{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,23]],"date-time":"2026-05-23T05:06:18Z","timestamp":1779512778635,"version":"3.53.1"},"reference-count":54,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000864","name":"Michael J. Fox Foundation for Parkinson's Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000864","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["206198"],"award-info":[{"award-number":["206198"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009307","name":"Parkinson Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009307","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000034","name":"Institute of Neurosciences Mental Health and Addiction","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000034","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018231","name":"Aligning Science Across Parkinson's","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100018231","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Current Opinion in Immunology"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.coi.2026.102761","type":"journal-article","created":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T04:23:02Z","timestamp":1774671782000},"page":"102761","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["A liver\u2013mitochondria\u2013immune axis in Parkinson\u2019s disease: emerging perspectives on a hepatic origin for mitochondrial autoimmunity as a driver of Parkinson\u2019s disease"],"prefix":"10.1016","volume":"100","author":[{"given":"Diana","family":"Matheoud","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irshad","family":"Akbar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julian","family":"Hercun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo Anne","family":"Stratton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.coi.2026.102761_bib1","doi-asserted-by":"crossref","first-page":"51","DOI":"10.3389\/fcell.2020.00051","article-title":"Mitochondria: an integrative hub coordinating circadian rhythms, metabolism, the microbiome, and immunity","volume":"8","author":"Aguilar-L\u00f3pez","year":"2020","journal-title":"Front Cell Dev Biol"},{"key":"10.1016\/j.coi.2026.102761_bib2","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1002\/ana.410360612","article-title":"Complex I, iron, and ferritin in Parkinson's disease substantia nigra","volume":"36","author":"Mann","year":"1994","journal-title":"Ann Neurol"},{"key":"10.1016\/j.coi.2026.102761_bib3","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.expneurol.2009.03.019","article-title":"Mitochondrial dynamics in Parkinson's disease","volume":"218","author":"Van Laar","year":"2009","journal-title":"Exp Neurol"},{"key":"10.1016\/j.coi.2026.102761_bib4","doi-asserted-by":"crossref","first-page":"12413","DOI":"10.1523\/JNEUROSCI.0719-07.2007","article-title":"Loss-of-function of human PINK1 results in mitochondrial pathology and can be rescued by parkin","volume":"27","author":"Exner","year":"2007","journal-title":"J Neurosci"},{"key":"10.1016\/j.coi.2026.102761_sbref5","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1038\/33416","article-title":"Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism","volume":"392","author":"Kitada","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.coi.2026.102761_sbref6","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1038\/nature14893","article-title":"The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy","volume":"524","author":"Lazarou","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.coi.2026.102761_sbref7","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1126\/science.1096284","article-title":"Hereditary early-onset Parkinson's disease caused by mutations in PINK1","volume":"304","author":"Valente","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.coi.2026.102761_sbref8","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1073\/pnas.0911187107","article-title":"PINK1-dependent recruitment of Parkin to mitochondria in mitophagy","volume":"107","author":"Vives-Bauza","year":"2010","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.coi.2026.102761_sbref9","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/j.cell.2016.05.039","article-title":"Parkinson's disease-related proteins PINK1 and parkin repress mitochondrial antigen presentation","volume":"166","author":"Matheoud","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.coi.2026.102761_sbref10","article-title":"Adoptive transfer of mitochondrial antigen-specific CD8+ T-cells in mice causes parkinsonism and compromises the dopamine system","author":"Elemeery","year":"2024","journal-title":"bioRxiv"},{"key":"10.1016\/j.coi.2026.102761_sbref11","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1038\/s41586-019-1405-y","article-title":"Intestinal infection triggers Parkinson's disease-like symptoms in Pink1(-\/-) mice","volume":"571","author":"Matheoud","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.coi.2026.102761_bib12","doi-asserted-by":"crossref","first-page":"2150","DOI":"10.1038\/s41467-019-09893-5","article-title":"Suppression of a broad spectrum of liver autoimmune pathologies by single peptide-MHC-based nanomedicines","volume":"10","author":"Umeshappa","year":"2019","journal-title":"Nat Commun"},{"key":"10.1016\/j.coi.2026.102761_bib13","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/S1568-9972(02)00122-2","article-title":"T cell immunity and primary biliary cirrhosis","volume":"2","author":"Ishibashi","year":"2003","journal-title":"Autoimmun Rev"},{"key":"10.1016\/j.coi.2026.102761_sbref14","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1084\/jem.20010956","article-title":"Identification of HLA-A2-restricted CD8(+) cytotoxic T cell responses in primary biliary cirrhosis: T cell activation is augmented by immune complexes cross-presented by dendritic cells","volume":"195","author":"Kita","year":"2002","journal-title":"J Exp Med"},{"key":"10.1016\/j.coi.2026.102761_bib15","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/S1937-6448(08)01802-9","article-title":"Import of nuclear-encoded mitochondrial proteins: a cotranslational perspective","volume":"273","author":"Ahmed","year":"2009","journal-title":"Int Rev Cell Mol Biol"},{"key":"10.1016\/j.coi.2026.102761_bib16","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1038\/ni.1817","article-title":"Mechanisms maintaining peripheral tolerance","volume":"11","author":"Mueller","year":"2010","journal-title":"Nat Immunol"},{"key":"10.1016\/j.coi.2026.102761_bib17","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1038\/cmi.2010.22","article-title":"The cytokine milieu in the interplay of pathogenic Th1\/Th17 cells and regulatory T cells in autoimmune disease","volume":"7","author":"Leung","year":"2010","journal-title":"Cell & Mol Immunol"},{"key":"10.1016\/j.coi.2026.102761_sbref18","article-title":"PINK1 deficiency rewires early immune responses in a mouse model of Parkinson\u2019s disease triggered by intestinal infection","author":"Recinto","year":"2024","journal-title":"bioRxiv"},{"key":"10.1016\/j.coi.2026.102761_bib19","doi-asserted-by":"crossref","first-page":"647","DOI":"10.3390\/antiox9080647","article-title":"Mitochondrial dysfunction, oxidative stress, and neuroinflammation: intertwined roads to neurodegeneration","volume":"9","author":"Picca","year":"2020","journal-title":"Antioxidants"},{"key":"10.1016\/j.coi.2026.102761_sbref20","article-title":"Myeloid PINK1 represses mtDNA release and immune signaling that impacts neuronal pathology in patient-derived idiopathic PD models","author":"Recinto","year":"2026","journal-title":"bioRxiv"},{"key":"10.1016\/j.coi.2026.102761_bib21","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1038\/nri.2017.21","article-title":"Mitochondrial DNA in innate immune responses and inflammatory pathology","volume":"17","author":"West","year":"2017","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.coi.2026.102761_bib22","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2024.1432819","article-title":"Comparative effects of 3,5-diiodo-L-thyronine and 3,5,3\u2019-triiodo-L-thyronine on mitochondrial damage and cGAS\/STING-driven inflammation in liver of hypothyroid rats","volume":"15","author":"Giacco","year":"2024","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.coi.2026.102761_sbref23","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1038\/s41392-024-01811-6","article-title":"Bile acid metabolism and signaling in health and disease: molecular mechanisms and therapeutic targets","volume":"9","author":"Fleishman","year":"2024","journal-title":"Signal Transduct Target Ther"},{"key":"10.1016\/j.coi.2026.102761_bib24","doi-asserted-by":"crossref","first-page":"461","DOI":"10.3233\/JAD-210608","article-title":"Bile acids as key modulators of the brain-gut-microbiota axis in Alzheimer's disease","volume":"84","author":"Mulak","year":"2021","journal-title":"J Alzheimers Dis"},{"key":"10.1016\/j.coi.2026.102761_bib25","doi-asserted-by":"crossref","first-page":"513","DOI":"10.7861\/clinmed.2020-0697","article-title":"An update on the management of cholestatic liver diseases","volume":"20","author":"Appanna","year":"2020","journal-title":"Clin Med"},{"key":"10.1016\/j.coi.2026.102761_sbref26","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1111\/j.1365-3083.1991.tb02549.x","article-title":"Primary biliary cirrhosis (PBC): characterization of a monoclonal antibody (PBC-MoAb) having specificity identical with disease-associated autoantibodies","volume":"33","author":"Bjorkland","year":"1991","journal-title":"Scand J Immunol"},{"key":"10.1016\/j.coi.2026.102761_bib27","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1136\/jcp.53.11.813","article-title":"Autoantigens in primary biliary cirrhosis","volume":"53","author":"Jones","year":"2000","journal-title":"J Clin Pathol"},{"key":"10.1016\/j.coi.2026.102761_bib28","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/0167-5699(89)90088-1","article-title":"Molecular basis of mitochondrial autoreactivity in primary biliary cirrhosis","volume":"10","author":"Mackay","year":"1989","journal-title":"Immunol Today"},{"key":"10.1016\/j.coi.2026.102761_bib29","doi-asserted-by":"crossref","first-page":"14556","DOI":"10.1073\/pnas.1203912109","article-title":"Autonomous phagosomal degradation and antigen presentation in dendritic cells","volume":"109","author":"Hoffmann","year":"2012","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.coi.2026.102761_sbref30","article-title":"Gut microbial profile of treatment-naive patients with primary biliary cholangitis","volume":"14","author":"Zhou","year":"2023","journal-title":"Front Immunol"},{"key":"10.1016\/j.coi.2026.102761_bib31","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/S0168-8278(98)80058-5","article-title":"Abnormal accumulation of endotoxin in biliary epithelial cells in primary biliary cirrhosis and primary sclerosing cholangitis","volume":"29","author":"Sasatomi","year":"1998","journal-title":"J Hepatol"},{"key":"10.1016\/j.coi.2026.102761_bib32","article-title":"The role of gut microbiota in some liver diseases: from an immunological perspective","volume":"13","author":"Wang","year":"2022","journal-title":"Front Immunol"},{"key":"10.1016\/j.coi.2026.102761_sbref33","doi-asserted-by":"crossref","first-page":"2653","DOI":"10.1172\/JCI116504","article-title":"Molecular mimicry in primary biliary cirrhosis. Evidence for biliary epithelial expression of a molecule cross-reactive with pyruvate dehydrogenase complex-E2","volume":"91","author":"Van de Water","year":"1993","journal-title":"J Clin Invest"},{"key":"10.1016\/j.coi.2026.102761_bib34","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1038\/s41395-018-0390-3","article-title":"Diagnosis and management of primary biliary cholangitis","volume":"114","author":"Younossi","year":"2019","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.coi.2026.102761_bib35","doi-asserted-by":"crossref","first-page":"1853","DOI":"10.3389\/fimmu.2018.01853","article-title":"Bile acids activated receptors regulate innate immunity","volume":"9","author":"Fiorucci","year":"2018","journal-title":"Front Immunol"},{"key":"10.1016\/j.coi.2026.102761_bib36","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1111\/j.1478-3231.2010.02259.x","article-title":"Impaired cerebral autoregulation in primary biliary cirrhosis: implications for the pathogenesis of cognitive decline","volume":"30","author":"Hollingsworth","year":"2010","journal-title":"Liver Int"},{"key":"10.1016\/j.coi.2026.102761_bib37","doi-asserted-by":"crossref","first-page":"1622","DOI":"10.1136\/gut.2005.065862","article-title":"Development, validation, and evaluation of the PBC-40, a disease specific health related quality of life measure for primary biliary cirrhosis","volume":"54","author":"Jacoby","year":"2005","journal-title":"Gut"},{"key":"10.1016\/j.coi.2026.102761_sbref38","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1111\/liv.12026","article-title":"Sleep-Wake profiles in patients with primary biliary cirrhosis","volume":"33","author":"Montagnese","year":"2013","journal-title":"Liver Int"},{"key":"10.1016\/j.coi.2026.102761_sbref39","doi-asserted-by":"crossref","DOI":"10.1038\/ctg.2017.34","article-title":"Primary biliary cholangitis alters functional connections of the brain's deep gray matter","volume":"8","author":"Mosher","year":"2017","journal-title":"Clin Transl Gastroenterol"},{"key":"10.1016\/j.coi.2026.102761_sbref40","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1038\/s41424-018-0038-z","article-title":"Magnetic resonance imaging evidence of hippocampal structural changes in patients with primary biliary cholangitis","volume":"9","author":"Mosher","year":"2018","journal-title":"Clin Transl Gastroenterol"},{"key":"10.1016\/j.coi.2026.102761_sbref41","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1097\/01.meg.0000252629.96043.67","article-title":"Autonomic dysfunction in primary biliary cirrhosis correlates with fatigue severity","volume":"19","author":"Newton","year":"2007","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"10.1016\/j.coi.2026.102761_sbref42","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1002\/hep.22371","article-title":"Cognitive impairment in primary biliary cirrhosis: symptom impact and potential etiology","volume":"48","author":"Newton","year":"2008","journal-title":"Hepatology"},{"key":"10.1016\/j.coi.2026.102761_bib43","doi-asserted-by":"crossref","first-page":"2221","DOI":"10.3748\/wjg.v26.i18.2221","article-title":"Prognostic significance of hepatic encephalopathy in patients with cirrhosis treated with current standards of care","volume":"26","author":"Bohra","year":"2020","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.coi.2026.102761_sbref44","doi-asserted-by":"crossref","first-page":"29","DOI":"10.3390\/metabo11010029","article-title":"Gut microbiota dysbiosis is associated with elevated bile acids in Parkinson's disease","volume":"11","author":"Li","year":"2021","journal-title":"Metabolites"},{"key":"10.1016\/j.coi.2026.102761_bib45","doi-asserted-by":"crossref","first-page":"2599","DOI":"10.1007\/s11033-012-2346-9","article-title":"Pathway analysis of genome-wide association studies for Parkinson's disease","volume":"40","author":"Song","year":"2013","journal-title":"Mol Biol Rep"},{"key":"10.1016\/j.coi.2026.102761_bib46","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1038\/s41531-021-00245-z","article-title":"Cholecystectomy and subsequent risk of Parkinson's disease: a nationwide retrospective cohort study","volume":"7","author":"Kim","year":"2021","journal-title":"NPJ Parkinsons Dis"},{"key":"10.1016\/j.coi.2026.102761_sbref47","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1002\/mds.29432","article-title":"The endotoxin hypothesis of Parkinson's disease","volume":"38","author":"Brown","year":"2023","journal-title":"Mov Disord"},{"key":"10.1016\/j.coi.2026.102761_bib48","doi-asserted-by":"crossref","first-page":"159","DOI":"10.3390\/brainsci15020159","article-title":"The inflammatory mechanism of Parkinson's disease: gut microbiota metabolites affect the development of the disease through the gut-brain axis","volume":"15","author":"Gao","year":"2025","journal-title":"Brain Sci"},{"key":"10.1016\/j.coi.2026.102761_bib49","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1038\/s41531-021-00156-z","article-title":"Meta-analysis of the Parkinson's disease gut microbiome suggests alterations linked to intestinal inflammation","volume":"7","author":"Romano","year":"2021","journal-title":"NPJ Parkinsons Dis"},{"key":"10.1016\/j.coi.2026.102761_sbref50","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1186\/s40168-025-02227-2","article-title":"Integrated multi-omics highlights alterations of gut microbiome functions in prodromal and idiopathic Parkinson's disease","volume":"13","author":"Villette","year":"2025","journal-title":"Microbiome"},{"key":"10.1016\/j.coi.2026.102761_bib51","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1016\/j.cell.2016.11.018","article-title":"Gut microbiota regulate motor deficits and neuroinflammation in a model of Parkinson's disease","volume":"167","author":"Sampson","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.coi.2026.102761_bib52","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1007\/s12264-022-00934-6","article-title":"Parkinson's disease: a multisystem disorder","volume":"39","author":"Costa","year":"2023","journal-title":"Neurosci Bull"},{"key":"10.1016\/j.coi.2026.102761_sbref53","doi-asserted-by":"crossref","DOI":"10.2991\/978-94-6463-932-2","article-title":"Beyond the brain: exploring the multi-organ axes in Parkinson's disease pathogenesis","author":"Liu","year":"2025","journal-title":"J Adv Res"},{"key":"10.1016\/j.coi.2026.102761_sbref54","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2025.1600782","article-title":"Parkinson's disease beyond the brain: implications for treatments","volume":"17","author":"Malekian Naeini","year":"2025","journal-title":"Front Aging Neurosci"}],"container-title":["Current Opinion in Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0952791526000385?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0952791526000385?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,23]],"date-time":"2026-05-23T04:21:34Z","timestamp":1779510094000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0952791526000385"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":54,"alternative-id":["S0952791526000385"],"URL":"https:\/\/doi.org\/10.1016\/j.coi.2026.102761","relation":{},"ISSN":["0952-7915"],"issn-type":[{"value":"0952-7915","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A liver\u2013mitochondria\u2013immune axis in Parkinson\u2019s disease: emerging perspectives on a hepatic origin for mitochondrial autoimmunity as a driver of Parkinson\u2019s disease","name":"articletitle","label":"Article Title"},{"value":"Current Opinion in Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.coi.2026.102761","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"102761"}}