{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T14:35:18Z","timestamp":1783953318013,"version":"3.55.0"},"reference-count":73,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T00:00:00Z","timestamp":1760659200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Current Opinion in Immunology"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.coi.2025.102688","type":"journal-article","created":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T14:43:41Z","timestamp":1762353821000},"page":"102688","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Role of ion channels in immune regulation of psoriasis"],"prefix":"10.1016","volume":"98","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-6480-3901","authenticated-orcid":false,"given":"Hideaki","family":"Uchida","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuesong","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heike","family":"Wulff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel T","family":"Hwang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.coi.2025.102688_bib1","doi-asserted-by":"crossref","first-page":"373","DOI":"10.4236\/pp.2020.1112030","article-title":"Psoriasis: a comprehensive review on the aetiopathogenesis and recent advances in long-term management of patients with plaque psoriasis","volume":"11","author":"Gmeiner","year":"2020","journal-title":"Pharmacol Pharm"},{"key":"10.1016\/j.coi.2025.102688_bib2","series-title":"Textbook of Ion Channels Volume III: Regulation, Physiology, and Diseases","author":"Trudeau","year":"2023"},{"key":"10.1016\/j.coi.2025.102688_sbref3","doi-asserted-by":"crossref","first-page":"2756","DOI":"10.3390\/ijms25052756","article-title":"Pathophysiological roles of ion channels in epidermal cells, immune cells, and sensory neurons in psoriasis","volume":"25","author":"Kim","year":"2024","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.coi.2025.102688_bib4","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1177\/0960327121991911","article-title":"Gene expression profiles of transient receptor potential (TRP) channels in the peripheral blood mononuclear cells of psoriasis patients","volume":"40","author":"\u00d6zcan","year":"2021","journal-title":"Hum Exp Toxicol"},{"key":"10.1016\/j.coi.2025.102688_bib5","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1038\/nri2152","article-title":"Calcium signalling in lymphocyte activation and disease","volume":"7","author":"Feske","year":"2007","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.coi.2025.102688_bib6","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0014716","article-title":"Reduced TRPC channel expression in psoriatic keratinocytes is associated with impaired differentiation and enhanced proliferation","volume":"6","author":"Leuner","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.coi.2025.102688_bib7","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1080\/00015550310014726","article-title":"Defective cyclic guanosine monophosphate-gated calcium channels and the pathogenesis of psoriasis","volume":"83","author":"McKenzie","year":"2003","journal-title":"Acta Derm Venereol"},{"issue":"Suppl 2","key":"10.1016\/j.coi.2025.102688_bib8","article-title":"Calcium signalling and related ion channels in neutrophil recruitment and function","volume":"48","author":"Immler","year":"2018","journal-title":"Eur J Clin Invest"},{"key":"10.1016\/j.coi.2025.102688_sbref9","article-title":"TRP (transient receptor potential) ion channel family: structures, biological functions and therapeutic interventions for diseases","volume":"8","author":"Zhang","year":"2023","journal-title":"Signal Transduct Target Ther"},{"key":"10.1016\/j.coi.2025.102688_bib10","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1038\/nature02196","article-title":"TRP channels as cellular sensors","volume":"426","author":"Clapham","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.coi.2025.102688_bib11","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1111\/bph.13392","article-title":"What is the evidence for the role of TRP channels in inflammatory and immune cells?","volume":"173","author":"Parenti","year":"2016","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.coi.2025.102688_bib12","doi-asserted-by":"crossref","first-page":"12111","DOI":"10.7150\/thno.52135","article-title":"Resolvin D3 controls mouse and human TRPV1-positive neurons and preclinical progression of psoriasis","volume":"10","author":"Lee","year":"2020","journal-title":"Theranostics"},{"issue":"Pt 2","key":"10.1016\/j.coi.2025.102688_sbref13","article-title":"Investigation of the anti-inflammatory, anti-pruritic, and analgesic effects of sophocarpine inhibiting TRP channels in a mouse model of inflammatory itch and pain","volume":"337","author":"Zeng","year":"2025","journal-title":"J Ethnopharmacol"},{"key":"10.1016\/j.coi.2025.102688_sbref14","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.2147\/CCID.S462446","article-title":"Inhibitory effect of evodiamine on psoriasis lesions and itching in mice","volume":"17","author":"Liang","year":"2024","journal-title":"Clin Cosmet Invest Dermatol"},{"key":"10.1016\/j.coi.2025.102688_sbref15","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.3390\/ph16121707","article-title":"Targeting transient receptor potential (TRP) channels, mas-related G-protein-coupled receptors (Mrgprs), and protease-activated receptors (PARs) to relieve itch","volume":"16","author":"Tsagareli","year":"2023","journal-title":"Pharmaceuticals"},{"key":"10.1016\/j.coi.2025.102688_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.ceca.2021.102429","article-title":"Cimifugin relieves pruritus in psoriasis by inhibiting TRPV4","volume":"97","author":"Yan","year":"2021","journal-title":"Cell Calcium"},{"key":"10.1016\/j.coi.2025.102688_bib17","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.1025499","article-title":"Gain-of-function of TRPM4 predisposes mice to psoriasiform dermatitis","volume":"13","author":"Yamada","year":"2022","journal-title":"Front Immunol"},{"key":"10.1016\/j.coi.2025.102688_bib18","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1016\/j.jid.2018.01.020","article-title":"Cooling the itch via TRPM8","volume":"138","author":"Liu","year":"2018","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.coi.2025.102688_sbref19","doi-asserted-by":"crossref","DOI":"10.1038\/s42003-023-04482-1","article-title":"TRPV3-ANO1 interaction positively regulates wound healing in keratinocytes","volume":"6","author":"Yamanoi","year":"2023","journal-title":"Commun Biol"},{"key":"10.1016\/j.coi.2025.102688_bib20","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1038\/nature13199","article-title":"Nociceptive sensory neurons drive interleukin-23-mediated psoriasiform skin inflammation","volume":"510","author":"Riol-Blanco","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.coi.2025.102688_bib21","doi-asserted-by":"crossref","first-page":"1578","DOI":"10.1096\/fj.201800395RR","article-title":"Sensory nerves mediate spontaneous behaviors in addition to inflammation in a murine model of psoriasis","volume":"33","author":"Kodji","year":"2019","journal-title":"FASEB J"},{"key":"10.1016\/j.coi.2025.102688_sbref22","doi-asserted-by":"crossref","first-page":"5001","DOI":"10.3390\/ijms24055001","article-title":"Molecular mechanisms of neurogenic inflammation of the skin","volume":"24","author":"Marek-Jozefowicz","year":"2023","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.coi.2025.102688_sbref23","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2023.110063","article-title":"Nerve growth factor mediates activation of transient receptor potential vanilloid 1 in neurogenic pruritus of psoriasis","volume":"118","author":"Shang","year":"2023","journal-title":"Int Immunopharmacol"},{"key":"10.1016\/j.coi.2025.102688_bib24","doi-asserted-by":"crossref","first-page":"77","DOI":"10.3390\/ph9040077","article-title":"TRP channels in skin biology and pathophysiology","volume":"9","author":"Caterina","year":"2016","journal-title":"Pharmaceuticals"},{"key":"10.1016\/j.coi.2025.102688_bib25","doi-asserted-by":"crossref","first-page":"e25","DOI":"10.1097\/itx.0000000000000025","article-title":"Signs of chronic itch in the mouse imiquimod model of psoriasiform dermatitis: sex differences and roles of TRPV1 and TRPA1","volume":"4","author":"Follansbee","year":"2019","journal-title":"Itch"},{"key":"10.1016\/j.coi.2025.102688_sbref26","doi-asserted-by":"crossref","first-page":"R319","DOI":"10.1152\/ajpregu.00269.2024","article-title":"TRPA1 channels modulate cutaneous vasodilation during exercise in the heat in young adults when NOS is inhibited","volume":"328","author":"Hattori","year":"2025","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"10.1016\/j.coi.2025.102688_bib27","doi-asserted-by":"crossref","first-page":"4819","DOI":"10.1111\/jcmm.14392","article-title":"Transient receptor potential ankyrin 1 (TRPA1) positively regulates imiquimod-induced, psoriasiform dermal inflammation in mice","volume":"23","author":"Zhou","year":"2019","journal-title":"J Cell Mol Med"},{"key":"10.1016\/j.coi.2025.102688_bib28","doi-asserted-by":"crossref","first-page":"1774","DOI":"10.1016\/j.jid.2018.02.040","article-title":"TRPA1 acts in a protective manner in imiquimod-induced psoriasiform dermatitis in mice","volume":"138","author":"Kem\u00e9ny","year":"2018","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.coi.2025.102688_bib29","doi-asserted-by":"crossref","first-page":"3065","DOI":"10.3390\/ijms22063065","article-title":"The role of TRPA1 in skin physiology and pathology","volume":"22","author":"Maglie","year":"2021","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.coi.2025.102688_sbref30","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2023.1037925","article-title":"TRPV1: a promising therapeutic target for skin aging and inflammatory skin diseases","volume":"14","author":"Xiao","year":"2023","journal-title":"Front Pharmacol"},{"key":"10.1016\/j.coi.2025.102688_bib31","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.jdermsci.2018.11.009","article-title":"TRPV1 mediates inflammation and hyperplasia in imiquimod (IMQ)-induced psoriasiform dermatitis (PsD) in mice","volume":"92","author":"Zhou","year":"2018","journal-title":"J Dermatol Sci"},{"key":"10.1016\/j.coi.2025.102688_sbref32","doi-asserted-by":"crossref","first-page":"513","DOI":"10.3390\/biom13030513","article-title":"Novel insights into the role of keratinocytes-expressed TRPV3 in the skin","volume":"13","author":"Guo","year":"2023","journal-title":"Biomolecules"},{"key":"10.1016\/j.coi.2025.102688_sbref33","doi-asserted-by":"crossref","DOI":"10.3389\/fgene.2024.1459109","article-title":"Pathogenesis and management of\u00a0TRPV3-related Olmsted syndrome","volume":"15","author":"Lu","year":"2024","journal-title":"Front Genet"},{"key":"10.1016\/j.coi.2025.102688_bib34","doi-asserted-by":"crossref","first-page":"14962","DOI":"10.3390\/ijms232314962","article-title":"TRPV3 and itch: the role of TRPV3 in chronic pruritus according to clinical and experimental evidence","volume":"23","author":"Um","year":"2022","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.coi.2025.102688_bib35","series-title":"Ion Transporters","article-title":"Hot on the trail of skin inflammation: focus on TRPV1\/TRPV3 channels in psoriasis","author":"Martin","year":"2022"},{"key":"10.1016\/j.coi.2025.102688_bib36","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.ceca.2007.06.004","article-title":"The TRPV3 mutation associated with the hairless phenotype in rodents is constitutively active","volume":"43","author":"Xiao","year":"2008","journal-title":"Cell Calcium"},{"key":"10.1016\/j.coi.2025.102688_bib37","doi-asserted-by":"crossref","first-page":"1964","DOI":"10.1016\/j.jid.2020.11.036","article-title":"Hair loss caused by gain-of-function mutant TRPV3 is associated with premature differentiation of follicular keratinocytes","volume":"141","author":"Song","year":"2021","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.coi.2025.102688_bib38","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/bs.ctm.2022.06.003","article-title":"The role of TRPV4 channels in cutaneous epithelia","volume":"89","author":"Moore","year":"2022","journal-title":"Curr Top Membr"},{"key":"10.1016\/j.coi.2025.102688_sbref39","doi-asserted-by":"crossref","first-page":"2356","DOI":"10.1016\/j.jid.2023.05.009","article-title":"TRPV4 regulates the development of psoriasis by controlling adenosine triphosphate expression in keratinocytes and the neuroimmune system","volume":"143","author":"Amalia","year":"2023","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.coi.2025.102688_sbref40","doi-asserted-by":"crossref","first-page":"81","DOI":"10.4049\/immunohorizons.2200100","article-title":"Anti-inflammatory role of TRPV4 in human macrophages","volume":"7","author":"Atsumi","year":"2023","journal-title":"Immunohorizons"},{"key":"10.1016\/j.coi.2025.102688_sbref41","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1152\/physrev.00012.2024","article-title":"The TRP channels serving as chemical-to-electrical signal converter","volume":"105","author":"Tian","year":"2025","journal-title":"Physiol Rev"},{"key":"10.1016\/j.coi.2025.102688_bib42","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1016\/j.jid.2018.10.044","article-title":"Gain-of-function mutations in TRPM4 activation gate cause progressive symmetric erythrokeratodermia","volume":"139","author":"Wang","year":"2019","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.coi.2025.102688_bib43","doi-asserted-by":"crossref","first-page":"40","DOI":"10.3390\/ph15010040","article-title":"Pharmacological modulation and (patho)physiological roles of TRPM4 channel-part 2: TRPM4 in health and disease","volume":"15","author":"Dienes","year":"2021","journal-title":"Pharmaceuticals"},{"key":"10.1016\/j.coi.2025.102688_bib44","doi-asserted-by":"crossref","first-page":"2504","DOI":"10.1111\/bph.14220","article-title":"Identification of potent and selective small molecule inhibitors of the cation channel TRPM4","volume":"175","author":"Ozhathil","year":"2018","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.coi.2025.102688_bib45","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2021.712354","article-title":"Species-specific effects of cation channel TRPM4 small-molecule inhibitors","volume":"12","author":"Arullampalam","year":"2021","journal-title":"Front Pharmacol"},{"key":"10.1016\/j.coi.2025.102688_bib46","article-title":"Thymol activates TRPM8-mediated Ca","volume":"407","author":"Wang","year":"2020","journal-title":"Toxicol Appl Pharmacol"},{"key":"10.1016\/j.coi.2025.102688_sbref47","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1111\/jocd.16079","article-title":"A randomized, double-blinded, vehicle-controlled clinical trial of topical cryosim-1, a synthetic TRPM8 agonist, in prurigo nodularis","volume":"23","author":"Choi","year":"2024","journal-title":"J Cosmet Dermatol"},{"key":"10.1016\/j.coi.2025.102688_bib48","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1016\/j.jid.2017.12.025","article-title":"Cooling relief of acute and chronic itch requires TRPM8 channels and neurons","volume":"138","author":"Palkar","year":"2018","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.coi.2025.102688_bib49","article-title":"Voltage-gated potassium channels (Kv) in GtoPdb v.2023.1","volume":"2023","author":"Bernard","year":"2023","journal-title":"IUPHAR\u00a0BPS Guide Pharmacol CITE"},{"key":"10.1016\/j.coi.2025.102688_bib50","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-022-31285-5","article-title":"Structures of the T cell potassium channel Kv1.3 with immunoglobulin modulators","volume":"13","author":"Selvakumar","year":"2022","journal-title":"Nat Commun"},{"key":"10.1016\/j.coi.2025.102688_bib51","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms14644","article-title":"Potassium channels Kv1.3 and KCa3.1 cooperatively and compensatorily regulate antigen-specific memory T cell functions","volume":"8","author":"Chiang","year":"2017","journal-title":"Nat Commun"},{"key":"10.1016\/j.coi.2025.102688_bib52","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1111\/j.1600-065X.2009.00816.x","article-title":"The functional network of ion channels in T lymphocytes","volume":"231","author":"Cahalan","year":"2009","journal-title":"Immunol Rev"},{"key":"10.1016\/j.coi.2025.102688_bib53","article-title":"Physiological role of Kv1.3 channel in T lymphocyte cell investigated quantitatively by kinetic modeling","volume":"9","author":"Hou","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.coi.2025.102688_bib54","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1038\/jid.2010.245","article-title":"The beneficial effect of blocking Kv1.3 in the psoriasiform SCID mouse model","volume":"131","author":"Gilhar","year":"2011","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.coi.2025.102688_bib55","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.jaut.2014.07.003","article-title":"Kv1.3 in psoriatic disease: PAP-1, a small molecule inhibitor of Kv1.3 is effective in the SCID mouse psoriasis\u00a0\u2014\u00a0xenograft model","volume":"55","author":"Kundu-Raychaudhuri","year":"2014","journal-title":"J Autoimmun"},{"key":"10.1016\/j.coi.2025.102688_bib56","doi-asserted-by":"crossref","first-page":"2882","DOI":"10.2174\/092986710792065072","article-title":"Use of Kv1.3 blockers for inflammatory skin conditions","volume":"17","author":"Nguyen","year":"2010","journal-title":"Curr Med Chem"},{"key":"10.1016\/j.coi.2025.102688_bib57","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0180762","article-title":"Safety and pharmacodynamics of dalazatide, a Kv1.3 channel inhibitor, in the treatment of plaque psoriasis: a randomized phase 1b trial","volume":"12","author":"Tarcha","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.coi.2025.102688_bib58","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2017.00859","article-title":"Differentially expressed potassium channels are associated with function of human effector memory CD8","volume":"8","author":"Sim","year":"2017","journal-title":"Front Immunol"},{"key":"10.1016\/j.coi.2025.102688_bib59","doi-asserted-by":"crossref","first-page":"17414","DOI":"10.1073\/pnas.0605136103","article-title":"Kv1.3 channels are a therapeutic target for T cell-mediated autoimmune diseases","volume":"103","author":"Beeton","year":"2006","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.coi.2025.102688_bib60","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1038\/sj.jid.5700717","article-title":"Targeting effector memory T cells with the small molecule Kv1.3 blocker PAP-1 suppresses allergic contact dermatitis","volume":"127","author":"Azam","year":"2007","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.coi.2025.102688_bib61","doi-asserted-by":"crossref","DOI":"10.1590\/1678-9199-jvatitd-1481-18","article-title":"Scorpion toxins targeting Kv1.3 channels: insights into immunosuppression","volume":"25","author":"Oliveira","year":"2019","journal-title":"J Venom Anim Toxins Incl Trop Dis"},{"key":"10.1016\/j.coi.2025.102688_bib62","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1002\/ddr.20467","article-title":"The lymphocyte potassium channels Kv1.3 and KCa3.1 as targets for immunosuppression","volume":"72","author":"Lam","year":"2011","journal-title":"Drug Dev Res"},{"key":"10.1016\/j.coi.2025.102688_bib63","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1146\/annurev-immunol-032414-112212","article-title":"Ion channels in innate and adaptive immunity","volume":"33","author":"Feske","year":"2015","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/j.coi.2025.102688_bib64","doi-asserted-by":"crossref","first-page":"2158","DOI":"10.3390\/ijms23042158","article-title":"Ca2+-activated chloride channels and phospholipid scramblases","volume":"23","author":"Pifferi","year":"2022","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.coi.2025.102688_bib65","doi-asserted-by":"crossref","first-page":"7145","DOI":"10.3390\/ijms22137145","article-title":"Anoctamin1 induces hyperproliferation of HaCaT keratinocytes and triggers imiquimod-induced psoriasis-like skin injury in mice","volume":"22","author":"Choi","year":"2021","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.coi.2025.102688_sbref66","doi-asserted-by":"crossref","DOI":"10.1177\/1759720X241266720","article-title":"The signature of the gut microbiota associated with psoriatic arthritis revealed by metagenomics","volume":"16","author":"Liu","year":"2024","journal-title":"Ther Adv Musculoskelet Dis"},{"key":"10.1016\/j.coi.2025.102688_sbref67","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.ade5915","article-title":"Repurposing an epithelial sodium channel inhibitor as a therapy for murine and human skin inflammation","volume":"16","author":"Winge","year":"2024","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.coi.2025.102688_bib68","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2022.102427","article-title":"Nav1.8 in keratinocytes contributes to ROS-mediated inflammation in inflammatory skin diseases","volume":"55","author":"Zhang","year":"2022","journal-title":"Redox Biol"},{"key":"10.1016\/j.coi.2025.102688_bib69","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.jid.2021.08.401","article-title":"Ode to Salt: Commentary on \"Skin sodium accumulates in psoriasis and reflects disease severity\"","volume":"142","author":"Mauro","year":"2022","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.coi.2025.102688_sbref70","article-title":"Sensory ASIC3 channel exacerbates psoriatic inflammation via a neurogenic pathway in female mice","volume":"15","author":"Huang","year":"2024","journal-title":"Nat Commun"},{"key":"10.1016\/j.coi.2025.102688_bib71","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1038\/ni.3009","article-title":"The ion channel TRPV1 regulates the activation and proinflammatory properties of CD4(+) T cells","volume":"15","author":"Bertin","year":"2014","journal-title":"Nat Immunol"},{"key":"10.1016\/j.coi.2025.102688_bib72","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1016\/j.jid.2017.12.029","article-title":"The genetics of chronic itch: gene expression in the skin of patients with atopic dermatitis and psoriasis with severe itch","volume":"138","author":"Nattkemper","year":"2018","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.coi.2025.102688_bib73","doi-asserted-by":"crossref","first-page":"2536","DOI":"10.1097\/j.pain.0000000000000674","article-title":"Mouse model of imiquimod-induced psoriatic itch","volume":"157","author":"Sakai","year":"2016","journal-title":"Pain"}],"container-title":["Current Opinion in Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0952791525001645?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0952791525001645?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T05:03:14Z","timestamp":1780635794000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0952791525001645"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":73,"alternative-id":["S0952791525001645"],"URL":"https:\/\/doi.org\/10.1016\/j.coi.2025.102688","relation":{},"ISSN":["0952-7915"],"issn-type":[{"value":"0952-7915","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Role of ion channels in immune regulation of psoriasis","name":"articletitle","label":"Article Title"},{"value":"Current Opinion in Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.coi.2025.102688","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"102688"}}