{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T17:52:51Z","timestamp":1771955571848,"version":"3.50.1"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,5,1]],"date-time":"2015-05-01T00:00:00Z","timestamp":1430438400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Colloids and Surfaces B: Biointerfaces"],"published-print":{"date-parts":[[2015,5]]},"DOI":"10.1016\/j.colsurfb.2015.03.012","type":"journal-article","created":{"date-parts":[[2015,3,7]],"date-time":"2015-03-07T16:02:56Z","timestamp":1425744176000},"page":"71-78","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Apolipoprotein B-100-targeted negatively charged nanoliposomes for the treatment of dyslipidemia"],"prefix":"10.1016","volume":"129","author":[{"given":"Amirhossein","family":"Sahebkar","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali","family":"Badiee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahdi","family":"Hatamipour","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Majid","family":"Ghayour-Mobarhan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahmoud Reza","family":"Jaafari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.colsurfb.2015.03.012_bib0405","series-title":"The Atlas of Heart Disease and Stroke","first-page":"48","author":"Mackay","year":"2014"},{"key":"10.1016\/j.colsurfb.2015.03.012_bib0210","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1161\/CIRCULATIONAHA.106.667428","article-title":"Lipid management to reduce cardiovascular risk: a new strategy is required","volume":"117","author":"Superko","year":"2008","journal-title":"Circulation"},{"key":"10.1016\/j.colsurfb.2015.03.012_bib0215","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1007\/BF02938395","article-title":"Residual risk in statin-treated patients: future therapeutic options","volume":"9","author":"Campbell","year":"2007","journal-title":"Curr. Cardiol. Rep."},{"key":"10.1016\/j.colsurfb.2015.03.012_bib0220","doi-asserted-by":"crossref","first-page":"3143","DOI":"10.1161\/circ.106.25.3143","article-title":"Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) final report","volume":"106","author":"National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III)","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.colsurfb.2015.03.012_bib0225","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1016\/S0002-9149(97)00965-X","article-title":"Comparative dose efficacy study of atorvastatin versus simvastatin, pravastatin, lovastatin, and fluvastatin in patients with hypercholesterolemia (the curves study)","volume":"81","author":"Jones","year":"1998","journal-title":"Am. J. Cardiol."},{"key":"10.1016\/j.colsurfb.2015.03.012_bib0230","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1016\/j.bbalip.2013.01.013","article-title":"Fat lowers fat: purified phospholipids as emerging therapies for dyslipidemia","volume":"1831","author":"Sahebkar","year":"2013","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.colsurfb.2015.03.012_bib0235","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1097\/MOL.0b013e3282ffaf96","article-title":"Dietary phospholipids, hepatic lipid metabolism and cardiovascular disease","volume":"19","author":"Cohn","year":"2008","journal-title":"Curr. Opin. Lipidol."},{"key":"10.1016\/j.colsurfb.2015.03.012_bib0240","first-page":"281","article-title":"Phospholipids as cardiovascular therapeutics","volume":"9","author":"Pandey","year":"2008","journal-title":"Curr. Opin. Investig. Drugs"},{"key":"10.1016\/j.colsurfb.2015.03.012_bib0245","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/0885-4505(86)90055-1","article-title":"Dietary soya lecithin decreases plasma triglyceride levels and inhibits collagen- and ADP-induced platelet aggregation","volume":"35","author":"Brook","year":"1986","journal-title":"Biochem. Med. Metab. Biol."},{"key":"10.1016\/j.colsurfb.2015.03.012_bib0250","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/0021-9150(81)90119-2","article-title":"The contrasting effects of a dietary soya lecithin product and corn oil on lipoprotein lipids in normolipidemic and familial hypercholesterolemic subjects","volume":"38","author":"Childs","year":"1981","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.colsurfb.2015.03.012_bib0255","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/0002-9610(80)90168-3","article-title":"Effects of long-term ingestion of soya phospholipids on serum lipids in humans","volume":"140","author":"Tompkins","year":"1980","journal-title":"Am. J. Surg."},{"key":"10.1016\/j.colsurfb.2015.03.012_bib0260","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/S0021-9150(98)00132-4","article-title":"Soy lecithin reduces plasma lipoprotein cholesterol and early atherogenesis in hypercholesterolemic monkeys and hamsters: Beyond linoleate","volume":"140","author":"Wilson","year":"1998","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.colsurfb.2015.03.012_bib0265","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1007\/BF02535661","article-title":"Infuence of dietary soybean and egg lecithins on lipid responses in cholesterol-fed guinea pigs","volume":"23","author":"O\u2019Brien","year":"1988","journal-title":"Lipids"},{"key":"10.1016\/j.colsurfb.2015.03.012_bib0270","first-page":"35","article-title":"Hyperlipoproteinemia and atherosclerosis in rabbits fed low-level cholesterol and lecithin","volume":"66","author":"Hunt","year":"1985","journal-title":"Br. J. Exp. Pathol."},{"key":"10.1016\/j.colsurfb.2015.03.012_bib0275","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1007\/s11894-004-0027-0","article-title":"New concepts of the pathogenesis of alcoholic liver disease lead to novel treatments","volume":"6","author":"Lieber","year":"2004","journal-title":"Curr. Gastroenterol. Rep."},{"key":"10.1016\/j.colsurfb.2015.03.012_bib0280","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.chemphyslip.2008.04.006","article-title":"Lipoprotein charge and vascular lipid metabolism","volume":"154","author":"Sparks","year":"2008","journal-title":"Chem. Phys. Lipids"},{"key":"10.1016\/j.colsurfb.2015.03.012_bib0285","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1002\/jps.10075","article-title":"Cell association of liposomes with high fluid anionic phospholipid content is mediated specifically by LDL and its receptor, LDLr","volume":"91","author":"Amin","year":"2002","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.colsurfb.2015.03.012_bib0290","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1023\/A:1010971808006","article-title":"LDL induced association of anionic liposomes with cells and delivery of contents as shown by the increase in potency of liposome dependent drugs","volume":"18","author":"Amin","year":"2001","journal-title":"Pharm. Res."},{"key":"10.1016\/j.colsurfb.2015.03.012_bib0295","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/0005-2760(95)00088-T","article-title":"Association of negatively-charged phospholipids with low-density lipoprotein (LDL) increases its uptake and the deposition of cholesteryl esters by macrophages","volume":"1257","author":"Greenspan","year":"1995","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.colsurfb.2015.03.012_bib0300","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/j.colsurfb.2014.07.045","article-title":"A simple and effective approach for the treatment of dyslipidaemia using anionic nanoliposomes","volume":"122","author":"Sahebkar","year":"2014","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"10.1016\/j.colsurfb.2015.03.012_bib0305","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S0169-409X(97)00130-0","article-title":"Structural and metabolic consequences of liposome\u2013lipoprotein interactions","volume":"32","author":"Williams","year":"1998","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.colsurfb.2015.03.012_bib0310","doi-asserted-by":"crossref","first-page":"4757","DOI":"10.1016\/j.vaccine.2007.04.029","article-title":"Enhanced delivery of immunoliposomes to human dendritic cells by targeting the multilectin receptor DEC-205","volume":"25","author":"Badiee","year":"2007","journal-title":"Vaccine"},{"key":"10.1016\/j.colsurfb.2015.03.012_bib0315","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.ijpharm.2011.01.044","article-title":"Characterization of the colloidal properties, in vitro antifungal activity, antileishmanial activity and toxicity in mice of a di-stigma-steryl-hemi-succinoyl-glycero-phosphocholine liposome-intercalated amphotericin B","volume":"408","author":"Iman","year":"2011","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.colsurfb.2015.03.012_bib0320","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1016\/S0021-9258(18)70226-3","article-title":"Phosphorus assay in column chromatography","volume":"234","author":"Bartlett","year":"1959","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.colsurfb.2015.03.012_bib0325","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1517\/14656566.2014.876992","article-title":"New peroxisome proliferator-activated receptor agonists: Potential treatments for atherogenic Dyslipidemia and non-alcoholic fatty liver disease","volume":"15","author":"Sahebkar","year":"2014","journal-title":"Expert Opin. Pharmacother."},{"key":"10.1016\/j.colsurfb.2015.03.012_bib0330","doi-asserted-by":"crossref","first-page":"221","DOI":"10.2217\/clp.14.14","article-title":"Managing recalcitrant hypercholesterolemia in patients on current best standard of care: Efficacy and safety of novel pharmacotherapies","volume":"9","author":"Sahebkar","year":"2014","journal-title":"Clin. Lipidol."},{"key":"10.1016\/j.colsurfb.2015.03.012_bib0335","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1007\/s10557-013-6479-4","article-title":"New therapies targeting apoB metabolism for high-risk patients with inherited dyslipidaemias: What can the clinician expect","volume":"27","author":"Sahebkar","year":"2013","journal-title":"Cardiovasc. Drugs Ther."},{"key":"10.1016\/j.colsurfb.2015.03.012_bib0340","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1016\/j.clinthera.2013.06.019","article-title":"New LDL-cholesterol lowering therapies: Pharmacology, clinical trials, and relevance to acute coronary syndromes","volume":"35","author":"Sahebkar","year":"2013","journal-title":"Clin. Ther."},{"key":"10.1016\/j.colsurfb.2015.03.012_bib0345","doi-asserted-by":"crossref","DOI":"10.1111\/dom.12277","article-title":"Role of selective peroxisome proliferator-activated receptor modulators in managing cardiometabolic disease: Tale of a roller-coaster","author":"Sahebkar","year":"2014","journal-title":"Diab. Obes. Metab."},{"key":"10.1016\/j.colsurfb.2015.03.012_bib0350","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.plipres.2014.07.002","article-title":"Recent advances in pharmacotherapy for hypertriglyceridemia","volume":"56","author":"Sahebkar","year":"2014","journal-title":"Prog. Lipid Res."},{"key":"10.1016\/j.colsurfb.2015.03.012_bib0410","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1002\/biof.1062","article-title":"Why it is necessary to translate curcumin into clinical practice for the prevention and treatment of metabolic syndrome?","volume":"39","author":"Sahebkar","year":"2013","journal-title":"BioFactors"},{"key":"10.1016\/j.colsurfb.2015.03.012_bib0415","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1002\/ptr.4715","article-title":"Effects of supplementation with curcuminoids on dyslipidemia in obese patients: A randomized crossover trial","volume":"27","author":"Mohammadi","year":"2013","journal-title":"Phytother. Res."},{"key":"10.1016\/j.colsurfb.2015.03.012_bib0420","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1038\/nrcardio.2013.140-c1","article-title":"Curcuminoids for the management of hypertriglyceridaemia","volume":"11","author":"Sahebkar","year":"2014","journal-title":"Nat. Rev. Cardiol."},{"key":"10.1016\/j.colsurfb.2015.03.012_bib0355","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/1476-511X-11-3","article-title":"Health effects of dietary phospholipids","volume":"11","author":"K\u00fcllenberg","year":"2012","journal-title":"Lipids Health Dis."},{"key":"10.1016\/j.colsurfb.2015.03.012_bib0360","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1016\/S0022-2275(20)33428-3","article-title":"Phosphatidylinositol promotes cholesterol transport in vivo","volume":"41","author":"Stamler","year":"2000","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.colsurfb.2015.03.012_bib0365","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1194\/jlr.M300062-JLR200","article-title":"Phosphatidylinositol promotes cholesterol transport and excretion","volume":"44","author":"Burgess","year":"2003","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.colsurfb.2015.03.012_bib0370","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/S0005-2736(98)00102-3","article-title":"Aggregation of dimyristoylphosphatidylglycerol liposomes by human plasma low density lipoprotein","volume":"1373","author":"Lauraeus","year":"1998","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.colsurfb.2015.03.012_bib0375","doi-asserted-by":"crossref","first-page":"35355","DOI":"10.1074\/jbc.273.52.35355","article-title":"The NH2-terminal region of apolipoprotein B is sufficient for lipoprotein association with glycosaminoglycans","volume":"273","author":"Goldberg","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.colsurfb.2015.03.012_bib0380","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1016\/S0022-2275(20)39140-9","article-title":"Evidence for electronegativity of plasma high density lipoprotein-3 as one major determinant of human cholesteryl ester transfer protein activity","volume":"37","author":"Masson","year":"1996","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.colsurfb.2015.03.012_bib0385","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/S0005-2760(97)00172-0","article-title":"Effect of the surface lipid composition of reconstituted LPA-I on apolipoprotein A-I structure and lecithin: Cholesterol acyltransferase activity","volume":"1390","author":"Sparks","year":"1998","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.colsurfb.2015.03.012_bib0390","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1194\/jlr.M400438-JLR200","article-title":"Phosphatidylinositol increases HDL-C levels in humans","volume":"46","author":"Burgess","year":"2005","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.colsurfb.2015.03.012_bib0395","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1139\/O07-137","article-title":"Lipoprotein electrostatic properties regulate hepatic lipase association and activity","volume":"85","author":"Boucher","year":"2007","journal-title":"Biochem. Cell Biol."},{"key":"10.1016\/j.colsurfb.2015.03.012_bib0400","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/0005-2760(90)90291-5","article-title":"Interaction of lipoprotein lipase with glycosaminoglycans and apolipoprotein C-II: Effects of free-fatty-acids","volume":"1043","author":"Saxena","year":"1990","journal-title":"Biochim. Biophys. Acta"}],"container-title":["Colloids and Surfaces B: Biointerfaces"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0927776515001460?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0927776515001460?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T17:18:24Z","timestamp":1651425504000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0927776515001460"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,5]]},"references-count":43,"alternative-id":["S0927776515001460"],"URL":"https:\/\/doi.org\/10.1016\/j.colsurfb.2015.03.012","relation":{},"ISSN":["0927-7765"],"issn-type":[{"value":"0927-7765","type":"print"}],"subject":[],"published":{"date-parts":[[2015,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Apolipoprotein B-100-targeted negatively charged nanoliposomes for the treatment of dyslipidemia","name":"articletitle","label":"Article Title"},{"value":"Colloids and Surfaces B: Biointerfaces","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.colsurfb.2015.03.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}