{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T08:47:52Z","timestamp":1765356472523,"version":"build-2065373602"},"reference-count":50,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T00:00:00Z","timestamp":1543622400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T00:00:00Z","timestamp":1543622400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","theclinics.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Critical Care Nursing Clinics of North America"],"published-print":{"date-parts":[[2018,12]]},"DOI":"10.1016\/j.cnc.2018.07.007","type":"journal-article","created":{"date-parts":[[2018,11,14]],"date-time":"2018-11-14T21:28:38Z","timestamp":1542230918000},"page":"509-521","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"title":["Neonatal Encephalopathy"],"prefix":"10.1016","volume":"30","author":[{"given":"Elizabeth A.","family":"Schump","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.cnc.2018.07.007_bib1","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1053\/j.semperi.2004.10.003","article-title":"Brain injury in the term infant","volume":"28","author":"Perlman","year":"2004","journal-title":"Semin Perinatol"},{"key":"10.1016\/j.cnc.2018.07.007_bib2","first-page":"1","article-title":"Births: final data for 2010","volume":"61","author":"Martin","year":"2012","journal-title":"Natl Vital Stat Rep"},{"unstructured":"Zanelli SA, Stanley DP, Kaufman DA. Hypoxic-ischemic encephalopathy. 2014. Available at: http:\/\/emedicine.medscape.com\/article\/973501-overview. Accessed November 20, 2017.","key":"10.1016\/j.cnc.2018.07.007_bib3"},{"key":"10.1016\/j.cnc.2018.07.007_bib4","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.nurx.2006.01.007","article-title":"Hypothermic neuroprotection","volume":"3","author":"Gunn","year":"2006","journal-title":"NeuroRx"},{"issue":"9460","key":"10.1016\/j.cnc.2018.07.007_bib5","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/S0140-6736(05)17946-X","article-title":"Selective head cooling with mild systemic hypothermia after neonatal encephalopathy: multicentre randomised trial","volume":"365","author":"Gluckman","year":"2005","journal-title":"Lancet"},{"issue":"15","key":"10.1016\/j.cnc.2018.07.007_bib6","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1056\/NEJMcps050929","article-title":"Whole body hypothermia for neonates with hypoxic-ischemic encephalopathy","volume":"353","author":"Shankaran","year":"2005","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.cnc.2018.07.007_bib7","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/1471-2431-8-17","article-title":"The TOBY Study. Whole body hypothermia for the treatment of perinatal asphyxial encephalopathy: a randomised controlled trial","volume":"8","author":"Azzopardi","year":"2008","journal-title":"BMC Pediatr"},{"issue":"10","key":"10.1016\/j.cnc.2018.07.007_bib8","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1001\/archneur.1976.00500100030012","article-title":"Neonatal encephalopathy following fetal distress. A clinical and electroencephalographic study","volume":"33","author":"Sarnat","year":"1976","journal-title":"Arch Neurol"},{"issue":"1","key":"10.1016\/j.cnc.2018.07.007_bib9","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1159\/000455819","article-title":"A\u00a0comparison of the Thompson Encephalopathy score and amplitude-integrated electroencephalography in infants with perinatal asphyxia and therapeutic hypothermia","volume":"112","author":"Weeke","year":"2017","journal-title":"Neonatology"},{"key":"10.1016\/j.cnc.2018.07.007_bib10","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.pediatrneurol.2016.03.014","article-title":"The Thompson encephalopathy score and short-term outcomes in asphyxiated newborns treated with therapeutic hypothermia","volume":"60","author":"Thorsen","year":"2016","journal-title":"Pediatr Neurol"},{"key":"10.1016\/j.cnc.2018.07.007_bib11","first-page":"1","article-title":"Cooling for newborns with hypoxic ischemic encephalopathy","volume":"4","author":"Jacobs","year":"2007","journal-title":"Cochrane Database Syst Rev"},{"issue":"24","key":"10.1016\/j.cnc.2018.07.007_bib12","doi-asserted-by":"crossref","first-page":"2629","DOI":"10.1001\/jama.2014.16058","article-title":"Effect of depth and duration of cooling on deaths in the NICU among neonates with hypoxic ischemic encephalopathy: a randomized clinical trial","volume":"312","author":"Shankaran","year":"2014","journal-title":"JAMA"},{"issue":"1","key":"10.1016\/j.cnc.2018.07.007_bib13","doi-asserted-by":"crossref","first-page":"27","DOI":"10.5152\/tpa.2015.2167","article-title":"Comparison of selective head cooling therapy and whole body cooling therapy in newborns with hypoxic ischemic encephalopathy: short term results","volume":"50","author":"Atici","year":"2015","journal-title":"Turk Pediatri Ars"},{"issue":"8","key":"10.1016\/j.cnc.2018.07.007_bib14","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1038\/jp.2009.37","article-title":"Effects of therapeutic hypothermia on multiorgan dysfunction in asphyxiated newborns: whole-body cooling versus selective head cooling","volume":"29","author":"Sarkar","year":"2009","journal-title":"J\u00a0Perinatol"},{"issue":"1","key":"10.1016\/j.cnc.2018.07.007_bib15","doi-asserted-by":"crossref","first-page":"e124","DOI":"10.1542\/peds.2009-2995","article-title":"A\u00a0comparison of cooling methods used in therapeutic hypothermia for perinatal asphyxia","volume":"126","author":"Hogue","year":"2010","journal-title":"Pediatrics"},{"issue":"1","key":"10.1016\/j.cnc.2018.07.007_bib16","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1111\/ped.12747","article-title":"Comparison of selective head cooling versus whole-body cooling","volume":"58","author":"Celik","year":"2016","journal-title":"Pediatr Int"},{"issue":"2 pt 1","key":"10.1016\/j.cnc.2018.07.007_bib17","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1542\/peds.110.2.377","article-title":"Whole-body hypothermia for neonatal encephalopathy: animal observations as a basis for a randomized, controlled pilot study in term infants","volume":"110","author":"Shankaran","year":"2002","journal-title":"Pediatrics"},{"issue":"1","key":"10.1016\/j.cnc.2018.07.007_bib18","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/S0952-3278(03)00055-3","article-title":"Selective head cooling with hypothermia suppresses the generation of platelet-activating factor in cerebrospinal fluid of newborn infants with perinatal asphyxia","volume":"69","author":"Akisu","year":"2003","journal-title":"Prostaglandins Leukot Essent Fatty Acids"},{"issue":"Suppl. 3","key":"10.1016\/j.cnc.2018.07.007_bib19","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1111\/dmcn.12726","article-title":"Early predictors of outcome in infants treated with hypothermia for hypoxic-ischaemic encephalopathy","volume":"57","author":"Merchant","year":"2015","journal-title":"Dev Med Child Neurol"},{"key":"10.1016\/j.cnc.2018.07.007_bib20","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1186\/1471-2431-13-52","article-title":"Early clinical signs in neonates with hypoxic ischemic encephalopathy predict an abnormal amplitude-integrated electroencephalogram at age 6 hours","volume":"13","author":"Horn","year":"2013","journal-title":"BMC Pediatr"},{"issue":"11","key":"10.1016\/j.cnc.2018.07.007_bib21","doi-asserted-by":"crossref","first-page":"e0165744","DOI":"10.1371\/journal.pone.0165744","article-title":"Amplitude integrated electroencephalogram as a prognostic tool in neonates with hypoxic-ischemic encephalopathy: a systematic review","volume":"11","author":"Del Rio","year":"2016","journal-title":"PLoS One"},{"issue":"6","key":"10.1016\/j.cnc.2018.07.007_bib22","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1038\/jp.2017.14","article-title":"Predictive value of amplitude-integrated EEG (aEEG) after rescue hypothermic neuroprotection for hypoxic ischemic encephalopathy: a meta-analysis","volume":"37","author":"Chandrasekaran","year":"2017","journal-title":"J\u00a0Perinatol"},{"issue":"3","key":"10.1016\/j.cnc.2018.07.007_bib23","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1159\/000339570","article-title":"aEEG evolution during therapeutic hypothermia and prediction of NICU outcome in encephalopathic neonates","volume":"102","author":"Massaro","year":"2012","journal-title":"Neonatology"},{"key":"10.1016\/j.cnc.2018.07.007_bib24","first-page":"46","article-title":"Monitoring cerebral oxygenation in neonates: an update","volume":"5","author":"Dix","year":"2017","journal-title":"Front Pediatr"},{"issue":"2","key":"10.1016\/j.cnc.2018.07.007_bib25","doi-asserted-by":"crossref","first-page":"128","DOI":"10.5507\/bp.2017.012","article-title":"Use of near-infrared spectroscopy (NIRS) in cerebral tissue oxygenation monitoring in neonates","volume":"161","author":"Gumulak","year":"2017","journal-title":"Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub"},{"issue":"2","key":"10.1016\/j.cnc.2018.07.007_bib26","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1038\/pr.2013.84","article-title":"Cerebral oxygenation and brain activity after perinatal asphyxia: does hypothermia change their prognostic value?","volume":"74","author":"Lemmers","year":"2013","journal-title":"Pediatr Res"},{"issue":"3","key":"10.1016\/j.cnc.2018.07.007_bib27","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1159\/000468976","article-title":"Prediction of outcomes in neonates with hypoxic-ischemic encephalopathy II: role of amplitude-integrated electroencephalography and cerebral oxygen saturation measured by near-infrared spectroscopy","volume":"112","author":"Goeral","year":"2017","journal-title":"Neonatology"},{"key":"10.1016\/j.cnc.2018.07.007_bib28","doi-asserted-by":"crossref","first-page":"F267","DOI":"10.1136\/archdischild-2011-300716","article-title":"Cooling and seizure burden in term neonates: an observational study","volume":"97","author":"Low","year":"2012","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"10.1016\/j.cnc.2018.07.007_bib29","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1542\/pir.33.9.387","article-title":"Neonatal hypoxia and seizures","volume":"33","author":"Gillam-Krakauer","year":"2012","journal-title":"Pediatr Rev"},{"key":"10.1016\/j.cnc.2018.07.007_bib30","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.seizure.2015.10.007","article-title":"The temporal characteristics of seizures in neonatal hypoxic ischemic encephalopathy treated with hypothermia","volume":"33","author":"Lynch","year":"2015","journal-title":"Seizure"},{"issue":"3","key":"10.1016\/j.cnc.2018.07.007_bib31","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1055\/s-2000-9293","article-title":"Hypoxic-ischemic encephalopathy","volume":"17","author":"Vanucci","year":"2000","journal-title":"Am J Perinatol"},{"key":"10.1016\/j.cnc.2018.07.007_bib32","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1055\/s-2007-979751","article-title":"Hypoxic ischaemic encephalopathy: early magnetic resonance imaging findings and their evolution","volume":"26","author":"Rutherford","year":"1995","journal-title":"Neuropediatrics"},{"issue":"5","key":"10.1016\/j.cnc.2018.07.007_bib33","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/j.pediatrneurol.2014.01.013","article-title":"Predictive value of neonatal MRI showing no or minor degrees of brain injury after hypothermia","volume":"50","author":"Rollins","year":"2014","journal-title":"Pediatr Neurol"},{"issue":"3","key":"10.1016\/j.cnc.2018.07.007_bib34","first-page":"407","article-title":"Diffusion weighted magnetic resonance imaging and its recent trend-a survey","volume":"5","author":"Chilla","year":"2015","journal-title":"Quant Imaging Med Surg"},{"key":"10.1016\/j.cnc.2018.07.007_bib35","first-page":"707","article-title":"Prognostic tests in term neonates with hypoxic-ischaemic encephalopathy: a systematic review","volume":"102","author":"Van Laerhoven","year":"2013","journal-title":"Pediatrics"},{"issue":"4","key":"10.1016\/j.cnc.2018.07.007_bib36","doi-asserted-by":"crossref","first-page":"e844","DOI":"10.1542\/peds.2007-1987","article-title":"Elevated morphine concentrations in neonates treated with morphine and prolonged hypothermia for hypoxic ischemic encephalopathy","volume":"121","author":"Roka","year":"2008","journal-title":"Pediatrics"},{"issue":"4","key":"10.1016\/j.cnc.2018.07.007_bib37","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1213\/01.ANE.0000146517.17910.54","article-title":"The effect of mild hypothermia on plasma fentanyl concentration and biotransformation in juvenile pigs","volume":"100","author":"Fritz","year":"2005","journal-title":"Anesth Analg"},{"issue":"6","key":"10.1016\/j.cnc.2018.07.007_bib38","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1038\/jp.2010.146","article-title":"Physiologic and pharmacologic considerations for hypothermia therapy in neonates","volume":"31","author":"Zanelli","year":"2011","journal-title":"J\u00a0Perinatol"},{"issue":"1","key":"10.1016\/j.cnc.2018.07.007_bib39","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1152\/jappl.1977.42.1.56","article-title":"Dependency of hypoxic pulmonary vasoconstriction on temperature","volume":"42","author":"Benumof","year":"1977","journal-title":"J\u00a0Appl Physiol Respir Environ Exerc Physiol"},{"issue":"1","key":"10.1016\/j.cnc.2018.07.007_bib40","first-page":"13","article-title":"Brain cooling for asphyxiated newborns: the impact on respiratory mechanics, oxygenation and ventilation","volume":"48","author":"Wintermark","year":"2012","journal-title":"Can J Respir Ther"},{"issue":"1","key":"10.1016\/j.cnc.2018.07.007_bib41","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1542\/peds.2008-1955","article-title":"Blood gas values during hypothermia in asphyxiated term neonates","volume":"123","author":"Groenendaal","year":"2009","journal-title":"Pediatrics"},{"issue":"11","key":"10.1016\/j.cnc.2018.07.007_bib42","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1203\/00006450-198411000-00015","article-title":"The effects of variations in PaCO2 on brain blood flow and cardiac output in the newborn piglet","volume":"18","author":"Hansen","year":"1984","journal-title":"Pediatr Res"},{"issue":"2","key":"10.1016\/j.cnc.2018.07.007_bib43","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1097\/FTD.0b013e3182834335","article-title":"Gentamicin pharmacokinetics in neonates undergoing therapeutic hypothermia","volume":"35","author":"Mark","year":"2013","journal-title":"Ther Drug Monit"},{"year":"2006","author":"Bayley","series-title":"Bayley scales of infant and toddler development: administration manual","key":"10.1016\/j.cnc.2018.07.007_bib44"},{"issue":"pt 1","key":"10.1016\/j.cnc.2018.07.007_bib45","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1093\/brain\/aws285","article-title":"Melatonin augments hypothermic neuroprotection in a perinatal asphyxia model","volume":"136","author":"Robertson","year":"2013","journal-title":"Brain"},{"key":"10.1016\/j.cnc.2018.07.007_bib46","doi-asserted-by":"crossref","first-page":"296","DOI":"10.3389\/fncel.2017.00296","article-title":"The beneficial effects of melatonin administration following hypoxia ischemia in preterm fetal sheep","volume":"11","author":"Yawno","year":"2017","journal-title":"Front Cell Neurosci"},{"key":"10.1016\/j.cnc.2018.07.007_bib47","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1159\/000346323","article-title":"Mechanisms of melatonin-induced protection in the brain of late gestation fetal sheep in response to hypoxia","volume":"34","author":"Yawno","year":"2012","journal-title":"Dev Neurosci"},{"key":"10.1016\/j.cnc.2018.07.007_bib48","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1159\/000355460","article-title":"Concurrent erythropoietin and hypothermia treatment improve outcomes in a term nonhuman primate model of perinatal asphyxia","volume":"35","author":"Traudt","year":"2013","journal-title":"Dev Neurosci"},{"key":"10.1016\/j.cnc.2018.07.007_bib49","doi-asserted-by":"crossref","DOI":"10.1542\/peds.2016-0191","article-title":"High-dose erythropoietin and hypothermia for hypoxic-ischemic encephalopathy: a phase II trial","volume":"137","author":"Wu","year":"2016","journal-title":"Pediatrics"},{"issue":"5","key":"10.1016\/j.cnc.2018.07.007_bib50","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/j.pediatrneurol.2014.08.010","article-title":"Erythropoietin and hypothermia for hypoxic-ischemic encephalopathy","volume":"51","author":"Rogers","year":"2014","journal-title":"Pediatr Neurol"}],"container-title":["Critical Care Nursing Clinics of North America"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0899588518309778?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0899588518309778?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T11:29:05Z","timestamp":1760268545000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0899588518309778"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12]]},"references-count":50,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,12]]}},"alternative-id":["S0899588518309778"],"URL":"https:\/\/doi.org\/10.1016\/j.cnc.2018.07.007","relation":{},"ISSN":["0899-5885"],"issn-type":[{"type":"print","value":"0899-5885"}],"subject":[],"published":{"date-parts":[[2018,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Neonatal Encephalopathy","name":"articletitle","label":"Article Title"},{"value":"Critical Care Nursing Clinics of North America","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cnc.2018.07.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}