{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T22:14:59Z","timestamp":1779228899092,"version":"3.51.4"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T00:00:00Z","timestamp":1533081600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T00:00:00Z","timestamp":1533081600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,4,25]],"date-time":"2019-04-25T00:00:00Z","timestamp":1556150400000},"content-version":"am","delay-in-days":267,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100000925","name":"NHMRC","doi-asserted-by":"publisher","award":["APP1061365"],"award-info":[{"award-number":["APP1061365"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000923","name":"ARC","doi-asserted-by":"publisher","award":["DP150103110"],"award-info":[{"award-number":["DP150103110"]}],"id":[{"id":"10.13039\/501100000923","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000923","name":"ARC Future Fellowship","doi-asserted-by":"publisher","award":["FT130101254"],"award-info":[{"award-number":["FT130101254"]}],"id":[{"id":"10.13039\/501100000923","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmn.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Current Opinion in Immunology"],"published-print":{"date-parts":[[2018,8]]},"DOI":"10.1016\/j.coi.2018.04.012","type":"journal-article","created":{"date-parts":[[2018,4,25]],"date-time":"2018-04-25T12:09:41Z","timestamp":1524658181000},"page":"81-87","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"special_numbering":"C","title":["Lymphatic endothelial progenitor cells: origins and roles in lymphangiogenesis"],"prefix":"10.1016","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6216-3444","authenticated-orcid":false,"given":"Jan","family":"Kazenwadel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natasha L","family":"Harvey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.coi.2018.04.012_bib0235","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1002\/aja.1000010310","article-title":"On the origin of the lymphatics system from the veins and the development of the lymph hearts and the thoracic duct in the pig","volume":"1","author":"Sabin","year":"1902","journal-title":"Am J Anat"},{"key":"10.1016\/j.coi.2018.04.012_bib0240","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1002\/aja.1000100108","article-title":"The anatomy and development of the jugular lymph sac in the domestic cat (Felis domestica)","volume":"10","author":"Huntington","year":"1910","journal-title":"Am J Anat"},{"key":"10.1016\/j.coi.2018.04.012_bib0245","doi-asserted-by":"crossref","DOI":"10.1002\/aja.1000150202","article-title":"Histogenesis and morphogenesis of the thoracic duct in the chick; development of blood cells and their passage to the blood stream via the thoracic duct","volume":"15","author":"Miller","year":"1913","journal-title":"Am J Anat"},{"key":"10.1016\/j.coi.2018.04.012_bib0250","article-title":"Sullo sviluppo dei cuori linfatici e dei dotti toracici ncll\u2019 embryone di pollo","volume":"7","author":"Sala","year":"1900","journal-title":"Ricerche fatta nel Laboratorio di Anatomia Nor- male della R Univ di Roma"},{"key":"10.1016\/j.coi.2018.04.012_bib0255","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1007\/978-3-7091-1646-3_13","article-title":"Visualization of lymphatic vessel development, growth, and function","volume":"214","author":"Pollmann","year":"2014","journal-title":"Adv Anat Embryol Cell Biol"},{"key":"10.1016\/j.coi.2018.04.012_bib0260","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1016\/S0092-8674(00)81511-1","article-title":"Prox1 function is required for the development of the murine lymphatic system","volume":"98","author":"Wigle","year":"1999","journal-title":"Cell"},{"key":"10.1016\/j.coi.2018.04.012_bib0265","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1093\/emboj\/21.7.1505","article-title":"An essential role for Prox1 in the induction of the lymphatic endothelial cell phenotype","volume":"21","author":"Wigle","year":"2002","journal-title":"EMBO J"},{"key":"10.1016\/j.coi.2018.04.012_bib0270","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.ydbio.2011.12.032","article-title":"Segmental territories along the cardinal veins generate lymph sacs via a ballooning mechanism during embryonic lymphangiogenesis in mice","volume":"364","author":"Francois","year":"2012","journal-title":"Dev Biol"},{"key":"10.1016\/j.coi.2018.04.012_bib0275","doi-asserted-by":"crossref","first-page":"2340","DOI":"10.1182\/blood-2012-05-428607","article-title":"Lymphatic endothelial progenitors bud from the cardinal vein and intersomitic vessels in mammalian embryos","volume":"120","author":"Yang","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.coi.2018.04.012_bib0280","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1038\/emboj.2012.340","article-title":"A novel multistep mechanism for initial lymphangiogenesis in mouse embryos based on ultramicroscopy","volume":"32","author":"Hagerling","year":"2013","journal-title":"EMBO J"},{"key":"10.1016\/j.coi.2018.04.012_bib0285","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1038\/ni1013","article-title":"Vascular endothelial growth factor C is required for sprouting of the first lymphatic vessels from embryonic veins","volume":"5","author":"Karkkainen","year":"2004","journal-title":"Nat Immunol"},{"key":"10.1016\/j.coi.2018.04.012_bib0290","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1038\/nm1427","article-title":"Live imaging of lymphatic development in the zebrafish","volume":"12","author":"Yaniv","year":"2006","journal-title":"Nat Med"},{"key":"10.1016\/j.coi.2018.04.012_bib0295","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.ydbio.2005.12.043","article-title":"Dual origin of avian lymphatics","volume":"292","author":"Wilting","year":"2006","journal-title":"Dev Biol"},{"key":"10.1016\/j.coi.2018.04.012_bib0300","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1038\/nm1285","article-title":"A genetic Xenopus laevis tadpole model to study lymphangiogenesis","volume":"11","author":"Ny","year":"2005","journal-title":"Nat Med"},{"key":"10.1016\/j.coi.2018.04.012_bib0305","doi-asserted-by":"crossref","first-page":"1554","DOI":"10.1002\/dvdy.20737","article-title":"Mesenchymal cells with leukocyte and lymphendothelial characteristics in murine embryos","volume":"235","author":"Buttler","year":"2006","journal-title":"Dev Dyn"},{"key":"10.1016\/j.coi.2018.04.012_bib0310","doi-asserted-by":"crossref","first-page":"2422","DOI":"10.1101\/gad.1588407","article-title":"Lineage tracing demonstrates the venous origin of the mammalian lymphatic vasculature","volume":"21","author":"Srinivasan","year":"2007","journal-title":"Genes Dev"},{"key":"10.1016\/j.coi.2018.04.012_sbref0315","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1038\/nature14425","article-title":"Lymphatic vessels arise from specialized angioblasts within a venous niche","volume":"522","author":"Nicenboim","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.coi.2018.04.012_bib0320","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1126\/science.1178577","article-title":"Arterial-venous segregation by selective cell sprouting: an alternative mode of blood vessel formation","volume":"326","author":"Herbert","year":"2009","journal-title":"Science"},{"key":"10.1016\/j.coi.2018.04.012_bib0325","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1242\/dev.101808","article-title":"Molecular identification of venous progenitors in the dorsal aorta reveals an aortic origin for the cardinal vein in mammals","volume":"141","author":"Lindskog","year":"2014","journal-title":"Development"},{"key":"10.1016\/j.coi.2018.04.012_bib0330","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1016\/j.devcel.2014.11.002","article-title":"The left-right Pitx2 pathway drives organ-specific arterial and lymphatic development in the intestine","volume":"31","author":"Mahadevan","year":"2014","journal-title":"Dev Cell"},{"key":"10.1016\/j.coi.2018.04.012_sbref0335","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2015.02.026","article-title":"cKit lineage hemogenic endothelium-derived cells contribute to mesenteric lymphatic vessels","author":"Stanczuk","year":"2015","journal-title":"Cell Rep"},{"key":"10.1016\/j.coi.2018.04.012_bib0340","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1002\/dvdy.24430","article-title":"Insights into blood cell formation from hemogenic endothelium in lesser-known anatomic sites","volume":"245","author":"Yzaguirre","year":"2016","journal-title":"Dev Dyn"},{"key":"10.1016\/j.coi.2018.04.012_sbref0345","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1038\/nature14483","article-title":"Cardiac lymphatics are heterogeneous in origin and respond to injury","volume":"522","author":"Klotz","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.coi.2018.04.012_bib0350","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.1161\/CIRCULATIONAHA.115.020143","article-title":"Selective stimulation of cardiac lymphangiogenesis reduces myocardial edema and fibrosis leading to improved cardiac function following myocardial infarction","volume":"133","author":"Henri","year":"2016","journal-title":"Circulation"},{"key":"10.1016\/j.coi.2018.04.012_bib0355","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.1161\/CIRCRESAHA.116.306170","article-title":"Nonvenous origin of dermal lymphatic vasculature","volume":"116","author":"Martinez-Corral","year":"2015","journal-title":"Circ Res"},{"key":"10.1016\/j.coi.2018.04.012_bib0360","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1002\/dvg.22939","article-title":"Pdgfrb-Cre targets lymphatic endothelial cells of both venous and non-venous origins","volume":"54","author":"Ulvmar","year":"2016","journal-title":"Genesis"},{"key":"10.1016\/j.coi.2018.04.012_bib0365","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1038\/ncomms2186","article-title":"Supporting conditional mouse mutagenesis with a comprehensive cre characterization resource","volume":"3","author":"Heffner","year":"2012","journal-title":"Nat Commun"},{"key":"10.1016\/j.coi.2018.04.012_sbref0370","doi-asserted-by":"crossref","DOI":"10.1242\/dev.160184","article-title":"A blood capillary plexus-derived population of progenitor cells contributes to genesis of the dermal lymphatic vasculature during embryonic development","author":"Pichol-Thievend","year":"2018","journal-title":"Development"},{"key":"10.1016\/j.coi.2018.04.012_sbref0375","doi-asserted-by":"crossref","first-page":"3645","DOI":"10.1084\/jem.20170391","article-title":"Development and plasticity of meningeal lymphatic vessels","volume":"214","author":"Antila","year":"2017","journal-title":"J Exp Med"},{"key":"10.1016\/j.coi.2018.04.012_bib0380","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1038\/ng.321","article-title":"Ccbe1 is required for embryonic lymphangiogenesis and venous sprouting","volume":"41","author":"Hogan","year":"2009","journal-title":"Nat Genet"},{"key":"10.1016\/j.coi.2018.04.012_bib0385","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1242\/dev.100495","article-title":"Ccbe1 regulates Vegfc-mediated induction of Vegfr3 signaling during embryonic lymphangiogenesis","volume":"141","author":"Le Guen","year":"2014","journal-title":"Development"},{"key":"10.1016\/j.coi.2018.04.012_bib0390","doi-asserted-by":"crossref","first-page":"3899","DOI":"10.1242\/dev.050021","article-title":"Macrophages define dermal lymphatic vessel calibre during development by regulating lymphatic endothelial cell proliferation","volume":"137","author":"Gordon","year":"2010","journal-title":"Development"},{"key":"10.1016\/j.coi.2018.04.012_bib0395","doi-asserted-by":"crossref","first-page":"e0181549","DOI":"10.1371\/journal.pone.0181549","article-title":"Myeloid Wnt ligands are required for normal development of dermal lymphatic vasculature","volume":"12","author":"Muley","year":"2017","journal-title":"PLOS ONE"},{"key":"10.1016\/j.coi.2018.04.012_bib0400","doi-asserted-by":"crossref","first-page":"2363","DOI":"10.1172\/JCI23874","article-title":"Inflammation-induced lymphangiogenesis in the cornea arises from CD11b-positive macrophages","volume":"115","author":"Maruyama","year":"2005","journal-title":"J Clin Invest"},{"key":"10.1016\/j.coi.2018.04.012_bib0405","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1038\/nm1340","article-title":"Lymphatic endothelial progenitor cells contribute to de novo lymphangiogenesis in human renal transplants","volume":"12","author":"Kerjaschki","year":"2006","journal-title":"Nat Med"},{"key":"10.1016\/j.coi.2018.04.012_bib0410","doi-asserted-by":"crossref","first-page":"e7067","DOI":"10.1371\/journal.pone.0007067","article-title":"Myeloid cells contribute to tumor lymphangiogenesis","volume":"4","author":"Zumsteg","year":"2009","journal-title":"PLOS ONE"},{"key":"10.1016\/j.coi.2018.04.012_bib0415","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1161\/CIRCULATIONAHA.110.941468","article-title":"Podoplanin-expressing cells derived from bone marrow play a crucial role in postnatal lymphatic neovascularization","volume":"122","author":"Lee","year":"2010","journal-title":"Circulation"},{"key":"10.1016\/j.coi.2018.04.012_bib0420","doi-asserted-by":"crossref","first-page":"3737","DOI":"10.1158\/0008-5472.CAN-04-0088","article-title":"Preexisting lymphatic endothelium but not endothelial progenitor cells are essential for tumor lymphangiogenesis and lymphatic metastasis","volume":"64","author":"He","year":"2004","journal-title":"Cancer Res"},{"key":"10.1016\/j.coi.2018.04.012_bib0425","doi-asserted-by":"crossref","first-page":"e0179257","DOI":"10.1371\/journal.pone.0179257","article-title":"Lymphatic endothelial progenitors originate from plastic myeloid cells activated by toll-like receptor-4","volume":"12","author":"Volk-Draper","year":"2017","journal-title":"PLOS ONE"},{"key":"10.1016\/j.coi.2018.04.012_bib0430","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1161\/CIRCRESAHA.116.305368","article-title":"Vascular wall progenitor cells in health and disease","volume":"116","author":"Psaltis","year":"2015","journal-title":"Circ Res"},{"key":"10.1016\/j.coi.2018.04.012_bib0435","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1186\/1471-2121-11-50","article-title":"Mouse lung contains endothelial progenitors with high capacity to form blood and lymphatic vessels","volume":"11","author":"Schniedermann","year":"2010","journal-title":"BMC Cell Biol"},{"key":"10.1016\/j.coi.2018.04.012_bib0440","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1007\/s00018-013-1460-8","article-title":"De novo hem- and lymphangiogenesis by endothelial progenitor and mesenchymal stem cells in immunocompetent mice","volume":"71","author":"Buttler","year":"2014","journal-title":"Cell Mol Life Sci"},{"key":"10.1016\/j.coi.2018.04.012_bib0445","doi-asserted-by":"crossref","first-page":"L855","DOI":"10.1152\/ajplung.00211.2013","article-title":"c-Kit immunoexpression delineates a putative endothelial progenitor cell population in developing human lungs","volume":"306","author":"Suzuki","year":"2014","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"10.1016\/j.coi.2018.04.012_sbref0450","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1038\/nm.3888","article-title":"c-kit(+) cells adopt vascular endothelial but not epithelial cell fates during lung maintenance and repair","volume":"21","author":"Liu","year":"2015","journal-title":"Nat Med"},{"key":"10.1016\/j.coi.2018.04.012_bib0455","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1161\/CIRCULATIONAHA.108.793208","article-title":"Multipotent mesenchymal stem cells acquire a lymphendothelial phenotype and enhance lymphatic regeneration in vivo","volume":"119","author":"Conrad","year":"2009","journal-title":"Circulation"},{"key":"10.1016\/j.coi.2018.04.012_bib0460","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.3892\/ijmm.2016.2502","article-title":"VEGF-C and TGF-beta reciprocally regulate mesenchymal stem cell commitment to differentiation into lymphatic endothelial or osteoblastic phenotypes","volume":"37","author":"Igarashi","year":"2016","journal-title":"Int J Mol Med"}],"container-title":["Current Opinion in Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0952791518300268?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0952791518300268?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T08:44:07Z","timestamp":1760604247000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0952791518300268"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8]]},"references-count":46,"alternative-id":["S0952791518300268"],"URL":"https:\/\/doi.org\/10.1016\/j.coi.2018.04.012","relation":{},"ISSN":["0952-7915"],"issn-type":[{"value":"0952-7915","type":"print"}],"subject":[],"published":{"date-parts":[[2018,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Lymphatic endothelial progenitor cells: origins and roles in lymphangiogenesis","name":"articletitle","label":"Article Title"},{"value":"Current Opinion in Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.coi.2018.04.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}