Bornemann","year":"2024","journal-title":"Comput. Biol. Med."},{"key":"10.1016\/j.cmpb.2026.109644_bib0106","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1007\/s12265-022-10333-x","article-title":"Subclinical leaflet thrombosis in supra-annular transcatheter aortic valves: the role of leaflet design","volume":"16","author":"Qiu","year":"2023","journal-title":"J. Cardiovasc. Transl. Res."},{"issue":"3","key":"10.1016\/j.cmpb.2026.109644_bib0107","doi-asserted-by":"crossref","DOI":"10.1115\/1.3005158","article-title":"Two-dimensional simulation of flow and platelet dynamics in the hinge region of a mechanical heart valve","volume":"131","author":"Govindarajan","year":"2009","journal-title":"J. Biomech. Eng."},{"issue":"6","key":"10.1016\/j.cmpb.2026.109644_bib0108","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1007\/s13239-021-00596-x","article-title":"Predictive model for thrombus formation after transcatheter valve replacement","volume":"12","author":"Hatoum","year":"2021","journal-title":"Cardiovasc. Eng. Technol."},{"issue":"1","key":"10.1016\/j.cmpb.2026.109644_bib0109","doi-asserted-by":"crossref","first-page":"67","DOI":"10.4244\/EIJ-D-19-00048","article-title":"Reducing the risk of leaflet thrombosis in transcatheter aortic valve-in-valve implantation by BASILICA: a computational simulation study","volume":"15","author":"Khodaee","year":"2019","journal-title":"EuroIntervention"},{"key":"10.1016\/j.cmpb.2026.109644_bib0110","doi-asserted-by":"crossref","first-page":"2400","DOI":"10.1007\/s10439-020-02532-x","article-title":"Influence of patient-specific characteristics on transcatheter heart valve neo-sinus flow: an in silico study","volume":"48","author":"Singh-Gryzbon","year":"2020","journal-title":"Ann. Biomed. Eng."},{"issue":"1","key":"10.1016\/j.cmpb.2026.109644_bib0111","doi-asserted-by":"crossref","first-page":"55","DOI":"10.4244\/EIJ-D-19-00056","article-title":"Bioprosthetic or native aortic scallop intentional laceration to prevent iatrogenic coronary artery obstruction. Part 2: how to perform BASILICA","volume":"15","author":"Komatsu","year":"2019","journal-title":"EuroIntervention"},{"issue":"12","key":"10.1016\/j.cmpb.2026.109644_bib0112","first-page":"990","article-title":"Aortic valve leaflet disruption techniques in transcatheter aortic valve replacement","volume":"19","author":"Shin","year":"2022","journal-title":"J. Geriatr. Cardiol."},{"key":"10.1016\/j.cmpb.2026.109644_bib0113","first-page":"1240","article-title":"The BASILICA trial: prospective multi-center investigation of intentional leaflet laceration to prevent TAVR coronary obstruction","volume":"12","author":"Khan","year":"2019","journal-title":"JACC: Cardiovasc. Interv."},{"issue":"2","key":"10.1016\/j.cmpb.2026.109644_bib0114","article-title":"Understanding the mechanisms of TAVI durability through computational modelling: a multidisciplinary review","volume":"7","author":"Rauseo","year":"2026","journal-title":"Eur. Heart. J. Digit. Health"},{"key":"10.1016\/j.cmpb.2026.109644_bib0115","doi-asserted-by":"crossref","DOI":"10.1016\/j.cmpb.2026.109404","article-title":"In silico modeling of transcatheter heart valve oversizing and ellipticity, Part I: establishing credibility of an advanced model","volume":"282","author":"Boxwell","year":"2026","journal-title":"Comput. Methods Programs Biomed."},{"key":"10.1016\/j.cmpb.2026.109644_bib0116","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1002\/nme.4943","article-title":"A monolithic geometric multigrid solver for fluid-structure interactions in ALE formulation","volume":"104","author":"Richter","year":"2015","journal-title":"Int. J. Numer. Methods Eng."},{"key":"10.1016\/j.cmpb.2026.109644_bib0117","doi-asserted-by":"crossref","first-page":"4506","DOI":"10.1016\/j.cma.2004.12.005","article-title":"Added-mass effect in the design of partitioned algorithms for fluid\u2013structure problems","volume":"194","author":"Causin","year":"2005","journal-title":"Comput. Methods Appl. Mech. Eng."},{"key":"10.1016\/j.cmpb.2026.109644_bib0118","article-title":"Analysis of turbulence models to simulate patient-specific vortex flows in aortic coarctation","volume":"11","author":"Skripka","year":"2026","journal-title":"Fluids"},{"key":"10.1016\/j.cmpb.2026.109644_bib0119","series-title":"Assessing Credibility of Computational Modeling through Verification and Validation: Application to Medical Devices","year":"2018"},{"issue":"4","key":"10.1016\/j.cmpb.2026.109644_bib0120","doi-asserted-by":"crossref","DOI":"10.1063\/5.0280958","article-title":"Credibility assessment of patient-specific modeling in transcatheter aortic valve implantation. I. A population-based validation of patient-specific modeling","volume":"9","author":"Catalano","year":"2025","journal-title":"APL. Bioeng."}],"container-title":["Computer Methods and Programs in Biomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0169260726003937?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0169260726003937?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T20:30:43Z","timestamp":1790800243000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0169260726003937"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":122,"alternative-id":["S0169260726003937"],"URL":"https:\/\/doi.org\/10.1016\/j.cmpb.2026.109644","relation":{},"ISSN":["0169-2607"],"issn-type":[{"value":"0169-2607","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Computational modeling of thrombosis after transcatheter aortic valve implantation: A systematic review of hemodynamic and mechanical risk metrics","name":"articletitle","label":"Article Title"},{"value":"Computer Methods and Programs in Biomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cmpb.2026.109644","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"109644"}}