{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T10:06:47Z","timestamp":1784542007381,"version":"3.55.0"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T00:00:00Z","timestamp":1767571200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005624","name":"Hannover Medical School","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005624","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Current Opinion in Immunology"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1016\/j.coi.2025.102722","type":"journal-article","created":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T01:25:22Z","timestamp":1768353922000},"page":"102722","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["New autoantibodies in Sj\u00f6gren's disease"],"prefix":"10.1016","volume":"99","author":[{"given":"Alaa","family":"Elsaghir","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Torsten","family":"Witte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.coi.2025.102722_bib1","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1007\/s10238-021-00728-6","article-title":"Sj\u00f6gren's syndrome: a systemic autoimmune disease","volume":"22","author":"Negrini","year":"2022","journal-title":"Clin Exp Med"},{"key":"10.1016\/j.coi.2025.102722_bib2","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1093\/rheumatology\/ket427","article-title":"Primary Sj\u00f6gren's syndrome as a multi-organ disease: impact of the serological profile on the clinical presentation of the disease in a large cohort of Italian patients","volume":"53","author":"Baldini","year":"2014","journal-title":"Rheumatology"},{"key":"10.1016\/j.coi.2025.102722_bib3","doi-asserted-by":"crossref","first-page":"1554","DOI":"10.1002\/acr.22859","article-title":"Association of anticentromere antibodies with more severe exocrine glandular dysfunction in Sj\u00f6gren's syndrome: analysis of the Sj\u00f6gren's International Collaborative Clinical Alliance Cohort","volume":"68","author":"Baer","year":"2016","journal-title":"Arthritis Care Res"},{"key":"10.1016\/j.coi.2025.102722_bib4","first-page":"2253","article-title":"Anticentromere antibodies identify patients with Sj\u00f6gren\u2019s syndrome and autoimmune overlap syndrome","volume":"34","author":"Salliot","year":"2007","journal-title":"J Rheumatol"},{"key":"10.1016\/j.coi.2025.102722_sbref5","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-025-63935-9","article-title":"Comparative single-cell and spatial profiling of anti-SSA-positive and anti-centromere-positive Sj\u00f6gren\u2019s disease reveals common and distinct immune activation and fibroblast-mediated inflammation","volume":"16","author":"Inamo","year":"2025","journal-title":"Nat Comm"},{"key":"10.1016\/j.coi.2025.102722_bib6","first-page":"73","article-title":"Prevalence and significance of anti-Saccharomyces cerevisiae antibodies in primary Sj\u00f6gren's syndrome","volume":"36","author":"Alunno","year":"2018","journal-title":"Clin Exp Rheumatol"},{"key":"10.1016\/j.coi.2025.102722_bib7","doi-asserted-by":"crossref","first-page":"17372","DOI":"10.1073\/pnas.1114465108","article-title":"Autoantibodies recognizing carbamylated proteins are present in sera of patients with rheumatoid arthritis and predict joint damage","volume":"108","author":"Shi","year":"2011","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.coi.2025.102722_bib8","doi-asserted-by":"crossref","first-page":"1494","DOI":"10.1136\/annrheumdis-2015-207751","article-title":"Antibodies against carbamylated proteins are present in primary Sj\u00f6gren's syndrome and are associated with disease severity). They were not associated with Ro\/SS-A antibodies and therefore may be useful in the detection of Ro\/SS-A- patients","volume":"75","author":"Bergum","year":"2016","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.coi.2025.102722_bib9","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1197458","article-title":"Distribution and clinical significance of anti-carbamylation protein antibodies in rheumatological diseases among the Chinese Han population","volume":"14","author":"Dong","year":"2023","journal-title":"Front Immunol"},{"key":"10.1016\/j.coi.2025.102722_bib10","doi-asserted-by":"crossref","first-page":"1672","DOI":"10.1002\/art.1780371117","article-title":"Interferon-g-inducible proteinp16: a new target of antinuclear antibodies in patients with systemic lupus erythematosus","volume":"37","author":"Seelig","year":"1994","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.coi.2025.102722_bib11","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1111\/j.1365-2567.2005.02197.x","article-title":"Identi\ufb01cation of speci\ufb01c autoantigens in Sj\u00f6gren\u2019s syndrome by SEREX","volume":"116","author":"Uchida","year":"2005","journal-title":"Immunology"},{"key":"10.1016\/j.coi.2025.102722_bib12","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1002\/acr.22632","article-title":"Association of antibodies to interferon-inducible protein-16 with markers of more severe disease in primary Sj\u00f6gren's syndrome","volume":"68","author":"Baer","year":"2016","journal-title":"Arthritis Care Res"},{"key":"10.1016\/j.coi.2025.102722_bib13","doi-asserted-by":"crossref","first-page":"708","DOI":"10.3109\/14397595.2016.1147404","article-title":"Insights from the ganglionic acetylcholine receptor autoantibodies in patients with Sj\u00f6gren's syndrome","volume":"26","author":"Mukaino","year":"2016","journal-title":"Mod Rheumatol"},{"key":"10.1016\/j.coi.2025.102722_bib14","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.cca.2012.10.035","article-title":"Detection of autoantibodies against platelet glycoproteins in patients with immune thrombocytopenic purpura by flow cytometric immunobead array","volume":"415","author":"He","year":"2013","journal-title":"Clin Chim Acta"},{"key":"10.1016\/j.coi.2025.102722_bib15","doi-asserted-by":"crossref","first-page":"3690","DOI":"10.12659\/MSM.895144","article-title":"Elevated plasma P-selectin autoantibodies in primary sj\u00f6gren syndrome patients with thrombocytopenia","volume":"21","author":"Hu","year":"2015","journal-title":"Med Sci Monit"},{"key":"10.1016\/j.coi.2025.102722_bib16","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.clim.2017.09.012","article-title":"Antibodies against citrullinated alpha enolase peptides in primary Sj\u00f6gren\u2019s syndrome","volume":"183","author":"Nezos","year":"2017","journal-title":"Clin Immunol"},{"key":"10.1016\/j.coi.2025.102722_bib17","first-page":"29","article-title":"\u03b1-enolase is an antigenic target in primary Sj\u00f6gren's syndrome","volume":"37","author":"Olivares-Mart\u00ednez","year":"2019","journal-title":"Clin Exp Rheumatol"},{"key":"10.1016\/j.coi.2025.102722_bib18","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1126\/science.276.5312.604","article-title":"Identification of \u03b1-fodrin as a candidate autoantigen in primary Sj\u00f6gren's syndrome","volume":"276","author":"Haneji","year":"1997","journal-title":"Science"},{"key":"10.1016\/j.coi.2025.102722_bib19","doi-asserted-by":"crossref","first-page":"1650","DOI":"10.1016\/S0002-9440(10)63274-9","article-title":"Molecular analysis of the human autoantibody response to \u03b1-fodrin in Sj\u00f6gren's syndrome reveals novel apoptosis-induced specificity","volume":"165","author":"Maruyama","year":"2004","journal-title":"Am J Pathol"},{"key":"10.1016\/j.coi.2025.102722_bib20","first-page":"2617","article-title":"IgA and IgG autoantibodies against alpha-fodrin as markers for Sj\u00f6gren's syndrome","volume":"27","author":"Witte","year":"2000","journal-title":"J Rheumatol"},{"key":"10.1016\/j.coi.2025.102722_bib21","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.clim.2012.09.013","article-title":"Novel autoantibodies in Sjogren's syndrome","volume":"145","author":"Shen","year":"2012","journal-title":"Clin Immunol"},{"key":"10.1016\/j.coi.2025.102722_bib22","article-title":"Utility of testing for murine tissue-specific autoantibodies for the diagnosis of Sjogren\u2019s syndrome","volume":"36","author":"Vivino","year":"2018","journal-title":"Clin Exp Rheumatol"},{"key":"10.1016\/j.coi.2025.102722_bib23","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1002\/art.39497","article-title":"Brief report: patients with primary Sj\u00f6gren's syndrome who are positive for autoantibodies to tripartite motif-containing Protein 38 show greater disease severity","volume":"68","author":"Wolska","year":"2016","journal-title":"Arthritis Rheumatol"},{"key":"10.1016\/j.coi.2025.102722_bib24","doi-asserted-by":"crossref","first-page":"1610","DOI":"10.1002\/art.40550","article-title":"Brief report: anti\u2013calponin 3 autoantibodies: a newly identified specificity in patients with Sj\u00f6gren\u2019s syndrome","volume":"70","author":"Birnbaum","year":"2018","journal-title":"Arthritis Rheumatol"},{"key":"10.1016\/j.coi.2025.102722_bib25","doi-asserted-by":"crossref","first-page":"1634","DOI":"10.1074\/jbc.273.3.1634","article-title":"NA14 is a novel nuclear autoantigen with a coiled-coil domain","volume":"273","author":"Ramos-Morales","year":"1998","journal-title":"J Biol Chem"},{"key":"10.1016\/j.coi.2025.102722_bib26","doi-asserted-by":"crossref","first-page":"3733","DOI":"10.2741\/3484","article-title":"Autoantibody to NA14 is an independent marker primarily for Sjogren's syndrome","volume":"14","author":"Nozawa","year":"2009","journal-title":"Front Biosci"},{"key":"10.1016\/j.coi.2025.102722_bib27","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1080\/08916934.2016.1196676","article-title":"A re-evaluation of anti-NA-14 antibodies in patients with primary Sj\u00f6gren\u2019s syndrome: significant role of interferon-\u03b3 in the production of autoantibodies against NA-14","volume":"49","author":"Uomori","year":"2016","journal-title":"Autoimmunity"},{"key":"10.1016\/j.coi.2025.102722_bib28","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1136\/annrheumdis-2015-207509","article-title":"PUF60: a prominent new target of the autoimmune response in dermatomyositis and Sj\u00f6gren's syndrome","volume":"75","author":"Fiorentino","year":"2016","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.coi.2025.102722_sbref29","first-page":"2420","article-title":"Anti-aquaporin-5 and anti-poly-U-binding-factor-60kDa protein antibodies in primary Sj\u00f6gren's disease patients: preliminary data and correlation with disease activity indices","volume":"42","author":"Stano","year":"2024","journal-title":"Clin Exp Rheumatol"},{"key":"10.1016\/j.coi.2025.102722_bib30","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/0014-5793(88)80947-5","article-title":"Tissue distribution of mRNAs encoding muscarinic acetylcholine receptor subtypes","volume":"239","author":"Maeda","year":"1988","journal-title":"FEBS Lett"},{"key":"10.1016\/j.coi.2025.102722_bib31","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1113\/jphysiol.2004.064626","article-title":"M3 muscarinic acetylcholine receptor plays a critical role in parasympathetic control of salivation in mice","volume":"558","author":"Nakamura","year":"2004","journal-title":"J Physiol"},{"key":"10.1016\/j.coi.2025.102722_bib32","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1046\/j.1365-2249.1996.42748.x","article-title":"Circulating antibodies against rat parotid gland M3 muscarinic receptors in primary Sj\u00f6gren's syndrome","volume":"104","author":"Bacman","year":"1996","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.coi.2025.102722_bib33","doi-asserted-by":"crossref","first-page":"7538","DOI":"10.1073\/pnas.95.13.7538","article-title":"Transfer of human serum IgG to nonobese diabetic Igmu null mice reveals a role for autoantibodies in the loss of secretory function of exocrine tissues in Sj\u00f6gren's syndrome","volume":"95","author":"Robinson","year":"1998","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.coi.2025.102722_bib34","first-page":"151","article-title":"Autoantibodies against lacrimal gland M3 muscarinic acetylcholine receptors in patients with primary Sj\u00f6gren's syndrome","volume":"39","author":"Bacman","year":"1998","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.coi.2025.102722_bib35","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1111\/apm.13349","article-title":"No evidence of increased anti-M3 muscarinic acetylcholine receptor autoantibodies in SSA-positive connective tissue disease patients","volume":"131","author":"Hatipo\u011flu","year":"2023","journal-title":"APMIS"},{"key":"10.1016\/j.coi.2025.102722_bib36","doi-asserted-by":"crossref","first-page":"795","DOI":"10.55563\/clinexprheumatol\/gy6udz","article-title":"Clinical usefulness of anti-muscarinic type 3 receptor autoantibodies in patients with primary Sj\u00f6gren's syndrome","volume":"39","author":"Mona","year":"2021","journal-title":"Clin Exp Rheumatol"},{"key":"10.1016\/j.coi.2025.102722_othref0005","unstructured":"Engelke F., Heidecke H., Schulze-Forster K., B\u00e4hre H., Liss Y., Doerner T. et al. Functional insights into autoantibodies targeting muscarinic acetylcholine receptors in Sj\u00f6gren\u2019s disease. in revision"},{"key":"10.1016\/j.coi.2025.102722_bib38","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1007\/s12026-016-8786-x","article-title":"Detection of autoantibodies against aquaporin-5 in the sera of patients with primary Sj\u00f6gren's syndrome","volume":"64","author":"Alam","year":"2016","journal-title":"Immunol Res"},{"key":"10.1016\/j.coi.2025.102722_bib39","doi-asserted-by":"crossref","first-page":"103","DOI":"10.4110\/in.2017.17.2.103","article-title":"Detection of autoantibodies against aquaporin-1 in the sera of patients with primary Sj\u00f6gren\u2019s syndrome","volume":"17","author":"Alam","year":"2017","journal-title":"Immune Netw"},{"key":"10.1016\/j.coi.2025.102722_bib40","doi-asserted-by":"crossref","first-page":"3781","DOI":"10.1007\/s10067-024-07190-1","article-title":"Autoantibody against aquaporin-5 may be a new diagnostic biomarker for primary Sj\u00f6gren\u2019s syndrome","volume":"43","author":"Wang","year":"2024","journal-title":"Clin Rheumatol"},{"key":"10.1016\/j.coi.2025.102722_bib41","doi-asserted-by":"crossref","first-page":"30039","DOI":"10.18632\/oncotarget.15613","article-title":"Investigation of three potential autoantibodies in Sjogren's syndrome and associated MALT lymphoma","volume":"8","author":"Cui","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.coi.2025.102722_sbref41","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1136\/ard-2022-223105","article-title":"Autoantibodies identify primary Sj\u00f6gren's syndrome in patients lacking serum IgG specific for Ro\/SS-A and La\/SS-B","volume":"82","author":"Longobardi","year":"2023","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.coi.2025.102722_sbref42","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2025.1524940","article-title":"Identification of novel autoantibodies in Sj\u00f6gren's disease","volume":"16","author":"Engelke","year":"2025","journal-title":"Front Immunol"}],"container-title":["Current Opinion in Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0952791525001980?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0952791525001980?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T09:33:01Z","timestamp":1784539981000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0952791525001980"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":43,"alternative-id":["S0952791525001980"],"URL":"https:\/\/doi.org\/10.1016\/j.coi.2025.102722","relation":{},"ISSN":["0952-7915"],"issn-type":[{"value":"0952-7915","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"New autoantibodies in Sj\u00f6gren's disease","name":"articletitle","label":"Article Title"},{"value":"Current Opinion in Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.coi.2025.102722","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"102722"}}