{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T08:24:31Z","timestamp":1775291071550,"version":"3.50.1"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2014,6,1]],"date-time":"2014-06-01T00:00:00Z","timestamp":1401580800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Colloids and Surfaces B: Biointerfaces"],"published-print":{"date-parts":[[2014,6]]},"DOI":"10.1016\/j.colsurfb.2014.02.011","type":"journal-article","created":{"date-parts":[[2014,3,1]],"date-time":"2014-03-01T22:30:55Z","timestamp":1393713055000},"page":"65-71","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"special_numbering":"C","title":["Design and in vitro evaluation of a novel poly(methacrylic acid)\/metronidazole antibacterial nanogel as an oral dosage form"],"prefix":"10.1016","volume":"118","author":[{"given":"Tao","family":"Chen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haicheng","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuhui","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huixin","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Shu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiyu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Changhui","family":"Cai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lina","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xianen","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiu","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.colsurfb.2014.02.011_bib0005","doi-asserted-by":"crossref","first-page":"2138","DOI":"10.1002\/jssc.201000880","volume":"34","author":"Huang","year":"2011","journal-title":"J. Sep. Sci."},{"key":"10.1016\/j.colsurfb.2014.02.011_bib0010","series-title":"Australian Medicines Handbook","year":"2006"},{"key":"10.1016\/j.colsurfb.2014.02.011_bib0015","doi-asserted-by":"crossref","first-page":"4918","DOI":"10.1002\/app.37611","volume":"127","author":"El-Newehy","year":"2013","journal-title":"J. Appl. Polym. Sci."},{"key":"10.1016\/j.colsurfb.2014.02.011_bib0020","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1111\/j.1600-051X.1997.tb00485.x","volume":"24","author":"Noyan","year":"1997","journal-title":"J. Clin. Periodontol."},{"key":"10.1016\/j.colsurfb.2014.02.011_bib0025","doi-asserted-by":"crossref","first-page":"S16","DOI":"10.1086\/647939","volume":"50","author":"Lofmark","year":"2010","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.colsurfb.2014.02.011_bib0030","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1038\/sj.bdj.4809695","volume":"184","author":"Palmer","year":"1998","journal-title":"Br. Dent. J."},{"key":"10.1016\/j.colsurfb.2014.02.011_bib0035","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1111\/j.1600-051X.1995.tb00133.x","volume":"22","author":"Stoltze","year":"1995","journal-title":"J. Clin. Periodontol."},{"key":"10.1016\/j.colsurfb.2014.02.011_bib0040","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1016\/j.dental.2013.03.014","volume":"29","author":"Lan","year":"2013","journal-title":"Dent. Mater."},{"key":"10.1016\/j.colsurfb.2014.02.011_bib0045","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.actbio.2010.08.019","volume":"7","author":"Bottino","year":"2011","journal-title":"Acta Biomater."},{"key":"10.1016\/j.colsurfb.2014.02.011_bib0050","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1002\/jbm.a.32066","volume":"90","author":"Inanc","year":"2009","journal-title":"J. Biomed. Mater. Res. B"},{"key":"10.1016\/j.colsurfb.2014.02.011_bib0055","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.ejpb.2010.02.002","volume":"75","author":"Zamani","year":"2010","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.colsurfb.2014.02.011_bib0060","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1179\/174328408X341708","volume":"24","author":"Viseras","year":"2008","journal-title":"Mater. Sci. Technol."},{"key":"10.1016\/j.colsurfb.2014.02.011_bib0065","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.ijpharm.2013.09.017","volume":"457","author":"Calabrese","year":"2013","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.colsurfb.2014.02.011_bib0070","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1039\/C3BM60024F","volume":"1","author":"Ding","year":"2013","journal-title":"Biomater. Sci."},{"key":"10.1016\/j.colsurfb.2014.02.011_bib0075","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.jconrel.2013.07.006","volume":"171","author":"Kim","year":"2013","journal-title":"J. Control. Release"},{"key":"10.1016\/j.colsurfb.2014.02.011_bib0080","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1039\/C2PY20871G","volume":"4","author":"Li","year":"2013","journal-title":"Polym. Chem."},{"key":"10.1016\/j.colsurfb.2014.02.011_bib0085","doi-asserted-by":"crossref","first-page":"16347","DOI":"10.1021\/jp204954a","volume":"115","author":"Argentiere","year":"2011","journal-title":"J. Phys. Chem. C"},{"key":"10.1016\/j.colsurfb.2014.02.011_bib0090","doi-asserted-by":"crossref","first-page":"3889","DOI":"10.1039\/c2jm15680f","volume":"22","author":"Shi","year":"2012","journal-title":"J. Mater. Chem."},{"key":"10.1016\/j.colsurfb.2014.02.011_bib0095","doi-asserted-by":"crossref","first-page":"6570","DOI":"10.1016\/j.biomaterials.2012.05.062","volume":"33","author":"Pan","year":"2012","journal-title":"Biomaterials"},{"key":"10.1016\/j.colsurfb.2014.02.011_bib0100","doi-asserted-by":"crossref","first-page":"3889","DOI":"10.1039\/c2jm15680f","volume":"22","author":"Shi","year":"2012","journal-title":"J. Mater. Chem."},{"key":"10.1016\/j.colsurfb.2014.02.011_bib0105","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1016\/j.carres.2010.02.008","volume":"345","author":"Cai","year":"2010","journal-title":"Carbohydr. Res."},{"key":"10.1016\/j.colsurfb.2014.02.011_bib0110","doi-asserted-by":"crossref","first-page":"4164","DOI":"10.1016\/j.biortech.2009.04.005","volume":"100","author":"Cai","year":"2009","journal-title":"Bioresource. Technol."},{"key":"10.1016\/j.colsurfb.2014.02.011_bib0115","doi-asserted-by":"crossref","first-page":"1554","DOI":"10.1002\/app.39293","volume":"130","author":"Ma","year":"2013","journal-title":"J. Appl. Polym. Sci."},{"key":"10.1016\/j.colsurfb.2014.02.011_bib0120","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1615\/CritRevTherDrugCarrierSyst.v19.i6.10","volume":"19","author":"Haupt","year":"2002","journal-title":"Ther. Drug Carrier Syst."},{"key":"10.1016\/j.colsurfb.2014.02.011_bib0125","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.ijpharm.2005.05.010","volume":"300","author":"Wilson","year":"2005","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.colsurfb.2014.02.011_bib0130","doi-asserted-by":"crossref","first-page":"2204","DOI":"10.1021\/bm100676a","volume":"11","author":"Ma","year":"2010","journal-title":"Biomacromolecules"},{"key":"10.1016\/j.colsurfb.2014.02.011_bib0135","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1586\/14787210.5.4.685","volume":"5","author":"Boyanova","year":"2007","journal-title":"Expert. Rev. Anti-Infect. Ther."},{"key":"10.1016\/j.colsurfb.2014.02.011_bib0140","doi-asserted-by":"crossref","first-page":"5279","DOI":"10.1021\/la400824f","volume":"29","author":"Cai","year":"2013","journal-title":"Langmuir"},{"key":"10.1016\/j.colsurfb.2014.02.011_bib0145","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.colsurfb.2013.01.073","volume":"107","author":"Ouyang","year":"2013","journal-title":"Colloid Surf. B"},{"key":"10.1016\/j.colsurfb.2014.02.011_bib0150","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.1166\/sam.2013.1602","volume":"5","author":"Ma","year":"2013","journal-title":"Sci. Adv. Mater."},{"key":"10.1016\/j.colsurfb.2014.02.011_bib0155","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.matlet.2011.09.041","volume":"67","author":"Cai","year":"2012","journal-title":"Mater. Lett."},{"key":"10.1016\/j.colsurfb.2014.02.011_bib0160","doi-asserted-by":"crossref","first-page":"3407","DOI":"10.1016\/j.carbon.2012.02.002","volume":"50","author":"Cai","year":"2012","journal-title":"Carbon"},{"key":"10.1016\/j.colsurfb.2014.02.011_bib0165","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.colsurfb.2011.04.009","volume":"86","author":"Wu","year":"2011","journal-title":"Colloid Surf. B"},{"key":"10.1016\/j.colsurfb.2014.02.011_bib0170","doi-asserted-by":"crossref","first-page":"1664","DOI":"10.1002\/asia.201200045","volume":"7","author":"Cai","year":"2012","journal-title":"Chem.-Asian J"},{"key":"10.1016\/j.colsurfb.2014.02.011_bib0175","doi-asserted-by":"crossref","first-page":"7828","DOI":"10.1021\/la201499s","volume":"27","author":"Cai","year":"2011","journal-title":"Langmuir"}],"container-title":["Colloids and Surfaces B: Biointerfaces"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0927776514000782?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0927776514000782?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,8,15]],"date-time":"2020-08-15T18:45:43Z","timestamp":1597517143000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0927776514000782"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,6]]},"references-count":35,"alternative-id":["S0927776514000782"],"URL":"https:\/\/doi.org\/10.1016\/j.colsurfb.2014.02.011","relation":{},"ISSN":["0927-7765"],"issn-type":[{"value":"0927-7765","type":"print"}],"subject":[],"published":{"date-parts":[[2014,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Design and in vitro evaluation of a novel poly(methacrylic acid)\/metronidazole antibacterial nanogel as an oral dosage form","name":"articletitle","label":"Article Title"},{"value":"Colloids and Surfaces B: Biointerfaces","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.colsurfb.2014.02.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Crown copyright \u00a9 2014 Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}