{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T03:38:22Z","timestamp":1793417902351,"version":"4.5.0"},"reference-count":17,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T00:00:00Z","timestamp":1773705600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Current Opinion in Immunology"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.coi.2026.102772","type":"journal-article","created":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T21:22:47Z","timestamp":1775683367000},"page":"102772","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Why Sj\u00f6gren\u2019s disease?"],"prefix":"10.1016","volume":"100","author":[{"given":"Haralampos M","family":"Moutsopoulos","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.coi.2026.102772_bib1","series-title":"Sj\u00f6gren\u2019s Syndrome Book","first-page":"3","article-title":"Historical perspective: the early years (1930\u20131960)","author":"Bjelle","year":"1987"},{"key":"10.1016\/j.coi.2026.102772_bib2","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/S0140-6736(61)92430-8","article-title":"Precipitating autoantibodies in Sjogren\u2019s disease","volume":"26","author":"Anderson","year":"1961","journal-title":"Lancet"},{"key":"10.1016\/j.coi.2026.102772_bib3","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1097\/00005792-196505000-00001","article-title":"Sj\u00f6gren\u2019s syndrome. A clinical, pathological, and serological study of sixty-two cases","volume":"May","author":"Bloch","year":"1965","journal-title":"Medicine"},{"key":"10.1016\/j.coi.2026.102772_bib4","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1136\/jcp.21.5.656","article-title":"Labial salivary gland biopsy in Sj\u00f6gren\u2019s disease","volume":"21","author":"Chisholm","year":"1968","journal-title":"J Clin Pathol"},{"key":"10.1016\/j.coi.2026.102772_sbref5","first-page":"S61","article-title":"The central role of epithelial cells in Sj\u00f6gren\u2019s syndrome or autoimmune epithelitis","volume":"Jun","author":"Kapsogeorgou","year":"2004","journal-title":"Autoimmun Rev"},{"key":"10.1016\/j.coi.2026.102772_sbref6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jaut.2014.01.001","article-title":"Sj\u00f6gren\u2019s syndrome: a forty-year scientific journey","volume":"51","author":"Moutsopoulos","year":"2014","journal-title":"J Autoimmun"},{"key":"10.1016\/j.coi.2026.102772_sbref7","article-title":"Salivary gland epithelial cell in Sj\u00f6gren\u2019s syndrome: metabolic shift and altered mitochondrial morphology toward an innate immune cell function","volume":"Apr","author":"Katsiougiannis","year":"2023","journal-title":"J Autoimmun"},{"key":"10.1016\/j.coi.2026.102772_bib8","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.1136\/annrheumdis-2019-216588","article-title":"Salivary gland epithelial cells from patients with Sj\u00f6gren\u2019s syndrome induce B-lymphocyte survival and activation","volume":"79","author":"Rivi\u00e8re","year":"2020","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.coi.2026.102772_bib9","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1038\/s41584-021-00605-2","article-title":"Epithelial\u2013immune cell interplay in primary Sj\u00f6gren syndrome salivary gland pathogenesis","volume":"17","author":"Verstappen","year":"2021","journal-title":"Nat Rev Rheumatol"},{"key":"10.1016\/j.coi.2026.102772_bib10","doi-asserted-by":"crossref","DOI":"10.3390\/ijms25094973","article-title":"Exploring salivary epithelial dysfunction in Sj\u00f6gren\u2019s disease","volume":"25","author":"Noll","year":"2024","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.coi.2026.102772_sbref11","doi-asserted-by":"crossref","DOI":"10.1016\/j.coi.2025.102707","article-title":"Salivary gland organoids and the future of modeling autoimmune epithelitis in Sj\u00f6gren\u2019s disease","volume":"98","author":"Yang","year":"2026","journal-title":"Curr Opin Immunol"},{"key":"10.1016\/j.coi.2026.102772_bib12","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1006\/clin.1994.1123","article-title":"Sj\u00f6gren\u2019s syndrome: autoimmune epithelitis","volume":"72","author":"Moutsopoulos","year":"1994","journal-title":"Clin Immunol Immunopathol"},{"key":"10.1016\/j.coi.2026.102772_bib13","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1038\/s41584-025-01268-z","article-title":"2023 International Rome consensus for the nomenclature of Sj\u00f6gren disease","volume":"21","author":"Ramos-Casals","year":"2025","journal-title":"Nat Rev Rheumatol"},{"key":"10.1016\/j.coi.2026.102772_bib14","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1136\/ard.56.9.521","article-title":"Prevalence of Sj\u00f6gren\u2019s syndrome in a closed rural community","volume":"56","author":"Dafni","year":"1997","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.coi.2026.102772_bib15","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1001\/archinte.164.12.1275","article-title":"Clinical manifestations and early diagnosis of Sj\u00f6gren syndrome","volume":"164","author":"Kassan","year":"2004","journal-title":"Arch Intern Med"},{"key":"10.1016\/j.coi.2026.102772_bib16","doi-asserted-by":"crossref","first-page":"212","DOI":"10.7326\/0003-4819-92-2-212","article-title":"Sjogren\u2019s syndrome (Sicca syndrome): current issues","volume":"92","author":"Moutsopoulos","year":"1980","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.coi.2026.102772_bib17","doi-asserted-by":"crossref","first-page":"2337","DOI":"10.1001\/archinte.165.20.2337","article-title":"The risk of lymphoma development in autoimmune diseases: a meta-analysis","volume":"165","author":"Zintzaras","year":"2005","journal-title":"Arch Intern Med"}],"container-title":["Current Opinion in Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S095279152600049X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S095279152600049X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,23]],"date-time":"2026-05-23T04:22:15Z","timestamp":1779510135000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S095279152600049X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":17,"alternative-id":["S095279152600049X"],"URL":"https:\/\/doi.org\/10.1016\/j.coi.2026.102772","relation":{},"ISSN":["0952-7915"],"issn-type":[{"value":"0952-7915","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Why Sj\u00f6gren\u2019s disease?","name":"articletitle","label":"Article Title"},{"value":"Current Opinion in Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.coi.2026.102772","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"102772"}}