{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T20:20:34Z","timestamp":1792095634255,"version":"4.4.0"},"reference-count":62,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,6,1]],"date-time":"2017-06-01T00:00:00Z","timestamp":1496275200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,6,1]],"date-time":"2017-06-01T00:00:00Z","timestamp":1496275200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 AR042527"],"award-info":[{"award-number":["R01 AR042527"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 HL 117913"],"award-info":[{"award-number":["R01 HL 117913"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 AI108906"],"award-info":[{"award-number":["R01 AI108906"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P01 HL129941"],"award-info":[{"award-number":["P01 HL129941"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 AI108891"],"award-info":[{"award-number":["R01 AI108891"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 AG045779"],"award-info":[{"award-number":["R01 AG045779"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U19 AI057266"],"award-info":[{"award-number":["U19 AI057266"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["I01 BX001669"],"award-info":[{"award-number":["I01 BX001669"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmn.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Current Opinion in Immunology"],"published-print":{"date-parts":[[2017,6]]},"DOI":"10.1016\/j.coi.2017.04.010","type":"journal-article","created":{"date-parts":[[2017,5,21]],"date-time":"2017-05-21T05:31:08Z","timestamp":1495344668000},"page":"112-120","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":146,"special_numbering":"C","title":["Metabolic signatures of T-cells and macrophages in rheumatoid arthritis"],"prefix":"10.1016","volume":"46","author":[{"given":"Cornelia M","family":"Weyand","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Zeisbrich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f6rg J","family":"Goronzy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.coi.2017.04.010_bib0005","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1002\/art.39603","article-title":"Preclinical rheumatoid arthritis: progress toward prevention","volume":"68","author":"Mankia","year":"2016","journal-title":"Arthritis Rheumatol."},{"key":"10.1016\/j.coi.2017.04.010_bib0010","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1136\/annrheumdis-2016-209830","article-title":"Possibilities for preventive treatment in rheumatoid arthritis? Lessons from experimental animal models of arthritis: a systematic literature review and meta-analysis","volume":"76","author":"Dekkers","year":"2017","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.coi.2017.04.010_bib0015","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.4049\/jimmunol.167.2.1072","article-title":"Lymphoid neogenesis in rheumatoid synovitis","volume":"167","author":"Takemura","year":"2001","journal-title":"J. Immunol."},{"key":"10.1016\/j.coi.2017.04.010_bib0020","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.semcdb.2015.10.013","article-title":"Mediators of inflammation and bone remodeling in rheumatic disease","volume":"49","author":"Shaw","year":"2016","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.coi.2017.04.010_bib0025","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1186\/s13075-016-1156-1","article-title":"Rheumatoid synovial fibroblasts differentiate into distinct subsets in the presence of cytokines and cartilage","volume":"18","author":"Croft","year":"2016","journal-title":"Arthritis. Res. Ther."},{"key":"10.1016\/j.coi.2017.04.010_bib0030","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.jbspin.2015.10.003","article-title":"New autoantibodies associated with rheumatoid arthritis recognize posttranslationally modified self-proteins","volume":"83","author":"Cantagrel","year":"2016","journal-title":"Joint Bone Spine"},{"key":"10.1016\/j.coi.2017.04.010_bib0035","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.berh.2015.09.001","article-title":"How does established rheumatoid arthritis develop, and are there possibilities for prevention","volume":"29","author":"van Beers-Tas","year":"2015","journal-title":"Best Pract. Res. Clin. Rheumatol."},{"key":"10.1016\/j.coi.2017.04.010_bib0040","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1111\/imr.12379","article-title":"Mechanisms involved in triggering rheumatoid arthritis","volume":"269","author":"Catrina","year":"2016","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.coi.2017.04.010_bib0045","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1186\/s13075-016-1008-z","article-title":"Unexpected arterial wall and cellular inflammation in patients with rheumatoid arthritis in remission using biological therapy: a cross-sectional study","volume":"18","author":"Bernelot Moens","year":"2016","journal-title":"Arthritis. Res. Ther."},{"key":"10.1016\/j.coi.2017.04.010_bib0050","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1136\/annrheumdis-2013-204820","article-title":"Evaluation of synovial angiogenesis in patients with rheumatoid arthritis using (6)(8)Ga-PRGD2 PET\/CT: a prospective proof-of-concept cohort study","volume":"73","author":"Zhu","year":"2014","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.coi.2017.04.010_bib0055","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aaf4953","article-title":"Metabolic control of arthritis: switch pathways to treat","volume":"8","author":"Tsokos","year":"2016","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.coi.2017.04.010_bib0060","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1615\/CritRevImmunol.2016017164","article-title":"Metabolic factors that contribute to lupus pathogenesis","volume":"36","author":"Li","year":"2016","journal-title":"Crit. Rev. Immunol."},{"key":"10.1016\/j.coi.2017.04.010_bib0065","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/s13075-015-0542-4","article-title":"T-cell metabolism in autoimmune disease","volume":"17","author":"Yang","year":"2015","journal-title":"Arthritis. Res. Ther."},{"key":"10.1016\/j.coi.2017.04.010_bib0070","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1038\/nrrheum.2017.49","article-title":"Immunometabolism in early and late stages of rheumatoid arthritis","volume":"13","author":"Weyand","year":"2017","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.coi.2017.04.010_bib0075","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/j.immuni.2017.03.010","article-title":"Successful and maladaptive T cell aging","volume":"46","author":"Goronzy","year":"2017","journal-title":"Immunity"},{"key":"10.1016\/j.coi.2017.04.010_sbref0080","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1084\/jem.20150900","article-title":"The glycolytic enzyme PKM2 bridges metabolic and inflammatory dysfunction in coronary artery disease","volume":"213","author":"Shirai","year":"2016","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.coi.2017.04.010_bib0085","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.smim.2016.09.003","article-title":"Nutrients and the microenvironment to feed a T cell army","volume":"28","author":"Johnson","year":"2016","journal-title":"Semin. Immunol."},{"key":"10.1016\/j.coi.2017.04.010_bib0090","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/j.molimm.2015.07.034","article-title":"Glucose, glycolysis and lymphocyte responses","volume":"68","author":"Donnelly","year":"2015","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.coi.2017.04.010_bib0095","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1111\/imm.12655","article-title":"T-cell metabolism governing activation, proliferation and differentiation; a modular view","volume":"150","author":"Dimeloe","year":"2017","journal-title":"Immunology"},{"key":"10.1016\/j.coi.2017.04.010_bib0100","doi-asserted-by":"crossref","first-page":"4661","DOI":"10.4049\/jimmunol.172.8.4661","article-title":"Regulation of T lymphocyte metabolism","volume":"172","author":"Frauwirth","year":"2004","journal-title":"J. Immunol."},{"key":"10.1016\/j.coi.2017.04.010_bib0105","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1016\/S1074-7613(02)00323-0","article-title":"The CD28 signaling pathway regulates glucose metabolism","volume":"16","author":"Frauwirth","year":"2002","journal-title":"Immunity"},{"key":"10.1016\/j.coi.2017.04.010_bib0110","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1111\/j.1600-065X.2012.01152.x","article-title":"mTOR, metabolism, and the regulation of T-cell differentiation and function","volume":"249","author":"Waickman","year":"2012","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.coi.2017.04.010_bib0115","doi-asserted-by":"crossref","first-page":"2119","DOI":"10.1084\/jem.20130252","article-title":"Phosphofructokinase deficiency impairs ATP generation, autophagy, and redox balance in rheumatoid arthritis T cells","volume":"210","author":"Yang","year":"2013","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.coi.2017.04.010_sbref0120","doi-asserted-by":"crossref","first-page":"331ra338","DOI":"10.1126\/scitranslmed.aad7151","article-title":"Restoring oxidant signaling suppresses proarthritogenic T cell effector functions in rheumatoid arthritis","volume":"8","author":"Yang","year":"2016","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.coi.2017.04.010_bib0125","doi-asserted-by":"crossref","first-page":"382","DOI":"10.4161\/auto.27345","article-title":"The glycolytic enzyme PFKFB3\/phosphofructokinase regulates autophagy","volume":"10","author":"Yang","year":"2014","journal-title":"Autophagy"},{"key":"10.1016\/j.coi.2017.04.010_bib0130","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.1002\/eji.200738047","article-title":"Human CD4(+) T cells maintain specific functions even under conditions of extremely restricted ATP production","volume":"38","author":"Tripmacher","year":"2008","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.coi.2017.04.010_bib0135","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1042\/BST20140097","article-title":"Intermolecular disulfide-dependent redox signalling","volume":"42","author":"Putker","year":"2014","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.coi.2017.04.010_bib0140","doi-asserted-by":"crossref","first-page":"2966","DOI":"10.1089\/ars.2013.5582","article-title":"Circadian redox and metabolic oscillations in mammalian systems","volume":"20","author":"O'Neill","year":"2014","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.coi.2017.04.010_bib0145","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.tibs.2011.10.002","article-title":"The ATM protein kinase and cellular redox signaling: beyond the DNA damage response","volume":"37","author":"Ditch","year":"2012","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.coi.2017.04.010_bib0150","doi-asserted-by":"crossref","first-page":"2877","DOI":"10.3390\/biom5042877","article-title":"ATM-dependent phosphorylation of all three members of the MRN complex: from sensor to adaptor","volume":"5","author":"Lavin","year":"2015","journal-title":"Biomolecules"},{"key":"10.1016\/j.coi.2017.04.010_bib0155","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1084\/jem.20082251","article-title":"Deficiency of the DNA repair enzyme ATM in rheumatoid arthritis","volume":"206","author":"Shao","year":"2009","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.coi.2017.04.010_sbref0160","doi-asserted-by":"crossref","first-page":"15171","DOI":"10.1038\/srep15171","article-title":"Fructose 1,6-bisphosphate, a high-energy intermediate of glycolysis, attenuates experimental arthritis by activating anti-inflammatory adenosinergic pathway","volume":"5","author":"Veras","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.coi.2017.04.010_bib0165","doi-asserted-by":"crossref","first-page":"409","DOI":"10.3389\/fimmu.2014.00409","article-title":"Nutrient sensing via mTOR in T cells maintains a tolerogenic microenvironment","volume":"5","author":"Howie","year":"2014","journal-title":"Front. Immunol."},{"key":"10.1016\/j.coi.2017.04.010_bib0170","doi-asserted-by":"crossref","first-page":"123","DOI":"10.3389\/fimmu.2016.00123","article-title":"The cAMP pathway as therapeutic target in autoimmune and inflammatory diseases","volume":"7","author":"Raker","year":"2016","journal-title":"Front. Immunol."},{"key":"10.1016\/j.coi.2017.04.010_bib0175","doi-asserted-by":"crossref","first-page":"3454","DOI":"10.1016\/j.febslet.2015.07.027","article-title":"CD73 and CD39 ectonucleotidases in T cell differentiation: beyond immunosuppression","volume":"589","author":"Bono","year":"2015","journal-title":"FEBS Lett."},{"key":"10.1016\/j.coi.2017.04.010_bib0180","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1016\/j.celrep.2016.01.002","article-title":"Expression of CD39 on activated T cells impairs their survival in older individuals","volume":"14","author":"Fang","year":"2016","journal-title":"Cell Rep."},{"key":"10.1016\/j.coi.2017.04.010_bib0185","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1172\/JCI106594","article-title":"A physiological approach to the assessment of disease activity in rheumatoid arthritis","volume":"50","author":"Goetzl","year":"1971","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.coi.2017.04.010_bib0190","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1002\/art.1780140407","article-title":"Synovial fluid pH, lactate, oxygen and carbon dioxide partial pressure in various joint diseases","volume":"14","author":"Treuhaft","year":"1971","journal-title":"Arthritis Rheumatol."},{"key":"10.1016\/j.coi.2017.04.010_bib0195","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1002\/0470868716.ch17","article-title":"\u2018The metabolism of tumours\u2019: 70 years later","volume":"240","author":"Semenza","year":"2001","journal-title":"Novartis Found. Symp."},{"key":"10.1016\/j.coi.2017.04.010_bib0200","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.cmet.2007.10.002","article-title":"The biology of cancer: metabolic reprogramming fuels cell growth and proliferation","volume":"7","author":"DeBerardinis","year":"2008","journal-title":"Cell Metab."},{"key":"10.1016\/j.coi.2017.04.010_bib0205","doi-asserted-by":"crossref","first-page":"1614","DOI":"10.1002\/art.39608","article-title":"Critical role of glucose metabolism in rheumatoid arthritis fibroblast-like synoviocytes","volume":"68","author":"Garcia-Carbonell","year":"2016","journal-title":"Arthritis Rheumatol."},{"key":"10.1016\/j.coi.2017.04.010_bib0210","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1016\/j.tibs.2016.02.003","article-title":"Intermediates of metabolism: from bystanders to signalling molecules","volume":"41","author":"Haas","year":"2016","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.coi.2017.04.010_bib0215","doi-asserted-by":"crossref","first-page":"1528","DOI":"10.1134\/S0006297914130069","article-title":"Acid-sensing ion channels and their modulators","volume":"79","author":"Osmakov","year":"2014","journal-title":"Biochemistry (Mosc)"},{"key":"10.1016\/j.coi.2017.04.010_bib0220","doi-asserted-by":"crossref","first-page":"491","DOI":"10.14336\/AD.2015.1213","article-title":"Novel insights into acid-sensing ion channels: implications for degenerative diseases","volume":"7","author":"Zhou","year":"2016","journal-title":"Aging Dis."},{"key":"10.1016\/j.coi.2017.04.010_sbref0225","doi-asserted-by":"crossref","first-page":"e1002202","DOI":"10.1371\/journal.pbio.1002202","article-title":"Lactate regulates metabolic and pro-inflammatory circuits in control of T-cell migration and effector functions","volume":"13","author":"Haas","year":"2015","journal-title":"PLoS Biol."},{"key":"10.1016\/j.coi.2017.04.010_bib0230","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1097\/BOR.0000000000000011","article-title":"T-cell aging in rheumatoid arthritis","volume":"26","author":"Weyand","year":"2014","journal-title":"Curr. Opin. Rheumatol."},{"key":"10.1016\/j.coi.2017.04.010_bib0235","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1038\/nrrheum.2009.180","article-title":"Rejuvenating the immune system in rheumatoid arthritis","volume":"5","author":"Weyand","year":"2009","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.coi.2017.04.010_sbref0240","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1016\/j.immuni.2016.09.013","article-title":"Deficient activity of the nuclease MRE11A induces T cell aging and promotes arthritogenic effector functions in patients with rheumatoid arthritis","volume":"45","author":"Li","year":"2016","journal-title":"Immunity"},{"key":"10.1016\/j.coi.2017.04.010_bib0245","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1016\/j.dnarep.2010.10.001","article-title":"Mre11-Rad50-Nbs1 conformations and the control of sensing, signaling, and effector responses at DNA double-strand breaks","volume":"9","author":"Williams","year":"2010","journal-title":"DNA Repair (Amst)"},{"key":"10.1016\/j.coi.2017.04.010_bib0250","doi-asserted-by":"crossref","first-page":"13471","DOI":"10.1073\/pnas.2233561100","article-title":"Premature telomeric loss in rheumatoid arthritis is genetically determined and involves both myeloid and lymphoid cell lineages","volume":"100","author":"Schonland","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.coi.2017.04.010_bib0255","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1002\/art.39419","article-title":"Association of elevations of specific T cell and monocyte subpopulations in rheumatoid arthritis with subclinical coronary artery atherosclerosis","volume":"68","author":"Winchester","year":"2016","journal-title":"Arthritis Rheumatol."},{"key":"10.1016\/j.coi.2017.04.010_bib0260","first-page":"2","article-title":"Rheumatoid arthritis: anti-TNF agents go head-to-head","volume":"13","author":"Onuora","year":"2017","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.coi.2017.04.010_bib0265","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.autrev.2016.01.006","article-title":"Coexistence of ischemic heart disease and rheumatoid arthritis patients\u2014a case control study","volume":"15","author":"Houri Levi","year":"2016","journal-title":"Autoimmun. Rev."},{"key":"10.1016\/j.coi.2017.04.010_bib0270","doi-asserted-by":"crossref","first-page":"139","DOI":"10.3109\/08916934.2015.1027815","article-title":"Macrophages in vascular inflammation\u2014from atherosclerosis to vasculitis","volume":"48","author":"Shirai","year":"2015","journal-title":"Autoimmunity"},{"key":"10.1016\/j.coi.2017.04.010_bib0275","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1007\/s10753-013-9799-4","article-title":"Insulin resistance is associated with increased concentrations of NT-proBNP in rheumatoid arthritis: IL-6 as a potential mediator","volume":"37","author":"Bradham","year":"2014","journal-title":"Inflammation"},{"key":"10.1016\/j.coi.2017.04.010_bib0280","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.1002\/art.25009","article-title":"Inflammatory mediators and premature coronary atherosclerosis in rheumatoid arthritis","volume":"61","author":"Rho","year":"2009","journal-title":"Arthritis Rheumatol."},{"key":"10.1016\/j.coi.2017.04.010_bib0285","doi-asserted-by":"crossref","first-page":"2888","DOI":"10.1002\/art.39270","article-title":"Monocarboxylate transporter 4, associated with the acidification of synovial fluid, is a novel therapeutic target for inflammatory arthritis","volume":"67","author":"Fujii","year":"2015","journal-title":"Arthritis Rheumatol."},{"key":"10.1016\/j.coi.2017.04.010_bib0290","first-page":"195","article-title":"In vitro studies of rheumatoid synovium; preliminary metabolic comparison between synovial membrane and villi","volume":"36","author":"Thomas","year":"1955","journal-title":"Br. J. Exp. Pathol."},{"key":"10.1016\/j.coi.2017.04.010_bib0295","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1002\/eji.201646477","article-title":"Lactate at the crossroads of metabolism, inflammation, and autoimmunity","volume":"47","author":"Pucino","year":"2017","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.coi.2017.04.010_bib0300","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1136\/annrheumdis-2013-203670","article-title":"AMPA\/kainate glutamate receptors contribute to inflammation, degeneration and pain related behaviour in inflammatory stages of arthritis","volume":"74","author":"Bonnet","year":"2015","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.coi.2017.04.010_sbref0305","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1084\/jem.20160061","article-title":"GPR91 senses extracellular succinate released from inflammatory macrophages and exacerbates rheumatoid arthritis","volume":"213","author":"Littlewood-Evans","year":"2016","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.coi.2017.04.010_bib0310","doi-asserted-by":"crossref","first-page":"e97501","DOI":"10.1371\/journal.pone.0097501","article-title":"Global metabolite profiling of synovial fluid for the specific diagnosis of rheumatoid arthritis from other inflammatory arthritis","volume":"9","author":"Kim","year":"2014","journal-title":"PLoS One"}],"container-title":["Current Opinion in Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S095279151730002X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S095279151730002X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T08:41:09Z","timestamp":1760604069000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S095279151730002X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6]]},"references-count":62,"alternative-id":["S095279151730002X"],"URL":"https:\/\/doi.org\/10.1016\/j.coi.2017.04.010","relation":{},"ISSN":["0952-7915"],"issn-type":[{"value":"0952-7915","type":"print"}],"subject":[],"published":{"date-parts":[[2017,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Metabolic signatures of T-cells and macrophages in rheumatoid arthritis","name":"articletitle","label":"Article Title"},{"value":"Current Opinion in Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.coi.2017.04.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}