{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T17:35:03Z","timestamp":1781804103720,"version":"3.54.5"},"reference-count":74,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,8,18]],"date-time":"2023-08-18T00:00:00Z","timestamp":1692316800000},"content-version":"am","delay-in-days":321,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["13PRE17100047"],"award-info":[{"award-number":["13PRE17100047"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HL096830"],"award-info":[{"award-number":["HL096830"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HL122494"],"award-info":[{"award-number":["HL122494"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["MH10461"],"award-info":[{"award-number":["MH10461"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Current Opinion in Endocrine and Metabolic Research"],"published-print":{"date-parts":[[2022,10]]},"DOI":"10.1016\/j.coemr.2022.100382","type":"journal-article","created":{"date-parts":[[2022,7,18]],"date-time":"2022-07-18T23:31:15Z","timestamp":1658187075000},"page":"100382","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Intrahypothalamic effects of oxytocin on PVN CRH neurons in response to acute stress"],"prefix":"10.1016","volume":"26","author":[{"given":"Dipa","family":"Pati","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric G.","family":"Krause","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3550-4789","authenticated-orcid":false,"given":"Charles J.","family":"Frazier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.coemr.2022.100382_bib1","doi-asserted-by":"crossref","first-page":"3458","DOI":"10.1210\/en.2018-00453","article-title":"The paraventricular nucleus of the hypothalamus: development, function, and human diseases","volume":"159","author":"Qin","year":"2018","journal-title":"Endocrinology"},{"key":"10.1016\/j.coemr.2022.100382_bib2","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1053\/meta.2002.33184","article-title":"Neuroendocrine aspects of the response to stress","volume":"51","author":"Miller","year":"2002","journal-title":"Metabolism"},{"key":"10.1016\/j.coemr.2022.100382_bib3","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1159\/000487755","article-title":"The hypothalamic-pituitary-adrenal Axis: a brief history","volume":"89","author":"Miller","year":"2018","journal-title":"Horm Res Paediat"},{"key":"10.1016\/j.coemr.2022.100382_bib4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1210\/edrv-5-1-1","article-title":"Corticosteroid inhibition of ACTH secretion","volume":"5","author":"Keller-Wood","year":"1984","journal-title":"Endocr Rev"},{"key":"10.1016\/j.coemr.2022.100382_bib5","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.yfrne.2007.10.002","article-title":"Corticosteroid hormones in the central stress response: quick-and-slow","volume":"29","author":"Kloet","year":"2008","journal-title":"Front Neuroendocrinol"},{"key":"10.1016\/j.coemr.2022.100382_bib6","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/S0166-2236(96)10069-2","article-title":"Neurocircuitry of stress: central control of the hypothalamo\u2013pituitary\u2013adrenocortical axis","volume":"20","author":"Herman","year":"1997","journal-title":"Trends Neurosci"},{"key":"10.1016\/j.coemr.2022.100382_bib7","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1038\/nrn2647","article-title":"Neural regulation of endocrine and autonomic stress responses","volume":"10","author":"Ulrich-Lai","year":"2009","journal-title":"Nat Rev Neurosci"},{"key":"10.1016\/j.coemr.2022.100382_bib8","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1152\/physrev.00041.2006","article-title":"Physiology and neurobiology of stress and adaptation: central role of the brain","volume":"87","author":"McEwen","year":"2007","journal-title":"Physiol Rev"},{"key":"10.1016\/j.coemr.2022.100382_bib9","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1146\/annurev.ne.06.030183.001413","article-title":"Hypothalamic integration: organization of the paraventricular and supraoptic nuclei","volume":"6","author":"Swanson","year":"1983","journal-title":"Annu Rev Neurosci"},{"key":"10.1016\/j.coemr.2022.100382_bib10","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1038\/s42003-018-0169-5","article-title":"Activation of oxytocin neurons in the paraventricular nucleus drives cardiac sympathetic nerve activation following myocardial infarction in rats","volume":"1","author":"Roy","year":"2018","journal-title":"Commun Biology"},{"key":"10.1016\/j.coemr.2022.100382_bib11","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1002\/cne.902050306","article-title":"Immunohistochemical identification of neurons in the paraventricular nucleus of the hypothalamus that project to the medulla or to the spinal cord in the rat","volume":"205","author":"Sawchenko","year":"1982","journal-title":"J\u00a0Comp Neurol"},{"key":"10.1016\/j.coemr.2022.100382_bib12","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S0006-8993(03)02690-8","article-title":"Actions of oxytocin and interactions with glutamate on spontaneous and evoked dorsal spinal cord neuronal activities","volume":"976","author":"Cond\u00e9s-Lara","year":"2003","journal-title":"Brain Res"},{"key":"10.1016\/j.coemr.2022.100382_bib13","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1152\/japplphysiol.00839.2001","article-title":"Paraventricular oxytocin neurons are involved in neural modulation of breathing","volume":"92","author":"Mack","year":"2002","journal-title":"J\u00a0Appl Physiol"},{"key":"10.1016\/j.coemr.2022.100382_bib14","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S0079-6123(02)39024-1","article-title":"Chapter 22 Cardiovascular effects of oxytocin","volume":"139","author":"Petersson","year":"2002","journal-title":"Prog Brain Res"},{"key":"10.1016\/j.coemr.2022.100382_bib15","first-page":"445","article-title":"Studies on the vasopressin and oxytocin storage in the hypothalamus and neurohypophysis","volume":"38","author":"Guzek","year":"1987","journal-title":"Acta Physiol Pol"},{"key":"10.1016\/j.coemr.2022.100382_bib16","first-page":"R109","article-title":"Total translation of vasopressin and oxytocin in neurohypophysis of rats","volume":"257","author":"Robinson","year":"1989","journal-title":"Am J Physiol"},{"key":"10.1016\/j.coemr.2022.100382_bib17","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/0301-0082(91)90013-Q","article-title":"Modulation of oxytocin and vasopressin release at the level of the neurohypophysis","volume":"36","author":"Falke","year":"1991","journal-title":"Prog Neurobiol"},{"key":"10.1016\/j.coemr.2022.100382_bib18","first-page":"127","article-title":"Oxytocin: the great facilitator of life","volume":"88","author":"Lee","year":"2009","journal-title":"Prog Neurobiol"},{"key":"10.1016\/j.coemr.2022.100382_bib19","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1210\/endo-128-3-1317","article-title":"Oxytocin produces natriuresis in rats at physiological plasma concentrations","volume":"128","author":"Verbalis","year":"1991","journal-title":"Endocrinology"},{"key":"10.1016\/j.coemr.2022.100382_bib20","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1002\/cne.902060402","article-title":"The magnocellular and parvocellular paraventricular nucleus of rat: intrinsic organization","volume":"206","author":"Pol","year":"1982","journal-title":"J\u00a0Comp Neurol"},{"key":"10.1016\/j.coemr.2022.100382_bib21","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/0361-9230(85)90072-3","article-title":"Extranuclear axon collaterals of paraventricular neurons in the rat hypothalamus: intracellular staining, immunocytochemistry and electrophysiology","volume":"14","author":"Hatton","year":"1985","journal-title":"Brain Res Bull"},{"key":"10.1016\/j.coemr.2022.100382_bib22","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/0306-4522(89)90091-2","article-title":"Dendrites of hypothalamic magnocellular neurons release neurohypophysial peptides by exocytosis","volume":"32","author":"Pow","year":"1989","journal-title":"Neuroscience"},{"key":"10.1016\/j.coemr.2022.100382_bib23","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1038\/nrn1845","article-title":"Dendritic peptide release and peptide-dependent behaviours","volume":"7","author":"Ludwig","year":"2006","journal-title":"Nat Rev Neurosci"},{"key":"10.1016\/j.coemr.2022.100382_bib24","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1038\/nature00822","article-title":"Intracellular calcium stores regulate activity-dependent neuropeptide release from dendrites","volume":"418","author":"Ludwig","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.coemr.2022.100382_sref25","doi-asserted-by":"crossref","DOI":"10.1111\/jne.12839","article-title":"Endogenous oxytocin inhibits hypothalamic CRH neurons following acute hypernatremia","author":"Pati","year":"2020","journal-title":"J\u00a0Neuroendocrinol"},{"key":"10.1016\/j.coemr.2022.100382_bib26","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.1016\/j.psyneuen.2011.03.003","article-title":"Neuroanatomical evidence for reciprocal regulation of the corticotrophin-releasing factor and oxytocin systems in the hypothalamus and the bed nucleus of the stria terminalis of the rat: implications for balancing stress and affect","volume":"36","author":"Dabrowska","year":"2011","journal-title":"Psychoneuroendocrino"},{"key":"10.1016\/j.coemr.2022.100382_bib27","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1016\/S0306-4522(97)00022-5","article-title":"Central c-Fos expression in neonatal and adult rats after subcutaneous injection of hypertonic saline","volume":"79","author":"Rinaman","year":"1997","journal-title":"Neuroscience"},{"key":"10.1016\/j.coemr.2022.100382_bib28","doi-asserted-by":"crossref","first-page":"R267","DOI":"10.1152\/ajpregu.1986.250.2.R267","article-title":"Interaction of osmotic and volume stimuli in regulation of neurohypophyseal secretion in rats","volume":"250","author":"Stricker","year":"1986","journal-title":"Am J Physiology-regulatory Integr Comp Physiology"},{"key":"10.1016\/j.coemr.2022.100382_sref29","doi-asserted-by":"crossref","first-page":"5470","DOI":"10.1523\/JNEUROSCI.6078-10.2011","article-title":"Hydration state controls stress responsiveness and social behavior","volume":"31","author":"Krause","year":"2011","journal-title":"J\u00a0Neurosci"},{"key":"10.1016\/j.coemr.2022.100382_sref30","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.physbeh.2014.03.027","article-title":"Acute hypernatremia promotes anxiolysis and attenuates stress-induced activation of the hypothalamic\u2013pituitary\u2013adrenal axis in male mice","volume":"136","author":"Smith","year":"2014","journal-title":"Physiol Behav"},{"key":"10.1016\/j.coemr.2022.100382_bib31","doi-asserted-by":"crossref","first-page":"2457","DOI":"10.1210\/en.2013-1049","article-title":"Acute hypernatremia exerts an inhibitory oxytocinergic tone that is associated with anxiolytic mood in male rats","volume":"154","author":"Frazier","year":"2013","journal-title":"Endocrinology"},{"key":"10.1016\/j.coemr.2022.100382_bib32","first-page":"E453","article-title":"Noradrenergic control of central oxytocin release during lactation in rats","volume":"274","author":"Bealer","year":"1998","journal-title":"Am J Physiol-endoc M"},{"key":"10.1016\/j.coemr.2022.100382_bib33","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/S0079-6123(01)33008-X","volume":"133","author":"Walker","year":"2001","journal-title":"Prog Brain Res"},{"key":"10.1016\/j.coemr.2022.100382_bib34","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S0006-8993(97)01159-1","article-title":"Stress increases oxytocin release within the hypothalamic paraventricular nucleus","volume":"781","author":"Nishioka","year":"1998","journal-title":"Brain Res"},{"key":"10.1016\/j.coemr.2022.100382_bib35","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.psyneuen.2016.12.006","article-title":"Forced swimming-induced oxytocin release into blood and brain: effects of adrenalectomy and corticosterone treatment","volume":"77","author":"Torner","year":"2017","journal-title":"Psychoneuroendocrino"},{"key":"10.1016\/j.coemr.2022.100382_bib36","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1016\/S0306-4522(97)00683-0","article-title":"Dissociated central and peripheral release of vasopressin, but not oxytocin, in response to repeated swim stress: new insights into the secretory capacities of peptidergic neurons","volume":"85","author":"Wotjak","year":"1998","journal-title":"Neuroscience"},{"key":"10.1016\/j.coemr.2022.100382_bib37","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1046\/j.1365-2826.1999.00403.x","article-title":"Wotjak1: emotional stress triggers intrahypothalamic but not peripheral release of oxytocin in male rats","volume":"11","author":"Engelmann","year":"1999","journal-title":"J\u00a0Neuroendocrinol"},{"key":"10.1016\/j.coemr.2022.100382_bib38","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1159\/000126436","article-title":"Paraventricular and supraoptic nuclei of the hypothalamus are not equally important for oxytocin release during stress","volume":"57","author":"Je\u017eov\u00e1","year":"1993","journal-title":"Neuroendocrinology"},{"key":"10.1016\/j.coemr.2022.100382_bib39","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.neuroscience.2003.11.028","article-title":"Release of oxytocin in the hypothalamic paraventricular nucleus, but not central amygdala or lateral septum in lactating residents and virgin intruders during maternal defence","volume":"124","author":"Bosch","year":"2004","journal-title":"Neuroscience"},{"key":"10.1016\/j.coemr.2022.100382_bib40","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1159\/000123566","article-title":"Oxytocin unlike vasopressin is a stress hormone in the rat","volume":"37","author":"Lang","year":"1983","journal-title":"Neuroendocrinology"},{"key":"10.1016\/j.coemr.2022.100382_bib41","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/0006-8993(92)90695-6","article-title":"Synaptic associations between oxytocin-containing magnocellular neurons and neurons containing corticotropin-releasing factor in the rat magnocellular paraventricular nucleus","volume":"576","author":"Hisano","year":"1992","journal-title":"Brain Res"},{"key":"10.1016\/j.coemr.2022.100382_bib42","doi-asserted-by":"crossref","first-page":"1558","DOI":"10.1210\/endo-119-4-1558","article-title":"Central administration of corticotropin-releasing factor modulates oxytocin secretion in the rat","volume":"119","author":"Bruhn","year":"1986","journal-title":"Endocrinology"},{"key":"10.1016\/j.coemr.2022.100382_bib43","doi-asserted-by":"crossref","first-page":"2974","DOI":"10.1523\/JNEUROSCI.3432-03.2004","article-title":"Oxytocin attenuates stress-induced c-fos mRNA expression in specific forebrain regions associated with modulation of hypothalamo\u2013pituitary\u2013adrenal activity","volume":"24","author":"Windle","year":"2004","journal-title":"J\u00a0Neurosci"},{"key":"10.1016\/j.coemr.2022.100382_bib44","doi-asserted-by":"crossref","first-page":"2829","DOI":"10.1210\/endo.138.7.5255","article-title":"Central oxytocin administration reduces stress-induced corticosterone release and anxiety behavior in Rats1","volume":"138","author":"Windle","year":"1997","journal-title":"Endocrinology"},{"key":"10.1016\/j.coemr.2022.100382_bib45","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1016\/j.psyneuen.2005.04.002","article-title":"Intranasal oxytocin administration attenuates the ACTH stress response in monkeys","volume":"30","author":"Parker","year":"2005","journal-title":"Psychoneuroendocrino"},{"key":"10.1016\/j.coemr.2022.100382_bib46","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1016\/j.biopsych.2008.10.011","article-title":"Intranasal oxytocin increases positive communication and reduces cortisol levels during couple conflict","volume":"65","author":"Ditzen","year":"2009","journal-title":"Biol Psychiatr"},{"key":"10.1016\/j.coemr.2022.100382_bib47","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1046\/j.1365-2826.2000.00442.x","article-title":"Brain oxytocin inhibits basal and stress-induced activity of the hypothalamo-pituitary-adrenal Axis in male and female rats: partial action within the paraventricular nucleus","volume":"12","author":"Neumann","year":"2000","journal-title":"J\u00a0Neuroendocrinol"},{"key":"10.1016\/j.coemr.2022.100382_bib48","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/S0306-4522(99)00433-9","article-title":"Brain oxytocin: differential inhibition of neuroendocrine stress responses and anxiety-related behaviour in virgin, pregnant and lactating rats","volume":"95","author":"Neumann","year":"1999","journal-title":"Neuroscience"},{"key":"10.1016\/j.coemr.2022.100382_bib49","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.psyneuen.2015.12.027","article-title":"Oxytocin modulates behavioral and physiological responses to a stressor in marmoset monkeys","volume":"66","author":"Cavanaugh","year":"2016","journal-title":"Psychoneuroendocrino"},{"key":"10.1016\/j.coemr.2022.100382_bib50","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1046\/j.1365-2826.2003.01095.x","article-title":"Enhanced up-regulation of corticotropin-releasing hormone gene expression in response to restraint stress in the hypothalamic paraventricular nucleus of oxytocin gene-deficient male mice","volume":"15","author":"Nomura","year":"2003","journal-title":"J\u00a0Neuroendocrinol"},{"key":"10.1016\/j.coemr.2022.100382_bib51","doi-asserted-by":"crossref","first-page":"1805","DOI":"10.1152\/physrev.00031.2017","article-title":"The oxytocin receptor: from intracellular signaling to behavior","volume":"98","author":"Jurek","year":"2018","journal-title":"Physiol Rev"},{"key":"10.1016\/j.coemr.2022.100382_bib52","article-title":"The interplay between oxytocin and the CRF system: regulation of the stress response","author":"Winter","year":"2018","journal-title":"Cell Tissue Res"},{"key":"10.1016\/j.coemr.2022.100382_bib53","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.yfrne.2004.09.001","article-title":"The hypothalamic\u2013neurohypophysial system regulates the hypothalamic\u2013pituitary\u2013adrenal axis under stress: an old concept revisited","volume":"25","author":"Engelmann","year":"2004","journal-title":"Front Neuroendocrinol"},{"key":"10.1016\/j.coemr.2022.100382_bib54","doi-asserted-by":"crossref","first-page":"150","DOI":"10.3390\/ijms23010150","article-title":"Roles of oxytocin in stress responses, allostasis and resilience","volume":"23","author":"Takayanagi","year":"2021","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.coemr.2022.100382_bib55","doi-asserted-by":"crossref","DOI":"10.1111\/jne.12700","article-title":"Role of oxytocin in the control of stress and food intake","volume":"31","author":"Onaka","year":"2019","journal-title":"J\u00a0Neuroendocrinol"},{"key":"10.1016\/j.coemr.2022.100382_bib56","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1111\/j.1365-2826.2012.02300.x","article-title":"Roles of oxytocin neurones in the control of stress, energy metabolism, and social behaviour","volume":"24","author":"Onaka","year":"2012","journal-title":"J\u00a0Neuroendocrinol"},{"key":"10.1016\/j.coemr.2022.100382_bib57","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1046\/j.1365-2826.2002.00867.x","article-title":"Neurosecretory and non-neurosecretory parvocellular neurones of the hypothalamic paraventricular nucleus express distinct electrophysiological properties","volume":"14","author":"Luther","year":"2002","journal-title":"J\u00a0Neuroendocrinol"},{"key":"10.1016\/j.coemr.2022.100382_bib58","doi-asserted-by":"crossref","DOI":"10.1111\/jne.12532","article-title":"Regulation of hypothalamic corticotropin-releasing hormone neurone excitability by oxytocin","volume":"29","author":"Jamieson","year":"2017","journal-title":"J\u00a0Neuroendocrinol"},{"key":"10.1016\/j.coemr.2022.100382_bib59","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1007\/s00429-008-0192-2","article-title":"Functional role of local GABAergic influences on the HPA axis","volume":"213","author":"Cullinan","year":"2008","journal-title":"Brain Struct Funct"},{"key":"10.1016\/j.coemr.2022.100382_bib60","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1111\/j.1460-9568.2004.03167.x","article-title":"Local \u03b3-aminobutyric acid and glutamate circuit control of hypophyseotrophic corticotropin-releasing factor neuron activity in the paraventricular nucleus of the hypothalamus","volume":"19","author":"Bartanusz","year":"2004","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.coemr.2022.100382_bib61","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1016\/j.lfs.2008.09.007","article-title":"GABAergic mediation of stress-induced secretion of corticosterone and oxytocin, but not prolactin, by the hypothalamic paraventricular nucleus","volume":"83","author":"Souza","year":"2008","journal-title":"Life Sci"},{"key":"10.1016\/j.coemr.2022.100382_bib62","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/S0091-3057(01)00681-5","article-title":"Local circuit regulation of paraventricular nucleus stress integration Glutamate\u2013GABA connections","volume":"71","author":"Herman","year":"2002","journal-title":"Pharmacol, Biochem Behav"},{"key":"10.1016\/j.coemr.2022.100382_bib63","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1002\/cne.903320109","article-title":"Local origins of some GABAergic projections to the paraventricular and supraoptic nuclei of the hypothalamus in the rat","volume":"332","author":"Roland","year":"1993","journal-title":"J\u00a0Comp Neurol"},{"key":"10.1016\/j.coemr.2022.100382_bib64","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1113\/jphysiol.1993.sp019810","article-title":"Local inhibitory synaptic inputs to neurones of the paraventricular nucleus in slices of rat hypothalamus","volume":"469","author":"Tasker","year":"1993","journal-title":"J\u00a0Physiol (London)"},{"key":"10.1016\/j.coemr.2022.100382_sref65","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.psyneuen.2015.09.017","article-title":"Local oxytocin tempers anxiety by activating GABAA receptors in the hypothalamic paraventricular nucleus","volume":"63","author":"Smith","year":"2016","journal-title":"Psychoneuroendocrino"},{"key":"10.1016\/j.coemr.2022.100382_sref66","doi-asserted-by":"crossref","first-page":"R815","DOI":"10.1152\/ajpregu.00452.2011","article-title":"Vasopressin and oxytocin excite MCH neurons, but not other lateral hypothalamic GABA neurons","volume":"302","author":"Yao","year":"2012","journal-title":"Am J Physiology-regulatory Integr Comp Physiology"},{"key":"10.1016\/j.coemr.2022.100382_sref67","doi-asserted-by":"crossref","first-page":"3348","DOI":"10.1038\/s41598-021-82773-5","article-title":"Involvement of MCH-oxytocin neural relay within the hypothalamus in murine nursing behavior","volume":"11","author":"Kato","year":"2021","journal-title":"Sci Rep-uk"},{"key":"10.1016\/j.coemr.2022.100382_bib68","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2021.108601","article-title":"Oxytocin excites BNST interneurons and inhibits BNST output neurons to the central amygdala","volume":"192","author":"Francesconi","year":"2021","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.coemr.2022.100382_bib69","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/j.neuron.2011.11.030","article-title":"Evoked axonal oxytocin release in the central amygdala attenuates fear response","volume":"73","author":"Knobloch","year":"2012","journal-title":"Neuron"},{"key":"10.1016\/j.coemr.2022.100382_bib70","doi-asserted-by":"crossref","first-page":"3249","DOI":"10.1523\/JNEUROSCI.2944-18.2019","article-title":"Oxytocin receptors are expressed by glutamatergic prefrontal cortical neurons that selectively modulate social recognition","volume":"39","author":"Tan","year":"2019","journal-title":"J\u00a0Neurosci"},{"key":"10.1016\/j.coemr.2022.100382_sref71","doi-asserted-by":"crossref","first-page":"1919","DOI":"10.1113\/JP275588","article-title":"Balancing tonic and phasic inhibition in hypothalamic corticotropin-releasing hormone neurons","volume":"596","author":"Colmers","year":"2018","journal-title":"J\u00a0Physiol"},{"key":"10.1016\/j.coemr.2022.100382_bib72","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.celrep.2016.03.013","article-title":"The timing of the excitatory-to-inhibitory GABA switch is regulated by the oxytocin receptor via KCC2","volume":"15","author":"Leonzino","year":"2016","journal-title":"Cell Rep"},{"key":"10.1016\/j.coemr.2022.100382_bib73","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1038\/nn.2274","article-title":"Altered chloride homeostasis removes synaptic inhibitory constraint of the stress axis","volume":"12","author":"Hewitt","year":"2009","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.coemr.2022.100382_bib74","doi-asserted-by":"crossref","first-page":"18198","DOI":"10.1523\/JNEUROSCI.2560-11.2011","article-title":"Neurosteroidogenesis is required for the physiological response to stress: role of neurosteroid-sensitive GABAA receptors","volume":"31","author":"Sarkar","year":"2011","journal-title":"J\u00a0Neurosci"}],"container-title":["Current Opinion in Endocrine and Metabolic Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2451965022000679?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2451965022000679?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T14:55:36Z","timestamp":1762527336000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2451965022000679"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10]]},"references-count":74,"alternative-id":["S2451965022000679"],"URL":"https:\/\/doi.org\/10.1016\/j.coemr.2022.100382","relation":{},"ISSN":["2451-9650"],"issn-type":[{"value":"2451-9650","type":"print"}],"subject":[],"published":{"date-parts":[[2022,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Intrahypothalamic effects of oxytocin on PVN CRH neurons in response to acute stress","name":"articletitle","label":"Article Title"},{"value":"Current Opinion in Endocrine and Metabolic Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.coemr.2022.100382","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"100382"}}