{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T11:03:09Z","timestamp":1789815789407,"version":"4.0.1"},"reference-count":53,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,10,1]],"date-time":"2015-10-01T00:00:00Z","timestamp":1443657600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,10,1]],"date-time":"2015-10-01T00:00:00Z","timestamp":1443657600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["bmn.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Current Opinion in Immunology"],"published-print":{"date-parts":[[2015,10]]},"DOI":"10.1016\/j.coi.2015.05.003","type":"journal-article","created":{"date-parts":[[2015,5,27]],"date-time":"2015-05-27T10:48:49Z","timestamp":1432723729000},"page":"14-21","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"special_numbering":"C","title":["Inflammatory damage on respiratory and nervous systems due to hRSV infection"],"prefix":"10.1016","volume":"36","author":[{"given":"Karen","family":"Bohmwald","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janyra A","family":"Espinoza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Becerra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1850-5560","authenticated-orcid":false,"given":"Katherine","family":"Rivera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margarita K","family":"Lay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan M","family":"Bueno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia A","family":"Riedel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexis M","family":"Kalergis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.coi.2015.05.003_bib0270","doi-asserted-by":"crossref","first-page":"740","DOI":"10.4161\/viru.32225","article-title":"Modulation of host adaptive immunity by hRSV proteins","volume":"5","author":"Espinoza","year":"2014","journal-title":"Virulence"},{"key":"10.1016\/j.coi.2015.05.003_bib0275","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1002\/jmv.24126","article-title":"Interleukin-23 facilitates th1 and th2 cell differentiation in vitro following respiratory syncytial virus infection","volume":"87","author":"Feng","year":"2015","journal-title":"J Med Virol"},{"issue":"Suppl B","key":"10.1016\/j.coi.2015.05.003_bib0280","doi-asserted-by":"crossref","first-page":"S9","DOI":"10.1053\/rmed.2002.1295","article-title":"Risk factors for severe respiratory syncytial virus infection in infants","volume":"96","author":"Aujard","year":"2002","journal-title":"Respir Med"},{"key":"10.1016\/j.coi.2015.05.003_bib0285","doi-asserted-by":"crossref","first-page":"8","DOI":"10.5409\/wjcp.v1.i3.8","article-title":"Burden of respiratory syncytial virus infection in young children","volume":"1","author":"Resch","year":"2012","journal-title":"World J Clin Pediatr"},{"key":"10.1016\/j.coi.2015.05.003_sbref0290","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1164\/rccm.201304-0750OC","article-title":"Relative respiratory syncytial virus cytopathogenesis in upper and lower respiratory tract epithelium","volume":"188","author":"Guo-Parke","year":"2013","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.coi.2015.05.003_sbref0295","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1002\/path.4462","article-title":"Respiratory syncytial virus (RSV) and its propensity for causing bronchiolitis","volume":"235","author":"Pickles","year":"2015","journal-title":"J Pathol"},{"key":"10.1016\/j.coi.2015.05.003_bib0300","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.jmii.2012.08.012","article-title":"Viral etiology of bronchiolitis among pediatric in patients in northern Taiwan with emphasis on newly identified respiratory viruses","volume":"47","author":"Chen","year":"2014","journal-title":"J Microbiol Immunol Infect"},{"key":"10.1016\/j.coi.2015.05.003_bib0305","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.coph.2006.11.014","article-title":"Adenovirus infections and lung disease","volume":"7","author":"Hayashi","year":"2007","journal-title":"Curr Opin Pharmacol"},{"key":"10.1016\/j.coi.2015.05.003_bib0310","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1183\/09031936.00186214","article-title":"Influenza virus-induced lung injury: pathogenesis and implications for treatment","volume":"45","author":"Herold","year":"2015","journal-title":"Eur Respir J"},{"key":"10.1016\/j.coi.2015.05.003_bib0315","doi-asserted-by":"crossref","first-page":"R107","DOI":"10.1186\/cc4984","article-title":"Extrapulmonary manifestations of severe respiratory syncytial virus infection\u2014a systematic review","volume":"10","author":"Eisenhut","year":"2006","journal-title":"Crit Care"},{"key":"10.1016\/j.coi.2015.05.003_bib0320","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1007\/s10156-011-0259-5","article-title":"Classification of acute encephalopathy in respiratory syncytial virus infection","volume":"17","author":"Morichi","year":"2011","journal-title":"J Infect Chemother"},{"key":"10.1016\/j.coi.2015.05.003_bib0325","doi-asserted-by":"crossref","first-page":"e747","DOI":"10.1542\/peds.2013-0929","article-title":"Status epilepticus: a possible association with human metapneumovirus infection","volume":"133","author":"Webster","year":"2014","journal-title":"Pediatrics"},{"key":"10.1016\/j.coi.2015.05.003_bib0330","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1093\/cid\/cit922","article-title":"Neurological manifestations of influenza infection in children and adults: results of a national British surveillance study","volume":"58","author":"Goenka","year":"2014","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.coi.2015.05.003_bib0335","doi-asserted-by":"crossref","first-page":"213","DOI":"10.7883\/yoken.67.213","article-title":"Acute encephalopathy associated with human metapneumovirus infection","volume":"67","author":"Niizuma","year":"2014","journal-title":"Jpn J Infect Dis"},{"key":"10.1016\/j.coi.2015.05.003_bib0340","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.tmaid.2008.03.003","article-title":"Influenza-associated central nervous system dysfunction: a literature review","volume":"6","author":"Toovey","year":"2008","journal-title":"Travel Med Infect Dis"},{"key":"10.1016\/j.coi.2015.05.003_sbref0345","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1002\/rmv.1813","article-title":"Central nervous system alterations caused by infection with the human respiratory syncytial virus","volume":"24","author":"Bohmwald","year":"2014","journal-title":"Rev Med Virol"},{"key":"10.1016\/j.coi.2015.05.003_bib0350","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.jcv.2013.03.017","article-title":"Adenovirus infection associated with central nervous system dysfunction in children","volume":"57","author":"Huang","year":"2013","journal-title":"J Clin Virol"},{"key":"10.1016\/j.coi.2015.05.003_bib0355","doi-asserted-by":"crossref","first-page":"5422","DOI":"10.1128\/JVI.06757-11","article-title":"Plasticity and virus specificity of the airway epithelial cell immune response during respiratory virus infection","volume":"86","author":"Ioannidis","year":"2012","journal-title":"J Virol"},{"key":"10.1016\/j.coi.2015.05.003_sbref0360","doi-asserted-by":"crossref","first-page":"e102368","DOI":"10.1371\/journal.pone.0102368","article-title":"Respiratory syncytial virus can infect basal cells and alter human airway epithelial differentiation","volume":"9","author":"Persson","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.coi.2015.05.003_bib0365","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1513\/pats.200504-032AW","article-title":"Antiviral immune responses and lung inflammation after respiratory syncytial virus infection","volume":"2","author":"Openshaw","year":"2005","journal-title":"Proc Am Thorac Soc"},{"key":"10.1016\/j.coi.2015.05.003_bib0370","doi-asserted-by":"crossref","first-page":"5040","DOI":"10.1073\/pnas.1110203109","article-title":"In vitro modeling of respiratory syncytial virus infection of pediatric bronchial epithelium, the primary target of infection in vivo","volume":"109","author":"Villenave","year":"2012","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.coi.2015.05.003_bib0375","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/imm.12313","article-title":"Induction of protective effector immunity to prevent pathogenesis caused by the respiratory syncytial virus. Implications on therapy and vaccine design","volume":"143","author":"Espinoza","year":"2014","journal-title":"Immunology"},{"key":"10.1016\/j.coi.2015.05.003_bib0380","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1038\/80833","article-title":"Pattern recognition receptors tlr4 and cd14 mediate response to respiratory syncytial virus","volume":"1","author":"Kurt-Jones","year":"2000","journal-title":"Nat Immunol"},{"key":"10.1016\/j.coi.2015.05.003_bib0385","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.virusres.2012.06.003","article-title":"Pattern recognition receptors for respiratory syncytial virus infection and design of vaccines","volume":"167","author":"Zeng","year":"2012","journal-title":"Virus Res"},{"key":"10.1016\/j.coi.2015.05.003_sbref0390","article-title":"Analysis of the local and systemic inflammatory response in hospitalized infants with respiratory syncitial virus bronchiolitis","author":"Moreno-Solis","year":"2014","journal-title":"Allergol Immunopathol (Madr)"},{"key":"10.1016\/j.coi.2015.05.003_bib0395","doi-asserted-by":"crossref","first-page":"6128","DOI":"10.1128\/JVI.00333-14","article-title":"Alpha\/beta interferon receptor signaling amplifies early proinflammatory cytokine production in the lung during respiratory syncytial virus infection","volume":"88","author":"Goritzka","year":"2014","journal-title":"J Virol"},{"key":"10.1016\/j.coi.2015.05.003_bib0400","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1111\/imr.12101","article-title":"Interferon induction and function at the mucosal surface","volume":"255","author":"Durbin","year":"2013","journal-title":"Immunol Rev"},{"key":"10.1016\/j.coi.2015.05.003_bib0405","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1128\/CMR.14.4.778-809.2001","article-title":"Antiviral actions of interferons","volume":"14","author":"Samuel","year":"2001","journal-title":"Clin Microbiol Rev"},{"key":"10.1016\/j.coi.2015.05.003_bib0410","doi-asserted-by":"crossref","first-page":"948","DOI":"10.4049\/jimmunol.1302007","article-title":"Attenuation of respiratory syncytial virus-induced and rig-i-dependent type i ifn responses in human neonates and very young children","volume":"192","author":"Marr","year":"2014","journal-title":"J Immunol"},{"key":"10.1016\/j.coi.2015.05.003_bib0415","article-title":"Defective innate immune responses to respiratory syncytial virus infection in ovalbumin-sensitized mice","author":"Lai","year":"2014","journal-title":"J Microbiol Immunol Infect"},{"key":"10.1016\/j.coi.2015.05.003_sbref0420","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/j.jinf.2013.12.010","article-title":"Interferon lambda 1\u20133 expression in infants hospitalized for rsv or hrv associated bronchiolitis","volume":"68","author":"Selvaggi","year":"2014","journal-title":"J Infect"},{"key":"10.1016\/j.coi.2015.05.003_bib0425","doi-asserted-by":"crossref","first-page":"e1000017","DOI":"10.1371\/journal.ppat.1000017","article-title":"Ifn-lambda (ifn-lambda) is expressed in a tissue-dependent fashion and primarily acts on epithelial cells in vivo","volume":"4","author":"Sommereyns","year":"2008","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.coi.2015.05.003_bib0430","doi-asserted-by":"crossref","first-page":"e29695","DOI":"10.1371\/journal.pone.0029695","article-title":"Tlr2\/myd88\/nf-kappab pathway, reactive oxygen species, potassium efflux activates nlrp3\/asc inflammasome during respiratory syncytial virus infection","volume":"7","author":"Segovia","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.coi.2015.05.003_bib0435","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1136\/thoraxjnl-2012-202182","article-title":"Human respiratory syncytial virus viroporin sh: a viral recognition pathway used by the host to signal inflammasome activation","volume":"68","author":"Triantafilou","year":"2013","journal-title":"Thorax"},{"key":"10.1016\/j.coi.2015.05.003_bib0440","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.imlet.2014.09.006","article-title":"Respiratory syncytial virus: pathology, therapeutic drugs and prophylaxis","volume":"162","author":"Gomez","year":"2014","journal-title":"Immunol Lett"},{"key":"10.1016\/j.coi.2015.05.003_bib0445","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.1016\/j.ajpath.2014.02.004","article-title":"Il-27r-mediated regulation of il-17 controls the development of respiratory syncytial virus-associated pathogenesis","volume":"184","author":"de Almeida Nagata","year":"2014","journal-title":"Am J Pathol"},{"key":"10.1016\/j.coi.2015.05.003_bib0450","doi-asserted-by":"crossref","first-page":"e0119509","DOI":"10.1371\/journal.pone.0119509","article-title":"A novel respiratory syncytial virus (RSV) f subunit vaccine adjuvanted with gla-se elicits robust protective th1-type humoral and cellular immunity in rodent models","volume":"10","author":"Lambert","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.coi.2015.05.003_bib0455","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1111\/j.1365-2249.2004.02582.x","article-title":"Severe respiratory syncytial virus infections and reduced interferon-gamma generation in vitro","volume":"138","author":"Schauer","year":"2004","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.coi.2015.05.003_bib0460","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1002\/jmv.23291","article-title":"Specific increase in local il-17 production during recovery from primary rsv bronchiolitis","volume":"84","author":"Faber","year":"2012","journal-title":"J Med Virol"},{"key":"10.1016\/j.coi.2015.05.003_bib0465","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1038\/nri2586","article-title":"Structure and signalling in the il-17 receptor family","volume":"9","author":"Gaffen","year":"2009","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.coi.2015.05.003_sbref0470","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1016\/j.ajpath.2014.01.033","article-title":"Elevated th17 response in infants undergoing respiratory viral infection","volume":"184","author":"Stoppelenburg","year":"2014","journal-title":"Am J Pathol"},{"key":"10.1016\/j.coi.2015.05.003_bib0475","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.ajpath.2011.03.003","article-title":"Il-17-induced pulmonary pathogenesis during respiratory viral infection and exacerbation of allergic disease","volume":"179","author":"Mukherjee","year":"2011","journal-title":"Am J Pathol"},{"key":"10.1016\/j.coi.2015.05.003_bib0480","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1007\/s11882-012-0278-z","article-title":"Mechanisms of respiratory syncytial virus modulation of airway immune responses","volume":"12","author":"Lotz","year":"2012","journal-title":"Curr Allergy Asthma Rep"},{"key":"10.1016\/j.coi.2015.05.003_bib0485","doi-asserted-by":"crossref","first-page":"1648","DOI":"10.4049\/jimmunol.179.3.1648","article-title":"Respiratory syncytial virus synergizes with th2 cytokines to induce optimal levels of tarc\/ccl17","volume":"179","author":"Monick","year":"2007","journal-title":"J Immunol"},{"key":"10.1016\/j.coi.2015.05.003_sbref0490","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.meegid.2012.12.030","article-title":"Respiratory syncytial virus infection and recurrent wheezing in Chilean infants: a genetic background?","volume":"16","author":"Tapia","year":"2013","journal-title":"Infect Genet Evol"},{"key":"10.1016\/j.coi.2015.05.003_bib0495","doi-asserted-by":"crossref","first-page":"2376","DOI":"10.4049\/jimmunol.180.4.2376","article-title":"Il-13 is required for eosinophil entry into the lung during respiratory syncytial virus vaccine-enhanced disease","volume":"180","author":"Castilow","year":"2008","journal-title":"J Immunol"},{"key":"10.1016\/j.coi.2015.05.003_bib0500","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1086\/499316","article-title":"Association between severe respiratory syncytial virus infection and il13\/il4 haplotypes","volume":"193","author":"Puthothu","year":"2006","journal-title":"J Infect Dis"},{"key":"10.1016\/j.coi.2015.05.003_sbref0505","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1007\/s10156-012-0418-3","article-title":"Production of chemokines in respiratory syncytial virus infection with central nervous system manifestations","volume":"18","author":"Kawashima","year":"2012","journal-title":"J Infect Chemother"},{"key":"10.1016\/j.coi.2015.05.003_sbref0510","doi-asserted-by":"crossref","first-page":"9112","DOI":"10.1073\/pnas.1217508110","article-title":"Impaired learning resulting from respiratory syncytial virus infection","volume":"110","author":"Espinoza","year":"2013","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.coi.2015.05.003_bib0515","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1046\/j.1462-5822.2001.00116.x","article-title":"Cellular mechanisms of microbial proteins contributing to invasion of the blood\u2013brain barrier","volume":"3","author":"Huang","year":"2001","journal-title":"Cell Microbiol"},{"key":"10.1016\/j.coi.2015.05.003_bib0520","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1128\/JVI.80.1.537-540.2006","article-title":"Respiratory syncytial virus (rsv) infects neuronal cells and processes that innervate the lung by a process involving rsv g protein","volume":"80","author":"Li","year":"2006","journal-title":"J Virol"},{"key":"10.1016\/j.coi.2015.05.003_bib0525","first-page":"401","article-title":"Respiratory syncytial virus receptor expression in the mouse and viral tropism","volume":"30","author":"Shakeri","year":"2015","journal-title":"Histol Histopathol"},{"key":"10.1016\/j.coi.2015.05.003_bib0530","doi-asserted-by":"crossref","first-page":"14063","DOI":"10.1073\/pnas.0900096106","article-title":"Highly pathogenic h5n1 influenza virus can enter the central nervous system and induce neuroinflammation and neurodegeneration","volume":"106","author":"Jang","year":"2009","journal-title":"Proc Natl Acad Sci U S A"}],"container-title":["Current Opinion in Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0952791515000655?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0952791515000655?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T08:37:14Z","timestamp":1760603834000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0952791515000655"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,10]]},"references-count":53,"alternative-id":["S0952791515000655"],"URL":"https:\/\/doi.org\/10.1016\/j.coi.2015.05.003","relation":{},"ISSN":["0952-7915"],"issn-type":[{"value":"0952-7915","type":"print"}],"subject":[],"published":{"date-parts":[[2015,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Inflammatory damage on respiratory and nervous systems due to hRSV infection","name":"articletitle","label":"Article Title"},{"value":"Current Opinion in Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.coi.2015.05.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}