{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T05:19:46Z","timestamp":1773292786365,"version":"3.50.1"},"reference-count":33,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,11,24]],"date-time":"2023-11-24T00:00:00Z","timestamp":1700784000000},"content-version":"am","delay-in-days":296,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["bmn.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Current Opinion in Immunology"],"published-print":{"date-parts":[[2023,2]]},"DOI":"10.1016\/j.coi.2022.102264","type":"journal-article","created":{"date-parts":[[2022,11,24]],"date-time":"2022-11-24T09:28:24Z","timestamp":1669282104000},"page":"102264","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["The signal transducer and activator of transcription 3 at the center of the causative gene network of the hyper-IgE syndrome"],"prefix":"10.1016","volume":"80","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9613-8586","authenticated-orcid":false,"given":"Yoshiyuki","family":"Minegishi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.coi.2022.102264_bib1","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1016\/S0140-6736(66)90119-X","article-title":"Job's Syndrome. Recurrent, \"cold\", staphylococcal abscesses","volume":"1","author":"Davis","year":"1966","journal-title":"Lancet"},{"key":"10.1016\/j.coi.2022.102264_bib2","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/0021-8707(66)90091-8","article-title":"Physicochemical properties of reaginic antibody. 1. Association of reaginic activity with an immunoglobulin other than gammaA- or gammaG-globulin","volume":"37","author":"Ishizaka","year":"1966","journal-title":"J Allergy"},{"key":"10.1016\/j.coi.2022.102264_bib3","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1542\/peds.49.1.59","article-title":"Extreme hyperimmunoglobulinemia E and undue susceptibility to infection","volume":"49","author":"Buckley","year":"1972","journal-title":"Pediatrics"},{"key":"10.1016\/j.coi.2022.102264_bib4","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1056\/NEJM199903043400904","article-title":"Hyper-IgE syndrome with recurrent infections \u2014 an autosomal dominant multisystem disorder","volume":"340","author":"Grimbacher","year":"1999","journal-title":"N Engl J Med"},{"key":"10.1016\/j.coi.2022.102264_bib5","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S0022-3476(03)00449-9","article-title":"Autosomal recessive hyperimmunoglobulin E syndrome: a distinct disease entity","volume":"144","author":"Renner","year":"2004","journal-title":"J Pediatr"},{"key":"10.1016\/j.coi.2022.102264_bib6","doi-asserted-by":"crossref","first-page":"2046","DOI":"10.1056\/NEJMoa0905506","article-title":"Combined immunodeficiency associated with DOCK8 mutations","volume":"361","author":"Zhang","year":"2009","journal-title":"N Engl J Med"},{"key":"10.1016\/j.coi.2022.102264_bib7","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1038\/nature06096","article-title":"Dominant-negative mutations in the DNA-binding domain of STAT3 cause hyper-IgE syndrome","volume":"448","author":"Minegishi","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.coi.2022.102264_bib8","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1038\/377591a0","article-title":"Cytokine receptor signaling","volume":"377","author":"Ihle","year":"1995","journal-title":"Nature"},{"key":"10.1016\/j.coi.2022.102264_bib9","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1146\/annurev.bi.64.070195.003201","article-title":"Transcriptional responses to polypeptide ligands: the JAK-STAT pathway","volume":"64","author":"Schindler","year":"1995","journal-title":"Annu Rev Biochem"},{"key":"10.1016\/j.coi.2022.102264_bib10","doi-asserted-by":"crossref","first-page":"3801","DOI":"10.1073\/pnas.94.8.3801","article-title":"Targeted disruption of the mouse Stat3 gene leads to early embryonic lethality","volume":"94","author":"Takeda","year":"1997","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.coi.2022.102264_bib11","doi-asserted-by":"crossref","first-page":"2607","DOI":"10.1038\/sj.onc.1203478","article-title":"Roles of STAT3 defined by tissue-specific gene targeting","volume":"19","author":"Akira","year":"2000","journal-title":"Oncogene"},{"key":"10.1016\/j.coi.2022.102264_bib12","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20202592","article-title":"Human STAT3 variants underlie autosomal dominant hyper-IgE syndrome by negative dominance","volume":"218","author":"Asano","year":"2021","journal-title":"J Exp Med"},{"key":"10.1016\/j.coi.2022.102264_bib13","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1016\/0091-6749(88)90873-1","article-title":"Impaired antibody responses in the hyperimmunoglobulin E syndrome","volume":"81","author":"Leung","year":"1988","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.coi.2022.102264_bib14","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1016\/0091-6749(91)90126-9","article-title":"Antibody responses to protein, polysaccharide, and phi X174 antigens in the hyperimmunoglobulinemia E (hyper-IgE) syndrome","volume":"87","author":"Sheerin","year":"1991","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.coi.2022.102264_bib15","doi-asserted-by":"crossref","first-page":"eaat4956","DOI":"10.1126\/sciimmunol.aat4956","article-title":"A recessive form of hyper-IgE syndrome by disruption of ZNF341-dependent STAT3 transcription and activity","volume":"3","author":"Beziat","year":"2018","journal-title":"Sci Immunol"},{"key":"10.1016\/j.coi.2022.102264_bib16","doi-asserted-by":"crossref","first-page":"eaat4941","DOI":"10.1126\/sciimmunol.aat4941","article-title":"ZNF341 controls STAT3 expression and thereby immunocompetence","volume":"3","author":"Frey-Jakobs","year":"2018","journal-title":"Sci Immunol"},{"key":"10.1016\/j.coi.2022.102264_bib17","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1038\/s41577-018-0066-7","article-title":"Recent insights into targeting the IL-6 cytokine family in inflammatory diseases and cancer","volume":"18","author":"Jones","year":"2018","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.coi.2022.102264_bib18","doi-asserted-by":"crossref","first-page":"a028415","DOI":"10.1101\/cshperspect.a028415","article-title":"Interleukin-6 family cytokines","volume":"10","author":"Rose-John","year":"2018","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"10.1016\/j.coi.2022.102264_bib19","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1073\/pnas.93.1.407","article-title":"Targeted disruption of gp130, a common signal transducer for the interleukin 6 family of cytokines, leads to myocardial and hematological disorders","volume":"93","author":"Yoshida","year":"1996","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.coi.2022.102264_bib20","doi-asserted-by":"crossref","first-page":"e20191306","DOI":"10.1084\/jem.20191306","article-title":"Absence of GP130 cytokine receptor signaling causes extended Stuve-Wiedemann syndrome","volume":"217","author":"Chen","year":"2020","journal-title":"J Exp Med"},{"key":"10.1016\/j.coi.2022.102264_sbref21","doi-asserted-by":"crossref","first-page":"2547","DOI":"10.1084\/jem.20161810","article-title":"A biallelic mutation in IL6ST encoding the GP130 co-receptor causes immunodeficiency and craniosynostosis","volume":"214","author":"Schwerd","year":"2017","journal-title":"J Exp Med"},{"key":"10.1016\/j.coi.2022.102264_bib22","doi-asserted-by":"crossref","first-page":"609","DOI":"10.3324\/haematol.2018.194233","article-title":"Selective loss of function variants in IL6ST cause Hyper-IgE syndrome with distinct impairments of T-cell phenotype and function","volume":"104","author":"Shahin","year":"2019","journal-title":"Haematologica"},{"key":"10.1016\/j.coi.2022.102264_bib23","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/j.jaci.2021.02.044","article-title":"Functional and structural analysis of cytokine-selective IL6ST defects that cause recessive hyper-IgE syndrome","volume":"148","author":"Chen","year":"2021","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.coi.2022.102264_sbref24","doi-asserted-by":"crossref","first-page":"e20191804","DOI":"10.1084\/jem.20191804","article-title":"Dominant-negative mutations in human IL6ST underlie hyper-IgE syndrome","volume":"217","author":"Beziat","year":"2020","journal-title":"J Exp Med"},{"key":"10.1016\/j.coi.2022.102264_bib25","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.ajhg.2011.05.024","article-title":"Inactivation of IL11 signaling causes craniosynostosis, delayed tooth eruption, and supernumerary teeth","volume":"89","author":"Nieminen","year":"2011","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.coi.2022.102264_sbref26","doi-asserted-by":"crossref","first-page":"1986","DOI":"10.1084\/jem.20190344","article-title":"Loss of the interleukin-6 receptor causes immunodeficiency, atopy, and abnormal inflammatory responses","volume":"216","author":"Spencer","year":"2019","journal-title":"J Exp Med"},{"key":"10.1016\/j.coi.2022.102264_sbref27","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1016\/j.jaci.2019.11.015","article-title":"Defining the biological responses of IL-6 by the study of a novel IL-6 receptor chain immunodeficiency","volume":"145","author":"Nahum","year":"2020","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.coi.2022.102264_bib28","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1084\/jem.20082767","article-title":"Molecular explanation for the contradiction between systemic Th17 defect and localized bacterial infection in hyper-IgE syndrome","volume":"206","author":"Minegishi","year":"2009","journal-title":"J Exp Med"},{"key":"10.1016\/j.coi.2022.102264_bib29","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.it.2012.05.004","article-title":"Defining the human T helper 17 cell phenotype","volume":"33","author":"Annunziato","year":"2012","journal-title":"Trends Immunol"},{"key":"10.1016\/j.coi.2022.102264_bib30","doi-asserted-by":"crossref","first-page":"647","DOI":"10.4049\/jimmunol.180.1.647","article-title":"Recurrent staphylococcal cellulitis and subcutaneous abscesses in a child with autoantibodies against IL-6","volume":"180","author":"Puel","year":"2008","journal-title":"J Immunol"},{"key":"10.1016\/j.coi.2022.102264_bib31","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1097\/MD.0b013e31825f95b9","article-title":"Autosomal dominant STAT3 deficiency and hyper-IgE syndrome: molecular, cellular, and clinical features from a French national survey","volume":"91","author":"Chandesris","year":"2012","journal-title":"Medicine"},{"key":"10.1016\/j.coi.2022.102264_bib32","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/j.alit.2021.07.007","article-title":"Hyper-IgE syndrome, 2021 update","volume":"70","author":"Minegishi","year":"2021","journal-title":"Allergol Int"},{"key":"10.1016\/j.coi.2022.102264_bib33","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.coi.2021.04.007","article-title":"Inborn errors of IL-6 family cytokine receptors","volume":"72","author":"Chen","year":"2021","journal-title":"Curr Opin Immunol"}],"container-title":["Current Opinion in Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S095279152200111X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S095279152200111X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T08:46:34Z","timestamp":1760604394000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S095279152200111X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2]]},"references-count":33,"alternative-id":["S095279152200111X"],"URL":"https:\/\/doi.org\/10.1016\/j.coi.2022.102264","relation":{},"ISSN":["0952-7915"],"issn-type":[{"value":"0952-7915","type":"print"}],"subject":[],"published":{"date-parts":[[2023,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The signal transducer and activator of transcription 3 at the center of the causative gene network of the hyper-IgE syndrome","name":"articletitle","label":"Article Title"},{"value":"Current Opinion in Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.coi.2022.102264","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"102264"}}