{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T17:37:41Z","timestamp":1790617061919,"version":"4.1.0"},"reference-count":54,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,9,17]],"date-time":"2021-09-17T00:00:00Z","timestamp":1631836800000},"content-version":"vor","delay-in-days":259,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Neurophysiology Practice"],"published-print":{"date-parts":[[2021]]},"DOI":"10.1016\/j.cnp.2021.09.001","type":"journal-article","created":{"date-parts":[[2021,9,23]],"date-time":"2021-09-23T12:14:20Z","timestamp":1632399260000},"page":"245-255","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":44,"special_numbering":"C","title":["Cerebral blood flow remains reduced after tilt testing in myalgic encephalomyelitis\/chronic fatigue syndrome patients"],"prefix":"10.1016","volume":"6","author":[{"given":"C. (Linda) M.C.","family":"van Campen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter C.","family":"Rowe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frans C.","family":"Visser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"11","key":"10.1016\/j.cnp.2021.09.001_b0005","first-page":"806","article-title":"Effect of postural challenges on non-invasive cardiac output measurement with impedance cardiography in young healthy adults using new horizontal electrode placement method","volume":"3","author":"Barde","year":"2012","journal-title":"IJBAR"},{"issue":"2","key":"10.1016\/j.cnp.2021.09.001_b0010","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1152\/jn.00692.2017","article-title":"Inflow of oxygen and glucose in brain tissue induced by intravenous norepinephrine: relationships with central metabolic and peripheral vascular responses","volume":"119","author":"Bola","year":"2018","journal-title":"J Neurophysiol"},{"issue":"12","key":"10.1016\/j.cnp.2021.09.001_b0015","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1001\/jama.1995.03530120053041","article-title":"The relationship between neurally mediated hypotension and the chronic fatigue syndrome","volume":"274","author":"Bou-Holaigah","year":"1995","journal-title":"JAMA"},{"issue":"4","key":"10.1016\/j.cnp.2021.09.001_b0020","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1111\/j.1365-2796.2011.02428.x","article-title":"Myalgic encephalomyelitis: international consensus criteria","volume":"270","author":"Carruthers","year":"2011","journal-title":"J Intern Med"},{"key":"10.1016\/j.cnp.2021.09.001_b0025","article-title":"Cardiac output and cerebral blood flow: a systematic review of cardio-cerebral coupling","author":"Castle-Kirszbaum","year":"2021","journal-title":"J Neurosurg Anesthesiol"},{"issue":"1-3","key":"10.1016\/j.cnp.2021.09.001_b0030","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cbpb.2012.01.008","article-title":"Neuroprotection: lessons from hibernators","volume":"162","author":"Dave","year":"2012","journal-title":"Comp Biochem Physiol B Biochem Mol Biol"},{"issue":"4","key":"10.1016\/j.cnp.2021.09.001_b0035","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1007\/BF02267980","article-title":"Pathogenesis and management of delayed orthostatic hypotension in patients with chronic fatigue syndrome","volume":"7","author":"De Lorenzo","year":"1997","journal-title":"Clin Auton Res"},{"issue":"3","key":"10.1016\/j.cnp.2021.09.001_b0040","doi-asserted-by":"crossref","first-page":"H397","DOI":"10.1152\/ajpheart.00194.2014","article-title":"Blunted cerebral blood flow velocity in response to a nitric oxide donor in postural tachycardia syndrome","volume":"307","author":"Del Pozzi","year":"2014","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.cnp.2021.09.001_b0045","doi-asserted-by":"crossref","unstructured":"Duprez, D.A., De Buyzere, M.L., Drieghe, B., Vanhaverbeke, F., Taes ,Y., Michielsen, W., et al. Long- and short-term blood pressure and RR-interval variability and psychosomatic distress in chronic fatigue syndrome. Clin Sci (Lond) 1998;94(1):57-63.","DOI":"10.1042\/cs0940057"},{"issue":"5","key":"10.1016\/j.cnp.2021.09.001_b0050","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1097\/HJH.0b013e3283279860","article-title":"Orthostatic hypotension in genetically related hypertensive and normotensive individuals","volume":"27","author":"Fedorowski","year":"2009","journal-title":"J Hypertens"},{"issue":"1-2","key":"10.1016\/j.cnp.2021.09.001_b0055","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.autneu.2011.02.004","article-title":"Consensus statement on the definition of orthostatic hypotension, neurally mediated syncope and the postural tachycardia syndrome","volume":"161","author":"Freeman","year":"2011","journal-title":"Auton Neurosci"},{"issue":"12","key":"10.1016\/j.cnp.2021.09.001_b0060","doi-asserted-by":"crossref","first-page":"953","DOI":"10.7326\/0003-4819-121-12-199412150-00009","article-title":"The chronic fatigue syndrome: a comprehensive approach to its definition and study. International Chronic Fatigue Syndrome Study Group","volume":"121","author":"Fukuda","year":"1994","journal-title":"Ann Intern Med"},{"issue":"3","key":"10.1016\/j.cnp.2021.09.001_b0065","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1002\/j.2040-4603.2019.tb00083.x","article-title":"Regulation of the cerebral circulation by arterial carbon dioxide","volume":"9","author":"Hoiland","year":"2019","journal-title":"Compr Physiol"},{"issue":"7","key":"10.1016\/j.cnp.2021.09.001_b0070","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1111\/j.1365-2362.2010.02310.x","article-title":"Impaired cardiovascular response to standing in chronic fatigue syndrome","volume":"40","author":"Hollingsworth","year":"2010","journal-title":"Eur J Clin Invest"},{"issue":"7","key":"10.1016\/j.cnp.2021.09.001_b0075","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1152\/japplphysiol.00637.2013","article-title":"Hyperventilation, cerebral perfusion, and syncope","volume":"116","author":"Immink","year":"2014","journal-title":"J Appl Physiol"},{"key":"10.1016\/j.cnp.2021.09.001_b0080","unstructured":"Institute Of Medicine (IOM). Beyond mayalgic encephalomyelitis\/chronic fatigue syndrome: redefining an illness. Washington DC: The National Academies Press; 2015. p. 304."},{"issue":"9","key":"10.1016\/j.cnp.2021.09.001_b0085","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1016\/S0002-9149(9X)00084-9","article-title":"Neurohormonal response to head-up tilt and its role in vasovagal syncope","volume":"79","author":"Jardine","year":"1997","journal-title":"Am J Cardiol"},{"issue":"12","key":"10.1016\/j.cnp.2021.09.001_b0090","doi-asserted-by":"crossref","first-page":"1415.e19","DOI":"10.1016\/j.amjmed.2005.06.013","article-title":"Orthostatic instability in a population-based study of chronic fatigue syndrome","volume":"118","author":"Jones","year":"2005","journal-title":"Am J Med"},{"issue":"3","key":"10.1016\/j.cnp.2021.09.001_b0095","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.119.015502","article-title":"Stunned and hibernating myocardium: Where are we nearly 4 decades later?","volume":"9","author":"Kloner","year":"2020","journal-title":"J Am Heart Assoc"},{"issue":"5","key":"10.1016\/j.cnp.2021.09.001_b0100","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1016\/S0894-7317(05)80378-5","article-title":"Measurement of aortic blood flow by Doppler echocardiography: temporal, technician, and reader variability in normal subjects and the application of generalizability theory in clinical research","volume":"8","author":"Kusumoto","year":"1995","journal-title":"J Am Soc Echocardiogr"},{"issue":"1","key":"10.1016\/j.cnp.2021.09.001_b0105","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1056\/NEJMra012457","article-title":"Hypocapnia","volume":"347","author":"Laffey","year":"2002","journal-title":"N Engl J Med"},{"issue":"2","key":"10.1016\/j.cnp.2021.09.001_b0110","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1046\/j.1365-2281.1999.00154.x","article-title":"Cardiovascular response during head-up tilt in chronic fatigue syndrome","volume":"19","author":"LaManca","year":"1999","journal-title":"Clin Physiol"},{"issue":"1","key":"10.1016\/j.cnp.2021.09.001_b0115","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1186\/2193-1801-3-191","article-title":"Carotid blood flow, cardiovascular and endocrine responses during head-up tilt in patients with acute cerebrovascular diseases","volume":"3","author":"Miyake","year":"2014","journal-title":"Springerplus"},{"issue":"2","key":"10.1016\/j.cnp.2021.09.001_b0120","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1177\/1358863X14568704","article-title":"Venous thoracic outlet syndrome","volume":"20","author":"Moore","year":"2015","journal-title":"Vasc Med"},{"issue":"2","key":"10.1016\/j.cnp.2021.09.001_b0125","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1053\/sarh.2000.9201","article-title":"The capnography head-up tilt test for evaluation of chronic fatigue syndrome","volume":"30","author":"Naschitz","year":"2000","journal-title":"Semin Arthritis Rheum"},{"issue":"3","key":"10.1016\/j.cnp.2021.09.001_b0130","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1053\/sarh.2002.34608","article-title":"Hemodynamics instability score in chronic fatigue syndrome and in non-chronic fatigue syndrome","volume":"32","author":"Naschitz","year":"2002","journal-title":"Semin Arthritis Rheum"},{"issue":"3","key":"10.1016\/j.cnp.2021.09.001_b0135","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.ijcard.2011.10.030","article-title":"Large and small artery endothelial dysfunction in chronic fatigue syndrome","volume":"154","author":"Newton","year":"2012","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.cnp.2021.09.001_b0140","doi-asserted-by":"crossref","first-page":"22","DOI":"10.3389\/fnagi.2016.00022","article-title":"Orthostatic cerebral hypoperfusion syndrome","volume":"8","author":"Novak","year":"2016","journal-title":"Front Aging Neurosci"},{"issue":"9","key":"10.1016\/j.cnp.2021.09.001_b0145","doi-asserted-by":"crossref","first-page":"e0204419","DOI":"10.1371\/journal.pone.0204419","article-title":"Hypocapnic cerebral hypoperfusion: a biomarker of orthostatic intolerance","volume":"13","author":"Novak","year":"2018","journal-title":"PLoS One"},{"issue":"9","key":"10.1016\/j.cnp.2021.09.001_b0150","doi-asserted-by":"crossref","first-page":"1876","DOI":"10.1161\/01.STR.29.9.1876","article-title":"Hypocapnia and cerebral hypoperfusion in orthostatic intolerance","volume":"29","author":"Novak","year":"1998","journal-title":"Stroke"},{"issue":"6","key":"10.1016\/j.cnp.2021.09.001_b0155","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1002\/jcu.22452","article-title":"Orthostatic dizziness in Parkinson's disease is attributed to cerebral hypoperfusion: a transcranial doppler study","volume":"45","author":"Park","year":"2017","journal-title":"J Clin Ultrasound"},{"issue":"22","key":"10.1016\/j.cnp.2021.09.001_b0160","doi-asserted-by":"crossref","first-page":"3461","DOI":"10.1001\/archinte.160.22.3461","article-title":"Results of isoproterenol tilt table testing in monozygotic twins discordant for chronic fatigue syndrome","volume":"160","author":"Poole","year":"2000","journal-title":"Arch Intern Med"},{"key":"10.1016\/j.cnp.2021.09.001_b0165","doi-asserted-by":"crossref","unstructured":"Razumovsky, A.Y., DeBusk, K., Calkins, H., Snader, S., Lucas, K.E., Vyas, P., et al. Cerebral and systemic hemodynamics changes during upright tilt in chronic fatigue syndrome. J Neuroimaging 2003;13(1):57-67.","DOI":"10.1177\/1051228402239719"},{"key":"10.1016\/j.cnp.2021.09.001_b0170","doi-asserted-by":"crossref","unstructured":"Sato, K., Sadamoto, T., Hirasawa, A., Oue, A., Subudhi, A.W., Miyazawa, T., et al. Differential blood flow responses to CO(2) in human internal and external carotid and vertebral arteries. J Physiol 2012;590(14):3277-3290.","DOI":"10.1113\/jphysiol.2012.230425"},{"issue":"3","key":"10.1016\/j.cnp.2021.09.001_b0175","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1002\/ehf2.12633","article-title":"Peripheral endothelial dysfunction in myalgic encephalomyelitis\/chronic fatigue syndrome","volume":"7","author":"Scherbakov","year":"2020","journal-title":"ESC Heart Fail"},{"issue":"2-3","key":"10.1016\/j.cnp.2021.09.001_b0180","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/S0165-1838(98)00177-5","article-title":"Orthostatic intolerance in the chronic fatigue syndrome","volume":"75","author":"Schondorf","year":"1999","journal-title":"J Auton Nerv Syst"},{"issue":"6","key":"10.1016\/j.cnp.2021.09.001_b0185","doi-asserted-by":"crossref","first-page":"e41","DOI":"10.1016\/j.hrthm.2015.03.029","article-title":"2015 heart rhythm society expert consensus statement on the diagnosis and treatment of postural tachycardia syndrome, inappropriate sinus tachycardia, and vasovagal syncope","volume":"12","author":"Sheldon","year":"2015","journal-title":"Heart Rhythm"},{"issue":"5","key":"10.1016\/j.cnp.2021.09.001_b0190","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1016\/j.jacc.2017.03.002","article-title":"2017 ACC\/AHA\/HRS guideline for the evaluation and management of patients with syncope: executive summary: A Report of the American College of Cardiology\/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Rhythm Society","volume":"70","author":"Shen","year":"2017","journal-title":"J Am Coll Cardiol"},{"issue":"2","key":"10.1016\/j.cnp.2021.09.001_b0195","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1111\/ane.12516","article-title":"Cerebral hemodynamics in orthostatic intolerance with normal head-up tilt test","volume":"134","author":"Shin","year":"2015","journal-title":"Acta Neurol Scand"},{"key":"10.1016\/j.cnp.2021.09.001_b0200","unstructured":"Statistics L. Leard Statistics. Multiple regression using SPSS Statistics. Statistical tutorials and software guides. Retrieved from https:\/\/statistics.laerd.com\/. 2015."},{"issue":"5","key":"10.1016\/j.cnp.2021.09.001_b0205","doi-asserted-by":"crossref","first-page":"1396","DOI":"10.1152\/japplphysiol.00377.2018","article-title":"Hemodynamic characteristics of postural hyperventilation: POTS with hyperventilation versus panic versus voluntary hyperventilation","volume":"125","author":"Stewart","year":"2018","journal-title":"J Appl Physiol"},{"issue":"13","key":"10.1016\/j.cnp.2021.09.001_b0210","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.118.008854","article-title":"Postural hyperventilation as a cause of postural tachycardia syndrome: increased systemic vascular resistance and decreased cardiac output when upright in all postural tachycardia syndrome variants","volume":"7","author":"Stewart","year":"2018","journal-title":"J Am Heart Assoc"},{"issue":"1","key":"10.1016\/j.cnp.2021.09.001_b0215","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0002-9629(15)40790-6","article-title":"The roles of orthostatic hypotension, orthostatic tachycardia, and subnormal erythrocyte volume in the pathogenesis of the chronic fatigue syndrome","volume":"320","author":"Streeten","year":"2000","journal-title":"Am J Med Sci"},{"issue":"4","key":"10.1016\/j.cnp.2021.09.001_b0220","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1007\/s10286-002-0014-1","article-title":"Hemodynamic and neurohumoral responses to head-up tilt in patients with chronic fatigue syndrome","volume":"12","author":"Timmers","year":"2002","journal-title":"Clin Auton Res"},{"issue":"4","key":"10.1016\/j.cnp.2021.09.001_b0225","doi-asserted-by":"crossref","first-page":"1671","DOI":"10.1152\/japplphysiol.00465.2000","article-title":"Dynamic time course of hemodynamic responses after passive head-up tilt and tilt back to supine position","volume":"92","author":"Toska","year":"2002","journal-title":"J Appl Physiol"},{"key":"10.1016\/j.cnp.2021.09.001_b0230","doi-asserted-by":"crossref","unstructured":"van Campen C(L)MC, Rowe PC, Verheugt FWA, Visser FC. Numeric rating scales show prolonged post-exertional symptoms after orthostatic testing of adults with myalgic encephalomyelitis\/chronic fatigue syndrome. Front Med 2021;7:10.","DOI":"10.3389\/fmed.2020.602894"},{"key":"10.1016\/j.cnp.2021.09.001_b0235","doi-asserted-by":"crossref","unstructured":"van Campen C(L)MC, Rowe PC, Visser FC. Cerebral blood flow is reduced in severe myalgic encephalomyelitis\/chronic fatigue syndrome patients during mild orthostatic stress testing: an exploratory study at 20 degrees of head-up tilt testing. Healthcare (Basel) 2020a;8(2):169.","DOI":"10.3390\/healthcare8020169"},{"key":"10.1016\/j.cnp.2021.09.001_b0240","doi-asserted-by":"crossref","unstructured":"van Campen C(L)MC, Rowe PC, Visser FC. Reductions in cerebral blood flow can be provoked by sitting in severe myalgic encephalomyelitis\/chronic fatigue syndrome patients. Healthcare 2020b;8:394.","DOI":"10.3390\/healthcare8040394"},{"key":"10.1016\/j.cnp.2021.09.001_b0245","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.cnp.2020.01.003","article-title":"Cerebral blood flow is reduced in ME\/CFS during head-up tilt testing even in the absence of hypotension or tachycardia: A quantitative, controlled study using Doppler echography","volume":"5","author":"van Campen","year":"2020","journal-title":"Clin Neurophysiol Pract"},{"issue":"4","key":"10.1016\/j.cnp.2021.09.001_b0250","doi-asserted-by":"crossref","first-page":"629","DOI":"10.3233\/THC-202669","article-title":"Comparison of the finger plethysmography derived stroke volumes by Nexfin CO Trek and suprasternal aortic Doppler derived stroke volume measurements in adults with myalgic encephalomyelitis\/chronic fatigue syndrome and in healthy controls","volume":"29","author":"van Campen","year":"2021","journal-title":"Techn. Health Care"},{"key":"10.1016\/j.cnp.2021.09.001_b0255","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.cnp.2018.02.004","article-title":"Cerebral blood flow changes during tilt table testing in healthy volunteers, as assessed by Doppler imaging of the carotid and vertebral arteries","volume":"3","author":"van Campen","year":"2018","journal-title":"Clin Neurophysiol Pract"},{"key":"10.1016\/j.cnp.2021.09.001_b0260","unstructured":"van Campen C(L)MC, Visser FC. The abnormal Cardiac Index and Stroke Volume Index changes during a normal Tilt Table Test in ME\/CFS patients compared to healthy volunteers, are not related to deconditioning. J. Thromb. Circ. 2018;JTC -107:1-8."},{"key":"10.1016\/j.cnp.2021.09.001_b0265","unstructured":"van Campen C(L)MC, Visser FC. Validation of Stroke volume measured with suprasternal aortic Doppler imaging: comparison to transthoracic Stroke Volume measurements. J Thromb Circ 2018;JTC -106:1-5."},{"issue":"12","key":"10.1016\/j.cnp.2021.09.001_b0270","doi-asserted-by":"crossref","first-page":"1795","DOI":"10.1136\/hrt.2004.050435","article-title":"Comparison of the haemodynamics of different pacing sites in patients undergoing resynchronisation treatment: need for individualisation of lead localisation","volume":"92","author":"van Campen","year":"2006","journal-title":"Heart"}],"container-title":["Clinical Neurophysiology Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2467981X21000408?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2467981X21000408?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T02:06:24Z","timestamp":1762826784000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2467981X21000408"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021]]},"references-count":54,"alternative-id":["S2467981X21000408"],"URL":"https:\/\/doi.org\/10.1016\/j.cnp.2021.09.001","relation":{},"ISSN":["2467-981X"],"issn-type":[{"value":"2467-981X","type":"print"}],"subject":[],"published":{"date-parts":[[2021]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cerebral blood flow remains reduced after tilt testing in myalgic encephalomyelitis\/chronic fatigue syndrome patients","name":"articletitle","label":"Article Title"},{"value":"Clinical Neurophysiology Practice","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cnp.2021.09.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 International Federation of Clinical Neurophysiology. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}