{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T20:12:54Z","timestamp":1790539974441,"version":"4.1.0"},"reference-count":25,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2012,3,1]],"date-time":"2012-03-01T00:00:00Z","timestamp":1330560000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,3,1]],"date-time":"2012-03-01T00:00:00Z","timestamp":1330560000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2012,3,1]],"date-time":"2012-03-01T00:00:00Z","timestamp":1330560000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2012,3,1]],"date-time":"2012-03-01T00:00:00Z","timestamp":1330560000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2012,3,1]],"date-time":"2012-03-01T00:00:00Z","timestamp":1330560000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2012,3,1]],"date-time":"2012-03-01T00:00:00Z","timestamp":1330560000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2012,3,1]],"date-time":"2012-03-01T00:00:00Z","timestamp":1330560000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001868","name":"National Science Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001868","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Colloids and Surfaces B: Biointerfaces"],"published-print":{"date-parts":[[2012,3]]},"DOI":"10.1016\/j.colsurfb.2011.11.007","type":"journal-article","created":{"date-parts":[[2011,11,11]],"date-time":"2011-11-11T23:43:27Z","timestamp":1321055007000},"page":"242-249","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":59,"special_numbering":"C","title":["Transcytosis of CRM197-grafted polybutylcyanoacrylate nanoparticles for delivering zidovudine across human brain-microvascular endothelial cells"],"prefix":"10.1016","volume":"91","author":[{"given":"Yung-Chih","family":"Kuo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiu-Yen","family":"Chung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.colsurfb.2011.11.007_bib0005","first-page":"39","article-title":"Structural and functional aspects of the blood\u2013brain barrier","volume":"61","author":"Begley","year":"2003","journal-title":"Prog. Drug Res."},{"key":"10.1016\/j.colsurfb.2011.11.007_bib0010","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/1357-4310(96)88720-X","article-title":"Transporting therapeutics across the blood\u2013brain barrier","volume":"2","author":"Abbott","year":"1996","journal-title":"Mol. Med. Today"},{"key":"10.1016\/j.colsurfb.2011.11.007_bib0015","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/S1359-0294(00)00046-7","article-title":"Physicochemical aspects of drug delivery and release from polymer-based colloids","volume":"5","author":"Yang","year":"2000","journal-title":"Curr. Opin. Colloid Interface Sci."},{"key":"10.1016\/j.colsurfb.2011.11.007_bib0020","first-page":"627","article-title":"Transport of zidovudine- and lamivudine-loaded polybutylcyanoacrylate and methylmethacrylate\u2013sulfopropylmethacrylate nanoparticles across the in vitro blood\u2013brain barrier: characteristics of the drug-delivery system","volume":"36","author":"Kuo","year":"2005","journal-title":"J. Chin. Inst. Chem. Eng."},{"key":"10.1016\/j.colsurfb.2011.11.007_bib0025","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.ijpharm.2007.03.012","article-title":"Transport of stavudine, delavirdine, and saquinavir across the blood\u2013brain barrier by polybutylcyanoacrylate, methylmethacrylate\u2013sulfopropylmethacrylate, and solid lipid nanoparticles","volume":"340","author":"Kuo","year":"2007","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.colsurfb.2011.11.007_bib0030","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/0168-3659(96)01342-9","article-title":"Co-polymerised peptide particles (CPP) I: synthesis, characterization and in vitro studies on a novel oral nanoparticulate delivery system","volume":"41","author":"Hillery","year":"1996","journal-title":"J. Control. Release"},{"key":"10.1016\/j.colsurfb.2011.11.007_bib0035","series-title":"Polymeric Nanoparticles and Microspheres","first-page":"27","article-title":"Biodegradable polymeric nanoparticles as drug carrier for antitumor agents","author":"Courveur","year":"1986"},{"key":"10.1016\/j.colsurfb.2011.11.007_bib0040","first-page":"529","article-title":"HIV resistance and the effectiveness of combination antiretroviral treatment","volume":"1","author":"Mugavero","year":"2004","journal-title":"Drug Discov. Today"},{"key":"10.1016\/j.colsurfb.2011.11.007_bib0045","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1056\/NEJM198707233170401","article-title":"The efficacy of azidothymidine (AZT) in the treatment of patients with AIDS and AIDS-related complex. A double-blind, placebo-controlled trial","volume":"317","author":"Fischl","year":"1987","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.colsurfb.2011.11.007_bib0050","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1007\/s00262-004-0546-4","article-title":"CRM197 (nontoxic diphtheria toxin): effects on advanced cancer patients","volume":"53","author":"Buzzi","year":"2004","journal-title":"Cancer Immunol. Immunother."},{"key":"10.1016\/j.colsurfb.2011.11.007_bib0055","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1093\/jb\/mvm116","article-title":"Diphtheria toxin mutant CRM197 possesses weak EF2-ADP-ribosyl activity that potentiates its anti-tumorigenic activity","volume":"142","author":"Kageyama","year":"2007","journal-title":"J. Biochem."},{"key":"10.1016\/j.colsurfb.2011.11.007_bib0060","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1542\/peds.101.4.604","article-title":"Safety and immunogenicity of heptavalent pneumococcal vaccine conjugated to CRM197 in United States infants","volume":"101","author":"Rennels","year":"1998","journal-title":"Pediatrics"},{"key":"10.1016\/j.colsurfb.2011.11.007_bib0065","doi-asserted-by":"crossref","first-page":"4178","DOI":"10.1016\/j.vaccine.2008.05.072","article-title":"Safety and immunogenicity of CRM197-conjugated pneumococcal\u2013meningococcal C combination vaccine (9vPnC\u2013MnCC) whether given in two or three primary doses","volume":"26","author":"Sigurdardottir","year":"2008","journal-title":"Vaccine"},{"key":"10.1016\/j.colsurfb.2011.11.007_bib0070","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.ijpharm.2004.11.025","article-title":"Loading efficiency of stavudine on polybutylcyanoacrylate and methylmethacrylate\u2013sulfopropylmethacrylate copolymer nanoparticles","volume":"290","author":"Kuo","year":"2005","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.colsurfb.2011.11.007_bib0075","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/j.colsurfb.2011.07.053","article-title":"Expression of ornithine decarboxylase during the transport of saquinavir across the blood\u2013brain barrier using composite polymeric nanocarriers under an electromagnetic field","volume":"88","author":"Kuo","year":"2011","journal-title":"Colloids Surf. B"},{"key":"10.1016\/j.colsurfb.2011.11.007_bib0080","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.ijpharm.2006.07.044","article-title":"Effect of nanoparticulate polybutylcyanoacrylate and methylmethacrylate\u2013sulfopropylmethacrylate on the permeability of zidovudine and lamivudine across the in vitro blood\u2013brain barrier","volume":"327","author":"Kuo","year":"2006","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.colsurfb.2011.11.007_bib0085","doi-asserted-by":"crossref","first-page":"e60","DOI":"10.1016\/j.jconrel.2006.09.050","article-title":"A novel opportunity for targeted drug delivery to the brain","volume":"116","author":"Gaillard","year":"2006","journal-title":"J. Control. Release"},{"key":"10.1016\/j.colsurfb.2011.11.007_bib0090","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/S0006-8993(97)01325-5","article-title":"Expression of heparin-binding epidermal growth factor-like growth factor in rat brain","volume":"784","author":"Hayase","year":"1998","journal-title":"Brain Res."},{"key":"10.1016\/j.colsurfb.2011.11.007_bib0095","first-page":"F179","article-title":"Heparin-binding EGF-like growth factor","volume":"1333","author":"Raab","year":"1997","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.colsurfb.2011.11.007_bib0100","doi-asserted-by":"crossref","first-page":"6866","DOI":"10.1016\/S0021-9258(17)38000-6","article-title":"Demonstration of diphtheria toxin receptors on surface membranes from both toxin-sensitive and toxin-resistant species","volume":"253","author":"Chang","year":"1978","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.colsurfb.2011.11.007_bib0105","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1517\/17425247.2.2.299","article-title":"Targeted delivery across the blood\u2013brain barrier","volume":"2","author":"Gaillard","year":"2005","journal-title":"Exp. Opin. Drug Deliv."},{"key":"10.1016\/j.colsurfb.2011.11.007_bib0110","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.ics.2005.02.022","article-title":"Diphtheria toxin receptor-targeted brain drug delivery","volume":"1277","author":"Gaillard","year":"2005","journal-title":"Int. Congress Ser."},{"key":"10.1016\/j.colsurfb.2011.11.007_bib0115","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1007\/s004010050901","article-title":"Heparinbinding epidermal growth factor-like growth factor stimulates mitogenic signaling and is highly expressed in human malignant gliomas","volume":"96","author":"Mishima","year":"1998","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.colsurfb.2011.11.007_bib0120","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/S0006-8993(99)01319-0","article-title":"Heparin-binding epidermal growth factor-like growth factor mRNA expression in neonatal rat brain with hypoxic\/ischemic injury","volume":"827","author":"Tanaka","year":"1999","journal-title":"Brain Res."},{"key":"10.1016\/j.colsurfb.2011.11.007_bib0125","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1007\/s10571-010-9496-x","article-title":"Diphtheria toxin mutant CRM197-mediated transcytosis across blood\u2013brain barrier in vitro","volume":"30","author":"Wang","year":"2010","journal-title":"Cell. Mol. Neurobiol."}],"container-title":["Colloids and Surfaces B: Biointerfaces"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0927776511006527?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0927776511006527?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T10:24:16Z","timestamp":1760523856000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0927776511006527"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,3]]},"references-count":25,"alternative-id":["S0927776511006527"],"URL":"https:\/\/doi.org\/10.1016\/j.colsurfb.2011.11.007","relation":{},"ISSN":["0927-7765"],"issn-type":[{"value":"0927-7765","type":"print"}],"subject":[],"published":{"date-parts":[[2012,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Transcytosis of CRM197-grafted polybutylcyanoacrylate nanoparticles for delivering zidovudine across human brain-microvascular endothelial cells","name":"articletitle","label":"Article Title"},{"value":"Colloids and Surfaces B: Biointerfaces","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.colsurfb.2011.11.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2011 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}