{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T23:41:10Z","timestamp":1793662870248,"version":"4.5.1"},"reference-count":77,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T00:00:00Z","timestamp":1765929600000},"content-version":"vor","delay-in-days":260,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100006492","name":"National Institute of Allergy and Infectious Diseases Division of Intramural Research","doi-asserted-by":"publisher","award":["F30 AI174437"],"award-info":[{"award-number":["F30 AI174437"]}],"id":[{"id":"10.13039\/100006492","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006492","name":"National Institute of Allergy and Infectious Diseases Division of Intramural Research","doi-asserted-by":"publisher","award":["R01 AI168047"],"award-info":[{"award-number":["R01 AI168047"]}],"id":[{"id":"10.13039\/100006492","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006492","name":"National Institute of Allergy and Infectious Diseases Division of Intramural Research","doi-asserted-by":"publisher","award":["R01 AI134834"],"award-info":[{"award-number":["R01 AI134834"]}],"id":[{"id":"10.13039\/100006492","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100002193","name":"Lupus Foundation of America Inc","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100002193","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006260","name":"Rheumatology Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006260","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["GM07170"],"award-info":[{"award-number":["GM07170"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012051","name":"Lupus Research Alliance","doi-asserted-by":"publisher","award":["R21 AR081588"],"award-info":[{"award-number":["R21 AR081588"]}],"id":[{"id":"10.13039\/100012051","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Current Opinion in Immunology"],"published-print":{"date-parts":[[2025,4]]},"DOI":"10.1016\/j.coi.2025.102543","type":"journal-article","created":{"date-parts":[[2025,2,27]],"date-time":"2025-02-27T07:40:31Z","timestamp":1740642031000},"page":"102543","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"special_numbering":"C","title":["More X\u2019s, more problems: how contributions from the X chromosomes enhance female predisposition for autoimmunity"],"prefix":"10.1016","volume":"93","author":[{"given":"Claudia D","family":"Lovell","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6406-0086","authenticated-orcid":false,"given":"Montserrat C","family":"Anguera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.coi.2025.102543_bib1","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1038\/s41577-024-00996-9","article-title":"The conneXion between sex and immune responses","volume":"24","author":"Forsyth","year":"2024","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.coi.2025.102543_bib2","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1016\/j.autrev.2015.03.008","article-title":"Google-driven search for big data in autoimmune geoepidemiology: analysis of 394,827 patients with systemic autoimmune diseases","volume":"14","author":"Ramos-Casals","year":"2015","journal-title":"Autoimmun Rev"},{"key":"10.1016\/j.coi.2025.102543_bib3","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1006\/clin.1997.4412","article-title":"Epidemiology and estimated population burden of selected autoimmune diseases in the United States","volume":"84","author":"Jacobson","year":"1997","journal-title":"Clin Immunol Immunopathol"},{"key":"10.1016\/j.coi.2025.102543_bib4","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1038\/nri.2016.90","article-title":"Sex differences in immune responses","volume":"16","author":"Klein","year":"2016","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.coi.2025.102543_bib5","doi-asserted-by":"crossref","first-page":"2511","DOI":"10.1002\/art.23701","article-title":"Klinefelter's syndrome (47,XXY) in male systemic lupus erythematosus patients: support for the notion of a gene-dose effect from the X chromosome","volume":"58","author":"Scofield","year":"2008","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.coi.2025.102543_bib6","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1111\/j.1651-2227.2011.02185.x","article-title":"Klinefelter's syndrome (47,XXY) among men with systemic lupus erythematosus","volume":"100","author":"Dillon","year":"2011","journal-title":"Acta Paediatr"},{"key":"10.1016\/j.coi.2025.102543_bib7","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1002\/acr2.11413","article-title":"47XXY and 47XXX in scleroderma and myositis","volume":"4","author":"Scofield","year":"2022","journal-title":"ACR Open Rheuma"},{"key":"10.1016\/j.coi.2025.102543_bib8","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.clim.2016.04.002","article-title":"Klinefelter's syndrome (47,XXY) is in excess among men with Sjogren's syndrome","volume":"168","author":"Harris","year":"2016","journal-title":"Clin Immunol"},{"key":"10.1016\/j.coi.2025.102543_bib9","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1146\/annurev.genet.42.110807.091711","article-title":"X chromosome dosage compensation: how mammals keep the balance","volume":"42","author":"Payer","year":"2008","journal-title":"Annu Rev Genet"},{"key":"10.1016\/j.coi.2025.102543_bib10","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1038\/s41580-022-00566-8","article-title":"Long non-coding RNAs: definitions, functions, challenges and recommendations","volume":"24","author":"Mattick","year":"2023","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.coi.2025.102543_bib11","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1038\/379131a0","article-title":"Requirement for Xist in X chromosome inactivation","volume":"379","author":"Penny","year":"1996","journal-title":"Nature"},{"key":"10.1016\/j.coi.2025.102543_bib12","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.cell.2018.11.041","article-title":"The implication of early chromatin changes in X chromosome inactivation","volume":"176","author":"Zylicz","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.coi.2025.102543_bib13","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1038\/nature24265","article-title":"Landscape of X chromosome inactivation across human tissues","volume":"550","author":"Tukiainen","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.coi.2025.102543_bib14","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1038\/nature03479","article-title":"X-inactivation profile reveals extensive variability in X-linked gene expression in females","volume":"434","author":"Carrel","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.coi.2025.102543_bib15","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1005079","article-title":"Escape from X inactivation varies in mouse tissues","volume":"11","author":"Berletch","year":"2015","journal-title":"PLoS Genet"},{"key":"10.1016\/j.coi.2025.102543_bib16","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1007\/s12041-015-0574-1","article-title":"X-chromosome inactivation and escape","volume":"94","author":"Disteche","year":"2015","journal-title":"J Genet"},{"key":"10.1016\/j.coi.2025.102543_bib17","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1101\/gr.103200.109","article-title":"Global survey of escape from X inactivation by RNA-sequencing in mouse","volume":"20","author":"Yang","year":"2010","journal-title":"Genome Res"},{"key":"10.1016\/j.coi.2025.102543_bib18","first-page":"E2029","article-title":"Unusual maintenance of X chromosome inactivation predisposes female lymphocytes for increased expression from the inactive X","volume":"113","author":"Wang","year":"2016","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.coi.2025.102543_bib19","article-title":"Diversity of epigenetic features of the inactive X-chromosome in NK cells, dendritic cells, and macrophages","volume":"9","author":"Syrett","year":"2018","journal-title":"Front Immunol"},{"key":"10.1016\/j.coi.2025.102543_bib20","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1007050","article-title":"Loss of Xist RNA from the inactive X during B cell development is restored in a dynamic YY1-dependent two-step process in activated B cells","volume":"13","author":"Syrett","year":"2017","journal-title":"PLoS Genet"},{"key":"10.1016\/j.coi.2025.102543_sbref21","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.ado0398","article-title":"Maintenance of X chromosome inactivation after T cell activation requires NF-kappaB signaling","volume":"9","author":"Forsyth","year":"2024","journal-title":"Sci Immunol"},{"key":"10.1016\/j.coi.2025.102543_bib22","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.126751","article-title":"Altered X-chromosome inactivation in T cells may promote sex-biased autoimmune diseases","volume":"4","author":"Syrett","year":"2019","journal-title":"JCI Insight"},{"key":"10.1016\/j.coi.2025.102543_bib23","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2024624118","article-title":"The dynamic epigenetic regulation of the inactive X chromosome in healthy human B cells is dysregulated in lupus patients","volume":"118","author":"Pyfrom","year":"2021","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.coi.2025.102543_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaut.2019.102357","article-title":"Loss of epigenetic modifications on the inactive X chromosome and sex-biased gene expression profiles in B cells from NZB\/W F1 mice with lupus-like disease","volume":"107","author":"Syrett","year":"2020","journal-title":"J Autoimmun"},{"key":"10.1016\/j.coi.2025.102543_sbref25","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaut.2023.103084","article-title":"Impaired dynamic X-chromosome inactivation maintenance in T cells is a feature of spontaneous murine SLE that is exacerbated in female-biased models","volume":"139","author":"Jiwrajka","year":"2023","journal-title":"J Autoimmun"},{"key":"10.1016\/j.coi.2025.102543_bib26","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1016\/j.autrev.2016.03.002","article-title":"The key culprit in the pathogenesis of systemic lupus erythematosus: aberrant DNA methylation","volume":"15","author":"Wu","year":"2016","journal-title":"Autoimmun Rev"},{"key":"10.1016\/j.coi.2025.102543_bib27","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1003678","article-title":"Genome-wide DNA methylation analysis of systemic lupus erythematosus reveals persistent hypomethylation of interferon genes and compositional changes to CD4+ T-cell populations","volume":"9","author":"Absher","year":"2013","journal-title":"PLoS Genet"},{"key":"10.1016\/j.coi.2025.102543_bib28","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1136\/annrheumdis-2017-212379","article-title":"DNA methylation mapping identifies gene regulatory effects in patients with systemic lupus erythematosus","volume":"77","author":"Imgenberg-Kreuz","year":"2018","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.coi.2025.102543_bib29","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2019.01686","article-title":"Shared and unique patterns of DNA methylation in systemic lupus erythematosus and primary Sjogren's syndrome","volume":"10","author":"Imgenberg-Kreuz","year":"2019","journal-title":"Front Immunol"},{"key":"10.1016\/j.coi.2025.102543_bib30","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1007\/s10067-017-3717-3","article-title":"Increased expression of Bruton's tyrosine kinase in peripheral blood is associated with lupus nephritis","volume":"37","author":"Kong","year":"2018","journal-title":"Clin Rheuma"},{"key":"10.1016\/j.coi.2025.102543_bib31","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1002\/art.1780310605","article-title":"Soluble interleukin-2 receptors in systemic lupus erythematosus","volume":"31","author":"Wolf","year":"1988","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.coi.2025.102543_bib32","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1080\/08820139.2018.1458105","article-title":"Upregulated IL-1 receptor-associated kinase 1 (IRAK1) in systemic lupus erythematosus: IRAK1 inhibition represses Th17 differentiation with therapeutic potential","volume":"47","author":"Zhou","year":"2018","journal-title":"Immunol Invest"},{"key":"10.1016\/j.coi.2025.102543_bib33","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-019-10106-2","article-title":"Interferon inducible X-linked gene CXorf21 may contribute to sexual dimorphism in Systemic Lupus Erythematosus","volume":"10","author":"Odhams","year":"2019","journal-title":"Nat Commun"},{"key":"10.1016\/j.coi.2025.102543_bib34","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2019.02160","article-title":"Characterization of cxorf21 provides molecular insight into female-bias immune response in SLE pathogenesis","volume":"10","author":"Harris","year":"2019","journal-title":"Front Immunol"},{"key":"10.1016\/j.coi.2025.102543_bib35","doi-asserted-by":"crossref","first-page":"10966","DOI":"10.1073\/pnas.93.20.10966","article-title":"An essential role for Bruton's [corrected] tyrosine kinase in the regulation of B-cell apoptosis","volume":"93","author":"Anderson","year":"1996","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.coi.2025.102543_bib36","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1073\/pnas.92.2.377","article-title":"Lymphoid development in mice with a targeted deletion of the interleukin 2 receptor gamma chain","volume":"92","author":"DiSanto","year":"1995","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.coi.2025.102543_bib37","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2017.01075","article-title":"The Toll for trafficking: Toll-like receptor 7 delivery to the endosome","volume":"8","author":"Petes","year":"2017","journal-title":"Front Immunol"},{"key":"10.1016\/j.coi.2025.102543_bib38","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1038\/s41586-020-2282-0","article-title":"TASL is the SLC15A4-associated adaptor for IRF5 activation by TLR7-9","volume":"581","author":"Heinz","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.coi.2025.102543_bib39","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.cellsig.2007.08.009","article-title":"IRAK1: a critical signaling mediator of innate immunity","volume":"20","author":"Gottipati","year":"2008","journal-title":"Cell Signal"},{"key":"10.1016\/j.coi.2025.102543_bib40","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s12016-015-8473-z","article-title":"Toll-like receptor pathways in autoimmune diseases","volume":"50","author":"Chen","year":"2016","journal-title":"Clin Rev Allergy Immunol"},{"key":"10.1016\/j.coi.2025.102543_bib41","doi-asserted-by":"crossref","DOI":"10.1007\/s11926-021-01047-1","article-title":"TLR7 signaling in Lupus B cells: new insights into synergizing factors and downstream signals","volume":"23","author":"Satterthwaite","year":"2021","journal-title":"Curr Rheuma Rep"},{"key":"10.1016\/j.coi.2025.102543_bib42","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-024-55692-y","article-title":"The TLR7\/9 adaptors TASL and TASL2 mediate IRF5-dependent antiviral responses and autoimmunity in mouse","volume":"16","author":"Drobek","year":"2025","journal-title":"Nat Commun"},{"key":"10.1016\/j.coi.2025.102543_sbref43","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-024-55690-0","article-title":"An essential role for TASL in mouse autoimmune pathogenesis and Toll-like receptor signaling","volume":"16","author":"Lau","year":"2025","journal-title":"Nat Commun"},{"key":"10.1016\/j.coi.2025.102543_bib44","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.aap8855","article-title":"TLR7 escapes X chromosome inactivation in immune cells","volume":"3","author":"Souyris","year":"2018","journal-title":"Sci Immunol"},{"key":"10.1016\/j.coi.2025.102543_sbref45","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20231809","article-title":"Altered X-chromosome inactivation of the TLR7\/8 locus and heterogeneity of pDCs in systemic sclerosis","volume":"222","author":"Du","year":"2025","journal-title":"J Exp Med"},{"key":"10.1016\/j.coi.2025.102543_bib46","doi-asserted-by":"crossref","first-page":"9970","DOI":"10.1073\/pnas.0603912103","article-title":"A Tlr7 translocation accelerates systemic autoimmunity in murine lupus","volume":"103","author":"Subramanian","year":"2006","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.coi.2025.102543_bib47","doi-asserted-by":"crossref","first-page":"1971","DOI":"10.1002\/eji.200838138","article-title":"Yaa autoimmune phenotypes are conferred by overexpression of TLR7","volume":"38","author":"Fairhurst","year":"2008","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.coi.2025.102543_bib48","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1016\/j.immuni.2007.09.009","article-title":"Control of toll-like receptor 7 expression is essential to restrict autoimmunity and dendritic cell proliferation","volume":"27","author":"Deane","year":"2007","journal-title":"Immunity"},{"key":"10.1016\/j.coi.2025.102543_sbref49","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1038\/s41586-022-04642-z","article-title":"TLR7 gain-of-function genetic variation causes human lupus","volume":"605","author":"Brown","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.coi.2025.102543_bib50","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1016\/j.yexcr.2010.12.017","article-title":"CXCR3 in T cell function","volume":"317","author":"Groom","year":"2011","journal-title":"Exp Cell Res"},{"key":"10.1016\/j.coi.2025.102543_bib51","doi-asserted-by":"crossref","first-page":"789","DOI":"10.4049\/jimmunol.1800931","article-title":"Cutting edge: CXCR3 escapes X chromosome inactivation in T cells during infection: potential implications for sex differences in immune responses","volume":"203","author":"Oghumu","year":"2019","journal-title":"J Immunol"},{"key":"10.1016\/j.coi.2025.102543_bib52","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1146\/annurev.immunol.14.1.591","article-title":"Immune regulation by CD40 and its ligand GP39","volume":"14","author":"Foy","year":"1996","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/j.coi.2025.102543_bib53","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1093\/intimm\/9.8.1111","article-title":"Thymus dysfunction and chronic inflammatory disease in gp39 transgenic mice","volume":"9","author":"Clegg","year":"1997","journal-title":"Int Immunol"},{"key":"10.1016\/j.coi.2025.102543_bib54","doi-asserted-by":"crossref","first-page":"2308","DOI":"10.1016\/j.jaci.2018.02.010","article-title":"CD40LG duplication-associated autoimmune disease is silenced by nonrandom X-chromosome inactivation","volume":"141","author":"Le Coz","year":"2018","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.coi.2025.102543_bib55","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1038\/nsmb.3365","article-title":"Xist-dependent imprinted X inactivation and the early developmental consequences of its failure","volume":"24","author":"Borensztein","year":"2017","journal-title":"Nat Struct Mol Biol"},{"key":"10.1016\/j.coi.2025.102543_bib56","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1101\/gad.11.2.156","article-title":"Xist-deficient mice are defective in dosage compensation but not spermatogenesis","volume":"11","author":"Marahrens","year":"1997","journal-title":"Genes Dev"},{"key":"10.1016\/j.coi.2025.102543_bib57","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1242\/dev.109.1.189","article-title":"Detrimental effects of two active X chromosomes on early mouse development","volume":"109","author":"Takagi","year":"1990","journal-title":"Development"},{"key":"10.1016\/j.coi.2025.102543_bib58","doi-asserted-by":"crossref","first-page":"1747","DOI":"10.1101\/gad.281162.116","article-title":"Female mice lacking Xist RNA show partial dosage compensation and survive to term","volume":"30","author":"Yang","year":"2016","journal-title":"Genes Dev"},{"key":"10.1016\/j.coi.2025.102543_bib59","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1016\/j.cell.2013.01.034","article-title":"Xist RNA is a potent suppressor of hematologic cancer in mice","volume":"152","author":"Yildirim","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.coi.2025.102543_bib60","doi-asserted-by":"crossref","first-page":"4262","DOI":"10.1073\/pnas.1917203117","article-title":"Widespread organ tolerance to Xist loss and X reactivation except under chronic stress in the gut","volume":"117","author":"Yang","year":"2020","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.coi.2025.102543_bib61","doi-asserted-by":"crossref","DOI":"10.1186\/s13072-018-0219-8","article-title":"Perturbed maintenance of transcriptional repression on the inactive X-chromosome in the mouse brain after Xist deletion","volume":"11","author":"Adrianse","year":"2018","journal-title":"Epigenetics Chromatin"},{"key":"10.1016\/j.coi.2025.102543_sbref62","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.adn6537","article-title":"Altered X-chromosome inactivation predisposes to autoimmunity","volume":"10","author":"Huret","year":"2024","journal-title":"Sci Adv"},{"key":"10.1016\/j.coi.2025.102543_bib63","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1093\/hmg\/ddq516","article-title":"Ftx is a non-coding RNA which affects Xist expression and chromatin structure within the X-inactivation center region","volume":"20","author":"Chureau","year":"2011","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.coi.2025.102543_sbref64","article-title":"Xist deletion in B cells results in systemic lupus erythematosus phenotypes","volume":"15","author":"Lovell","year":"2024","journal-title":"bioRxiv"},{"key":"10.1016\/j.coi.2025.102543_bib65","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-021-84786-6","article-title":"Generation and characterization of CD19-iCre mice as a tool for efficient and specific conditional gene targeting in B cells","volume":"11","author":"Yasuda","year":"2021","journal-title":"Sci Rep"},{"key":"10.1016\/j.coi.2025.102543_sbref66","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.169344","article-title":"The XIST lncRNA is a sex-specific reservoir of TLR7 ligands in SLE","volume":"8","author":"Crawford","year":"2023","journal-title":"JCI Insight"},{"key":"10.1016\/j.coi.2025.102543_bib67","first-page":"359","article-title":"Type I interferon in systemic lupus erythematosus","author":"Crow","year":"2007","journal-title":"Curr Top Microbiol Immunol 316"},{"key":"10.1016\/j.coi.2025.102543_bib68","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.cophys.2020.09.015","article-title":"Time to get ill: the intersection of viral infections, sex, and the X chromosome","volume":"19","author":"Forsyth","year":"2021","journal-title":"Curr Opin Physiol"},{"key":"10.1016\/j.coi.2025.102543_bib69","doi-asserted-by":"crossref","DOI":"10.1126\/science.aab2276","article-title":"Chromosomes. A comprehensive Xist interactome reveals cohesin repulsion and an RNA-directed chromosome conformation","volume":"349","author":"Minajigi","year":"2015","journal-title":"Science"},{"key":"10.1016\/j.coi.2025.102543_bib70","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1038\/nature14443","article-title":"The Xist lncRNA interacts directly with SHARP to silence transcription through HDAC3","volume":"521","author":"McHugh","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.coi.2025.102543_bib71","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1016\/j.cell.2015.03.025","article-title":"Systematic discovery of Xist RNA binding proteins","volume":"161","author":"Chu","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.coi.2025.102543_sbref72","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1016\/j.cell.2023.12.037","article-title":"Xist ribonucleoproteins promote female sex-biased autoimmunity","volume":"187","author":"Dou","year":"2024","journal-title":"Cell"},{"key":"10.1016\/j.coi.2025.102543_bib73","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1038\/ng820","article-title":"Chromosomal silencing and localization are mediated by different domains of Xist RNA","volume":"30","author":"Wutz","year":"2002","journal-title":"Nat Genet"},{"key":"10.1016\/j.coi.2025.102543_bib74","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1126\/science.adf8531","article-title":"The transcription factor ZEB2 drives the formation of age-associated B cells","volume":"383","author":"Dai","year":"2024","journal-title":"Science"},{"key":"10.1016\/j.coi.2025.102543_bib75","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.jaut.2012.12.006","article-title":"Overexpression of X-linked genes in T cells from women with lupus","volume":"41","author":"Hewagama","year":"2013","journal-title":"J Autoimmun"},{"key":"10.1016\/j.coi.2025.102543_bib76","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1002\/JLB.6RI0319-094R","article-title":"When the balance is broken: X-linked gene dosage from two X chromosomes and female-biased autoimmunity","volume":"106","author":"Syrett","year":"2019","journal-title":"J Leukoc Biol"},{"key":"10.1016\/j.coi.2025.102543_bib77","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1038\/s41590-023-01463-8","article-title":"The X-linked epigenetic regulator UTX controls NK cell-intrinsic sex differences","volume":"24","author":"Cheng","year":"2023","journal-title":"Nat Immunol"}],"container-title":["Current Opinion in Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0952791525000196?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0952791525000196?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:26:15Z","timestamp":1777595175000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0952791525000196"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4]]},"references-count":77,"alternative-id":["S0952791525000196"],"URL":"https:\/\/doi.org\/10.1016\/j.coi.2025.102543","relation":{},"ISSN":["0952-7915"],"issn-type":[{"value":"0952-7915","type":"print"}],"subject":[],"published":{"date-parts":[[2025,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"More X\u2019s, more problems: how contributions from the X chromosomes enhance female predisposition for autoimmunity","name":"articletitle","label":"Article Title"},{"value":"Current Opinion in Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.coi.2025.102543","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"102543"}}