{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T20:10:38Z","timestamp":1789935038051,"version":"4.0.1"},"reference-count":50,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100020884","name":"National Agency for Research and Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100020884","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002850","name":"Fondo Nacional de Desarrollo Cient\u00edfico y Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["1230852"],"award-info":[{"award-number":["1230852"]}],"id":[{"id":"10.13039\/501100002850","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002850","name":"Fondo Nacional de Desarrollo Cient\u00edfico y Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["1241526"],"award-info":[{"award-number":["1241526"]}],"id":[{"id":"10.13039\/501100002850","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002850","name":"Fondo Nacional de Desarrollo Cient\u00edfico y Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["1210055"],"award-info":[{"award-number":["1210055"]}],"id":[{"id":"10.13039\/501100002850","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Current Opinion in Immunology"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.coi.2026.102838","type":"journal-article","created":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T17:57:50Z","timestamp":1789667870000},"page":"102838","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Cellular stress leading to epithelial cell dysfunction in Sj\u00f6gren\u2019s syndrome"],"prefix":"10.1016","volume":"103","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6061-216X","authenticated-orcid":false,"given":"Mar\u00eda-Jos\u00e9","family":"Barrera","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel","family":"Castro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda-Julieta","family":"Gonz\u00e1lez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.coi.2026.102838_sbref1","doi-asserted-by":"crossref","DOI":"10.1016\/j.coi.2026.102815","article-title":"The epithelial cell in Sj\u00f6gren's syndrome: from passive target to orchestrator of autoimmune reactivity","volume":"102","author":"Moutsopoulos","year":"2026","journal-title":"Curr Opin Immunol"},{"key":"10.1016\/j.coi.2026.102838_bib2","doi-asserted-by":"crossref","DOI":"10.1111\/sji.13145","article-title":"Disease mechanisms in Sj\u00f6gren's syndrome: what do we know?","volume":"95","author":"Jonsson","year":"2022","journal-title":"Scand J Immunol"},{"key":"10.1016\/j.coi.2026.102838_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.coi.2025.102707","article-title":"Salivary gland organoids and the future of modeling autoimmune epithelitis in Sj\u00f6gren's disease","volume":"98","author":"Yang","year":"2026","journal-title":"Curr Opin Immunol"},{"key":"10.1016\/j.coi.2026.102838_bib4","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1038\/s41584-021-00605-2","article-title":"Epithelial-immune cell interplay in primary Sj\u00f6gren syndrome salivary gland pathogenesis","volume":"17","author":"Verstappen","year":"2021","journal-title":"Nat Rev Rheumatol"},{"key":"10.1016\/j.coi.2026.102838_sbref5","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1186\/s40001-024-01967-5","article-title":"Primary Sj\u00f6gren's syndrome: new perspectives on salivary gland epithelial cells","volume":"29","author":"Hou","year":"2024","journal-title":"Eur J Med Res"},{"key":"10.1016\/j.coi.2026.102838_bib6","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.jaut.2013.02.001","article-title":"Sj\u00f6gren's syndrome and the epithelial target: a comprehensive review","volume":"42","author":"Barrera","year":"2013","journal-title":"J Autoimmun"},{"key":"10.1016\/j.coi.2026.102838_bib7","doi-asserted-by":"crossref","first-page":"2573","DOI":"10.1002\/art.11178","article-title":"Enhanced degradation of proteins of the basal lamina and stroma by matrix metalloproteinases from the salivary glands of Sj\u00f6gren's syndrome patients: correlation with reduced structural integrity of acini and ducts","volume":"48","author":"Goicovich","year":"2003","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.coi.2026.102838_sbref8","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1016\/j.ard.2026.03.022","article-title":"Altered mitochondrial ultrastructure in salivary epithelial cells of patients with Sj\u00f6gren's disease is associated with mitochondrial DNA release and increased activation of pattern recognition receptors: potential use of tofacitinib as therapy","volume":"85","author":"Carvajal","year":"2026","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.coi.2026.102838_bib9","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1093\/rheumatology\/kez316","article-title":"Aberrant MUC1 accumulation in salivary glands of Sj\u00f6gren's syndrome patients is reversed by TUDCA in vitro","volume":"59","author":"Castro","year":"2020","journal-title":"Rheumatology"},{"key":"10.1016\/j.coi.2026.102838_bib10","doi-asserted-by":"crossref","DOI":"10.1126\/science.aat5314","article-title":"The integrated stress response: from mechanism to disease","volume":"368","author":"Costa-Mattioli","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.coi.2026.102838_bib11","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.devcel.2007.07.005","article-title":"ATF6alpha optimizes long-term endoplasmic reticulum function to protect cells from chronic stress","volume":"13","author":"Wu","year":"2007","journal-title":"Dev Cell"},{"key":"10.1016\/j.coi.2026.102838_bib12","doi-asserted-by":"crossref","first-page":"4368","DOI":"10.1038\/sj.emboj.7600903","article-title":"XBP-1 is required for biogenesis of cellular secretory machinery of exocrine glands","volume":"24","author":"Lee","year":"2005","journal-title":"EMBO J"},{"key":"10.1016\/j.coi.2026.102838_bib13","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/j.devcel.2007.07.018","article-title":"Transcriptional induction of mammalian ER quality control proteins is mediated by single or combined action of ATF6alpha and XBP1","volume":"13","author":"Yamamoto","year":"2007","journal-title":"Dev Cell"},{"key":"10.1016\/j.coi.2026.102838_bib14","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1038\/nrm3270","article-title":"The unfolded protein response: controlling cell fate decisions under ER stress and beyond","volume":"13","author":"Hetz","year":"2012","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.coi.2026.102838_bib15","doi-asserted-by":"crossref","DOI":"10.1093\/jimmun\/vkag151","article-title":"ER stress amplifies inflammation via a dual mechanism involving I\u03baB\u03b6-XBP1s synergism and Regnase-1 degradation","volume":"215","author":"Nakaminami","year":"2026","journal-title":"J Immunol"},{"key":"10.1016\/j.coi.2026.102838_bib16","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1016\/j.autrev.2018.02.009","article-title":"Endoplasmic reticulum stress in autoimmune diseases: can altered protein quality control and\/or unfolded protein response contribute to autoimmunity? A critical review on Sj\u00f6gren's syndrome","volume":"17","author":"Barrera","year":"2018","journal-title":"Autoimmun Rev"},{"key":"10.1016\/j.coi.2026.102838_sbref17","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1038\/s41401-023-01225-0","article-title":"Mammalian integrated stress responses in stressed organelles and their functions","volume":"45","author":"Lu","year":"2024","journal-title":"Acta Pharmacol Sin"},{"key":"10.1016\/j.coi.2026.102838_bib18","doi-asserted-by":"crossref","DOI":"10.1177\/03946320241263034","article-title":"Exploring the relationship between oxidative stress status and inflammatory markers during primary Sj\u00f6gren's syndrome: a new approach for patient monitoring","volume":"38","author":"Benchabane","year":"2024","journal-title":"Int J Immunopathol Pharmacol"},{"key":"10.1016\/j.coi.2026.102838_bib19","doi-asserted-by":"crossref","first-page":"2814","DOI":"10.3389\/fimmu.2019.02814","article-title":"JAK inhibitors and oxidative stress control","volume":"10","author":"Charras","year":"2019","journal-title":"Front Immunol"},{"key":"10.1016\/j.coi.2026.102838_bib20","doi-asserted-by":"crossref","DOI":"10.1136\/rmdopen-2018-000772","article-title":"Salivary gland secretome: a novel tool towards molecular stratification of patients with primary Sj\u00f6gren's syndrome and non-autoimmune sicca","volume":"5","author":"Blokland","year":"2019","journal-title":"RMD Open"},{"key":"10.1016\/j.coi.2026.102838_sbref21","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaut.2025.103412","article-title":"Integrated stress response inhibition restores hsa-miR-145-5p levels after IFN-\u03b2 stimulation in salivary gland epithelial cells. Association between cellular stress and miRNA biogenesis in Sj\u00f6gren's disease","volume":"153","author":"Castro","year":"2025","journal-title":"J Autoimmun"},{"key":"10.1016\/j.coi.2026.102838_bib22","doi-asserted-by":"crossref","DOI":"10.3389\/fmed.2023.1118703","article-title":"The integrated stress response is activated in the salivary glands of Sj\u00f6gren's syndrome patients","volume":"10","author":"Carvajal","year":"2023","journal-title":"Front Med"},{"key":"10.1016\/j.coi.2026.102838_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaut.2023.103037","article-title":"hsa-miR-424-5p and hsa-miR-513c-3p dysregulation mediated by IFN-\u03b3 is associated with salivary gland dysfunction in Sj\u00f6gren's syndrome patients","volume":"138","author":"Carvajal","year":"2023","journal-title":"J Autoimmun"},{"key":"10.1016\/j.coi.2026.102838_bib24","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.tibs.2011.03.001","article-title":"Modulating stress responses by the UPRosome: a matter of life and death","volume":"36","author":"Woehlbier","year":"2011","journal-title":"Trends Biochem Sci"},{"key":"10.1016\/j.coi.2026.102838_sbref25","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1093\/cei\/uxae054","article-title":"Beta-adrenergic stimulation promotes an endoplasmic reticulum stress-dependent inflammatory program in salivary gland epithelial cells","volume":"218","author":"Moustaka","year":"2024","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.coi.2026.102838_sbref26","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1002\/art.43347","article-title":"Investigation of lysosome-associated membrane protein 3 highlighting the role of lysosome in pathophysiology and treatment of Sj\u00f6gren disease","volume":"78","author":"Nakamura","year":"2026","journal-title":"Arthritis Rheumatol"},{"key":"10.1016\/j.coi.2026.102838_bib27","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-020-71669-5","article-title":"LAMP3 induces apoptosis and autoantigen release in Sj\u00f6gren's syndrome patients","volume":"10","author":"Tanaka","year":"2020","journal-title":"Sci Rep"},{"key":"10.1016\/j.coi.2026.102838_bib28","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1136\/annrheumdis-2020-219649","article-title":"Lysosome-associated membrane protein 3 misexpression in salivary glands induces a Sj\u00f6gren's syndrome-like phenotype in mice","volume":"80","author":"Nakamura","year":"2021","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.coi.2026.102838_bib29","doi-asserted-by":"crossref","DOI":"10.15252\/emmm.202012476","article-title":"Hydroxychloroquine in rheumatic autoimmune disorders and beyond","volume":"12","author":"Nirk","year":"2020","journal-title":"EMBO Mol Med"},{"key":"10.1016\/j.coi.2026.102838_bib30","doi-asserted-by":"crossref","first-page":"1629","DOI":"10.1080\/15548627.2021.1995150","article-title":"LAMP3 inhibits autophagy and contributes to cell death by lysosomal membrane permeabilization","volume":"18","author":"Tanaka","year":"2022","journal-title":"Autophagy"},{"key":"10.1016\/j.coi.2026.102838_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.autrev.2026.104040","article-title":"Autoimmunity, diet and autophagy","volume":"25","author":"Blaise","year":"2026","journal-title":"Autoimmun Rev"},{"key":"10.1016\/j.coi.2026.102838_bib32","doi-asserted-by":"crossref","first-page":"1951","DOI":"10.1093\/rheumatology\/keaa670","article-title":"Tofacitinib counteracts IL-6 overexpression induced by deficient autophagy: implications in Sj\u00f6gren's syndrome","volume":"60","author":"Barrera","year":"2021","journal-title":"Rheumatology"},{"key":"10.1016\/j.coi.2026.102838_bib33","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1080\/15548627.2025.2608973","article-title":"Proteotoxic stress triggers TFEB- and TFE3-mediated autophagy and lysosomal biogenesis via non-canonical MTORC1 inactivation","volume":"22","author":"Zhu","year":"2026","journal-title":"Autophagy"},{"key":"10.1016\/j.coi.2026.102838_bib34","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1146\/annurev-cellbio-111315-125407","article-title":"TFEB and TFE3: linking lysosomes to cellular adaptation to stress","volume":"32","author":"Raben","year":"2016","journal-title":"Annu Rev Cell Dev Biol"},{"key":"10.1016\/j.coi.2026.102838_bib35","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1093\/jb\/mvv010","article-title":"Organelle autoregulation-stress responses in the ER, Golgi, mitochondria and lysosome","volume":"157","author":"Sasaki","year":"2015","journal-title":"J Biochem"},{"key":"10.1016\/j.coi.2026.102838_bib36","doi-asserted-by":"crossref","first-page":"38","DOI":"10.3892\/ijmm.2021.4871","article-title":"The role of the Golgi apparatus in disease (Review)","volume":"47","author":"Liu","year":"2021","journal-title":"Int J Mol Med"},{"key":"10.1016\/j.coi.2026.102838_bib37","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1247\/csf.16023","article-title":"TFE3, HSP47, and CREB3 pathways of the mammalian Golgi stress response","volume":"42","author":"Taniguchi","year":"2017","journal-title":"Cell Struct Funct"},{"key":"10.1016\/j.coi.2026.102838_bib38","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1247\/csf.14015","article-title":"TFE3 is a bHLH-ZIP-type transcription factor that regulates the mammalian Golgi stress response","volume":"40","author":"Taniguchi","year":"2015","journal-title":"Cell Struct Funct"},{"key":"10.1016\/j.coi.2026.102838_bib39","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1247\/csf.10014","article-title":"Novel cis-acting element GASE regulates transcriptional induction by the Golgi stress response","volume":"36","author":"Oku","year":"2011","journal-title":"Cell Struct Funct"},{"key":"10.1016\/j.coi.2026.102838_bib40","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.171585","article-title":"Giantin mediates Golgi localization of Gal3-O-sulfotransferases and affects salivary mucin sulfation in patients with Sj\u00f6gren's disease","volume":"9","author":"Nu\u00f1ez","year":"2024","journal-title":"JCI Insight"},{"key":"10.1016\/j.coi.2026.102838_bib41","doi-asserted-by":"crossref","first-page":"3979","DOI":"10.1016\/j.molcel.2024.08.026","article-title":"A TBK1-independent primordial function of STING in lysosomal biogenesis","volume":"84","author":"Lv","year":"2024","journal-title":"Mol Cell"},{"key":"10.1016\/j.coi.2026.102838_bib42","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1146\/annurev-micro-102215-095605","article-title":"Detection of microbial infections through innate immune sensing of nucleic acids","volume":"72","author":"Tan","year":"2018","journal-title":"Annu Rev Microbiol"},{"key":"10.1016\/j.coi.2026.102838_bib43","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1016\/j.immuni.2024.03.002","article-title":"DAMPs and DAMP-sensing receptors in inflammation and diseases","volume":"57","author":"Ma","year":"2024","journal-title":"Immunity"},{"key":"10.1016\/j.coi.2026.102838_bib44","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.jaut.2018.02.010","article-title":"Systemic activation of NLRP3 inflammasome in patients with severe primary Sj\u00f6gren's syndrome fueled by inflammagenic DNA accumulations","volume":"91","author":"Vakrakou","year":"2018","journal-title":"J Autoimmun"},{"key":"10.1016\/j.coi.2026.102838_bib45","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaut.2019.102381","article-title":"Cell-autonomous epithelial activation of AIM2 (absent in melanoma-2) inflammasome by cytoplasmic DNA accumulations in primary Sj\u00f6gren's syndrome","volume":"108","author":"Vakrakou","year":"2020","journal-title":"J Autoimmun"},{"key":"10.1016\/j.coi.2026.102838_bib46","doi-asserted-by":"crossref","first-page":"3735","DOI":"10.1038\/s41388-022-02365-z","article-title":"TFAM downregulation promotes autophagy and ESCC survival through mtDNA stress-mediated STING pathway","volume":"41","author":"Li","year":"2022","journal-title":"Oncogene"},{"key":"10.1016\/j.coi.2026.102838_bib47","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.97069","article-title":"Dysregulated Ca2+ signaling, fluid secretion, and mitochondrial function in a mouse model of early Sj\u00f6gren's disease","volume":"13","author":"Huang","year":"2024","journal-title":"Elife"},{"key":"10.1016\/j.coi.2026.102838_bib48","article-title":"A link between mitochondrial dysfunction and the immune microenvironment of salivary glands in primary Sjogren's syndrome","volume":"13","author":"Li","year":"2022","journal-title":"Front Immunol"},{"key":"10.1016\/j.coi.2026.102838_sbref49","doi-asserted-by":"crossref","first-page":"1784","DOI":"10.1016\/j.ard.2026.05.014","article-title":"Mitochondrial-impaired ductal epithelium fuels TLS formation in Sj\u00f6gren's disease","volume":"85","author":"Zong","year":"2026","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.coi.2026.102838_bib50","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaut.2023.103014","article-title":"Salivary gland epithelial cell in Sj\u00f6gren's syndrome: metabolic shift and altered mitochondrial morphology toward an innate immune cell function","volume":"136","author":"Katsiougiannis","year":"2023","journal-title":"J Autoimmun"}],"container-title":["Current Opinion in Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0952791526001159?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0952791526001159?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T19:53:42Z","timestamp":1789934022000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0952791526001159"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":50,"alternative-id":["S0952791526001159"],"URL":"https:\/\/doi.org\/10.1016\/j.coi.2026.102838","relation":{},"ISSN":["0952-7915"],"issn-type":[{"value":"0952-7915","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cellular stress leading to epithelial cell dysfunction in Sj\u00f6gren\u2019s syndrome","name":"articletitle","label":"Article Title"},{"value":"Current Opinion in Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.coi.2026.102838","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"102838"}}