{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T07:46:53Z","timestamp":1789372013993,"version":"build-2803163510"},"reference-count":51,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2014,6,1]],"date-time":"2014-06-01T00:00:00Z","timestamp":1401580800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"INCT-Nanobiofar (CNPq\/MCT\/FAPEMIG)"},{"DOI":"10.13039\/501100003593","name":"CNPq","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004901","name":"FAPEMIG","doi-asserted-by":"crossref","award":["APQ 02348-10"],"award-info":[{"award-number":["APQ 02348-10"]}],"id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Colloids and Surfaces B: Biointerfaces"],"published-print":{"date-parts":[[2014,6]]},"DOI":"10.1016\/j.colsurfb.2014.01.028","type":"journal-article","created":{"date-parts":[[2014,4,19]],"date-time":"2014-04-19T15:45:59Z","timestamp":1397922359000},"page":"194-201","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":50,"special_numbering":"C","title":["Structural and thermodynamic characterization of doxycycline\/\u03b2-cyclodextrin supramolecular complex and its bacterial membrane interactions"],"prefix":"10.1016","volume":"118","author":[{"given":"Diego F.","family":"Su\u00e1rez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3185-803X","authenticated-orcid":false,"given":"Jessika","family":"Consuegra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivianne C.","family":"Trajano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e1vio M.L.","family":"Gontijo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro P.G.","family":"Guimar\u00e3es","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria E.","family":"Cort\u00e9s","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c2ngelo L.","family":"Denadai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rub\u00e9n D.","family":"Sinisterra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.colsurfb.2014.01.028_bib0005","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1111\/j.1600-0765.1999.tb02271.x","article-title":"Staphylococcus aureus-muoed inflammation and bone destruction in experimental models of septic arthritis","volume":"34","author":"Josefsson","year":"1999","journal-title":"J. Periodontal. Res."},{"key":"10.1016\/j.colsurfb.2014.01.028_bib0010","doi-asserted-by":"crossref","first-page":"2323","DOI":"10.1086\/420851","article-title":"Virulence potential of the Staphylococcal adhesin CNA in experimental arthritis is determined by its affinity for collagen","volume":"189","author":"Xu","year":"2004","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.colsurfb.2014.01.028_bib0015","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1111\/j.1365-2249.2005.02840.x","article-title":"The paradox of matrix metalloproteinases in infectious disease","volume":"142","author":"Elkington","year":"2005","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.colsurfb.2014.01.028_bib0020","doi-asserted-by":"crossref","first-page":"529","DOI":"10.2741\/1817","article-title":"Matrix metalloproteinases: role in arthritis","volume":"11","author":"Burrage","year":"2006","journal-title":"Front. Biosci."},{"key":"10.1016\/j.colsurfb.2014.01.028_bib0025","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1111\/j.1600-051X.1995.tb01767.x","article-title":"Tetracyclines in the management of periodontal-diseases. A review","volume":"22","author":"Seymour","year":"1995","journal-title":"J. Clin. Periodontol."},{"key":"10.1016\/j.colsurfb.2014.01.028_bib0030","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1016\/j.bcp.2007.09.012","article-title":"A novel formulation of inhaled doxycycline reduces allergen-induced inflammation, hyperresponsiveness and remodeling by matrix metalloproteinases and cytokines modulation in a mouse model of asthma","volume":"75","author":"Gueders","year":"2008","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.colsurfb.2014.01.028_bib0035","doi-asserted-by":"crossref","first-page":"C539","DOI":"10.1152\/ajpcell.00047.2010","article-title":"Tetracyclines: a pleitropic family of compounds with promising therapeutic properties. Review of the literature","volume":"299","author":"Griffin","year":"2010","journal-title":"Am. J. Physiol.-Cell Physiol."},{"key":"10.1016\/j.colsurfb.2014.01.028_bib0040","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.archoralbio.2006.10.005","article-title":"Effect of therapeutic levels of doxycycline and minocycline in the proliferation and differentiation of human bone marrow osteoblastic cells","volume":"52","author":"Gomes","year":"2007","journal-title":"Arch. Oral Biol."},{"key":"10.1016\/j.colsurfb.2014.01.028_bib0045","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1128\/MMBR.65.2.232-260.2001","article-title":"Tetracycline antibiotics: mode of action, applications, molecular biology, and epidemiology of bacterial resistance","volume":"65","author":"Chopra","year":"2001","journal-title":"Microbiol Mol. Biol. Rev."},{"key":"10.1016\/j.colsurfb.2014.01.028_bib0050","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S1368-7646(03)00003-7","article-title":"Insights on antibiotic resistance of Staphylococcus aureus from its whole genome: genomic island SCC","volume":"6","author":"Ito","year":"2003","journal-title":"Drug Resist. Updat."},{"key":"10.1016\/j.colsurfb.2014.01.028_bib0055","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/S0040-6031(02)00238-1","article-title":"The interaction of rough and smooth form lipopolysaccharides with polymyxins as studied by titration calorimetry","volume":"394","author":"Brandenburg","year":"2002","journal-title":"Thermochim. Acta"},{"key":"10.1016\/j.colsurfb.2014.01.028_bib0060","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1002\/(SICI)1099-1352(199901\/02)12:1<3::AID-JMR441>3.0.CO;2-6","article-title":"Isothermal titration calorimetry and differential scanning calorimetry as complementary tools to investigate the energetics of biomolecular recognition","volume":"12","author":"Jelesarov","year":"1999","journal-title":"J. Mol. Recognit."},{"key":"10.1016\/j.colsurfb.2014.01.028_bib0065","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/j.drudis.2012.01.023","article-title":"How to conduct and interpret ITC experiments accurately for cyclodextrin-guest interactions","volume":"17","author":"Bouchemal","year":"2012","journal-title":"Drug Discov. Today"},{"key":"10.1016\/j.colsurfb.2014.01.028_bib0070","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1002\/jps.20047","article-title":"Self-association of cyclodextrins and cyclodextrin complexes","volume":"93","author":"Loftsson","year":"2004","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.colsurfb.2014.01.028_bib0075","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1038\/nrd1576","article-title":"Cyclodextrin-based pharmaceutics: past, present and future","volume":"3","author":"Davis","year":"2004","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.colsurfb.2014.01.028_bib0080","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1007\/s10847-008-9456-y","article-title":"Cyclodextrin based novel drug delivery systems","volume":"62","author":"Vyas","year":"2008","journal-title":"J. Incl. Phenom. Macro. Chemistry"},{"key":"10.1016\/j.colsurfb.2014.01.028_bib0085","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/j.rvsc.2007.07.003","article-title":"Pharmacokinetic study of an injectable long-acting parenteral formulation of doxycycline hyclate in calves","volume":"84","author":"Vargas-Estrada","year":"2008","journal-title":"Res. Vet. Sci."},{"key":"10.1016\/j.colsurfb.2014.01.028_bib0090","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.apsb.2011.10.004","article-title":"Doxycycline and hydroxypropyl-\u03b2-cyclodextrin complex in poloxamer thermal sensitive hydrogel for ophthalmic delivery","volume":"1","author":"He","year":"2011","journal-title":"Acta Pharma. Sin. B"},{"key":"10.1016\/j.colsurfb.2014.01.028_bib0095","series-title":"Advance User's Guide, Brucker. <940712>","author":"Werner","year":"1994"},{"key":"10.1016\/j.colsurfb.2014.01.028_bib0100","series-title":"One and Two Dimensional NMR Spectroscopy","author":"Rahman","year":"1989"},{"key":"10.1016\/j.colsurfb.2014.01.028_bib0105","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1590\/S0103-50532006000800021","article-title":"Three new complexes of platinum(II) with doxycycline, oxytetracycline and chlortetracycline and their antimicrobial activity","volume":"17","author":"Guerra","year":"2006","journal-title":"J. Braz. Chem. Soc."},{"key":"10.1016\/j.colsurfb.2014.01.028_bib0110","doi-asserted-by":"crossref","first-page":"1755","DOI":"10.1021\/cr970019t","article-title":"NMR studies of cyclodextrins and cyclodextrin complexes","volume":"98","author":"Schneider","year":"1998","journal-title":"Chem. Rev."},{"key":"10.1016\/j.colsurfb.2014.01.028_bib0115","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/j.colsurfb.2011.02.001","article-title":"Inhibition of Candida albicans CC biofilms formation in polystyrene plate surfaces by biosurfactant produced by Trichosporon montevideense CLOA72","volume":"84","author":"Monteiro","year":"2011","journal-title":"Colloids Surf. B- Biointerfaces"},{"key":"10.1016\/j.colsurfb.2014.01.028_bib0120","series-title":"Performance Standards for Antimicrobial Susceptibility Testing; Twenty-First Informational Supplement. CLSI document M100-S21.","author":"CLSI","year":"2011"},{"key":"10.1016\/j.colsurfb.2014.01.028_bib0125","series-title":"Z.N.S.U. Manual","year":"2004"},{"key":"10.1016\/j.colsurfb.2014.01.028_bib0130","doi-asserted-by":"crossref","first-page":"4067","DOI":"10.3390\/molecules15064067","article-title":"Pharmaceutical composition of valsartan: beta-cyclodextrin: physico-chemical characterization and anti-hypertensive evaluation","volume":"15","author":"Jensen","year":"2010","journal-title":"Molecules"},{"key":"10.1016\/j.colsurfb.2014.01.028_bib0135","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1515\/zna-2004-4-515","article-title":"Study of aqueous solution of sodiumdodecylsulfate and polyethyleneoxide 10000 by NMR NOESY","volume":"59","author":"de Alvarenga","year":"2004","journal-title":"Z. Naturforsch A"},{"key":"10.1016\/j.colsurfb.2014.01.028_bib0140","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.msec.2009.12.008","article-title":"New insights regarding the cyclodextrin\/AAS self-assembly: a molar ratio dependent system","volume":"30","author":"Denadai","year":"2010","journal-title":"Mater. Sci. Eng. C: Mater. Biol. Appl."},{"key":"10.1016\/j.colsurfb.2014.01.028_bib0145","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.msec.2011.10.025","article-title":"Interaction between bradykinin potentiating nonapeptide (BPP9a) and beta-cyclodextrin: a structural and thermodynamic study","volume":"32","author":"Lula","year":"2012","journal-title":"Mater. Sci. Eng. C: Mater. Biol. Appl."},{"key":"10.1016\/j.colsurfb.2014.01.028_bib0150","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1007\/s10847-005-5108-7","article-title":"Formation of cyclodextrin inclusion complexes with doxycyclin-hyclate: NMR investigation of their characterisation and stability","volume":"54","author":"Bakkour","year":"2006","journal-title":"J. Incl. Phenom. Macro Chemistry"},{"key":"10.1016\/j.colsurfb.2014.01.028_bib0155","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.ijpharm.2006.11.040","article-title":"Novel pharmaceutical composition of bradykinin potentiating penta peptide with beta-cyclodextrin: physical-chemical characterization and anti-hypertensive evaluation","volume":"336","author":"Denadai","year":"2007","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.colsurfb.2014.01.028_bib0160","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.ijpharm.2010.11.008","article-title":"Supramolecular interactions between losartan and hydroxypropyl-beta-CD: ESI mass-spectrometry, NMR techniques, phase solubility, isothermal titration calorimetry and anti-hypertensive studies","volume":"404","author":"de Paula","year":"2011","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.colsurfb.2014.01.028_bib0165","doi-asserted-by":"crossref","first-page":"8426","DOI":"10.1021\/ja801080v","article-title":"Supramolecular self-assembly of cyclodextrin and higher water soluble guest: thermodynamics and topological studies","volume":"130","author":"deSousa","year":"2008","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.colsurfb.2014.01.028_bib0170","doi-asserted-by":"crossref","first-page":"14859","DOI":"10.1021\/ja036166s","article-title":"On the value of c: can low affinity systems be studied by isothermal titration calorimetry?","volume":"125","author":"Turnbull","year":"2003","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.colsurfb.2014.01.028_bib0175","doi-asserted-by":"crossref","first-page":"283","DOI":"10.2165\/00063030-200620050-00004","article-title":"A supramolecular complex between proteinases and beta-cyclodextrin that preserves enzymatic activity: physicochemical characterization","volume":"20","author":"Denadai","year":"2006","journal-title":"BioDrugs"},{"key":"10.1016\/j.colsurfb.2014.01.028_bib0180","doi-asserted-by":"crossref","first-page":"1875","DOI":"10.1021\/cr970015o","article-title":"Complexation thermodynamics of cyclodextrins","volume":"98","author":"Rekharsky","year":"1998","journal-title":"Chem. Rev."},{"key":"10.1016\/j.colsurfb.2014.01.028_bib0185","doi-asserted-by":"crossref","first-page":"4119","DOI":"10.1128\/JCM.01981-08","article-title":"Characterization of vancomycin-heteroresistant Staphylococcus aureus from the metropolitan area of Detroit, Michigan, over a 22-year period (1986 to 2007) (vol. 46, p. 2950, 2008)","volume":"46","author":"Rybak","year":"2008","journal-title":"J. Clin. Microbiol."},{"key":"10.1016\/j.colsurfb.2014.01.028_bib0190","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1128\/MMBR.00016-10","article-title":"Origins and evolution of antibiotic resistance","volume":"74","author":"Davies","year":"2010","journal-title":"Microbiol. Mol. Biol. Rev."},{"key":"10.1016\/j.colsurfb.2014.01.028_bib0195","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1002\/jps.2600581003","article-title":"pH-partition behavior of tetracyclines","volume":"58","author":"Colaizzi","year":"1969","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.colsurfb.2014.01.028_bib0200","first-page":"237","article-title":"Structure\u2013activity relationships in the tetracycline series","volume":"vol. 13","author":"Blackwood","year":"1970"},{"key":"10.1016\/j.colsurfb.2014.01.028_bib0205","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1007\/BF01053637","article-title":"Aggregation of cyclodextrins\u2013an explanation of the abnormal solubility of beta-cyclodextrin","volume":"13","author":"Coleman","year":"1992","journal-title":"J. Inclus. Phenom. Mol."},{"key":"10.1016\/j.colsurfb.2014.01.028_bib0210","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.ijpharm.2011.02.008","article-title":"Self-assembly of cyclodextrins: the effect of the guest molecule","volume":"408","author":"Messner","year":"2011","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.colsurfb.2014.01.028_bib0215","doi-asserted-by":"crossref","first-page":"2286","DOI":"10.1016\/j.carres.2007.05.002","article-title":"Supramolecular self-assembly of beta-cyclodextrin: an effective carrier of the antimicrobial agent chlorhexidine","volume":"342","author":"Denadai","year":"2007","journal-title":"Carbohydr. Res."},{"key":"10.1016\/j.colsurfb.2014.01.028_bib0220","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/0011-9164(94)00064-6","article-title":"Measuring the zeta (electrokinetic) potential of reverse-osmosis membranes by a streaming potential analyzer","volume":"95","author":"Elimelech","year":"1994","journal-title":"Desalination"},{"key":"10.1016\/j.colsurfb.2014.01.028_bib0225","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.1093\/jac\/dkn106","article-title":"Increased resistance to cationic antimicrobial peptide LL-37 in methicillin-resistant strains of Staphylococcus aureus","volume":"61","author":"Ouhara","year":"2008","journal-title":"J. Antimicrob. Chemother."},{"key":"10.1016\/j.colsurfb.2014.01.028_bib0230","doi-asserted-by":"crossref","first-page":"3263","DOI":"10.1016\/S0021-9258(18)69662-0","article-title":"Composition of the cell wall of Staphylococcus aureus\u2014its relation to the mechanism of action of penicillin","volume":"234","author":"Strominger","year":"1959","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.colsurfb.2014.01.028_bib0235","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1099\/00221287-14-3-583","article-title":"The chemical composition of the cell wall in some gram-positive bacteria and its possible value as a taxonomic character","volume":"14","author":"Cummins","year":"1956","journal-title":"J. Gen. Microbiol."},{"key":"10.1016\/j.colsurfb.2014.01.028_bib0240","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1128\/MMBR.63.1.174-229.1999","article-title":"Surface proteins of gram-positive bacteria and mechanisms of their targeting to the cell wall envelope","volume":"63","author":"Navarre","year":"1999","journal-title":"Microbiol. Mol. Biol. Rev."},{"key":"10.1016\/j.colsurfb.2014.01.028_bib0245","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/S0167-7012(00)00224-4","article-title":"Status of methods for assessing bacterial cell surface charge properties based on zeta potential measurements","volume":"43","author":"Wilson","year":"2001","journal-title":"J. Microbiol. Methods"},{"key":"10.1016\/j.colsurfb.2014.01.028_bib0250","first-page":"20","article-title":"Ultrastructural changes in bacterial membranes induced by nano-assemblies beta-cyclodextrin chlorhexidine: SEM, AFM, and TEM evaluation","volume":"20","author":"Teixeira","year":"2012","journal-title":"Pharm. Dev. Technol."},{"key":"10.1016\/j.colsurfb.2014.01.028_bib0255","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1111\/j.1601-0825.2005.01160.x","article-title":"Is the excessive inhibition of matrix metalloproteinases (MMPs) by potent synthetic MMP inhibitors (MMPIs) desirable in periodontitis and other inflammatory diseases? That is: \u2018Leaky\u2019 MMPIs vs excessively efficient drugs","volume":"11","author":"Sorsa","year":"2005","journal-title":"Oral Dis."}],"container-title":["Colloids and Surfaces B: Biointerfaces"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0927776514000290?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0927776514000290?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T19:39:34Z","timestamp":1648841974000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0927776514000290"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,6]]},"references-count":51,"alternative-id":["S0927776514000290"],"URL":"https:\/\/doi.org\/10.1016\/j.colsurfb.2014.01.028","relation":{},"ISSN":["0927-7765"],"issn-type":[{"value":"0927-7765","type":"print"}],"subject":[],"published":{"date-parts":[[2014,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Structural and thermodynamic characterization of doxycycline\/\u03b2-cyclodextrin supramolecular complex and its bacterial membrane interactions","name":"articletitle","label":"Article Title"},{"value":"Colloids and Surfaces B: Biointerfaces","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.colsurfb.2014.01.028","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}