{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T14:29:39Z","timestamp":1789655379251,"version":"4.0.1"},"reference-count":178,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100011878","name":"Vlaamse regering","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011878","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Current Opinion in Immunology"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1016\/j.coi.2025.102718","type":"journal-article","created":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T08:07:22Z","timestamp":1767946042000},"page":"102718","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["A throwback on 25 years in pannexin research"],"prefix":"10.1016","volume":"99","author":[{"given":"Daan","family":"Peeters","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathieu","family":"Vinken","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4340-0210","authenticated-orcid":false,"given":"Raf","family":"Van Campenhout","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.coi.2025.102718_bib1","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2023.1220405","article-title":"Pannexin1 channels in the liver: an open enemy","volume":"11","author":"Van Campenhout","year":"2023","journal-title":"Front Cell Dev Biol"},{"key":"10.1016\/j.coi.2025.102718_bib2","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2014.00392","article-title":"Pannexin 2 protein expression is not restricted to the CNS","volume":"8","author":"Le Vasseur","year":"2014","journal-title":"Front Cell Neurosci"},{"key":"10.1016\/j.coi.2025.102718_sbref3","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.bbamem.2012.01.017","article-title":"The biochemistry and function of pannexin channels","volume":"1828","author":"Penuela","year":"2013","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.coi.2025.102718_bib4","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1007\/s00018-007-7200-1","article-title":"Pannexins and gap junction protein diversity","volume":"65","author":"Shestopalov","year":"2008","journal-title":"Cell Mol Life Sci"},{"key":"10.1016\/j.coi.2025.102718_bib5","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1007\/s11302-021-09805-7","article-title":"Pannexin 3 channels in health and disease","volume":"17","author":"O\u2019Donnell","year":"2021","journal-title":"Purinergic Signal"},{"key":"10.1016\/j.coi.2025.102718_sbref6","doi-asserted-by":"crossref","first-page":"PR473","DOI":"10.1016\/S0960-9822(00)00576-5","article-title":"A ubiquitous family of putative gap junction molecules","volume":"10","author":"Panchin","year":"2000","journal-title":"Curr Biol"},{"key":"10.1016\/j.coi.2025.102718_bib7","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.brainres.2012.04.058","article-title":"Pannexin: from discovery to bedside in 11\u00b14 years?","volume":"1487","author":"Dahl","year":"2012","journal-title":"Brain Res"},{"key":"10.1016\/j.coi.2025.102718_bib8","doi-asserted-by":"crossref","first-page":"13644","DOI":"10.1073\/pnas.2233464100","article-title":"Pannexins, a family of gap junction proteins expressed in brain","volume":"100","author":"Bruzzone","year":"2003","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.coi.2025.102718_sbref9","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1016\/j.ygeno.2003.09.025","article-title":"The mammalian pannexin family is homologous to the invertebrate innexin gap junction proteins","volume":"83","author":"Baranova","year":"2004","journal-title":"Genomics"},{"key":"10.1016\/j.coi.2025.102718_bib10","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1124\/jpet.108.146365","article-title":"Pharmacological characterization of pannexin-1 currents expressed in mammalian cells","volume":"328","author":"Ma","year":"2009","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.coi.2025.102718_bib11","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.ygcen.2011.08.019","article-title":"Characterization of novel Pannexin 1 isoforms from rat pituitary cells and their association with ATP-gated P2X channels","volume":"174","author":"Li","year":"2011","journal-title":"Gen Comp Endocrinol"},{"key":"10.1016\/j.coi.2025.102718_bib12","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1002\/wmts.63","article-title":"The cellular life of pannexins","volume":"1","author":"Penuela","year":"2012","journal-title":"Wiley Interdiscip Rev Membr Transp Signal"},{"key":"10.1016\/j.coi.2025.102718_bib13","doi-asserted-by":"crossref","DOI":"10.1095\/biolreprod.114.122168","article-title":"Regulation of the pannexin-1 promoter in the rat epididymis1","volume":"91","author":"Dufresne","year":"2014","journal-title":"Biol Reprod"},{"key":"10.1016\/j.coi.2025.102718_bib14","doi-asserted-by":"crossref","first-page":"2911","DOI":"10.1002\/jbmr.509","article-title":"Pannexin 3 is a novel target for Runx2, expressed by osteoblasts and mature growth plate chondrocytes","volume":"26","author":"Bond","year":"2011","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.coi.2025.102718_bib15","doi-asserted-by":"crossref","first-page":"4313","DOI":"10.1091\/mbc.e09-01-0067","article-title":"Glycosylation regulates pannexin intermixing and cellular localization","volume":"20","author":"Penuela","year":"2009","journal-title":"Mol Biol Cell"},{"key":"10.1016\/j.coi.2025.102718_sbref16","doi-asserted-by":"crossref","first-page":"31733","DOI":"10.1074\/jbc.M702422200","article-title":"Pannexin1 channels contain a glycosylation site that targets the hexamer to the plasma membrane","volume":"282","author":"Boassa","year":"2007","journal-title":"J Biol Chem"},{"key":"10.1016\/j.coi.2025.102718_bib17","doi-asserted-by":"crossref","first-page":"9147","DOI":"10.1074\/jbc.M109.082008","article-title":"Pannexin1 and pannexin3 delivery, cell surface dynamics, and cytoskeletal interactions","volume":"285","author":"Bhalla-Gehi","year":"2010","journal-title":"J Biol Chem"},{"key":"10.1016\/j.coi.2025.102718_bib18","doi-asserted-by":"crossref","DOI":"10.3390\/ijms19071837","article-title":"N-Glycosylation regulates pannexin 2 localization but Is not required for interacting with pannexin 1","volume":"19","author":"Sanchez-Pupo","year":"2018","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.coi.2025.102718_bib19","doi-asserted-by":"crossref","first-page":"193","DOI":"10.4161\/chan.5.3.15765","article-title":"Pannexin channels are not gap junction hemichannels","volume":"5","author":"Sosinsky","year":"2011","journal-title":"Channels"},{"key":"10.1016\/j.coi.2025.102718_bib20","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1080\/09537104.2021.1902971","article-title":"Mind the gap: connexins and pannexins in platelet function","volume":"32","author":"Taylor","year":"2021","journal-title":"Platelets"},{"key":"10.1016\/j.coi.2025.102718_sbref21","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1038\/s41586-020-2357-y","article-title":"Structures of human pannexin 1 reveal ion pathways and mechanism of gating","volume":"584","author":"Ruan","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.coi.2025.102718_bib22","first-page":"1","article-title":"Cryo-EM structure of human heptameric pannexin 2 channel","volume":"14","author":"Zhang","year":"2023","journal-title":"Nat Commun"},{"key":"10.1016\/j.coi.2025.102718_sbref23","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41467-024-47142-6","article-title":"Cryo-EM structures of pannexin 1 and 3 reveal differences among pannexin isoforms","volume":"15","author":"Hussain","year":"2024","journal-title":"Nat Commun"},{"key":"10.1016\/j.coi.2025.102718_sbref24","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.febslet.2004.07.009","article-title":"Pannexin membrane channels are mechanosensitive conduits for ATP","volume":"572","author":"Bao","year":"2004","journal-title":"FEBS Lett"},{"key":"10.1016\/j.coi.2025.102718_bib25","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.febslet.2005.12.004","article-title":"Activation of pannexin 1 channels by ATP through P2Y receptors and by cytoplasmic calcium","volume":"580","author":"Locovei","year":"2006","journal-title":"FEBS Lett"},{"key":"10.1016\/j.coi.2025.102718_bib26","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/j.neuroscience.2008.08.036","article-title":"Elevated pressure triggers a physiological release of ATP from the retina: possible role for pannexin hemichannels","volume":"157","author":"Reigada","year":"2008","journal-title":"Neuroscience"},{"key":"10.1016\/j.coi.2025.102718_bib27","doi-asserted-by":"crossref","first-page":"18948","DOI":"10.1074\/jbc.M110.127027","article-title":"Pannexin 3 regulates intracellular ATP\/cAMP levels and promotes chondrocyte differentiation","volume":"285","author":"Iwamoto","year":"2010","journal-title":"J Biol Chem"},{"key":"10.1016\/j.coi.2025.102718_bib28","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1083\/jcb.201101050","article-title":"Pannexin 3 functions as an ER Ca2+ channel, hemichannel, and gap junction to promote osteoblast differentiation","volume":"193","author":"Ishikawa","year":"2011","journal-title":"J Cell Biol"},{"key":"10.1016\/j.coi.2025.102718_bib29","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1007\/s00424-012-1077-z","article-title":"Pannexin 1 forms an anion-selective channel","volume":"463","author":"Ma","year":"2012","journal-title":"Pflugers Arch"},{"key":"10.1016\/j.coi.2025.102718_bib30","doi-asserted-by":"crossref","first-page":"18143","DOI":"10.1074\/jbc.M109.004804","article-title":"The pannexin 1 channel activates the inflammasome in neurons and astrocytes","volume":"284","author":"Silverman","year":"2009","journal-title":"J Biol Chem"},{"key":"10.1016\/j.coi.2025.102718_bib31","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1038\/s41594-020-0401-0","article-title":"Cryo-EM structures of the ATP release channel pannexin 1","volume":"27","author":"Deng","year":"2020","journal-title":"Nat Struct Mol Biol"},{"key":"10.1016\/j.coi.2025.102718_bib32","first-page":"5514","article-title":"Dispensable ATP permeability of Pannexin 1 channels in a heterologous system and in mammalian taste cells","volume":"125","author":"Romanov","year":"2012","journal-title":"J Cell Sci"},{"key":"10.1016\/j.coi.2025.102718_bib33","doi-asserted-by":"crossref","DOI":"10.1126\/scisignal.2005431","article-title":"The membrane protein Pannexin1 forms two open-channel conformations depending on the mode of activation","volume":"7","author":"Wang","year":"2014","journal-title":"Sci Signal"},{"key":"10.1016\/j.coi.2025.102718_sbref34","doi-asserted-by":"crossref","first-page":"3201","DOI":"10.1002\/1873-3468.13115","article-title":"The Pannexin1 membrane channel: distinct conformations and functions","volume":"592","author":"Dahl","year":"2018","journal-title":"FEBS Lett"},{"key":"10.1016\/j.coi.2025.102718_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.coph.2023.102359","article-title":"Pharmacology of pannexin channels","volume":"69","author":"Koval","year":"2023","journal-title":"Curr Opin Pharmacol"},{"key":"10.1016\/j.coi.2025.102718_sbref36","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1038\/nature09413","article-title":"Pannexin 1 channels mediate \u2018find-me\u2019 signal release and membrane permeability during apoptosis","volume":"467","author":"Chekeni","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.coi.2025.102718_bib37","doi-asserted-by":"crossref","first-page":"6940","DOI":"10.1074\/jbc.RA118.006982","article-title":"Constitutive SRC-mediated phosphorylation of pannexin 1 at tyrosine 198 occurs at the plasma membrane","volume":"294","author":"DeLalio","year":"2019","journal-title":"J Biol Chem"},{"key":"10.1016\/j.coi.2025.102718_bib38","doi-asserted-by":"crossref","first-page":"12579","DOI":"10.1523\/JNEUROSCI.1267-12.2012","article-title":"Anoxia-induced NMDA receptor activation opens pannexin channels via Src family kinases","volume":"32","author":"Weilinger","year":"2012","journal-title":"J Neurosci"},{"key":"10.1016\/j.coi.2025.102718_bib39","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.95118","article-title":"Human pannexin 1 channel is not phosphorylated by Src tyrosine kinase at Tyr199 and Tyr309","volume":"13","author":"Ruan","year":"2024","journal-title":"Elife"},{"key":"10.1016\/j.coi.2025.102718_bib40","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23095059","article-title":"Pannexin-1 activation by phosphorylation is crucial for platelet aggregation and thrombus formation","volume":"23","author":"Metz","year":"2022","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.coi.2025.102718_bib41","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2025.1647765","article-title":"Pannexin channels in inflammation and tumorigenesis","volume":"13","author":"Jiang","year":"2025","journal-title":"Front Cell Dev Biol"},{"key":"10.1016\/j.coi.2025.102718_bib42","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-021-24825-y","article-title":"Deacetylation as a receptor-regulated direct activation switch for pannexin channels","volume":"12","author":"Chiu","year":"2021","journal-title":"Nat Commun"},{"key":"10.1016\/j.coi.2025.102718_bib43","doi-asserted-by":"crossref","first-page":"3772","DOI":"10.1242\/jcs.009514","article-title":"Pannexin 1 and pannexin 3 are glycoproteins that exhibit many distinct characteristics from the connexin family of gap junction proteins","volume":"120","author":"Penuela","year":"2007","journal-title":"J Cell Sci"},{"key":"10.1016\/j.coi.2025.102718_bib44","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41413-024-00334-8","article-title":"Pannexins in the musculoskeletal system: new targets for development and disease progression","volume":"12","author":"Luo","year":"2024","journal-title":"Bone Res"},{"key":"10.1016\/j.coi.2025.102718_bib45","doi-asserted-by":"crossref","first-page":"39602","DOI":"10.1074\/jbc.M112.397976","article-title":"S-nitrosylation inhibits pannexin 1 channel function","volume":"287","author":"Lohman","year":"2012","journal-title":"J Biol Chem"},{"key":"10.1016\/j.coi.2025.102718_bib46","doi-asserted-by":"crossref","first-page":"124","DOI":"10.4161\/chan.27422","article-title":"Diverse post-translational modifications of the pannexin family of channel-forming proteins","volume":"8","author":"Penuela","year":"2014","journal-title":"Channels"},{"key":"10.1016\/j.coi.2025.102718_bib47","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21239180","article-title":"Stretch-induced activation of pannexin 1 channels can be prevented by PKA-dependent phosphorylation","volume":"21","author":"L\u00f3pez","year":"2020","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.coi.2025.102718_sbref48","doi-asserted-by":"crossref","first-page":"343","DOI":"10.3390\/cancers11030343","article-title":"Pannexin 2 localizes at ER-mitochondria contact sites","volume":"11","author":"Le Vasseur","year":"2019","journal-title":"Cancers"},{"key":"10.1016\/j.coi.2025.102718_bib49","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1083\/jcb.200601115","article-title":"Functional implications of calcium permeability of the channel formed by pannexin 1","volume":"174","author":"Vanden Abeele","year":"2006","journal-title":"J Cell Biol"},{"key":"10.1016\/j.coi.2025.102718_sbref50","doi-asserted-by":"crossref","first-page":"5071","DOI":"10.1038\/sj.emboj.7601378","article-title":"Pannexin-1 mediates large pore formation and interleukin-1\u03b2 release by the ATP-gated P2\u00d77 receptor","volume":"25","author":"Pelegrin","year":"2006","journal-title":"EMBO J"},{"key":"10.1016\/j.coi.2025.102718_bib51","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1038\/jcbfm.2009.46","article-title":"Therapeutic neutralization of the NLRP1 inflammasome reduces the innate immune response and improves histopathology after traumatic brain injury","volume":"29","author":"De Rivero Vaccari","year":"2009","journal-title":"J Cereb Blood Flow Metab"},{"key":"10.1016\/j.coi.2025.102718_bib52","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.1016\/j.febslet.2014.03.009","article-title":"The role of pannexin1 in the induction and resolution of inflammation","volume":"588","author":"Adamson","year":"2014","journal-title":"FEBS Lett"},{"key":"10.1016\/j.coi.2025.102718_sbref53","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/ncomms8965","article-title":"Pannexin 1 channels regulate leukocyte emigration through the venous endothelium during acute inflammation","volume":"6","author":"Lohman","year":"2015","journal-title":"Nat Commun"},{"key":"10.1016\/j.coi.2025.102718_bib54","doi-asserted-by":"crossref","first-page":"2245","DOI":"10.1007\/s00204-016-1885-6","article-title":"Inhibition of pannexin1 channels alleviates acetaminophen-induced hepatotoxicity","volume":"91","author":"Maes","year":"2017","journal-title":"Arch Toxicol"},{"key":"10.1016\/j.coi.2025.102718_bib55","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1111\/jcmm.12988","article-title":"Pannexin3 inhibits TNF-\u03b1-induced inflammatory response by suppressing NF-\u03baB signalling pathway in human dental pulp cells","volume":"21","author":"Song","year":"2017","journal-title":"J Cell Mol Med"},{"key":"10.1016\/j.coi.2025.102718_bib56","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1002\/cbin.12010","article-title":"Pannexin 3 activates P2\u00d77 receptor to mediate inflammation and cartilage matrix degradation in temporomandibular joint osteoarthritis","volume":"47","author":"Xiao","year":"2023","journal-title":"Cell Biol Int"},{"key":"10.1016\/j.coi.2025.102718_bib57","doi-asserted-by":"crossref","DOI":"10.1177\/00368504211011836","article-title":"PANX2 and brain lower grade glioma genesis: a bioinformatic analysis","volume":"104","author":"Xu","year":"2021","journal-title":"Sci Prog"},{"key":"10.1016\/j.coi.2025.102718_bib58","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.mce.2017.04.001","article-title":"Pannexin-2-deficiency sensitizes pancreatic \u03b2-cells to cytokine-induced apoptosis in vitro and impairs glucose tolerance in vivo","volume":"448","author":"Berchtold","year":"2017","journal-title":"Mol Cell Endocrinol"},{"key":"10.1016\/j.coi.2025.102718_bib59","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1016\/j.jid.2018.08.033","article-title":"Pannexin-3 deficiency delays skin wound healing in mice due to defects in channel functionality","volume":"139","author":"Zhang","year":"2019","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.coi.2025.102718_bib60","doi-asserted-by":"crossref","first-page":"2225","DOI":"10.1007\/s13346-022-01206-6","article-title":"An inter-laboratory comparison of an NLRP3 inflammasome activation assay and dendritic cell maturation assay using a nanostructured lipid carrier and a polymeric nanomedicine, as exemplars","volume":"12","author":"Vandebriel","year":"2022","journal-title":"Drug Deliv Transl Res"},{"key":"10.1016\/j.coi.2025.102718_bib61","doi-asserted-by":"crossref","DOI":"10.1098\/rstb.2014.0191","article-title":"ATP release through pannexon channels","volume":"370","author":"Dahl","year":"2015","journal-title":"Philos Trans R Soc Lond B Biol Sci"},{"key":"10.1016\/j.coi.2025.102718_bib62","doi-asserted-by":"crossref","DOI":"10.1007\/s11302-017-9567-2","article-title":"P2\u00d77 receptor-pannexin 1 interaction mediates extracellular alpha-synuclein-induced ATP release in neuroblastoma SH-SY5Y cells","volume":"13","author":"Wilkaniec","year":"2017","journal-title":"Purinergic Signal"},{"key":"10.1016\/j.coi.2025.102718_bib63","doi-asserted-by":"crossref","first-page":"C250","DOI":"10.1152\/ajpcell.00433.2008","article-title":"A permeant regulating its permeation pore: inhibition of pannexin 1 channels by ATP","volume":"296","author":"Qiu","year":"2009","journal-title":"Am J Physiol\u00a0Cell Physiol"},{"key":"10.1016\/j.coi.2025.102718_bib64","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.immuni.2007.03.008","article-title":"Pannexin-1-mediated recognition of bacterial molecules activates the cryopyrin inflammasome independent of Toll-like receptor signaling","volume":"26","author":"Kanneganti","year":"2007","journal-title":"Immunity"},{"key":"10.1016\/j.coi.2025.102718_sbref65","doi-asserted-by":"crossref","first-page":"ra6","DOI":"10.1126\/scisignal.1160583","article-title":"Purinergic control of T cell Activation by ATP released through pannexin-1 hemichannels","volume":"1","author":"Schenk","year":"2008","journal-title":"Sci Signal"},{"key":"10.1016\/j.coi.2025.102718_bib66","doi-asserted-by":"crossref","first-page":"3475","DOI":"10.1182\/blood-2010-04-277707","article-title":"Pannexin-1 hemichannel\u2013mediated ATP release together with P2\u00d71 and P2\u00d74 receptors regulate T-cell activation at the immune synapse","volume":"116","author":"Woehrle","year":"2010","journal-title":"Blood"},{"key":"10.1016\/j.coi.2025.102718_bib67","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2024.110290","article-title":"The ATP-exporting channel Pannexin 1 promotes CD8+ T cell effector and memory responses","volume":"27","author":"Vardam-Kaur","year":"2024","journal-title":"iScience"},{"key":"10.1016\/j.coi.2025.102718_bib68","doi-asserted-by":"crossref","first-page":"3815","DOI":"10.2337\/db14-0150","article-title":"Nucleotides released from palmitate-challenged muscle cells through pannexin-3 attract Monocytes","volume":"63","author":"Pillon","year":"2014","journal-title":"Diabetes"},{"key":"10.1016\/j.coi.2025.102718_bib69","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41467-022-29233-4","article-title":"Endothelial pannexin-1 channels modulate macrophage and smooth muscle cell activation in abdominal aortic aneurysm formation","volume":"13","author":"Filiberto","year":"2022","journal-title":"Nat Commun"},{"key":"10.1016\/j.coi.2025.102718_bib70","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1038\/nature08296","article-title":"Nucleotides released by apoptotic cells act as a find-me signal to promote phagocytic clearance","volume":"461","author":"Elliott","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.coi.2025.102718_bib71","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1038\/nature13147","article-title":"Unexpected link between an antibiotic, pannexin channels and apoptosis","volume":"507","author":"Poon","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.coi.2025.102718_sbref72","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1038\/ncb3194","article-title":"Mechanosensitive pannexin-1 channels mediate microvascular metastatic cell survival","volume":"17","author":"Furlow","year":"2015","journal-title":"Nat Cell Biol"},{"key":"10.1016\/j.coi.2025.102718_bib73","doi-asserted-by":"crossref","DOI":"10.1091\/mbc.E21-08-0387","article-title":"Pannexin 2 is expressed in murine skin and promotes UVB-induced apoptosis of keratinocytes","volume":"33","author":"Sanchez-Pupo","year":"2022","journal-title":"Mol Biol Cell"},{"key":"10.1016\/j.coi.2025.102718_bib74","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1016\/j.immuni.2015.10.009","article-title":"Caspase-11 requires the pannexin-1 channel and the purinergic P2\u00d77 pore to mediate pyroptosis and endotoxic shock","volume":"43","author":"Yang","year":"2015","journal-title":"Immunity"},{"key":"10.1016\/j.coi.2025.102718_bib75","doi-asserted-by":"crossref","DOI":"10.1038\/s41421-021-00259-0","article-title":"Structure of the full-length human Pannexin1 channel and insights into its role in pyroptosis","volume":"7","author":"Zhang","year":"2021","journal-title":"Cell Discov"},{"key":"10.1016\/j.coi.2025.102718_bib76","doi-asserted-by":"crossref","first-page":"19395","DOI":"10.1074\/jbc.RA119.010949","article-title":"Pannexin 1 mediates ferroptosis that contributes to renal ischemia\/reperfusion injury","volume":"294","author":"Su","year":"2019","journal-title":"J Biol Chem"},{"key":"10.1016\/j.coi.2025.102718_bib77","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1111\/imm.13948","article-title":"Pannexin-1 aggravates inflammatory bowel disease via unbalancing macrophage polarisation and triggering ferroptosis in mice","volume":"176","author":"Zheng","year":"2025","journal-title":"Immunology"},{"key":"10.1016\/j.coi.2025.102718_bib78","doi-asserted-by":"crossref","DOI":"10.1016\/j.cellsig.2025.111908","article-title":"Panx3 mediates ferroptosis via the AKT\/mTOR signaling pathway in oral squamous cell carcinoma","volume":"134","author":"Li","year":"2025","journal-title":"Cell Signal"},{"key":"10.1016\/j.coi.2025.102718_bib79","doi-asserted-by":"crossref","first-page":"4411","DOI":"10.2147\/OTT.S249752","article-title":"Identification of pannexin 2 as a novel marker correlating with ferroptosis and malignant phenotypes of prostate cancer cells","volume":"13","author":"Liao","year":"2020","journal-title":"Onco Targets Ther"},{"key":"10.1016\/j.coi.2025.102718_bib80","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1080\/15384101.2022.2060655","article-title":"Pannexin1 inhibits autophagy of cisplatin-resistant testicular cancer cells by mediating ATP release","volume":"21","author":"Yuan","year":"2022","journal-title":"Cell Cycle"},{"key":"10.1016\/j.coi.2025.102718_bib81","doi-asserted-by":"crossref","DOI":"10.15252\/embr.201947840","article-title":"Pannexin-1 limits the production of proinflammatory cytokines during necroptosis","volume":"20","author":"Douanne","year":"2019","journal-title":"EMBO Rep"},{"key":"10.1016\/j.coi.2025.102718_bib82","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1042\/BJ20140447","article-title":"Pannexin channels and their links to human disease","volume":"461","author":"Penuela","year":"2014","journal-title":"Biochem J"},{"key":"10.1016\/j.coi.2025.102718_bib83","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.molbrainres.2005.08.002","article-title":"Pannexin1 and Pannexin2 expression in the developing and mature rat brain","volume":"141","author":"Vogt","year":"2005","journal-title":"Mol Brain Res"},{"key":"10.1016\/j.coi.2025.102718_bib84","doi-asserted-by":"crossref","first-page":"24977","DOI":"10.1074\/jbc.M110.130054","article-title":"Pannexin 2 is expressed by postnatal hippocampal neural progenitors and modulates neuronal commitment","volume":"285","author":"Swayne","year":"2010","journal-title":"J Biol Chem"},{"key":"10.1016\/j.coi.2025.102718_bib85","doi-asserted-by":"crossref","DOI":"10.3389\/fnmol.2018.00135","article-title":"A potential compensatory role of Panx3 in the VNO of a Panx1 knock out mouse model","volume":"11","author":"Whyte-Fagundes","year":"2018","journal-title":"Front Mol Neurosci"},{"key":"10.1016\/j.coi.2025.102718_bib86","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.1126\/science.1165209","article-title":"Activation of pannexin-1 hemichannels augments aberrant bursting in the hippocampus","volume":"322","author":"Thompson","year":"2008","journal-title":"Science"},{"key":"10.1016\/j.coi.2025.102718_bib87","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0025178","article-title":"Targeting Pannexin1 improves seizure outcome","volume":"6","author":"Santiago","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.coi.2025.102718_bib88","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aar3796","article-title":"Pannexin-1 channels contribute to seizure generation in human epileptic brain tissue and in a mouse model of epilepsy","volume":"10","author":"Dossi","year":"2018","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.coi.2025.102718_bib89","doi-asserted-by":"crossref","first-page":"2108","DOI":"10.1016\/j.pain.2014.07.024","article-title":"Pannexin 1: a novel participant in neuropathic pain signaling in the rat spinal cord","volume":"155","author":"Bravo","year":"2014","journal-title":"Pain"},{"key":"10.1016\/j.coi.2025.102718_bib90","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1038\/jcbfm.2014.262","article-title":"Blockade of P2\u00d77 receptors or pannexin-1 channels similarly attenuates postischemic damage","volume":"35","author":"Cisneros-Mejorado","year":"2015","journal-title":"J Cereb Blood Flow Metab"},{"key":"10.1016\/j.coi.2025.102718_bib91","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1038\/nm.4281","article-title":"Blocking microglial pannexin-1 channels alleviates morphine withdrawal in rodents","volume":"23","author":"Burma","year":"2017","journal-title":"Nat Med"},{"key":"10.1016\/j.coi.2025.102718_bib92","doi-asserted-by":"crossref","DOI":"10.1186\/s12974-018-1069-9","article-title":"Trovafloxacin attenuates neuroinflammation and improves outcome after traumatic brain injury in mice","volume":"15","author":"Garg","year":"2018","journal-title":"J Neuroinflammation"},{"key":"10.1016\/j.coi.2025.102718_bib93","doi-asserted-by":"crossref","first-page":"20772","DOI":"10.1073\/pnas.1018262108","article-title":"Pannexins in ischemia-induced neurodegeneration","volume":"108","author":"Bargiotas","year":"2011","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.coi.2025.102718_bib94","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.cca.2018.11.015","article-title":"Evaluation of serum pannexin-1 as a prognostic biomarker for traumatic brain injury","volume":"488","author":"Ni","year":"2019","journal-title":"Clin Chim Acta"},{"key":"10.1016\/j.coi.2025.102718_bib95","doi-asserted-by":"crossref","DOI":"10.1016\/j.cca.2023.117218","article-title":"Increased serum pannexin-1 concentrations reflect illness severity and predict a poor prognosis after acute supratentorial intracerebral hemorrhage: a prospective longitudinal cohort study","volume":"540","author":"Zhang","year":"2023","journal-title":"Clin Chim Acta"},{"key":"10.1016\/j.coi.2025.102718_bib96","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22105189","article-title":"Pannexin-1 channels as mediators of neuroinflammation","volume":"22","author":"Seo","year":"2021","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.coi.2025.102718_bib97","doi-asserted-by":"crossref","DOI":"10.1371\/annotation\/cedbee08-9c0e-42e3-862f-df7409c273ef","article-title":"Contribution of pannexin1 to experimental autoimmune encephalomyelitis","volume":"8","author":"Lutz","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.coi.2025.102718_bib98","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1007\/s10753-015-0230-1","article-title":"Probenecid application prevents clinical symptoms and inflammation in experimental autoimmune encephalomyelitis","volume":"39","author":"Hainz","year":"2016","journal-title":"Inflammation"},{"key":"10.1016\/j.coi.2025.102718_bib99","doi-asserted-by":"crossref","first-page":"4338","DOI":"10.4049\/jimmunol.1502440","article-title":"Pannexin1 channels are required for chemokine-mediated migration of CD4+ T lymphocytes: role in inflammation and experimental autoimmune encephalomyelitis","volume":"196","author":"Velasquez","year":"2016","journal-title":"J Immunol"},{"key":"10.1016\/j.coi.2025.102718_bib100","doi-asserted-by":"crossref","first-page":"1598","DOI":"10.1002\/glia.23631","article-title":"Connexin 43 hemichannels and pannexin-1 channels contribute to the \u03b1-synuclein-induced dysfunction and death of astrocytes","volume":"67","author":"D\u00edaz","year":"2019","journal-title":"Glia"},{"key":"10.1016\/j.coi.2025.102718_bib101","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2020.00046","article-title":"Acute pannexin 1 blockade mitigates early synaptic plasticity defects in a mouse model of alzheimer\u2019s disease","volume":"14","author":"Flores-Mu\u00f1oz","year":"2020","journal-title":"Front Cell Neurosci"},{"key":"10.1016\/j.coi.2025.102718_bib102","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1038\/nm.2679","article-title":"Activation of neuronal P2\u00d77 receptor\u2013pannexin-1 mediates death of enteric neurons during colitis","volume":"18","author":"Gulbransen","year":"2012","journal-title":"Nat Med"},{"key":"10.1016\/j.coi.2025.102718_bib103","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2018.00865","article-title":"Blockade of pannexin-1 channels and purinergic P2\u00d77 receptors shows protective effects against cytokines-induced colitis of human colonic mucosa","volume":"9","author":"Diezmos","year":"2018","journal-title":"Front Pharmacol"},{"key":"10.1016\/j.coi.2025.102718_bib104","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202411538","article-title":"Novel naphthyridones targeting pannexin 1 for colitis management","volume":"12","author":"Hsueh","year":"2025","journal-title":"Adv Sci"},{"key":"10.1016\/j.coi.2025.102718_bib105","doi-asserted-by":"crossref","DOI":"10.1007\/s11302-015-9456-5","article-title":"Lipoapoptosis induced by saturated free fatty acids stimulates monocyte migration: a novel role for Pannexin1 in liver cells","volume":"11","author":"Xiao","year":"2015","journal-title":"Purinergic Signal"},{"key":"10.1016\/j.coi.2025.102718_bib106","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1016\/j.bbadis.2017.12.013","article-title":"Protective effect of genetic deletion of pannexin1 in experimental mouse models of acute and chronic liver disease","volume":"1864","author":"Willebrords","year":"2018","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"key":"10.1016\/j.coi.2025.102718_bib107","doi-asserted-by":"crossref","first-page":"2607","DOI":"10.1007\/s00204-018-2255-3","article-title":"Genetic ablation of pannexin1 counteracts liver fibrosis in a chemical, but not in a surgical mouse model","volume":"92","author":"Crespo Yanguas","year":"2018","journal-title":"Arch Toxicol"},{"key":"10.1016\/j.coi.2025.102718_bib108","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0188135","article-title":"The antiviral drug tenofovir, an inhibitor of Pannexin-1-mediated ATP release, prevents liver and skin fibrosis by downregulating adenosine levels in the liver and skin","volume":"12","author":"Feig","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.coi.2025.102718_bib109","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/j.ajt.2024.10.021","article-title":"Blocking donor liver Pannexin 1 channels facilitates mitochondria protection during liver transplantation","volume":"25","author":"Xu","year":"2025","journal-title":"Am J Transplant"},{"key":"10.1016\/j.coi.2025.102718_bib110","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aaz6169","article-title":"Reduced pannexin 1\u2013IL-33 axis function in donor livers increases risk of MRSA infection in liver transplant recipients","volume":"13","author":"Li","year":"2021","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.coi.2025.102718_bib111","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1159\/000338758","article-title":"Expression of pannexin isoforms in the systemic murine arterial network","volume":"49","author":"Lohman","year":"2012","journal-title":"J Vasc Res"},{"key":"10.1016\/j.coi.2025.102718_bib112","doi-asserted-by":"crossref","first-page":"4030","DOI":"10.1073\/pnas.0807044106","article-title":"\u03b1-Hemolysin from Escherichia coli uses endogenous amplification through P2X receptor activation to induce hemolysis","volume":"106","author":"Skals","year":"2009","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.coi.2025.102718_bib113","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1007\/s00424-011-1010-x","article-title":"Haemolysis induced by \u03b1-toxin from Staphylococcus aureus requires P2X receptor activation","volume":"462","author":"Skals","year":"2011","journal-title":"Pflugers Arch"},{"key":"10.1016\/j.coi.2025.102718_bib114","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1161\/CIRCRESAHA.110.237594","article-title":"Pannexin1 regulates \u03b11-adrenergic receptor\u2013 mediated vasoconstriction","volume":"109","author":"Billaud","year":"2011","journal-title":"Circ Res"},{"key":"10.1016\/j.coi.2025.102718_bib115","doi-asserted-by":"crossref","DOI":"10.1126\/scisignal.2005824","article-title":"A molecular signature in the pannexin1 intracellular loop confers channel activation by the \u03b11 adrenoreceptor in smooth muscle cells","volume":"8","author":"Billaud","year":"2015","journal-title":"Sci Signal"},{"key":"10.1016\/j.coi.2025.102718_bib116","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1016\/j.febslet.2015.03.018","article-title":"Pannexin 1 facilitates arterial relaxation via an endothelium-derived hyperpolarization mechanism","volume":"589","author":"Gaynullina","year":"2015","journal-title":"FEBS Lett"},{"key":"10.1016\/j.coi.2025.102718_bib117","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1016\/j.kint.2020.04.041","article-title":"Pannexin 1 channels in renin-expressing cells influence renin secretion and blood pressure homeostasis","volume":"98","author":"DeLalio","year":"2020","journal-title":"Kidney Int"},{"key":"10.1016\/j.coi.2025.102718_bib118","doi-asserted-by":"crossref","DOI":"10.1126\/scisignal.adg2622","article-title":"Pannexin-3 stabilizes the transcription factor Bcl6 in a channel-independent manner to protect against vascular oxidative stress","volume":"17","author":"Wolpe","year":"2024","journal-title":"Sci Signal"},{"key":"10.1016\/j.coi.2025.102718_bib119","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1111\/jth.12566","article-title":"Amplification of human platelet activation by surface pannexin-1 channels","volume":"12","author":"Taylor","year":"2014","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.coi.2025.102718_bib120","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.thromres.2019.09.028","article-title":"Selective inhibition of Panx1 channels decreases hemostasis and thrombosis in vivo","volume":"183","author":"Molica","year":"2019","journal-title":"Thromb Res"},{"key":"10.1016\/j.coi.2025.102718_bib121","doi-asserted-by":"crossref","first-page":"L301","DOI":"10.1152\/ajplung.00004.2018","article-title":"Pannexin-1 channels on endothelial cells mediate vascular inflammation during lung ischemia-reperfusion injury","volume":"315","author":"Sharma","year":"2018","journal-title":"Am J Physiol\u00a0Lung Cell Mol Physiol"},{"key":"10.1016\/j.coi.2025.102718_bib122","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1161\/CIRCRESAHA.117.312380","article-title":"Pannexin 1 channels as an unexpected new target of the anti-hypertensive drug spironolactone","volume":"122","author":"Good","year":"2018","journal-title":"Circ Res"},{"key":"10.1016\/j.coi.2025.102718_bib123","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.addr.2019.05.011","article-title":"Cardiac fibrosis \u2014 a short review of causes and therapeutic strategies","volume":"146","author":"Hinderer","year":"2019","journal-title":"Adv Drug Deliv Rev"},{"key":"10.1016\/j.coi.2025.102718_bib124","doi-asserted-by":"crossref","first-page":"H1208","DOI":"10.1152\/ajpheart.00251.2012","article-title":"Cardiomyocyte ATP release through pannexin 1 aids in early fibroblast activation","volume":"303","author":"Dolmatova","year":"2012","journal-title":"Am J Physiol\u00a0Heart Circ Physiol"},{"key":"10.1016\/j.coi.2025.102718_bib125","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1093\/abbs\/gmv028","article-title":"Pannexin-1 channels and their emerging functions in cardiovascular diseases","volume":"47","author":"Li","year":"2015","journal-title":"Acta Biochim Biophys Sin"},{"key":"10.1016\/j.coi.2025.102718_bib126","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1164\/rccm.201003-0359OC","article-title":"Extracellular ATP Is a danger signal activating P2\u00d77 receptor in lung inflammation and fibrosis","volume":"182","author":"Riteau","year":"2010","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.coi.2025.102718_bib127","doi-asserted-by":"crossref","DOI":"10.1186\/s12931-016-0438-0","article-title":"Extracellular ATP is involved in dsRNA-induced MUC5AC production via P2Y2R in human airway epithelium","volume":"17","author":"Shishikura","year":"2016","journal-title":"Respir Res"},{"key":"10.1016\/j.coi.2025.102718_bib128","article-title":"Blocking pannexin1 reduces airway inflammation in a murine model of asthma","volume":"12","author":"Khan","year":"2020","journal-title":"Am J Transl Res"},{"key":"10.1016\/j.coi.2025.102718_bib129","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2021.103478","article-title":"Pannexin-1 channel opening is critical for COVID-19 pathogenesis","volume":"24","author":"Luu","year":"2021","journal-title":"iScience"},{"key":"10.1016\/j.coi.2025.102718_bib130","doi-asserted-by":"crossref","first-page":"26277","DOI":"10.1074\/jbc.M111.260562","article-title":"Rho signaling regulates pannexin 1-mediated ATP release from airway epithelia","volume":"286","author":"Seminario-Vidal","year":"2011","journal-title":"J Biol Chem"},{"key":"10.1016\/j.coi.2025.102718_bib131","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.abm4032","article-title":"Pannexin 1 drives efficient epithelial repair after tissue injury","volume":"7","author":"Lucas","year":"2022","journal-title":"Sci Immunol"},{"key":"10.1016\/j.coi.2025.102718_bib132","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-025-55936-5","article-title":"Tracheal tuft cells release ATP and link innate to adaptive immunity in pneumonia","volume":"16","author":"Abdel Wadood","year":"2025","journal-title":"Nat Commun"},{"key":"10.1016\/j.coi.2025.102718_bib133","doi-asserted-by":"crossref","first-page":"L466","DOI":"10.1152\/ajplung.00450.2020","article-title":"Blocking ATP-releasing channels prevents high extracellular ATP levels and airway hyperreactivity in an asthmatic mouse model","volume":"321","author":"Arzola-Mart\u00ednez","year":"2021","journal-title":"Am J Physiol\u00a0Lung Cell Mol Physiol"},{"key":"10.1016\/j.coi.2025.102718_bib134","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1089\/hum.2023.078","article-title":"Adeno-associated viral vector-delivered pannexin-1 mimetic peptide alleviates airway inflammation in an allergen-sensitized mouse model","volume":"34","author":"Huang","year":"2023","journal-title":"Hum Gene Ther"},{"key":"10.1016\/j.coi.2025.102718_bib135","doi-asserted-by":"crossref","first-page":"1715","DOI":"10.1016\/j.immuni.2021.06.014","article-title":"Pannexin 1 channels facilitate communication between T cells to restrict the severity of airway inflammation","volume":"54","author":"Medina","year":"2021","journal-title":"Immunity"},{"key":"10.1016\/j.coi.2025.102718_bib136","doi-asserted-by":"crossref","first-page":"1951","DOI":"10.1038\/jid.2014.93","article-title":"Nonmetal haptens induce ATP release from keratinocytes through opening of pannexin hemichannels by reactive oxygen species","volume":"134","author":"Onami","year":"2014","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.coi.2025.102718_bib137","doi-asserted-by":"crossref","first-page":"45","DOI":"10.3109\/15419061.2012.712575","article-title":"Pannexin1 and pannexin3 exhibit distinct localization patterns in human skin appendages and are regulated during keratinocyte differentiation and carcinogenesis","volume":"19","author":"Cowan","year":"2012","journal-title":"Cell Commun Adhes"},{"key":"10.1016\/j.coi.2025.102718_bib138","doi-asserted-by":"crossref","first-page":"29184","DOI":"10.1074\/jbc.M112.377176","article-title":"Loss of pannexin 1 attenuates melanoma progression by reversion to a melanocytic phenotype","volume":"287","author":"Penuela","year":"2012","journal-title":"J Biol Chem"},{"key":"10.1016\/j.coi.2025.102718_bib139","doi-asserted-by":"crossref","first-page":"4409","DOI":"10.1113\/JP286172","article-title":"Pannexin 1 and pannexin 3 differentially regulate the cancer cell properties of cutaneous squamous cell carcinoma","volume":"603","author":"O\u2019Donnell","year":"2025","journal-title":"J Physiol"},{"key":"10.1016\/j.coi.2025.102718_sbref140","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2021.100478","article-title":"Pannexin 1 binds \u03b2-catenin to modulate melanoma cell growth and metabolism","volume":"296","author":"Sayedyahossein","year":"2021","journal-title":"J Biol Chem"},{"key":"10.1016\/j.coi.2025.102718_bib141","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1111\/febs.17396","article-title":"Pannexin 1 crosstalk with the Hippo pathway in malignant melanoma","volume":"292","author":"Sayedyahossein","year":"2025","journal-title":"FEBS J"},{"key":"10.1016\/j.coi.2025.102718_bib142","doi-asserted-by":"crossref","first-page":"1743","DOI":"10.1038\/s41591-018-0230-4","article-title":"Cancer cells exploit an orphan RNA to drive metastatic progression","volume":"24","author":"Fish","year":"2018","journal-title":"Nat Med"},{"key":"10.1016\/j.coi.2025.102718_bib143","doi-asserted-by":"crossref","DOI":"10.3390\/cancers11121967","article-title":"Pannexin1 is associated with enhanced epithelial-to-mesenchymal transition in human patient breast cancer tissues and in breast cancer cell lines","volume":"11","author":"Jalaleddine","year":"2019","journal-title":"Cancers"},{"key":"10.1016\/j.coi.2025.102718_bib144","article-title":"High PANX1 expression leads to neutrophil recruitment and the formation of a high adenosine immunosuppressive tumor microenvironment in basal-like breast cancer","volume":"14","author":"Chen","year":"2022","journal-title":"Cancers"},{"key":"10.1016\/j.coi.2025.102718_bib145","doi-asserted-by":"crossref","DOI":"10.1186\/s12860-016-0094-8","article-title":"Connexin and pannexin channels in cancer","volume":"17","author":"Jiang","year":"2016","journal-title":"BMC Cell Biol"},{"key":"10.1016\/j.coi.2025.102718_bib146","doi-asserted-by":"crossref","DOI":"10.1038\/s41420-023-01638-0","article-title":"Tumor suppressor p53 mediates interleukin-6 expression to enable cancer cell evasion of genotoxic stress","volume":"9","author":"Phan","year":"2023","journal-title":"Cell Death Discov"},{"key":"10.1016\/j.coi.2025.102718_bib147","doi-asserted-by":"crossref","DOI":"10.1038\/srep02152","article-title":"Pannexin 1 involvement in bladder dysfunction in a multiple sclerosis model","volume":"3","author":"Negoro","year":"2013","journal-title":"Sci Rep"},{"key":"10.1016\/j.coi.2025.102718_bib148","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1007\/s11255-017-1597-8","article-title":"Involvement of interstitial cells of Cajal in bladder dysfunction in mice with experimental autoimmune encephalomyelitis","volume":"49","author":"Jin","year":"2017","journal-title":"Int Urol Nephrol"},{"key":"10.1016\/j.coi.2025.102718_bib149","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.bcp.2013.11.007","article-title":"ATP released via pannexin-1 hemichannels mediates bladder overactivity triggered by urothelial P2Y6 receptors","volume":"87","author":"Tim\u00f3teo","year":"2014","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.coi.2025.102718_bib150","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2020.117791","article-title":"Inhibiting pannexin-1 alleviates sepsis-induced acute kidney injury via decreasing NLRP3 inflammasome activation and cell apoptosis","volume":"254","author":"Huang","year":"2020","journal-title":"Life Sci"},{"key":"10.1016\/j.coi.2025.102718_bib151","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1038\/s41401-021-00619-2","article-title":"Caspase-11 promotes NLRP3 inflammasome activation via the cleavage of pannexin1 in acute kidney disease","volume":"43","author":"Yin","year":"2022","journal-title":"Acta Pharmacol Sin"},{"key":"10.1016\/j.coi.2025.102718_bib152","doi-asserted-by":"crossref","DOI":"10.1038\/s41420-022-01032-2","article-title":"TLR2\/caspase-5\/Panx1 pathway mediates necrosis-induced NLRP3 inflammasome activation in macrophages during acute kidney injury","volume":"8","author":"Liu","year":"2022","journal-title":"Cell Death Discov"},{"key":"10.1016\/j.coi.2025.102718_bib153","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s42003-023-05226-x","article-title":"Pannexin 1 targets mitophagy to mediate renal ischemia\/reperfusion injury","volume":"6","author":"Su","year":"2023","journal-title":"Commun Biol"},{"key":"10.1016\/j.coi.2025.102718_bib154","doi-asserted-by":"crossref","first-page":"1734","DOI":"10.1007\/s10157-025-02742-4","article-title":"Probenecid protects against contrast\u2013induced nephropathy through modulation of small Rho GTPases and Pannexin1 channels in Wistar rats","volume":"29","author":"\u00c7al\u0131\u015fkan","year":"2025","journal-title":"Clin Exp Nephrol"},{"key":"10.1016\/j.coi.2025.102718_bib155","doi-asserted-by":"crossref","first-page":"6382","DOI":"10.1096\/fj.201902901R","article-title":"Pannexin-1 mediates fluid shear stress-sensitive purinergic signaling and cyst growth in polycystic kidney disease","volume":"34","author":"Verschuren","year":"2020","journal-title":"FASEB J"},{"key":"10.1016\/j.coi.2025.102718_bib156","doi-asserted-by":"crossref","DOI":"10.14814\/phy2.15652","article-title":"Probenecid slows disease progression in a murine model of autosomal dominant polycystic kidney disease","volume":"11","author":"Arkhipov","year":"2023","journal-title":"Physiol Rep"},{"key":"10.1016\/j.coi.2025.102718_bib157","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2024.1387234","article-title":"Activation of Pannexin-1 channels causes cell dysfunction and damage in mesangial cells derived from angiotensin II-exposed mice","volume":"12","author":"Lucero","year":"2024","journal-title":"Front Cell Dev Biol"},{"key":"10.1016\/j.coi.2025.102718_bib158","doi-asserted-by":"crossref","DOI":"10.1186\/s13048-024-01462-9","article-title":"A novel heterozygous missense variant of PANX1 causes human oocyte death and female infertility","volume":"17","author":"Zhou","year":"2024","journal-title":"J Ovarian Res"},{"key":"10.1016\/j.coi.2025.102718_bib159","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1016\/j.molmet.2015.06.009","article-title":"Pannexin 1 is required for full activation of insulin-stimulated glucose uptake in adipocytes","volume":"4","author":"Adamson","year":"2015","journal-title":"Mol Metab"},{"key":"10.1016\/j.coi.2025.102718_bib160","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-018-27281-9","article-title":"The P2\u00d77 receptor and pannexin-1 are involved in glucose-induced autocrine regulation in \u03b2-cells","volume":"8","author":"Tozzi","year":"2018","journal-title":"Sci Rep"},{"key":"10.1016\/j.coi.2025.102718_bib161","doi-asserted-by":"crossref","DOI":"10.1111\/apha.13360","article-title":"Pannexin-1 mediated ATP release in adipocytes is sensitive to glucose and insulin and modulates lipolysis and macrophage migration","volume":"228","author":"Tozzi","year":"2020","journal-title":"Acta Physiol"},{"key":"10.1016\/j.coi.2025.102718_bib162","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1007\/s00125-021-05418-2","article-title":"High extracellular ATP levels released through pannexin-1 channels mediate inflammation and insulin resistance in skeletal muscle fibres of diet-induced obese mice","volume":"64","author":"Jorquera","year":"2021","journal-title":"Diabetologia"},{"key":"10.1016\/j.coi.2025.102718_bib163","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1161\/CIRCRESAHA.125.326260","article-title":"Arterial myocyte pannexin 1 channel controls vascular reactivity in diabetic hyperglycemia","volume":"137","author":"Hong","year":"2025","journal-title":"Circ Res"},{"key":"10.1016\/j.coi.2025.102718_bib164","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines10050944","article-title":"Expression of pannexin 1 in the human kidney during embryonal, early fetal and postnatal development and its prognostic significance in diabetic Nephropathy","volume":"10","author":"Jeli\u010di\u0107","year":"2022","journal-title":"Biomedicines"},{"key":"10.1016\/j.coi.2025.102718_bib165","doi-asserted-by":"crossref","first-page":"7057","DOI":"10.1002\/jcp.26629","article-title":"Expression of Pannexin 1 and Pannexin 3 during skeletal muscle development, regeneration, and Duchenne muscular dystrophy","volume":"233","author":"Pham","year":"2018","journal-title":"J Cell Physiol"},{"key":"10.1016\/j.coi.2025.102718_bib166","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22031080","article-title":"The role of Panx3 in age-associated and injury-induced intervertebral disc degeneration","volume":"22","author":"Serjeant","year":"2021","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.coi.2025.102718_bib167","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1007\/s00109-015-1311-1","article-title":"Deletion of Panx3 prevents the development of surgically induced osteoarthritis","volume":"93","author":"Moon","year":"2015","journal-title":"J Mol Med"},{"key":"10.1016\/j.coi.2025.102718_bib168","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1002\/art.41651","article-title":"Global deletion of pannexin 3 resulting in accelerated development of aging-induced osteoarthritis in mice","volume":"73","author":"Moon","year":"2021","journal-title":"Arthritis Rheumatol"},{"key":"10.1016\/j.coi.2025.102718_bib169","doi-asserted-by":"crossref","first-page":"1696","DOI":"10.1002\/jor.25830","article-title":"Pannexin 3 deletion in mice results in knee osteoarthritis and intervertebral disc degeneration after forced treadmill running","volume":"42","author":"Wakefield","year":"2024","journal-title":"J Orthop Res"},{"key":"10.1016\/j.coi.2025.102718_bib170","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.aas9846","article-title":"Microglial pannexin-1 channel activation is a spinal determinant of joint pain","volume":"4","author":"Mousseau","year":"2018","journal-title":"Sci Adv"},{"key":"10.1016\/j.coi.2025.102718_bib171","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13395-024-00340-8","article-title":"Pannexin 1 dysregulation in Duchenne muscular dystrophy and its exacerbation of dystrophic features in mdx mice","volume":"14","author":"Freeman","year":"2024","journal-title":"Skelet Muscle"},{"key":"10.1016\/j.coi.2025.102718_bib172","article-title":"Structural and functional analysis of human pannexin 2 channel","volume":"14","author":"He","year":"2023","journal-title":"Nat Commun"},{"key":"10.1016\/j.coi.2025.102718_bib173","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2023.106612","article-title":"Determination of structural features that underpin the pannexin1 channel inhibitory activity of the peptide 10Panx1","volume":"138","author":"Caufriez","year":"2023","journal-title":"Bioorg Chem"},{"key":"10.1016\/j.coi.2025.102718_bib174","doi-asserted-by":"crossref","DOI":"10.3390\/biom11010063","article-title":"Therapeutic nanobodies targeting cell plasma membrane transport proteins: a high-risk\/high-gain endeavor","volume":"11","author":"Van Campenhout","year":"2021","journal-title":"Biomolecules"},{"key":"10.1016\/j.coi.2025.102718_bib175","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1038\/s41422-020-0298-5","article-title":"Cryo-EM structure of human heptameric Pannexin 1 channel","volume":"30","author":"Qu","year":"2020","journal-title":"Cell Res"},{"key":"10.1016\/j.coi.2025.102718_bib176","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2021.113650","article-title":"Design and synthesis of the first indole-based blockers of Panx-1 channel","volume":"223","author":"Crocetti","year":"2021","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.coi.2025.102718_bib177","doi-asserted-by":"crossref","DOI":"10.1186\/s12951-023-02137-1","article-title":"Nanobody-based pannexin1 channel inhibitors reduce inflammation in acute liver injury","volume":"21","author":"Van Campenhout","year":"2023","journal-title":"J Nanobiotechnology"},{"key":"10.1016\/j.coi.2025.102718_bib178","doi-asserted-by":"crossref","first-page":"13086","DOI":"10.1021\/acs.jmedchem.3c01116","article-title":"Structure-based design and synthesis of stapled 10Panx1 analogues for use in cardiovascular inflammatory diseases","volume":"66","author":"Lamouroux","year":"2023","journal-title":"J Med Chem"}],"container-title":["Current Opinion in Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0952791525001943?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0952791525001943?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T09:33:36Z","timestamp":1784540016000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0952791525001943"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":178,"alternative-id":["S0952791525001943"],"URL":"https:\/\/doi.org\/10.1016\/j.coi.2025.102718","relation":{},"ISSN":["0952-7915"],"issn-type":[{"value":"0952-7915","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A throwback on 25 years in pannexin research","name":"articletitle","label":"Article Title"},{"value":"Current Opinion in Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.coi.2025.102718","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"102718"}}