{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T12:42:33Z","timestamp":1792586553168,"version":"4.5.0"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T00:00:00Z","timestamp":1775520000000},"content-version":"vor","delay-in-days":96,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["24K10648"],"award-info":[{"award-number":["24K10648"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["19K07964"],"award-info":[{"award-number":["19K07964"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012628","name":"Public Interest Incorporated Foundation Japan Epilepsy Research Foundation","doi-asserted-by":"publisher","award":["JERF TENKAN 24002"],"award-info":[{"award-number":["JERF TENKAN 24002"]}],"id":[{"id":"10.13039\/501100012628","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Neurophysiology Practice"],"published-print":{"date-parts":[[2026]]},"DOI":"10.1016\/j.cnp.2026.04.005","type":"journal-article","created":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T16:58:05Z","timestamp":1775667485000},"page":"321-331","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Hippocampal interictal discharges induce frontal spindles and enhance spindle\u2013slow oscillation coupling in temporal lobe epilepsy"],"prefix":"10.1016","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4292-4602","authenticated-orcid":false,"given":"Taira","family":"Uehara","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ela Austria","family":"Barcelon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5437-943X","authenticated-orcid":false,"given":"Hiroshi","family":"Shigeto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4091-5988","authenticated-orcid":false,"given":"Takahiko","family":"Mukaino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6001-1244","authenticated-orcid":false,"given":"Toshiki","family":"Okadome","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobutaka","family":"Mukae","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-9262-0424","authenticated-orcid":false,"given":"Ayumi","family":"Sakata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1612-1440","authenticated-orcid":false,"given":"Hiroyuki","family":"Murai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shozo","family":"Tobimatsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noriko","family":"Isobe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun-ichi","family":"Kira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cnp.2026.04.005_b0005","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1001\/jamaneurol.2022.0888","article-title":"Noninvasive detection of hippocampal epileptiform activity on scalp electroencephalogram","volume":"79","author":"Abou Jaoude","year":"2022","journal-title":"JAMA Neurol."},{"key":"10.1016\/j.cnp.2026.04.005_b0010","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","article-title":"Controlling the false discovery rate: a practical and powerful approach to multiple testing","volume":"57","author":"Benjamini","year":"1995","journal-title":"J. R. Stat. Soc. B. Methodol."},{"key":"10.1016\/j.cnp.2026.04.005_b0015","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1093\/brain\/123.3.472","article-title":"Accelerated forgetting in patients with epilepsy: evidence for an impairment in memory consolidation","volume":"123","author":"Blake","year":"2000","journal-title":"Brain"},{"key":"10.1016\/j.cnp.2026.04.005_b0020","doi-asserted-by":"crossref","first-page":"2243","DOI":"10.1093\/brain\/awn127","article-title":"Recent insights into the impairment of memory in epilepsy: transient epileptic amnesia, accelerated long-term forgetting and remote memory impairment","volume":"131","author":"Butler","year":"2008","journal-title":"Brain"},{"key":"10.1016\/j.cnp.2026.04.005_b0025","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1111\/epi.17518","article-title":"A region-specific modulation of sleep slow waves on interictal epilepsy markers in focal epilepsy","volume":"64","author":"Chen","year":"2023","journal-title":"Epilepsia"},{"key":"10.1016\/j.cnp.2026.04.005_b0030","doi-asserted-by":"crossref","first-page":"2868","DOI":"10.1093\/brain\/awm146","article-title":"Temporal coupling of parahippocampal ripples, sleep spindles and slow oscillations in humans","volume":"130","author":"Clemens","year":"2007","journal-title":"Brain"},{"key":"10.1016\/j.cnp.2026.04.005_b0035","doi-asserted-by":"crossref","first-page":"3502","DOI":"10.1093\/brain\/awz269","article-title":"Interictal epileptiform discharges shape large-scale intercortical communication","volume":"142","author":"Dahal","year":"2019","journal-title":"Brain"},{"key":"10.1016\/j.cnp.2026.04.005_b0040","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.jneumeth.2003.10.009","article-title":"EEGLAB: an open source toolbox for analysis of single-trial EEG dynamics including independent component analysis","volume":"134","author":"Delorme","year":"2004","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.cnp.2026.04.005_b0045","doi-asserted-by":"crossref","first-page":"e27","DOI":"10.1093\/brain\/awaa041","article-title":"Interactions of interictal epileptic discharges with sleep slow waves and spindles","volume":"143","author":"von Ellenrieder","year":"2020","journal-title":"Brain"},{"key":"10.1016\/j.cnp.2026.04.005_b0050","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1152\/physrev.00042.2018","article-title":"Sleep spindles: Mechanisms and functions","volume":"100","author":"Fernandez","year":"2020","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.cnp.2026.04.005_b0055","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1016\/S1388-2457(00)00246-7","article-title":"Sleep-EEG modulation of interictal epileptiform discharges in adult partial epilepsy: a spectral analysis study","volume":"111","author":"Ferrillo","year":"2000","journal-title":"Clin. Neurophysiol."},{"key":"10.1016\/j.cnp.2026.04.005_b0060","doi-asserted-by":"crossref","first-page":"1927","DOI":"10.5665\/sleep.5242","article-title":"Interictal hippocampal spiking influences the occurrence of hippocampal sleep spindles","volume":"38","author":"Frauscher","year":"2015","journal-title":"Sleep"},{"key":"10.1016\/j.cnp.2026.04.005_b0065","doi-asserted-by":"crossref","first-page":"1629","DOI":"10.1093\/brain\/awv073","article-title":"Facilitation of epileptic activity during sleep is mediated by high amplitude slow waves","volume":"138","author":"Frauscher","year":"2015","journal-title":"Brain"},{"key":"10.1016\/j.cnp.2026.04.005_b0070","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1038\/nm.4084","article-title":"Interictal epileptiform discharges induce hippocampal-cortical coupling in temporal lobe epilepsy","volume":"22","author":"Gelinas","year":"2016","journal-title":"Nat. Med."},{"key":"10.1016\/j.cnp.2026.04.005_b0075","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1038\/s41593-023-01324-5","article-title":"Augmenting hippocampal\u2013prefrontal neuronal synchrony during sleep enhances memory consolidation in humans","volume":"26","author":"Geva-Sagiv","year":"2023","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.cnp.2026.04.005_b0080","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1038\/nn.2384","article-title":"Selective suppression of hippocampal ripples impairs spatial memory","volume":"12","author":"Girardeau","year":"2009","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.cnp.2026.04.005_b0085","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1016\/j.euroneuro.2012.10.018","article-title":"The hippocampal\u2013prefrontal pathway: the weak link in psychiatric disorders?","volume":"23","author":"Godsil","year":"2013","journal-title":"Eur. Neuropsychopharmacol."},{"key":"10.1016\/j.cnp.2026.04.005_b0090","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.53730","article-title":"Slow oscillation-spindle coupling predicts enhanced memory formation from childhood to adolescence","volume":"9","author":"Hahn","year":"2020","journal-title":"Elife"},{"key":"10.1016\/j.cnp.2026.04.005_b0095","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1016\/j.tics.2021.04.009","article-title":"Aperiodic sleep networks promote memory consolidation","volume":"25","author":"Helfrich","year":"2021","journal-title":"Trends Cogn. Sci."},{"key":"10.1016\/j.cnp.2026.04.005_b0100","doi-asserted-by":"crossref","first-page":"3572","DOI":"10.1038\/s41467-019-11444-x","article-title":"Bidirectional prefrontal-hippocampal dynamics organize information transfer during sleep in humans","volume":"10","author":"Helfrich","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cnp.2026.04.005_b0105","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.neuron.2017.11.020","article-title":"Old brains come uncoupled in sleep: Slow wave-spindle synchrony, brain atrophy, and forgetting","volume":"97","author":"Helfrich","year":"2018","journal-title":"Neuron"},{"key":"10.1016\/j.cnp.2026.04.005_b0110","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.neuroimage.2015.05.044","article-title":"Measuring directionality between neuronal oscillations of different frequencies","volume":"118","author":"Jiang","year":"2015","journal-title":"Neuroimage"},{"key":"10.1016\/j.cnp.2026.04.005_b0115","doi-asserted-by":"crossref","unstructured":"Kane N, Acharya J, Benickzy S, Caboclo L, Finnigan S, Kaplan PW, et al. A revised glossary of terms most commonly used by clinical electroencephalographers and updated proposal for the report format of the EEG findings. Revision 2017. Clin Neurophysiol Pract 2017;2:170\u201385. 10.1016\/j.cnp.2017.07.002.","DOI":"10.1016\/j.cnp.2017.07.002"},{"key":"10.1016\/j.cnp.2026.04.005_b0120","doi-asserted-by":"crossref","first-page":"1598","DOI":"10.1038\/s41593-019-0467-3","article-title":"Mechanisms of systems memory consolidation during sleep","volume":"22","author":"Klinzing","year":"2019","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.cnp.2026.04.005_b0125","doi-asserted-by":"crossref","first-page":"1816","DOI":"10.1523\/JNEUROSCI.2009-20.2020","article-title":"Focal sleep spindle deficits reveal focal thalamocortical dysfunction and predict cognitive deficits in sleep activated developmental epilepsy","volume":"41","author":"Kramer","year":"2021","journal-title":"J. Neurosci."},{"key":"10.1016\/j.cnp.2026.04.005_b0130","doi-asserted-by":"crossref","first-page":"2679","DOI":"10.1093\/brain\/aww198","article-title":"Widespread changes in network activity allow non-invasive detection of mesial temporal lobe seizures","volume":"139","author":"Lam","year":"2016","journal-title":"Brain"},{"key":"10.1016\/j.cnp.2026.04.005_b0135","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1111\/epi.16823","article-title":"Accelerated long-term forgetting in focal epilepsy: do interictal spikes during sleep matter?","volume":"62","author":"Lambert","year":"2021","journal-title":"Epilepsia"},{"key":"10.1016\/j.cnp.2026.04.005_b0140","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1002\/ana.25744","article-title":"Hippocampal interictal spikes during sleep impact long-term memory consolidation","volume":"87","author":"Lambert","year":"2020","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.cnp.2026.04.005_b0145","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.yebeh.2016.07.035","article-title":"PatientsLikeMe\u00ae online epilepsy community: patient characteristics and predictors of poor health-related quality of life","volume":"63","author":"de la Loge","year":"2016","journal-title":"Epilepsy Behav."},{"key":"10.1016\/j.cnp.2026.04.005_b0150","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1038\/nn.4304","article-title":"Hippocampo-cortical coupling mediates memory consolidation during sleep","volume":"19","author":"Maingret","year":"2016","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.cnp.2026.04.005_b0155","doi-asserted-by":"crossref","first-page":"8496","DOI":"10.1073\/pnas.0702495104","article-title":"Triggering sleep slow waves by transcranial magnetic stimulation","volume":"104","author":"Massimini","year":"2007","journal-title":"PNAS"},{"key":"10.1016\/j.cnp.2026.04.005_b0160","doi-asserted-by":"crossref","first-page":"2623","DOI":"10.1111\/epi.17378","article-title":"Atrophy of the hippocampal CA1 subfield relates to long\u2010term forgetting in focal epilepsy","volume":"63","author":"Mukaino","year":"2022","journal-title":"Epilepsia"},{"key":"10.1016\/j.cnp.2026.04.005_b0165","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1111\/j.1528-1157.2000.tb00140.x","article-title":"Spindles-inducing mechanism modulates sleep activation of interictal epileptiform discharges in the Landau-Kleffner syndrome","volume":"41","author":"Nobili","year":"2000","journal-title":"Epilepsia"},{"key":"10.1016\/j.cnp.2026.04.005_b0170","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/S0168-5597(98)00041-0","article-title":"Relationship of sleep interictal epileptiform discharges to sigma activity (12\u201316 Hz) in benign epilepsy of childhood with rolandic spikes","volume":"110","author":"Nobili","year":"1999","journal-title":"Clin. Neurophysiol."},{"key":"10.1016\/j.cnp.2026.04.005_b0175","doi-asserted-by":"crossref","DOI":"10.1103\/PhysRevLett.100.234101","article-title":"Robustly estimating the flow direction of information in complex physical systems","volume":"100","author":"Nolte","year":"2008","journal-title":"Phys. Rev. Lett."},{"key":"10.1016\/j.cnp.2026.04.005_b0180","doi-asserted-by":"crossref","DOI":"10.1155\/2011\/156869","article-title":"FieldTrip: Open source software for advanced analysis of MEG, EEG, and invasive electrophysiological data","volume":"2011","author":"Oostenveld","year":"2011","journal-title":"Comput. Intell. Neurosci."},{"key":"10.1016\/j.cnp.2026.04.005_b0185","doi-asserted-by":"crossref","first-page":"17207","DOI":"10.1073\/pnas.1103612108","article-title":"Inhibition recruitment in prefrontal cortex during sleep spindles and gating of hippocampal inputs","volume":"108","author":"Peyrache","year":"2011","journal-title":"PNAS"},{"key":"10.1016\/j.cnp.2026.04.005_b0190","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1152\/physrev.00032.2012","article-title":"About sleep\u2019s role in memory","volume":"93","author":"Rasch","year":"2013","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.cnp.2026.04.005_b0195","doi-asserted-by":"crossref","first-page":"2256","DOI":"10.1111\/epi.17337","article-title":"Prolongation of cortical sleep spindles during hippocampal interictal epileptiform discharges in epilepsy patients","volume":"63","author":"S\u00e1kovics","year":"2022","journal-title":"Epilepsia"},{"key":"10.1016\/j.cnp.2026.04.005_b0200","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1152\/jn.00106.2010","article-title":"Measuring phase-amplitude coupling between neuronal oscillations of different frequencies","volume":"104","author":"Tort","year":"2010","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.cnp.2026.04.005_b0205","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.neulet.2017.08.020","article-title":"Epileptic interictal discharges are more frequent during NREM slow wave downstates","volume":"658","author":"Ujma","year":"2017","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.cnp.2026.04.005_b0210","doi-asserted-by":"crossref","first-page":"1921","DOI":"10.1152\/jn.91157.2008","article-title":"Triggering slow waves during NREM sleep in the rat by intracortical electrical stimulation: effects of sleep\/wake history and background activity","volume":"101","author":"Vyazovskiy","year":"2009","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.cnp.2026.04.005_b0215","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1038\/nmeth.2855","article-title":"Sleep-spindle detection: crowdsourcing and evaluating performance of experts, non-experts and automated methods","volume":"11","author":"Warby","year":"2014","journal-title":"Nat. Methods"},{"key":"10.1016\/j.cnp.2026.04.005_b0220","doi-asserted-by":"crossref","first-page":"2803","DOI":"10.1093\/brain\/awae119","article-title":"Thalamic epileptic spikes disrupt sleep spindles in patients with epileptic encephalopathy","volume":"147","author":"Wodeyar","year":"2024","journal-title":"Brain"},{"key":"10.1016\/j.cnp.2026.04.005_b0225","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.neuron.2021.10.030","article-title":"Beyond t test and ANOVA: applications of mixed-effects models for more rigorous statistical analysis in neuroscience research","volume":"110","author":"Yu","year":"2022","journal-title":"Neuron"},{"key":"10.1016\/j.cnp.2026.04.005_b0230","doi-asserted-by":"crossref","first-page":"288","DOI":"10.3389\/fneur.2017.00288","article-title":"Correlating interictal spikes with sigma and delta dynamics during non-rapid-eye-movement-sleep","volume":"8","author":"Zubler","year":"2017","journal-title":"Front. Neurol."}],"container-title":["Clinical Neurophysiology Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2467981X26000314?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2467981X26000314?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T11:59:36Z","timestamp":1792583976000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2467981X26000314"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":46,"alternative-id":["S2467981X26000314"],"URL":"https:\/\/doi.org\/10.1016\/j.cnp.2026.04.005","relation":{},"ISSN":["2467-981X"],"issn-type":[{"value":"2467-981X","type":"print"}],"subject":[],"published":{"date-parts":[[2026]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hippocampal interictal discharges induce frontal spindles and enhance spindle\u2013slow oscillation coupling in temporal lobe epilepsy","name":"articletitle","label":"Article Title"},{"value":"Clinical Neurophysiology Practice","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cnp.2026.04.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier B.V. on behalf of International Federation of Clinical Neurophysiology.","name":"copyright","label":"Copyright"}]}}