{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T16:15:39Z","timestamp":1791389739292,"version":"4.3.3"},"reference-count":76,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["R35-GM136352-01"],"award-info":[{"award-number":["R35-GM136352-01"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmn.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Current Opinion in Immunology"],"published-print":{"date-parts":[[2021,10]]},"DOI":"10.1016\/j.coi.2021.04.005","type":"journal-article","created":{"date-parts":[[2021,5,15]],"date-time":"2021-05-15T17:07:00Z","timestamp":1621098420000},"page":"126-134","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":78,"special_numbering":"C","title":["Membrane cofactor protein (MCP; CD46): deficiency states and pathogen connections"],"prefix":"10.1016","volume":"72","author":[{"given":"M Kathryn","family":"Liszewski","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John P","family":"Atkinson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.coi.2021.04.005_bib0005","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1111\/imr.12474","article-title":"Evolution of the complement system: from defense of the single cell to guardian of the intravascular space","volume":"274","author":"Elvington","year":"2016","journal-title":"Immunol Rev"},{"key":"10.1016\/j.coi.2021.04.005_bib0010","series-title":"The Evolution of the Immune System. Conservation and Diversification","first-page":"151","article-title":"The evolution of complement system functions and pathways in vertebrates","author":"Nakao","year":"2016"},{"key":"10.1016\/j.coi.2021.04.005_bib0015","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1038\/s41577-019-0168-x","article-title":"New insights into the immune functions of complement","volume":"19","author":"Reis","year":"2019","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.coi.2021.04.005_bib0020","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1111\/cei.12952","article-title":"Production of complement components by cells of the immune system","volume":"188","author":"Lubbers","year":"2017","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.coi.2021.04.005_bib0025","series-title":"The Complement Factsbook","year":"2018"},{"key":"10.1016\/j.coi.2021.04.005_bib0030","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/s40246-015-0029-z","article-title":"Complement regulator CD46: genetic variants and disease associations","volume":"9","author":"Liszewski","year":"2015","journal-title":"Hum Genomics"},{"key":"10.1016\/j.coi.2021.04.005_bib0035","doi-asserted-by":"crossref","first-page":"3","DOI":"10.4049\/jimmunol.1900527","article-title":"Complement in motion: the evolution of CD46 from a complement regulator to an orchestrator of normal cell physiology","volume":"203","author":"Liszewski","year":"2019","journal-title":"J Immunol"},{"key":"10.1016\/j.coi.2021.04.005_bib0040","doi-asserted-by":"crossref","first-page":"2808","DOI":"10.1016\/j.biocel.2013.09.016","article-title":"CD46: the \u2018multitasker\u2019 of complement proteins","volume":"45","author":"Yamamoto","year":"2013","journal-title":"Int J Biochem Cell Biol"},{"key":"10.1016\/j.coi.2021.04.005_bib0045","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.4049\/jimmunol.151.3.1519","article-title":"Membrane cofactor protein (CD46) protects cells predominantly from alternative complement pathway-mediated C3-fragment deposition and cytolysis","volume":"151","author":"Kojima","year":"1993","journal-title":"J Immunol"},{"key":"10.1016\/j.coi.2021.04.005_bib0050","doi-asserted-by":"crossref","first-page":"4415","DOI":"10.4049\/jimmunol.156.11.4415","article-title":"Membrane cofactor protein (MCP; CD46). Isoforms differ in protection against the classical pathway of complement","volume":"156","author":"Liszewski","year":"1996","journal-title":"J Immunol"},{"key":"10.1016\/j.coi.2021.04.005_bib0055","article-title":"CD46 and oncologic interactions: friendly fire against cancer","volume":"9","author":"Elvington","year":"2020","journal-title":"Antibodies (Basel)"},{"key":"10.1016\/j.coi.2021.04.005_bib0060","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.3389\/fimmu.2019.01074","article-title":"The role of membrane bound complement regulatory proteins in tumor development and cancer immunotherapy","volume":"10","author":"Geller","year":"2019","journal-title":"Front Immunol"},{"key":"10.1016\/j.coi.2021.04.005_bib0065","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1038\/s41568-019-0210-0","article-title":"Context-dependent roles of complement in cancer","volume":"19","author":"Roumenina","year":"2019","journal-title":"Nat Rev Cancer"},{"key":"10.1016\/j.coi.2021.04.005_bib0070","doi-asserted-by":"crossref","first-page":"5143","DOI":"10.4049\/jimmunol.165.9.5143","article-title":"Functional modulation of human macrophages through CD46 (measles virus receptor): production of IL-12 p40 and nitric oxide in association with recruitment of protein-tyroxine phosphatase SHP-1 to CD46","volume":"165","author":"Kurita-Taniguchi","year":"2000","journal-title":"J Immunol"},{"key":"10.1016\/j.coi.2021.04.005_bib0075","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1002\/eji.201646397","article-title":"CD46 accelerates macrophage-mediated host susceptibility to meningococcal sepsis in a murine model","volume":"47","author":"Wang","year":"2017","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.coi.2021.04.005_bib0080","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/j.chom.2009.09.006","article-title":"Autophagy induction by the pathogen receptor CD46","volume":"6","author":"Joubert","year":"2009","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.coi.2021.04.005_bib0085","doi-asserted-by":"crossref","first-page":"12973","DOI":"10.1038\/s41598-018-31317-5","article-title":"Complement regulatory protein CD46 induces autophagy against oxidative stress-mediated apoptosis in normal and asthmatic airway epithelium","volume":"8","author":"Tsai","year":"2018","journal-title":"Sci Rep"},{"key":"10.1016\/j.coi.2021.04.005_bib0090","doi-asserted-by":"crossref","first-page":"6091","DOI":"10.4049\/jimmunol.164.12.6091","article-title":"Cutting edge: CD46, a new costimulatory molecule for T cells, that induces p120CBL and LAT phosphorylation","volume":"164","author":"Astier","year":"2000","journal-title":"J Immunol"},{"key":"10.1016\/j.coi.2021.04.005_sbref0095","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1016\/j.immuni.2013.10.018","article-title":"Intracellular complement activation sustains T cell homeostasis and mediates effector differentiation","volume":"39","author":"Liszewski","year":"2013","journal-title":"Immunity"},{"key":"10.1016\/j.coi.2021.04.005_bib0100","doi-asserted-by":"crossref","first-page":"4186","DOI":"10.1038\/s41467-018-06706-z","article-title":"Complement receptor CD46 co-stimulates optimal human CD8+ T cell effector function via fatty acid metabolism","volume":"9","author":"Arbore","year":"2018","journal-title":"Nat Commun"},{"key":"10.1016\/j.coi.2021.04.005_bib0105","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1111\/imr.12852","article-title":"Complement and human T cell metabolism: location, location, location","volume":"295","author":"West","year":"2020","journal-title":"Immunol Rev"},{"key":"10.1016\/j.coi.2021.04.005_bib0110","doi-asserted-by":"crossref","DOI":"10.20900\/immunometab20190006","article-title":"Complement and T cell metabolism: food for thought","volume":"1","author":"West","year":"2019","journal-title":"Immunometabolism"},{"key":"10.1016\/j.coi.2021.04.005_bib0115","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1038\/nri3761","article-title":"Complement - tapping into new sites and effector systems","volume":"14","author":"Kolev","year":"2014","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.coi.2021.04.005_bib0120","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.molimm.2017.05.012","article-title":"Intracellular complement - the complosome - in immune cell regulation","volume":"89","author":"Arbore","year":"2017","journal-title":"Mol Immunol"},{"key":"10.1016\/j.coi.2021.04.005_bib0125","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1002\/eji.201546131","article-title":"A novel \"complement-metabolism-inflammasome axis\" as a key regulator of immune cell effector function","volume":"46","author":"Arbore","year":"2016","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.coi.2021.04.005_bib0130","doi-asserted-by":"crossref","DOI":"10.1111\/aji.12997","article-title":"Timing and mechanism of conceptus demise in a complement regulatory membrane protein deficient mouse","volume":"80","author":"Triebwasser","year":"2018","journal-title":"Am J Reprod Immunol"},{"key":"10.1016\/j.coi.2021.04.005_bib0135","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.2215\/CJN.00280117","article-title":"Hemolytic uremic syndrome in pregnancy and postpartum","volume":"12","author":"Bruel","year":"2017","journal-title":"Clin J Am Soc Nephrol"},{"key":"10.1016\/j.coi.2021.04.005_bib0140","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1159\/000445127","article-title":"Comprehensive analysis of complement genes in patients with atypical hemolytic uremic syndrome","volume":"43","author":"Zhang","year":"2016","journal-title":"Am J Nephrol"},{"key":"10.1016\/j.coi.2021.04.005_bib0145","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1681\/ASN.2016090995","article-title":"Maternal and fetal outcomes of pregnancies in women with atypical hemolytic uremic syndrome","volume":"29","author":"Gaggl","year":"2018","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.coi.2021.04.005_bib0150","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1111\/jth.13189","article-title":"The role of ADAMTS-13 activity and complement mutational analysis in differentiating acute thrombotic microangiopathies","volume":"14","author":"Phillips","year":"2016","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.coi.2021.04.005_sbref0155","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.molimm.2015.03.246","article-title":"Atypical aHUS: State of the art","volume":"67","author":"Nester","year":"2015","journal-title":"Mol Immunol"},{"key":"10.1016\/j.coi.2021.04.005_bib0160","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1002\/eji.201646822","article-title":"Dysregulated CD46 shedding interferes with Th1-contraction in systemic lupus erythematosus","volume":"47","author":"Ellinghaus","year":"2017","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.coi.2021.04.005_bib0165","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1038\/ni.1917","article-title":"Complement regulator CD46 promotes immunoregulation by distinct effects on conventional and unconventional human T cells","volume":"11","author":"Cardone","year":"2010","journal-title":"Nat Immunol"},{"key":"10.1016\/j.coi.2021.04.005_bib0170","doi-asserted-by":"crossref","first-page":"2803","DOI":"10.3389\/fimmu.2018.02803","article-title":"Induction of proinflammatory multiple sclerosis-associated retrovirus envelope protein by human herpesvirus-6A and CD46 receptor engagement","volume":"9","author":"Charvet","year":"2018","journal-title":"Front Immunol"},{"key":"10.1016\/j.coi.2021.04.005_bib0175","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.imbio.2011.06.003","article-title":"CD46 processing: a means of expression","volume":"217","author":"Ni Choileain","year":"2012","journal-title":"Immunobiology"},{"key":"10.1016\/j.coi.2021.04.005_bib0180","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1002\/alz.12092","article-title":"Genome-wide transcriptome analysis identifies novel dysregulated genes implicated in Alzheimer\u2019s pathology","volume":"16","author":"Nho","year":"2020","journal-title":"Alzheimers Dement"},{"key":"10.1016\/j.coi.2021.04.005_bib0185","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1038\/s41598-017-00235-3","article-title":"Dysregulation of mCD46 and sCD46 contribute to the pathogenesis of bullous pemphigoid","volume":"7","author":"Qiao","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/j.coi.2021.04.005_sbref0190","article-title":"Complement activation and regulation in preeclampsia and hemolysis, elevated liver enzymes, and low platelet count syndrome","author":"Burwick","year":"2020","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.coi.2021.04.005_bib0195","doi-asserted-by":"crossref","first-page":"2464","DOI":"10.4049\/jimmunol.1701695","article-title":"Statistical validation of rare complement variants provides insights into the molecular basis of atypical hemolytic uremic syndrome and C3 glomerulopathy","volume":"200","author":"Osborne","year":"2018","journal-title":"J Immunol"},{"key":"10.1016\/j.coi.2021.04.005_bib0200","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1016\/j.semnephrol.2013.08.003","article-title":"Atypical hemolytic uremic syndrome","volume":"33","author":"Kavanagh","year":"2013","journal-title":"Semin Nephrol"},{"key":"10.1016\/j.coi.2021.04.005_bib0205","article-title":"Molecular studies and an ex vivo complement assay on endothelium highlight the genetic complexity of atypical hemolytic uremic syndrome: the case of a pedigree with a null CD46 variant","volume":"7","author":"Piras","year":"2020","journal-title":"Front Med (Lausanne)"},{"key":"10.1016\/j.coi.2021.04.005_bib0210","doi-asserted-by":"crossref","first-page":"2017","DOI":"10.1681\/ASN.2005101051","article-title":"Genetic and functional analyses of membrane cofactor protein (CD46) mutations in atypical hemolytic uremic syndrome","volume":"17","author":"Fremeaux-Bacchi","year":"2006","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.coi.2021.04.005_bib0215","doi-asserted-by":"crossref","first-page":"1348","DOI":"10.3389\/fimmu.2020.01348","article-title":"The relevance of the MCP risk polymorphism to the outcome of aHUS associated with C3 mutations. A case report","volume":"11","author":"Lumbreras","year":"2020","journal-title":"Front Immunol"},{"key":"10.1016\/j.coi.2021.04.005_bib0220","article-title":"Is the atypical hemolytic uremic syndrome risk polymorphism in membrane cofactor protein MCPggaac relevant in kidney transplantation? A case report","author":"Sanchez-Moreno","year":"2020","journal-title":"Pediatr Transplant"},{"key":"10.1016\/j.coi.2021.04.005_bib0225","doi-asserted-by":"crossref","first-page":"E1445","DOI":"10.1002\/humu.21256","article-title":"Mutations in alternative pathway complement proteins in American patients with atypical hemolytic uremic syndrome","volume":"31","author":"Maga","year":"2010","journal-title":"Hum Mutat"},{"key":"10.1016\/j.coi.2021.04.005_bib0230","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1093\/ckj\/sfx078","article-title":"Mutations in membrane cofactor protein (CD46) gene in Indian children with hemolytic uremic syndrome","volume":"11","author":"Khandelwal","year":"2018","journal-title":"Clin Kidney J"},{"key":"10.1016\/j.coi.2021.04.005_bib0235","doi-asserted-by":"crossref","first-page":"2201","DOI":"10.1111\/ajt.12297","article-title":"Two patients with history of STEC-HUS, posttransplant recurrence and complement gene mutations","volume":"13","author":"Alberti","year":"2013","journal-title":"Am J Transplant"},{"key":"10.1016\/j.coi.2021.04.005_bib0240","doi-asserted-by":"crossref","first-page":"364","DOI":"10.2215\/CJN.05830518","article-title":"Complement gene variants and shiga toxin-producing Escherichia coli-associated hemolytic uremic syndrome: retrospective genetic and clinical study","volume":"14","author":"Fremeaux-Bacchi","year":"2019","journal-title":"Clin J Am Soc Nephrol"},{"key":"10.1016\/j.coi.2021.04.005_bib0245","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1001013","article-title":"Mutations in complement regulatory proteins predispose to preeclampsia: a genetic analysis of the PROMISSE cohort","volume":"8","author":"Salmon","year":"2011","journal-title":"PLoS Med"},{"key":"10.1016\/j.coi.2021.04.005_bib0250","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.1002\/eji.201243196","article-title":"Analysis of genes coding for CD46, CD55, and C4b-binding protein in patients with idiopathic, recurrent, spontaneous pregnancy loss","volume":"43","author":"Mohlin","year":"2013","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.coi.2021.04.005_bib0255","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1136\/annrheumdis-2017-212224","article-title":"Complement activation predicts adverse pregnancy outcome in patients with systemic lupus erythematosus and\/or antiphospholipid antibodies","volume":"77","author":"Kim","year":"2018","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.coi.2021.04.005_bib0260","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.99128","article-title":"Germline mutations in the alternative pathway of complement predispose to HELLP syndrome","volume":"3","author":"Vaught","year":"2018","journal-title":"JCI Insight"},{"key":"10.1016\/j.coi.2021.04.005_bib0265","doi-asserted-by":"crossref","first-page":"50","DOI":"10.2215\/CJN.06440616","article-title":"Pathogenic variants in complement genes and risk of atypical hemolytic uremic syndrome relapse after eculizumab discontinuation","volume":"12","author":"Fakhouri","year":"2017","journal-title":"Clin J Am Soc Nephrol"},{"key":"10.1016\/j.coi.2021.04.005_bib0270","doi-asserted-by":"crossref","first-page":"4385","DOI":"10.1128\/JVI.78.9.4385-4388.2004","article-title":"Four viruses, two bacteria, and one receptor: membrane cofactor protein (CD46) as pathogens\u2019 magnet","volume":"78","author":"Cattaneo","year":"2004","journal-title":"J Virol"},{"key":"10.1016\/j.coi.2021.04.005_sbref0275","doi-asserted-by":"crossref","first-page":"2699","DOI":"10.1038\/s41467-019-10587-1","article-title":"CD46 facilitates entry and dissemination of human cytomegalovirus","volume":"10","author":"Stein","year":"2019","journal-title":"Nat Commun"},{"key":"10.1016\/j.coi.2021.04.005_bib0280","doi-asserted-by":"crossref","first-page":"1767","DOI":"10.1128\/IAI.72.3.1767-1774.2004","article-title":"C3 promotes clearance of Klebsiella pneumoniae by A549 epithelial cells","volume":"72","author":"de Astorza","year":"2004","journal-title":"Infect Immun"},{"key":"10.1016\/j.coi.2021.04.005_bib0285","doi-asserted-by":"crossref","first-page":"116","DOI":"10.3390\/v12010116","article-title":"Real time analysis of bovine viral diarrhea virus (BVDV) infection and its dependence on bovine CD46","volume":"12","author":"Riedel","year":"2020","journal-title":"Viruses"},{"key":"10.1016\/j.coi.2021.04.005_bib0290","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1007\/s00705-014-2313-y","article-title":"Porcine complement regulatory protein CD46 and heparan sulfates are the major factors for classical swine fever virus attachment in vitro","volume":"160","author":"Drager","year":"2015","journal-title":"Arch Virol"},{"key":"10.1016\/j.coi.2021.04.005_bib0295","doi-asserted-by":"crossref","first-page":"15028","DOI":"10.1038\/s41598-017-15124-y","article-title":"A teleost CD46 is involved in the regulation of complement activation and pathogen infection","volume":"7","author":"Li","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/j.coi.2021.04.005_sbref0300","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1007495","article-title":"Neisseria gonorrhoeae evades autophagic killing by downregulating CD46-cyt1 and remodeling lysosomes","volume":"15","author":"Kim","year":"2019","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.coi.2021.04.005_sbref0305","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2020732118","article-title":"Human species D adenovirus hexon capsid protein mediates cell entry through a direct interaction with CD46","volume":"118","author":"Persson","year":"2021","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.coi.2021.04.005_bib0310","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1146\/annurev.iy.09.040191.002243","article-title":"Membrane cofactor protein (MCP or CD46): newest member of the regulators of complement activation gene cluster","volume":"9","author":"Liszewski","year":"1991","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/j.coi.2021.04.005_bib0315","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.3389\/fmicb.2017.01117","article-title":"Complement evasion strategies of viruses: an overview","volume":"8","author":"Agrawal","year":"2017","journal-title":"Front Microbiol"},{"key":"10.1016\/j.coi.2021.04.005_bib0320","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1007\/s00281-005-0002-3","article-title":"Emerging roles and new functions of CD46","volume":"27","author":"Liszewski","year":"2005","journal-title":"Springer Semin Immunopathol"},{"key":"10.1016\/j.coi.2021.04.005_bib0325","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.121497","article-title":"Targeting CD46 for both adenocarcinoma and neuroendocrine prostate cancer","volume":"3","author":"Su","year":"2018","journal-title":"JCI Insight"},{"key":"10.1016\/j.coi.2021.04.005_bib0330","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1038\/s41586-020-2798-3","article-title":"SARS-CoV-2 vaccines in development","volume":"586","author":"Krammer","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.coi.2021.04.005_bib0335","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13045-020-00922-1","article-title":"Oncolytic viruses for cancer immunotherapy","volume":"13","author":"Hemminki","year":"2020","journal-title":"J Hematol Oncol"},{"key":"10.1016\/j.coi.2021.04.005_bib0340","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.cytogfr.2020.07.005","article-title":"Engineering and combining oncolytic measles virus for cancer therapy","volume":"56","author":"Leber","year":"2020","journal-title":"Cytokine Growth Factor Rev"},{"key":"10.1016\/j.coi.2021.04.005_bib0345","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.omto.2017.03.003","article-title":"Preclinical safety studies of enadenotucirev, a chimeric group B human-specific oncolytic adenovirus","volume":"5","author":"Illingworth","year":"2017","journal-title":"Mol Ther Oncolytics"},{"key":"10.1016\/j.coi.2021.04.005_bib0350","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s40425-019-0510-7","article-title":"A phase 1 dose escalation study of the oncolytic adenovirus enadenotucirev, administered intravenously to patients with epithelial solid tumors (EVOLVE)","volume":"7","author":"Machiels","year":"2019","journal-title":"J Immunother Cancer"},{"key":"10.1016\/j.coi.2021.04.005_bib0355","doi-asserted-by":"crossref","first-page":"583077","DOI":"10.3389\/fimmu.2020.583077","article-title":"Emerging concepts and technologies in vaccine development","volume":"11","author":"Brisse","year":"2020","journal-title":"Front Immunol"},{"key":"10.1016\/j.coi.2021.04.005_bib0360","doi-asserted-by":"crossref","DOI":"10.3390\/ijms19092694","article-title":"Targeting CD46 enhances anti-tumoral activity of adenovirus type 5 for bladder cancer","volume":"19","author":"Do","year":"2018","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.coi.2021.04.005_bib0365","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.omto.2021.01.015","article-title":"Efficient antitumor effects of a novel oncolytic adenovirus fully composed of species B adenovirus serotype 35","volume":"20","author":"Ono","year":"2021","journal-title":"Mol Ther Oncolytics"},{"key":"10.1016\/j.coi.2021.04.005_bib0370","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13014-020-01593-5","article-title":"A phase 1 trial of the safety, tolerability and biological effects of intravenous enadenotucirev, a novel oncolytic virus, in combination with chemoradiotherapy in locally advanced rectal cancer (CEDAR)","volume":"15","author":"O\u2019Cathail","year":"2020","journal-title":"Radiat Oncol"},{"key":"10.1016\/j.coi.2021.04.005_bib0375","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1182\/blood-2009-05-222463","article-title":"A recombinant adenovirus type 35 fiber knob protein sensitizes lymphoma cells to rituximab therapy","volume":"115","author":"Wang","year":"2010","journal-title":"Blood"},{"key":"10.1016\/j.coi.2021.04.005_bib0380","article-title":"Preclinical safety, pharmacokinetics, pharmacodynamics, and biodistribution studies with Ad35K++ protein: a novel rituximab cotherapeutic","volume":"5","author":"Richter","year":"2016","journal-title":"Mol Ther Methods Clin Dev"}],"container-title":["Current Opinion in Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0952791521000443?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0952791521000443?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T08:48:07Z","timestamp":1760604487000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0952791521000443"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10]]},"references-count":76,"alternative-id":["S0952791521000443"],"URL":"https:\/\/doi.org\/10.1016\/j.coi.2021.04.005","relation":{},"ISSN":["0952-7915"],"issn-type":[{"value":"0952-7915","type":"print"}],"subject":[],"published":{"date-parts":[[2021,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Membrane cofactor protein (MCP; CD46): deficiency states and pathogen connections","name":"articletitle","label":"Article Title"},{"value":"Current Opinion in Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.coi.2021.04.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}