{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T02:28:25Z","timestamp":1793845705490,"version":"4.6.1"},"reference-count":82,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:00:00Z","timestamp":1791417600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ENDOVIRE ANR grant ANR-22-CE20-0005-01"],"award-info":[{"award-number":["ENDOVIRE ANR grant ANR-22-CE20-0005-01"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100022077","name":"Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100022077","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009081","name":"Institut National des Sciences Appliqu\u00e9es de Lyon","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009081","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Current Opinion in Insect Science"],"published-print":{"date-parts":[[2027,2]]},"DOI":"10.1016\/j.cois.2026.101633","type":"journal-article","created":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T16:12:24Z","timestamp":1791562344000},"page":"101633","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Gene regulatory network reconstruction to decipher the molecular mechanisms governing bacteriocyte-based symbioses"],"prefix":"10.1016","volume":"79","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-1936-5687","authenticated-orcid":false,"given":"Erwan","family":"Cruch\u00e9","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e9lanie","family":"Ribeiro Lopes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4530-4561","authenticated-orcid":false,"given":"Patrick","family":"Callaerts","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9004-3033","authenticated-orcid":false,"given":"Sergio","family":"Peignier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7856-9617","authenticated-orcid":false,"given":"Federica","family":"Calevro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cois.2026.101633_bib1","doi-asserted-by":"crossref","DOI":"10.1186\/1741-7007-5-48","article-title":"Nutritional upgrading for omnivorous carpenter ants by the endosymbiont Blochmannia","volume":"5","author":"Feldhaar","year":"2007","journal-title":"BMC Biol"},{"key":"10.1016\/j.cois.2026.101633_bib2","article-title":"Symbiotic bacteria enable insect to use a nutritionally inadequate diet","volume":"276","author":"G\u00fcnd\u00fcz","year":"2008","journal-title":"Proc R Soc B Biol Sci"},{"key":"10.1016\/j.cois.2026.101633_bib3","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1111\/mec.12421","article-title":"The impact of microbial symbionts on host plant utilization by herbivorous insects","volume":"23","author":"Hansen","year":"2014","journal-title":"Mol Ecol"},{"key":"10.1016\/j.cois.2026.101633_bib4","doi-asserted-by":"crossref","first-page":"2635","DOI":"10.1093\/gbe\/evv170","article-title":"Metabolic coevolution in the bacterial symbiosis of whiteflies and related plant sap-feeding insects","volume":"7","author":"Luan","year":"2015","journal-title":"Genome Biol Evol"},{"key":"10.1016\/j.cois.2026.101633_bib5","doi-asserted-by":"crossref","first-page":"4075","DOI":"10.1128\/AEM.00358-11","article-title":"Specific developmental window for establishment of an insect-microbe gut symbiosis","volume":"77","author":"Kikuchi","year":"2011","journal-title":"Appl Environ Microbiol"},{"key":"10.1016\/j.cois.2026.101633_bib6","doi-asserted-by":"crossref","first-page":"1520","DOI":"10.1016\/j.cell.2017.10.029","article-title":"Drastic genome reduction in an herbivore\u2019s pectinolytic symbiont","volume":"171","author":"Salem","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.cois.2026.101633_bib7","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.0000021","article-title":"Developmental origin and evolution of bacteriocytes in the aphid\u2013Buchnera symbiosis","volume":"1","author":"Braendle","year":"2003","journal-title":"PLoS Biol"},{"key":"10.1016\/j.cois.2026.101633_bib8","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1002\/jez.b.3","article-title":"A comparison of parthenogenetic and sexual embryogenesis of the pea aphid Acyrthosiphon pisum (Hemiptera: Aphidoidea)","volume":"295B","author":"Miura","year":"2003","journal-title":"J Exp Zool B Mol Dev Evol"},{"key":"10.1016\/j.cois.2026.101633_bib9","doi-asserted-by":"crossref","first-page":"4187","DOI":"10.1128\/AEM.68.9.4187-4193.2002","article-title":"Tissue localization of the endosymbiotic bacterium \u201cCandidatus Blochmannia floridanus\u201d in adults and larvae of the carpenter ant Camponotus floridanus","volume":"68","author":"Sauer","year":"2002","journal-title":"Appl Environ Microbiol"},{"key":"10.1016\/j.cois.2026.101633_bib10","series-title":"Endosymbiosis of Animals with Plant Microorganisms","author":"Buchner","year":"1965"},{"key":"10.1016\/j.cois.2026.101633_bib11","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1146\/annurev.micro.59.030804.121041","article-title":"Biology of bacteriocyte-associated endosymbionts of plant sap-sucking insects","volume":"59","author":"Baumann","year":"2005","journal-title":"Annu Rev Microbiol"},{"key":"10.1016\/j.cois.2026.101633_bib12","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.tim.2017.02.014","article-title":"Symbiont acquisition and replacement as a source of ecological innovation","volume":"25","author":"Sudakaran","year":"2017","journal-title":"Trends Microbiol"},{"key":"10.1016\/j.cois.2026.101633_bib13","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2023.1248654","article-title":"Symbiotic organs in insects: development, metabolism, and physiological regulation","volume":"14","author":"Calevro","year":"2023","journal-title":"Front Physiol"},{"key":"10.1016\/j.cois.2026.101633_bib14","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/j.ibmb.2011.03.002","article-title":"Immune response of the ant Camponotus floridanus against pathogens and its obligate mutualistic endosymbiont","volume":"41","author":"Ratzka","year":"2011","journal-title":"Insect Biochem Mol Biol"},{"key":"10.1016\/j.cois.2026.101633_bib15","doi-asserted-by":"crossref","DOI":"10.1186\/s40168-022-01334-8","article-title":"Efficient compartmentalization in insect bacteriomes protects symbiotic bacteria from host immune system","volume":"10","author":"Ferrarini","year":"2022","journal-title":"Microbiome"},{"key":"10.1016\/j.cois.2026.101633_bib16","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1126\/science.1209728","article-title":"Antimicrobial peptides keep insect endosymbionts under control","volume":"334","author":"Login","year":"2011","journal-title":"Science"},{"key":"10.1016\/j.cois.2026.101633_bib17","doi-asserted-by":"crossref","DOI":"10.1038\/srep19967","article-title":"Direct flow cytometry measurements reveal a fine-tuning of symbiotic cell dynamics according to the host developmental needs in aphid symbiosis","volume":"6","author":"Simonet","year":"2016","journal-title":"Sci Rep"},{"key":"10.1016\/j.cois.2026.101633_bib18","article-title":"Autophagy regulates whitefly-symbiont metabolic interactions","volume":"88","author":"Wang","year":"2022","journal-title":"Appl Environ Microbiol"},{"key":"10.1016\/j.cois.2026.101633_bib19","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.cois.2014.08.007","article-title":"Molecular dissection of nutrient exchange at the insect-microbial interface","volume":"4","author":"Douglas","year":"2014","journal-title":"Curr Opin Insect Sci"},{"key":"10.1016\/j.cois.2026.101633_bib20","doi-asserted-by":"crossref","first-page":"9376","DOI":"10.1073\/pnas.1503371112","article-title":"Ultrabithorax is essential for bacteriocyte development","volume":"112","author":"Matsuura","year":"2015","journal-title":"Proc Natl Acad Sci"},{"key":"10.1016\/j.cois.2026.101633_bib21","series-title":"Oocytes: Maternal Information and Functions","first-page":"43","article-title":"Transovarial transmission of symbionts in insects","author":"Szklarzewicz","year":"2017"},{"key":"10.1016\/j.cois.2026.101633_sbref22","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1146\/annurev-ento-010323-124159","article-title":"Insect bacteriocytes: adaptation, development, and evolution","volume":"69","author":"Luan","year":"2024","journal-title":"Annu Rev Entomol"},{"key":"10.1016\/j.cois.2026.101633_bib23","first-page":"1","article-title":"Ueber das regalm\u00e4ssige Vorkommen von bakterien\u00e4hn-lichen Gebilden in den Geweben und Eiern verschiedener Insecten","volume":"6","author":"Blochmann","year":"1887","journal-title":"Zeit F Biol"},{"key":"10.1016\/j.cois.2026.101633_bib24","doi-asserted-by":"crossref","DOI":"10.1098\/rstb.2024.0386","article-title":"Symbiotic organs in insects: diversity, functional implications, and terminology","volume":"381","author":"Ba\u00f1os-Quintana","year":"2026","journal-title":"Philos Trans R Soc B"},{"key":"10.1016\/j.cois.2026.101633_bib25","doi-asserted-by":"crossref","first-page":"2923","DOI":"10.1038\/s41396-020-0717-0","article-title":"Intracellular symbionts drive sex ratio in the whitefly by facilitating fertilization and provisioning of B vitamins","volume":"14","author":"Wang","year":"2020","journal-title":"ISME J"},{"key":"10.1016\/j.cois.2026.101633_bib26","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1111\/j.1469-185X.1989.tb00682.x","article-title":"Mycetocyte symbiosis in insects","volume":"64","author":"Douglas","year":"1989","journal-title":"Biol Rev"},{"key":"10.1016\/j.cois.2026.101633_bib27","doi-asserted-by":"crossref","DOI":"10.1186\/s40168-017-0397-9","article-title":"An IMD-like pathway mediates both endosymbiont control and host immunity in the cereal weevil Sitophilus spp.","volume":"6","author":"Maire","year":"2018","journal-title":"Microbiome"},{"key":"10.1016\/j.cois.2026.101633_bib28","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.0040188","article-title":"Metabolic complementarity and genomics of the dual bacterial symbiosis of sharpshooters","volume":"4","author":"Wu","year":"2006","journal-title":"PLoS Biol"},{"key":"10.1016\/j.cois.2026.101633_bib29","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1038\/35024074","article-title":"Genome sequence of the endocellular bacterial symbiont of aphids Buchnera sp. APS","volume":"407","author":"Shigenobu","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.cois.2026.101633_bib30","doi-asserted-by":"crossref","DOI":"10.1186\/1471-2180-10-142","article-title":"Co-infection and localization of secondary symbionts in two whitefly species","volume":"10","author":"Skaljac","year":"2010","journal-title":"BMC Microbiol"},{"key":"10.1016\/j.cois.2026.101633_bib31","doi-asserted-by":"crossref","first-page":"2748","DOI":"10.1128\/AEM.66.7.2748-2758.2000","article-title":"The secondary endosymbiotic bacterium of the pea aphid Acyrthosiphon pisum (Insecta: Homoptera)","volume":"66","author":"Fukatsu","year":"2000","journal-title":"Appl Environ Microbiol"},{"key":"10.1016\/j.cois.2026.101633_bib32","doi-asserted-by":"crossref","DOI":"10.1128\/spectrum.00457-22","article-title":"Compartmentalized into bacteriocytes but highly invasive: the puzzling case of the co-obligate symbiont Serratia symbiotica in the aphid Periphyllus lyropictus","volume":"10","author":"Renoz","year":"2022","journal-title":"Microbiol Spectr"},{"key":"10.1016\/j.cois.2026.101633_bib33","first-page":"3073","article-title":"Genome-wide transcriptional dynamics in the companion bacterial symbionts of the glassy-winged sharpshooter (Cicadellidae: Homalodisca vitripennis) reveal differential gene expression in bacteria occupying multiple host organs","volume":"7","author":"Bennett","year":"2017","journal-title":"G3 Genes"},{"key":"10.1016\/j.cois.2026.101633_bib34","doi-asserted-by":"crossref","first-page":"E1230","DOI":"10.1073\/pnas.1119212109","article-title":"Cellular mechanism for selective vertical transmission of an obligate insect symbiont at the bacteriocyte\u2013embryo interface","volume":"109","author":"Koga","year":"2012","journal-title":"Proc Natl Acad Sci"},{"key":"10.1016\/j.cois.2026.101633_bib35","doi-asserted-by":"crossref","DOI":"10.1186\/s40851-025-00257-0","article-title":"Cockroach bacteriocytes migrate into the ovaries for vertical transmission of the bacterial endosymbiont Blattabacterium","volume":"12","author":"Noda","year":"2026","journal-title":"Zool Lett"},{"key":"10.1016\/j.cois.2026.101633_bib36","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.cub.2017.12.041","article-title":"Maternal inheritance of a single somatic animal cell displayed by the bacteriocyte in the whitefly Bemisia tabaci","volume":"28","author":"Luan","year":"2018","journal-title":"Curr Biol"},{"key":"10.1016\/j.cois.2026.101633_bib37","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1038\/s41586-020-2653-6","article-title":"Origin and elaboration of a major evolutionary transition in individuality","volume":"585","author":"Rafiqi","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.cois.2026.101633_bib38","doi-asserted-by":"crossref","DOI":"10.1186\/s40168-023-01714-8","article-title":"Coordination of host and endosymbiont gene expression governs endosymbiont growth and elimination in the cereal weevil Sitophilus spp.","volume":"11","author":"Ferrarini","year":"2023","journal-title":"Microbiome"},{"key":"10.1016\/j.cois.2026.101633_bib39","article-title":"The boom and bust of the aphid\u2019s essential amino acid metabolism across nymphal development","volume":"11","author":"Pers","year":"2021","journal-title":"G3 Genes"},{"key":"10.1016\/j.cois.2026.101633_bib40","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1242\/dev.122.3.937","article-title":"The Drosophila stonewall gene encodes a putative transcription factor essential for germ cell development","volume":"122","author":"Clark","year":"1996","journal-title":"Development"},{"key":"10.1016\/j.cois.2026.101633_bib41","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.110613","article-title":"Bacteriocyte development is sexually differentiated in Bemisia tabaci","volume":"38","author":"Li","year":"2022","journal-title":"Cell Rep"},{"key":"10.1016\/j.cois.2026.101633_bib42","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2018.01498","article-title":"Bacteriocyte reprogramming to cope with nutritional stress in a phloem sap feeding hemipteran, the pea aphid Acyrthosiphon pisum","volume":"9","author":"Colella","year":"2018","journal-title":"Front Physiol"},{"key":"10.1016\/j.cois.2026.101633_sbref43","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1011864","article-title":"Expanding the fly eye gene regulatory network: from Drosophila to the hoverfly Episyrphus balteatus","volume":"22","author":"Navarro","year":"2026","journal-title":"PLoS Genet"},{"key":"10.1016\/j.cois.2026.101633_sbref44","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1038\/s41576-026-00939-1","article-title":"Gene regulatory networks: from correlative models to causal explanations","volume":"27","author":"Maizels","year":"2026","journal-title":"Nat Rev Genet"},{"key":"10.1016\/j.cois.2026.101633_bib45","series-title":"Gene Regulatory Networks: Methods and Protocols","first-page":"1","article-title":"Gene regulatory network inference: an introductory survey","author":"Huynh-Thu","year":"2019"},{"key":"10.1016\/j.cois.2026.101633_bib46","series-title":"Computational Methods in Systems Biology","first-page":"258","article-title":"Decoding gene regulation in Alzheimer\u2019s disease with transfer learning and explainable machine learning","author":"Peignier","year":"2026"},{"key":"10.1016\/j.cois.2026.101633_bib47","doi-asserted-by":"crossref","DOI":"10.1186\/s40537-016-0043-6","article-title":"A survey of transfer learning","volume":"3","author":"Weiss","year":"2016","journal-title":"J Big Data"},{"key":"10.1016\/j.cois.2026.101633_bib48","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1038\/ng2049","article-title":"Using FlyAtlas to identify better Drosophila melanogaster models of human disease","volume":"39","author":"Chintapalli","year":"2007","journal-title":"Nat Genet"},{"key":"10.1016\/j.cois.2026.101633_bib49","doi-asserted-by":"crossref","DOI":"10.1126\/science.abk2432","article-title":"Fly Cell Atlas: a single-nucleus transcriptomic atlas of the adult fruit fly","volume":"375","author":"Li","year":"2022","journal-title":"Science"},{"key":"10.1016\/j.cois.2026.101633_bib50","doi-asserted-by":"crossref","first-page":"1334","DOI":"10.1101\/gr.127191.111","article-title":"Predictive regulatory models in Drosophila melanogaster by integrative inference of transcriptional networks","volume":"22","author":"Marbach","year":"2012","journal-title":"Genome Res"},{"key":"10.1016\/j.cois.2026.101633_bib51","doi-asserted-by":"crossref","first-page":"2290","DOI":"10.1016\/j.celrep.2014.11.038","article-title":"Mapping gene regulatory networks in Drosophila eye development by large-scale transcriptome perturbations and motif inference","volume":"9","author":"Potier","year":"2014","journal-title":"Cell Rep"},{"key":"10.1016\/j.cois.2026.101633_bib52","article-title":"Reprogramming of regulatory network using expression uncovers sex-specific gene regulation in Drosophila","volume":"9","author":"Wang","year":"2018","journal-title":"Nat Commun"},{"key":"10.1016\/j.cois.2026.101633_sbref53","article-title":"Evolution of gene regulatory networks in insects","volume":"69","author":"Karasawa","year":"2025","journal-title":"Curr Opin Insect Sci"},{"key":"10.1016\/j.cois.2026.101633_sbref54","first-page":"1","article-title":"Gut microbiota shape gene regulatory networks to direct intestinal stem cell differentiation trajectories in Apis mellifera","volume":"0","author":"Liu","year":"2025","journal-title":"Insect Sci"},{"key":"10.1016\/j.cois.2026.101633_bib55","doi-asserted-by":"crossref","DOI":"10.1098\/rstb.2019.0603","article-title":"Housing microbial symbionts: evolutionary origins and diversification of symbiotic organs in animals","volume":"375","author":"Douglas","year":"2020","journal-title":"Philos Trans R Soc B Biol Sci"},{"key":"10.1016\/j.cois.2026.101633_bib56","doi-asserted-by":"crossref","first-page":"10169","DOI":"10.1073\/pnas.1421388112","article-title":"Heritable symbiosis: the advantages and perils of an evolutionary rabbit hole","volume":"112","author":"Bennett","year":"2015","journal-title":"Proc Natl Acad Sci"},{"key":"10.1016\/j.cois.2026.101633_bib57","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-026-69238-x","article-title":"Convergent extreme reductive evolution in ancient planthopper symbioses","volume":"17","author":"Michalik","year":"2026","journal-title":"Nat Commun"},{"key":"10.1016\/j.cois.2026.101633_sbref58","article-title":"The spatial cell biology of host control in bacteriocyte-associated symbioses","volume":"77","author":"Dial","year":"2026","journal-title":"Curr Opin Insect Sci"},{"key":"10.1016\/j.cois.2026.101633_bib59","doi-asserted-by":"crossref","first-page":"3302","DOI":"10.1128\/AEM.71.6.3302-3310.2005","article-title":"Evolutionary relationships of three new species of enterobacteriaceae living as symbionts of aphids and other insects","volume":"71","author":"Moran","year":"2005","journal-title":"Appl Environ Microbiol"},{"key":"10.1016\/j.cois.2026.101633_bib60","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1093\/bioinformatics\/btl682","article-title":"AphidBase: a database for aphid genomic resources","volume":"23","author":"Gauthier","year":"2007","journal-title":"Bioinformatics"},{"key":"10.1016\/j.cois.2026.101633_bib61","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1111\/j.1365-2583.2009.00930.x","article-title":"AphidBase: a centralized bioinformatic resource for annotation of the pea aphid genome","volume":"19","author":"Legeai","year":"2010","journal-title":"Insect Mol Biol"},{"key":"10.1016\/j.cois.2026.101633_bib62","article-title":"AphidCyc, une collection de bases de donn\u00e9es m\u00e9taboliques d\u00e9di\u00e9e \u00e0 l\u2019\u00e9tude et la comparaison du m\u00e9tabolisme chez les pucerons","volume":"2018","author":"Baa-Puyoulet","year":"2018"},{"key":"10.1016\/j.cois.2026.101633_bib63","series-title":"JOBIM 2015 - Journ\u00e9es Ouvertes Biologie Informatique Math\u00e9matiques","article-title":"From SymbAphidBase to SymbAphidCyc: two companion databases to study and compare aphid symbionts from genomes to metabolic pathways","author":"Baa-Puyoulet","year":"2015"},{"key":"10.1016\/j.cois.2026.101633_bib64","doi-asserted-by":"crossref","DOI":"10.1093\/database\/baw081","article-title":"ArthropodaCyc: a CycADS powered collection of BioCyc databases to analyse and compare metabolism of arthropods","volume":"2016","author":"Baa-Puyoulet","year":"2016","journal-title":"Database"},{"key":"10.1016\/j.cois.2026.101633_sbref65","doi-asserted-by":"crossref","DOI":"10.1128\/msystems.00140-25","article-title":"ArtSymbioCyc, a metabolic network database collection dedicated to arthropod symbioses: a case study, the tripartite cooperation in Sipha maydis","volume":"10","author":"Baa-Puyoulet","year":"2025","journal-title":"mSystems"},{"key":"10.1016\/j.cois.2026.101633_bib66","doi-asserted-by":"crossref","first-page":"E1819","DOI":"10.1073\/pnas.1720237115","article-title":"Bacteriocyte cell death in the pea aphid\/Buchnera symbiotic system","volume":"115","author":"Simonet","year":"2018","journal-title":"Proc Natl Acad Sci"},{"key":"10.1016\/j.cois.2026.101633_bib67","doi-asserted-by":"crossref","first-page":"32545","DOI":"10.1073\/pnas.2013847117","article-title":"Evolutionary novelty in the apoptotic pathway of aphids","volume":"117","author":"Ribeiro Lopes","year":"2020","journal-title":"Proc Natl Acad Sci"},{"key":"10.1016\/j.cois.2026.101633_bib68","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2022.982920","article-title":"Bacteriocyte plasticity in pea aphids facing amino acid stress or starvation during development","volume":"13","author":"Ribeiro Lopes","year":"2022","journal-title":"Front Physiol"},{"key":"10.1016\/j.cois.2026.101633_bib69","doi-asserted-by":"crossref","DOI":"10.1093\/molbev\/msag078","article-title":"Evolutionary trajectories, early diversification, and species-specific amplification of the metazoan inhibitor of apoptosis (IAP) repertoire","volume":"43","author":"Ribeiro Lopes","year":"2026","journal-title":"Mol Biol Evol"},{"key":"10.1016\/j.cois.2026.101633_sbref70","doi-asserted-by":"crossref","DOI":"10.1111\/ede.70021","article-title":"Analysis of duplication and potential functional divergence of wing gene network components in pea aphids","volume":"27","author":"Saleh Ziabari","year":"2025","journal-title":"Evol Dev"},{"key":"10.1016\/j.cois.2026.101633_bib71","series-title":"Gene Regulatory Networks: Methods and Protocols","first-page":"1","article-title":"Gene regulatory network inference: an introductory survey","author":"Huynh-Thu","year":"2019"},{"key":"10.1016\/j.cois.2026.101633_bib72","article-title":"Genome sequence of the pea aphid Acyrthosiphon pisum","volume":"8","author":"IAGC","year":"2010","journal-title":"PLoS Biol"},{"key":"10.1016\/j.cois.2026.101633_bib73","doi-asserted-by":"crossref","first-page":"2143","DOI":"10.1093\/molbev\/msz138","article-title":"Gene family evolution in the pea aphid based on chromosome-level genome assembly","volume":"36","author":"Li","year":"2019","journal-title":"Mol Biol Evol"},{"key":"10.1016\/j.cois.2026.101633_sbref74","doi-asserted-by":"crossref","DOI":"10.1016\/j.ibmb.2024.104217","article-title":"Annotation of transcription factors, chromatin-associated factors, and basal transcription machinery in the pea aphid, Acyrthosiphon pisum, and development of the ATFdb database, a resource for studies of transcriptional regulation","volume":"177","author":"Parisot","year":"2025","journal-title":"Insect Biochem Mol Biol"},{"key":"10.1016\/j.cois.2026.101633_bib75","doi-asserted-by":"crossref","first-page":"8950","DOI":"10.1073\/pnas.1900917116","article-title":"Exaggeration and cooption of innate immunity for social defense","volume":"116","author":"Kutsukake","year":"2019","journal-title":"Proc Natl Acad Sci"},{"key":"10.1016\/j.cois.2026.101633_bib76","doi-asserted-by":"crossref","first-page":"1554","DOI":"10.1093\/gbe\/evy097","article-title":"Fast evolution and lineage-specific gene family expansions of aphid salivary effectors driven by interactions with host-plants","volume":"10","author":"Boulain","year":"2018","journal-title":"Genome Biol Evol"},{"key":"10.1016\/j.cois.2026.101633_bib77","doi-asserted-by":"crossref","DOI":"10.1093\/gbe\/evac069","article-title":"Gene structure-based homology search identifies highly divergent putative effector gene family","volume":"14","author":"Stern","year":"2022","journal-title":"Genome Biol Evol"},{"key":"10.1016\/j.cois.2026.101633_bib78","doi-asserted-by":"crossref","first-page":"2113","DOI":"10.1073\/pnas.1916748117","article-title":"Coordination of host and symbiont gene expression reveals a metabolic tug-of-war between aphids and Buchnera","volume":"117","author":"Smith","year":"2020","journal-title":"Proc Natl Acad Sci"},{"key":"10.1016\/j.cois.2026.101633_bib79","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.ibmb.2014.05.005","article-title":"New insight into the RNA interference response against cathepsin-L gene in the pea aphid, Acyrthosiphon pisum: molting or gut phenotypes specifically induced by injection or feeding treatments","volume":"51","author":"Sapountzis","year":"2014","journal-title":"Insect Biochem Mol Biol"},{"key":"10.1016\/j.cois.2026.101633_bib80","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.ibmb.2019.04.016","article-title":"An integrated protocol for targeted mutagenesis with CRISPR-Cas9 system in the pea aphid","volume":"110","author":"Le Trionnaire","year":"2019","journal-title":"Insect Biochem Mol Biol"},{"key":"10.1016\/j.cois.2026.101633_othref0005","doi-asserted-by":"crossref","unstructured":"Liu X., Brisson J.A.: A Chromatin Accessibility Map of Pea Aphid Brain and Embryo Identifies Tissue-specific Regulatory Elements; 2026, doi:10.64898\/2026.05.14.725175, https:\/\/doi.org\/10.64898\/2026.05.14.725175.","DOI":"10.64898\/2026.05.14.725175"},{"key":"10.1016\/j.cois.2026.101633_bib82","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-023-32291-3","article-title":"Comparative transcriptomics of aphid species that diverged > 22 MYA reveals genes that are important for the maintenance of their symbiosis","volume":"13","author":"Argandona","year":"2023","journal-title":"Sci Rep"}],"container-title":["Current Opinion in Insect Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2214574526001495?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2214574526001495?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T02:02:39Z","timestamp":1793844159000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2214574526001495"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2027,2]]},"references-count":82,"alternative-id":["S2214574526001495"],"URL":"https:\/\/doi.org\/10.1016\/j.cois.2026.101633","relation":{},"ISSN":["2214-5745"],"issn-type":[{"value":"2214-5745","type":"print"}],"subject":[],"published":{"date-parts":[[2027,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Gene regulatory network reconstruction to decipher the molecular mechanisms governing bacteriocyte-based symbioses","name":"articletitle","label":"Article Title"},{"value":"Current Opinion in Insect Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cois.2026.101633","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"101633"}}