{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T17:16:06Z","timestamp":1786986966222,"version":"build-2736575974"},"reference-count":34,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","theclinics.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Nursing Clinics of North America"],"published-print":{"date-parts":[[2021,3]]},"DOI":"10.1016\/j.cnur.2020.10.002","type":"journal-article","created":{"date-parts":[[2020,12,28]],"date-time":"2020-12-28T21:25:24Z","timestamp":1609190724000},"page":"23-32","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["The Role of Vitamin B6 in Women\u2019s Health"],"prefix":"10.1016","volume":"56","author":[{"given":"Amy S.D.","family":"Lee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"7","key":"10.1016\/j.cnur.2020.10.002_bib1","doi-asserted-by":"crossref","first-page":"84","DOI":"10.3390\/cells7070084","article-title":"Vitamin B6 and its role in cell metabolism and physiology","volume":"7","author":"Parra","year":"2018","journal-title":"Cells"},{"key":"10.1016\/j.cnur.2020.10.002_bib2","article-title":"Inflammation, vitamin B6 and related pathways","author":"Ueland","year":"20175310","journal-title":"Mol Aspects Med"},{"issue":"6","key":"10.1016\/j.cnur.2020.10.002_bib3","first-page":"1227","article-title":"Plasma riboflavin and vitamin B-6, but not homocysteine, folate, or vitamin B-12, are inversely associated with breast cancer risk in the european prospective investigation into cancer and nutrition-varese cohort","volume":"146","author":"Agnoli","year":"2016","journal-title":"J\u00a0Nutr"},{"issue":"4","key":"10.1016\/j.cnur.2020.10.002_bib4","first-page":"635","article-title":"Lower plasma vitamin B-6 is associated with 2-year cognitive decline in the Boston Puerto Rican health study","volume":"149","author":"Palacios","year":"2019","journal-title":"J\u00a0Nutr"},{"issue":"4","key":"10.1016\/j.cnur.2020.10.002_bib5","doi-asserted-by":"crossref","first-page":"897","DOI":"10.3945\/ajcn.116.139337","article-title":"Vitamin B-6 and colorectal cancer risk: a prospective population-based study using 3 distinct plasma markers of vitamin B-6 status","volume":"105","author":"Gylling","year":"2017","journal-title":"Am J Clin Nutr"},{"issue":"9","key":"10.1016\/j.cnur.2020.10.002_bib8","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1080\/1028415X.2017.1422904","article-title":"Vitamin B-6 and depressive symptomatology, over time, in older latino adults","volume":"22","author":"Ar\u00e9valo","year":"2019","journal-title":"Nutr Neurosci"},{"issue":"12","key":"10.1016\/j.cnur.2020.10.002_bib9","doi-asserted-by":"crossref","first-page":"e0208454","DOI":"10.1371\/journal.pone.0208454","article-title":"Superiority of magnesium and vitamin B6 over magnesium alone on severe stress in healthy adults with low magnesemia: a randomized, single-blind clinical trial","volume":"13","author":"Pouteau","year":"2018","journal-title":"PloS one"},{"issue":"1","key":"10.1016\/j.cnur.2020.10.002_bib10","doi-asserted-by":"crossref","first-page":"67","DOI":"10.15171\/jcs.2016.007","article-title":"Effect of combined use of calcium and vitamin B6 on premenstrual syndrome symptoms: a randomized clinical trial","volume":"5","author":"Masoumi","year":"2016","journal-title":"J\u00a0Caring Sci"},{"issue":"2","key":"10.1016\/j.cnur.2020.10.002_bib11","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1089\/acm.2019.0305","article-title":"A\u00a0pilot randomized treatment-controlled trial comparing vitamin B6 with broad-spectrum micronutrients for premenstrual syndrome","volume":"26","author":"Retallick-Brown","year":"2020","journal-title":"J\u00a0Altern Complement Med"},{"issue":"1","key":"10.1016\/j.cnur.2020.10.002_bib12","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.ijgo.2006.09.014","article-title":"Pyridoxine (vitamin B6) therapy for premenstrual syndrome","volume":"96","author":"Kashanian","year":"2007","journal-title":"Int J Gynaecol Obstet"},{"issue":"3","key":"10.1016\/j.cnur.2020.10.002_bib13","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1080\/01674820801893011","article-title":"A\u00a0controlled trial of Chinese herbal medicine for premenstrual syndrome","volume":"29","author":"Chou","year":"2008","journal-title":"J\u00a0Psychosom Obstet Gynaecol"},{"issue":"3","key":"10.1016\/j.cnur.2020.10.002_bib14","first-page":"e73","article-title":"Management of premenstrual syndrome: green-top guideline no. 48","volume":"124","author":"Panay","year":"2009","journal-title":"BJOG"},{"key":"10.1016\/j.cnur.2020.10.002_bib15","doi-asserted-by":"crossref","unstructured":"Khodadad M, Kheirabadi G, Bahadoran P. View of efficacy of vitamin B6 on pregnancy outcomes. A randomized clinical trial. Journal of Pharmaceutical Research International 2017. https:\/\/doi.org\/10.9734\/JPRI\/2017\/32675.","DOI":"10.9734\/JPRI\/2017\/32675"},{"issue":"4","key":"10.1016\/j.cnur.2020.10.002_bib16","doi-asserted-by":"crossref","first-page":"343","DOI":"10.3177\/jnsv.59.343","article-title":"Changes in plasma pyridoxal 5-phosphate concentration during pregnancy stages in japanese women","volume":"59","author":"Shibata","year":"2013","journal-title":"J\u00a0Nutr Sci Vitaminol"},{"issue":"3","key":"10.1016\/j.cnur.2020.10.002_bib18","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1093\/ajcn\/82.3.627","article-title":"Highhomocysteine and low B vitamins predict cognitive decline in aging men: the veterans affairs normative aging study","volume":"82","author":"Tucker","year":"2005","journal-title":"Am J Clin Nutr"},{"issue":"53","key":"10.1016\/j.cnur.2020.10.002_bib19","first-page":"1","article-title":"B-vitamin intake and biomarker status in relation to cognitive decline in healthy older adults in a 4-year follow-up study","volume":"9","author":"Hughes","year":"2017","journal-title":"Nutrients"},{"key":"10.1016\/j.cnur.2020.10.002_bib20","series-title":"Chapter 15 - novel preventive mechanisms of vitamin B6 against inflammation, inflammasome, and chronic diseases. In: Molecular nutrition","first-page":"283","author":"Zhang","year":"2020"},{"key":"10.1016\/j.cnur.2020.10.002_bib22","series-title":"What to expect from colon cancer in women","author":"Roland","year":"2019"},{"issue":"11","key":"10.1016\/j.cnur.2020.10.002_bib23","doi-asserted-by":"crossref","first-page":"1942","DOI":"10.1158\/1055-9965.EPI-12-0717-T","article-title":"Prediagnostic plasma pyridoxal 5'-phosphate (vitamin B6) levels and invasive breast carcinoma risk: the multiethnic cohort","volume":"21","author":"Lurie","year":"2012","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"issue":"5","key":"10.1016\/j.cnur.2020.10.002_bib24","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1080\/01635581.2017.1324633","article-title":"Vitamin B 6 intake and the risk of colorectal cancer: a meta-analysis of prospective cohort studies","volume":"69","author":"Jia","year":"2017","journal-title":"Nutr Cancer"},{"key":"10.1016\/j.cnur.2020.10.002_bib25","article-title":"Vitamin B6 prevents endothelial dysfunction, insulin resistance, and hepatic lipid accumulation in [apoe.sup.-\/-] mice fed with high-fat diet","volume":"2015","author":"Liu","year":"2015","journal-title":"J\u00a0Diabetes Res"},{"issue":"9","key":"10.1016\/j.cnur.2020.10.002_bib29","doi-asserted-by":"crossref","first-page":"538","DOI":"10.3390\/nu8090538","article-title":"Prevalence and predictors of low vitamin B6 status in healthy young adult women in metro Vancouver","volume":"8","author":"Ho","year":"2016","journal-title":"Nutrients"},{"key":"10.1016\/j.cnur.2020.10.002_bib31","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1111\/j.1365-3016.2012.01277.x","article-title":"Interventions with vitamins B6, B12 and C in pregnancy","volume":"26","author":"Dror","year":"2012","journal-title":"Paediatr Perinat Epidemiol"},{"key":"10.1016\/j.cnur.2020.10.002_bib32","first-page":"177","article-title":"Influence of vitamin B6 on the incidence of preeclampsia","volume":"8","author":"Wachstein","year":"1956","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.cnur.2020.10.002_bib33","doi-asserted-by":"crossref","first-page":"2249","DOI":"10.1093\/ajcn\/32.11.2249","article-title":"Vitamin B6 nutriture during pregnancy and lactation","volume":"32","author":"Roepke","year":"1969","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.cnur.2020.10.002_bib34","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.1093\/ajcn\/34.9.1731","article-title":"Vitamin B6 status of low-income adolescent and adult pregnant women and the condition of their infants at birth","volume":"34","author":"Schuster","year":"1981","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.cnur.2020.10.002_bib35","first-page":"107","article-title":"Preconception folate and vitamin B(6) status and clinical spontaneous abortion in Chinese women","volume":"100","author":"Ronnenberg","year":"2002","journal-title":"Obstet Gynecol"},{"issue":"19","key":"10.1016\/j.cnur.2020.10.002_bib36","doi-asserted-by":"crossref","first-page":"2509","DOI":"10.1080\/14767058.2017.1344965","article-title":"A\u00a0comparison between the effects of ginger, pyridoxine (vitamin B6) and placebo for the treatment of the first trimester nausea and vomiting of pregnancy (NVP)","volume":"31","author":"Sharifzadeh","year":"2018","journal-title":"J\u00a0Matern Fetal Neonatal Med"},{"issue":"13","key":"10.1016\/j.cnur.2020.10.002_bib37","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1001\/jama.2016.14337","article-title":"Treatments for hyperemesis gravidarum and nausea and vomiting in pregnancy: a systematic review","volume":"316","author":"McParlin","year":"2016","journal-title":"JAMA"},{"issue":"1","key":"10.1016\/j.cnur.2020.10.002_bib38","doi-asserted-by":"crossref","first-page":"e15","DOI":"10.1097\/AOG.0000000000002456","article-title":"ACOG practice bulletin no. 189: nausea and vomiting of pregnancy","volume":"131","year":"2018","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.cnur.2020.10.002_bib39","first-page":"1405","article-title":"Nausea and vomiting in early pregnancy","volume":"2014","author":"Festin","year":"2014","journal-title":"BMJ Clin Evid"},{"issue":"12","key":"10.1016\/j.cnur.2020.10.002_bib40","first-page":"17","article-title":"What is menopause","volume":"30","year":"2017","journal-title":"Nurs Stand"},{"key":"10.1016\/j.cnur.2020.10.002_bib41","unstructured":"Ferrari N. Menopause-related hot flashes and night sweats can last for years. 2015. Available at: https:\/\/www.health.harvard.edu\/blog\/menopause-related-hot-flashes-night-sweats-can-last-years-201502237745. Accessed May 18, 2020."},{"issue":"6","key":"10.1016\/j.cnur.2020.10.002_bib42","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1080\/13697137.2019.1609440","article-title":"Severity of hot flushes is inversely associated with dietary intake of vitamin B6 and oily fish","volume":"22","author":"Odai","year":"2019","journal-title":"Climacteric"}],"container-title":["Nursing Clinics of North America"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0029646520300803?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0029646520300803?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T09:29:13Z","timestamp":1758446953000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0029646520300803"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3]]},"references-count":34,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,3]]}},"alternative-id":["S0029646520300803"],"URL":"https:\/\/doi.org\/10.1016\/j.cnur.2020.10.002","relation":{},"ISSN":["0029-6465"],"issn-type":[{"value":"0029-6465","type":"print"}],"subject":[],"published":{"date-parts":[[2021,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The Role of Vitamin B6 in Women\u2019s Health","name":"articletitle","label":"Article Title"},{"value":"Nursing Clinics of North America","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cnur.2020.10.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}