{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T03:28:13Z","timestamp":1791170893849,"version":"4.1.0"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2014,4,1]],"date-time":"2014-04-01T00:00:00Z","timestamp":1396310400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,4,1]],"date-time":"2014-04-01T00:00:00Z","timestamp":1396310400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100004263","name":"Funda\u00c3\u00a7\u00c3\u00a3o de Amparo \u00c3\u00a0 Pesquisa do Estado do Rio Grande do Sul","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004263","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Colloids and Surfaces B: Biointerfaces"],"published-print":{"date-parts":[[2014,4]]},"DOI":"10.1016\/j.colsurfb.2014.01.011","type":"journal-article","created":{"date-parts":[[2014,1,19]],"date-time":"2014-01-19T12:30:52Z","timestamp":1390134652000},"page":"270-276","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":73,"special_numbering":"C","title":["Formulation and in vitro evaluation of coconut oil-core cationic nanocapsules intended for vaginal delivery of clotrimazole"],"prefix":"10.1016","volume":"116","author":[{"given":"Sara S.","family":"Santos","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Lorenzoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nath\u00e1li S.","family":"Pegoraro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura B.","family":"Denardi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sydney H.","family":"Alves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scheila R.","family":"Schaffazick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Let\u00edcia","family":"Cruz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.colsurfb.2014.01.011_bib0005","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.ijpharm.2009.10.018","volume":"385","author":"Mora-Huertas","year":"2010","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.colsurfb.2014.01.011_bib0010","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.biopha.2004.01.007","volume":"58","author":"Alonso","year":"2004","journal-title":"Biomed. Pharmacother"},{"key":"10.1016\/j.colsurfb.2014.01.011_bib0015","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.colsurfb.2009.09.001","volume":"75","author":"Kumari","year":"2010","journal-title":"Colloids Surf. B"},{"key":"10.1016\/j.colsurfb.2014.01.011_bib0020","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.3109\/03639049809108571","volume":"24","author":"Quintanar-Guerrero","year":"1998","journal-title":"Drug. Dev. Ind. Pharm"},{"key":"10.1016\/j.colsurfb.2014.01.011_bib0025","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1590\/S0100-40422003000500017","volume":"25","author":"Schaffazick","year":"2003","journal-title":"Quim Nova"},{"key":"10.1016\/j.colsurfb.2014.01.011_bib0030","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1615\/CritRevTherDrugCarrierSyst.v19.i2.10","volume":"19","author":"Couvreur","year":"2002","journal-title":"Crit. Rev Ther. Drug Carrier Syst."},{"key":"10.1016\/j.colsurfb.2014.01.011_bib0035","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.nano.2008.03.003","volume":"4","author":"Preetz","year":"2008","journal-title":"Nanomedicine"},{"key":"10.1016\/j.colsurfb.2014.01.011_bib0040","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.ijpharm.2006.06.022","volume":"325","author":"Limayem","year":"2006","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.colsurfb.2014.01.011_bib0045","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.colsurfb.2013.04.014","volume":"110","author":"Adamczak","year":"2013","journal-title":"Colloids Surf. B"},{"key":"10.1016\/j.colsurfb.2014.01.011_bib0050","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1590\/S0100-40422008000500038","volume":"31","author":"Friedrich","year":"2008","journal-title":"Quim Nova"},{"key":"10.1016\/j.colsurfb.2014.01.011_bib0055","first-page":"165","volume":"28","author":"Almeida","year":"2009","journal-title":"Lat. Am. J. Pharm."},{"key":"10.1016\/j.colsurfb.2014.01.011_bib0060","first-page":"1","author":"Contri","year":"2012","journal-title":"J. Exp. Nanosci."},{"key":"10.1016\/j.colsurfb.2014.01.011_bib0065","doi-asserted-by":"crossref","first-page":"5144","DOI":"10.3390\/molecules14125144","volume":"14","author":"Yong","year":"2009","journal-title":"Molecules"},{"key":"10.1016\/j.colsurfb.2014.01.011_bib0070","unstructured":"British Pharmacopeia, British Pharmacopeia Comission, vol. 1, Her Majesty Stationary Office, London, 2010."},{"key":"10.1016\/j.colsurfb.2014.01.011_bib0075","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1089\/jmf.2006.1209","volume":"10","author":"Ogbolu","year":"2007","journal-title":"J. Med. Food"},{"key":"10.1016\/j.colsurfb.2014.01.011_bib0080","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/S1684-1182(10)60069-2","volume":"43","author":"Agarwal","year":"2010","journal-title":"J. Microbiol. Immunol. Infect."},{"key":"10.1016\/j.colsurfb.2014.01.011_bib0085","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/S1995-7645(11)60078-3","volume":"4","author":"DebMandal","year":"2011","journal-title":"Asian Pac. J. Trop. Med."},{"key":"10.1016\/j.colsurfb.2014.01.011_bib0090","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.foodchem.2005.06.056","volume":"99","author":"Nevin","year":"2006","journal-title":"Food Chem."},{"key":"10.1016\/j.colsurfb.2014.01.011_bib0095","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1080\/09637480802549127","volume":"60","author":"Marina","year":"2009","journal-title":"Int. J. Food Sci. Nutr."},{"key":"10.1016\/j.colsurfb.2014.01.011_bib0100","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/S0925-5214(96)00032-4","volume":"9","author":"Guarte","year":"1996","journal-title":"Postharvest. Biol. Tec."},{"key":"10.1016\/j.colsurfb.2014.01.011_bib0105","doi-asserted-by":"crossref","unstructured":"U. Bazylinska, A. Lewinska, L. Lamch, K.A. Wilk, Colloids Surf. A: Physicochem. Eng. Aspects (2013), doi:10.1016\/j.colsurfa.2013.02.023.","DOI":"10.1016\/j.colsurfa.2013.02.023"},{"key":"10.1016\/j.colsurfb.2014.01.011_bib0110","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1007\/BF03218581","volume":"16","author":"Lee","year":"2008","journal-title":"Macromol. Res."},{"key":"10.1016\/j.colsurfb.2014.01.011_bib0115","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/j.jiec.2009.02.004","volume":"15","author":"Kang","year":"2009","journal-title":"J. Ind. Eng. Chem."},{"key":"10.1016\/j.colsurfb.2014.01.011_bib0120","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1080\/10717540490280697","volume":"11","author":"Fang","year":"2004","journal-title":"Drug Deliv."},{"key":"10.1016\/j.colsurfb.2014.01.011_bib0125","doi-asserted-by":"crossref","first-page":"429","DOI":"10.4028\/www.scientific.net\/AMR.506.429","volume":"506","author":"Piriyaprasarth","year":"2012","journal-title":"Adv. Mater. Res."},{"key":"10.1016\/j.colsurfb.2014.01.011_bib0130","first-page":"339","volume":"9","author":"Sudeendra","year":"2010","journal-title":"Trop. J. Pharm. Res."},{"key":"10.1016\/j.colsurfb.2014.01.011_bib0135","first-page":"482","volume":"31","author":"Santos","year":"2012","journal-title":"Lat. Am. J. Pharm"},{"key":"10.1016\/j.colsurfb.2014.01.011_bib0140","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/0378-5173(83)90064-9","volume":"15","author":"Korsmeyer","year":"1983","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.colsurfb.2014.01.011_bib0145","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.ijpharm.2006.01.035","volume":"313","author":"Cruz","year":"2006","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.colsurfb.2014.01.011_bib0150","first-page":"110","volume":"60","author":"Peppas","year":"1985","journal-title":"Pharm. Acta Helv."},{"key":"10.1016\/j.colsurfb.2014.01.011_bib0155","unstructured":"Clinical and Laboratory Standards Institute (CLSI), Reference Method for Broth Dilution Antifungal Susceptibility Testing Yeasts, 3rd ed. Approved Standard M27-A3, Wayne, PA, 2008."},{"key":"10.1016\/j.colsurfb.2014.01.011_bib0160","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1128\/AAC.48.3.693-715.2004","volume":"48","author":"Johnson","year":"2004","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.colsurfb.2014.01.011_bib0165","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1080\/107175400455119","volume":"7","author":"Guterres","year":"2000","journal-title":"Drug Deliv."},{"key":"10.1016\/j.colsurfb.2014.01.011_bib0170","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1590\/S0103-50532006000300020","volume":"17","author":"Schaffazick","year":"2006","journal-title":"J. Braz. Chem. Soc."},{"key":"10.1016\/j.colsurfb.2014.01.011_bib0175","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.ijpharm.2005.05.027","volume":"301","author":"Pandey","year":"2005","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.colsurfb.2014.01.011_bib0180","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1517\/13543776.2012.714369","volume":"22","author":"Bassi","year":"2012","journal-title":"Expert Opin. Ther. Pat."},{"key":"10.1016\/j.colsurfb.2014.01.011_bib0185","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.ijpharm.2004.02.032","volume":"278","author":"Souto","year":"2004","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.colsurfb.2014.01.011_bib0190","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/S0378-5173(02)00356-3","volume":"246","author":"Perugini","year":"2002","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.colsurfb.2014.01.011_bib0195","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ijpharm.2007.12.035","volume":"352","author":"Ourique","year":"2008","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.colsurfb.2014.01.011_bib0200","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1007\/s11671-010-9683-1","volume":"5","author":"Almeida","year":"2010","journal-title":"Nanoscale Res. Lett."},{"key":"10.1016\/j.colsurfb.2014.01.011_bib0205","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1208\/s12249-009-9233-2","volume":"10","author":"Bachhav","year":"2009","journal-title":"AAPS Pharmscitech."},{"key":"10.1016\/j.colsurfb.2014.01.011_bib0210","unstructured":"R.C. Rowe, P.J., Sheskey, W.G., Cook, M.E. Fenton, Handbook of Pharmaceutical Excipients, 6rd edition, 2009."},{"key":"10.1016\/j.colsurfb.2014.01.011_bib0215","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1016\/j.msec.2012.12.040","volume":"3","author":"Santos","year":"2013","journal-title":"Mater. Sci. Eng. C"},{"key":"10.1016\/j.colsurfb.2014.01.011_bib0220","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.ijpharm.2007.07.041","volume":"349","author":"Dillen","year":"2008","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.colsurfb.2014.01.011_bib0225","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.nano.2007.03.003","volume":"3","author":"Esmaeili","year":"2007","journal-title":"Nanomed. Nanotech. Biol. Med."},{"key":"10.1016\/j.colsurfb.2014.01.011_bib0230","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.ijpharm.2007.10.009","volume":"352","author":"Peng","year":"2008","journal-title":"Int. J. Pharm."}],"container-title":["Colloids and Surfaces B: Biointerfaces"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0927776514000125?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0927776514000125?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T10:25:48Z","timestamp":1760523948000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0927776514000125"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,4]]},"references-count":46,"alternative-id":["S0927776514000125"],"URL":"https:\/\/doi.org\/10.1016\/j.colsurfb.2014.01.011","relation":{},"ISSN":["0927-7765"],"issn-type":[{"value":"0927-7765","type":"print"}],"subject":[],"published":{"date-parts":[[2014,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Formulation and in vitro evaluation of coconut oil-core cationic nanocapsules intended for vaginal delivery of clotrimazole","name":"articletitle","label":"Article Title"},{"value":"Colloids and Surfaces B: Biointerfaces","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.colsurfb.2014.01.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}