{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T06:38:07Z","timestamp":1790750287009,"version":"4.1.0"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T00:00:00Z","timestamp":1480550400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Ministry of Science and Higher Education for Young Researchers administered by the Faculty of Chemistry"},{"name":"Statutory Project Science"},{"name":"EU European Regional Development Fund","award":["TEAM\/2008-2\/6"],"award-info":[{"award-number":["TEAM\/2008-2\/6"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Colloids and Surfaces B: Biointerfaces"],"published-print":{"date-parts":[[2016,12]]},"DOI":"10.1016\/j.colsurfb.2016.09.031","type":"journal-article","created":{"date-parts":[[2016,9,22]],"date-time":"2016-09-22T15:16:23Z","timestamp":1474557383000},"page":"607-614","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":45,"special_numbering":"C","title":["Biopolymeric hydrogels \u2212 nanostructured TiO2 hybrid materials as potential injectable scaffolds for bone regeneration"],"prefix":"10.1016","volume":"148","author":[{"given":"Karolina","family":"Zazakowny","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanna","family":"Lewandowska-\u0141a\u0144cucka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanna","family":"Mastalska-Pop\u0142awska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamil","family":"Kami\u0144ski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Kusior","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Radecka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Nowakowska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.colsurfb.2016.09.031_bib0005","doi-asserted-by":"crossref","first-page":"4844","DOI":"10.1039\/c3cp43938k","article-title":"Recent progress in biomedical applications of titanium dioxide","volume":"15","author":"Yin","year":"2013","journal-title":"Phys. Chem. Chem. Phys."},{"key":"10.1016\/j.colsurfb.2016.09.031_bib0010","doi-asserted-by":"crossref","first-page":"062002","DOI":"10.1088\/0957-4484\/26\/6\/062002","article-title":"Titanium nanostructures for biomedical applications","volume":"26","author":"Kulkarni","year":"2015","journal-title":"Nanotechnology"},{"key":"10.1016\/j.colsurfb.2016.09.031_bib0015","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.colsurfb.2016.03.029","article-title":"The role of surface modification for TiO2 nanoparticles in cancer cells","volume":"143","author":"Xie","year":"2016","journal-title":"Colloids Surf. B"},{"key":"10.1016\/j.colsurfb.2016.09.031_bib0020","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.msec.2007.01.004","article-title":"Biocompatibility and bioactivity of PDLLA\/TiO2 and PDLLA\/TiO2\/Bioglass\u00ae nanocomposites","volume":"28","author":"Wei","year":"2008","journal-title":"Mater. Sci. Eng. C"},{"key":"10.1016\/j.colsurfb.2016.09.031_bib0025","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/0142-9612(91)90057-H","article-title":"A study of the mechanism of protein adsorption to TiO2","volume":"12","author":"Ellingsen","year":"1991","journal-title":"Biomaterials"},{"key":"10.1016\/j.colsurfb.2016.09.031_bib0030","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1002\/1097-4636(200104)55:1<45::AID-JBM70>3.0.CO;2-0","article-title":"Interactions between calcium, phosphate and albumin on the surface of titanium","volume":"55","author":"Lima","year":"2001","journal-title":"J. Biomed. Mater. Res."},{"key":"10.1016\/j.colsurfb.2016.09.031_bib0035","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1002\/jbm.a.10414","article-title":"Structural dependence of apatite formation on titania gels in a simulated body fluid","volume":"64","author":"Uchida","year":"2003","journal-title":"J. Biomed. Mater. Res. A"},{"key":"10.1016\/j.colsurfb.2016.09.031_bib0040","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1002\/jbm.a.30677","article-title":"Hydroxyaptite growth on anodicTiO2 nanotubes","volume":"77","author":"Tsuchiya","year":"2006","journal-title":"J. Biomed. Mater. Res. A"},{"key":"10.1016\/j.colsurfb.2016.09.031_bib0045","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1007\/s10856-006-0062-5","article-title":"Titanium dioxide (TiO2) nanoparticles filled poly(D,L lactid acid) (PDLLA) matrix composites for bone tissue engineering","volume":"18","author":"Gerhardt","year":"2007","journal-title":"J. Mater. Sci. Mater. Med."},{"key":"10.1016\/j.colsurfb.2016.09.031_bib0050","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1007\/s10856-007-2317-1","article-title":"Mechanical properties and apatite forming ability of TiO2 nanoparticles\/high density polyethylene composite: effect of filler content","volume":"18","author":"Hashimoto","year":"2007","journal-title":"J. Mater. Sci. Mater. Med."},{"key":"10.1016\/j.colsurfb.2016.09.031_bib0055","doi-asserted-by":"crossref","first-page":"015020","DOI":"10.1088\/1748-6041\/10\/1\/015020","article-title":"Bioactive hydrogel-nanosilica hybrid materials: a potential injectable scaffold for bone tissue engineering","volume":"10","author":"Lewandowska-\u0141a\u0144cucka","year":"2015","journal-title":"Biomed. Mater."},{"key":"10.1016\/j.colsurfb.2016.09.031_bib0060","doi-asserted-by":"crossref","first-page":"4938","DOI":"10.1016\/j.biomaterials.2005.01.048","article-title":"Growth of nano-scale hydroxyapatite using chemically treated titanium oxide nanotubes","volume":"26","author":"Oh","year":"2005","journal-title":"Biomaterials"},{"key":"10.1016\/j.colsurfb.2016.09.031_bib0065","doi-asserted-by":"crossref","first-page":"2155","DOI":"10.1016\/S0142-9612(00)00116-2","article-title":"Novel injectable neutral solutions of chitosan form biodegradable gels in situ","volume":"21","author":"Chenite","year":"2000","journal-title":"Biomaterials"},{"key":"10.1016\/j.colsurfb.2016.09.031_bib0070","doi-asserted-by":"crossref","first-page":"024105","DOI":"10.1088\/1748-6041\/7\/2\/024105","article-title":"Injectable hydrogels for bone and cartilage repair","volume":"7","author":"Amini","year":"2012","journal-title":"Biomed. Mater."},{"key":"10.1016\/j.colsurfb.2016.09.031_bib0075","series-title":"Integrated Biomaterials for Biomedical Technology","author":"Singh","year":"2012"},{"key":"10.1016\/j.colsurfb.2016.09.031_bib0080","doi-asserted-by":"crossref","first-page":"2405","DOI":"10.1016\/S0142-9612(00)00108-3","article-title":"Injectable materials for orthopedic tissue engineering","volume":"21","author":"Temenoff","year":"2000","journal-title":"Biomaterials"},{"key":"10.1016\/j.colsurfb.2016.09.031_bib0085","doi-asserted-by":"crossref","first-page":"035013","DOI":"10.1088\/1748-6041\/8\/3\/035013","article-title":"Nowakowska Biopolymer-based hydrogels as injectable materials for tissue repair scaffolds","volume":"8","author":"S.Fiejdasz","year":"2013","journal-title":"Biomed. Mater."},{"key":"10.1016\/j.colsurfb.2016.09.031_bib0090","doi-asserted-by":"crossref","first-page":"2907","DOI":"10.1016\/j.biomaterials.2006.01.017","article-title":"How useful is SBF in predicting in vivo bone bioactivity","volume":"27","author":"Kokubo","year":"2006","journal-title":"Biomaterials"},{"key":"10.1016\/j.colsurfb.2016.09.031_bib0095","doi-asserted-by":"crossref","first-page":"2994","DOI":"10.1039\/c0ce00851f","article-title":"3D hierarchical flower-like TiO2 nanostructure: morphology control and its photocatalytic property","volume":"13","author":"Tian","year":"2011","journal-title":"Cryst. Eng. Comm."},{"key":"10.1016\/j.colsurfb.2016.09.031_bib0100","doi-asserted-by":"crossref","first-page":"2285","DOI":"10.1016\/j.jeurceramsoc.2013.01.022","article-title":"TiO2-SnO2 nanomaterials for gassensing and photocatalysis","volume":"33","author":"Kusior","year":"2013","journal-title":"J. Eur. Ceram. Soc."},{"key":"10.1016\/j.colsurfb.2016.09.031_bib0105","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.snb.2015.01.050","article-title":"Grain-size-dependent gas-sensingproperties of TiO2 nanomaterials","volume":"211","author":"Lyson-Sypien","year":"2015","journal-title":"Sens. Actuators B-Chem."},{"key":"10.1016\/j.colsurfb.2016.09.031_bib0110","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1002\/jbm.b.30096","article-title":"Antigencity and immunogenicity of collagen","volume":"71","author":"Lynn","year":"2004","journal-title":"J. Biomed. Mater. Res. B Appl. Biomater."},{"key":"10.1016\/j.colsurfb.2016.09.031_bib0115","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.carbpol.2009.01.016","article-title":"Genipin crosslinked chitosan hydrogel as biomedical and pharmaceutical aids","volume":"77","author":"Muzzarelli","year":"2009","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.colsurfb.2016.09.031_bib0120","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1002\/(SICI)1097-4636(19981215)42:4<568::AID-JBM13>3.0.CO;2-7","article-title":"Biocompatibilty study of a biological tissue fixed with a naturally occurring crosslining reagent","volume":"42","author":"Huang","year":"1998","journal-title":"J. Biomed. Mater. Res."},{"key":"10.1016\/j.colsurfb.2016.09.031_bib0125","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1021\/bm200083n","article-title":"Biopolymer-based hydrogels as scaffolds for tissue engineering applications: a review","volume":"12","author":"Van Vlierberghe","year":"2011","journal-title":"Biomacromolecules"},{"key":"10.1016\/j.colsurfb.2016.09.031_bib0130","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.colsurfb.2011.06.019","article-title":"Surface modification of PDMS by surface-initiated atom transfer radical polymerization of water-soluble dendronized PEG methacrylate","volume":"88","author":"Zhang","year":"2011","journal-title":"Colloids Surf. B"},{"key":"10.1016\/j.colsurfb.2016.09.031_bib0135","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1016\/j.eurpolymj.2015.06.033","article-title":"Cross-linkable alginate-graft-gelatin copolymers for tissue engineering applications","volume":"72","author":"Graulus","year":"2015","journal-title":"Eur. Polym. J."},{"key":"10.1016\/j.colsurfb.2016.09.031_bib0140","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.colsurfb.2016.03.025","article-title":"Preparation of collagen\/hydroxyapatite\/alendronate hybrid hydrogels as potential scaffolds for bone regeneration","volume":"143","author":"Ma","year":"2016","journal-title":"Colloids Surf. B"},{"key":"10.1016\/j.colsurfb.2016.09.031_bib0145","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.molliq.2016.07.135","article-title":"Biopolymer-based hydrogels for encapsulation of photocatalytic TiO2 nanoparticles prepared by the freezing\/thawing method","volume":"223","author":"Badranova","year":"2016","journal-title":"J. Mol. Liq."},{"key":"10.1016\/j.colsurfb.2016.09.031_bib0150","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.colsurfb.2011.09.044","article-title":"Preosteoblasts and fibroblasts respond differently to anatase titanium dioxide nanoparticles: a cytotoxicity and inflammation study","volume":"90","author":"Bernier","year":"2012","journal-title":"Colloids Surf. B"},{"key":"10.1016\/j.colsurfb.2016.09.031_bib0155","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1007\/s10856-015-5564-6","article-title":"Novel hybrid materials for preparation of bone tissue engineering scaffolds","volume":"26","author":"Lewandowska-\u0141a\u0144cucka","year":"2015","journal-title":"J. Mater. Sci. Mater. Med."},{"key":"10.1016\/j.colsurfb.2016.09.031_bib0160","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1016\/S0142-9612(02)00511-2","article-title":"A comparative study between in vivo bone ingrowth and in vitro apatite formation on Na2O\u2013CaO\u2013SiO2 glasses","volume":"24","author":"Fujibayashi","year":"2003","journal-title":"Biomaterials"},{"key":"10.1016\/j.colsurfb.2016.09.031_bib0165","doi-asserted-by":"crossref","first-page":"4742","DOI":"10.1021\/cr800427g","article-title":"Calcium phosphate-Based osteoinductive materials","volume":"108","author":"LeGeros","year":"2008","journal-title":"Chem. Rev."},{"key":"10.1016\/j.colsurfb.2016.09.031_bib0170","article-title":"Biocybernetyka i in\u017cynieria biomedyczna, vol. 4 biomateria\u0142y, akademicka oficyna wydawnicza EXIT","author":"B\u0142a\u017cewicz","year":"2003","journal-title":"Warszawa"},{"key":"10.1016\/j.colsurfb.2016.09.031_bib0175","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1146\/annurev.ms.06.080176.001241","article-title":"Chemical properties of bone mineral","volume":"6","author":"Brown","year":"1976","journal-title":"Annu. Rev. Mater. Sci."},{"key":"10.1016\/j.colsurfb.2016.09.031_bib0180","doi-asserted-by":"crossref","first-page":"2161","DOI":"10.1016\/S0142-9612(03)00044-9","article-title":"Novel bioactive materials with different mechanical properties","volume":"24","author":"Kokubo","year":"2003","journal-title":"Biomaterials"},{"key":"10.1016\/j.colsurfb.2016.09.031_bib0185","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1016\/S0142-9612(03)00626-4","article-title":"Preparation of bioactive titanium metal via anodic oxidation treatment","volume":"25","author":"Yang","year":"2004","journal-title":"Biomaterials"}],"container-title":["Colloids and Surfaces B: Biointerfaces"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0927776516306853?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0927776516306853?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,4,30]],"date-time":"2019-04-30T03:47:19Z","timestamp":1556596039000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0927776516306853"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12]]},"references-count":37,"alternative-id":["S0927776516306853"],"URL":"https:\/\/doi.org\/10.1016\/j.colsurfb.2016.09.031","relation":{},"ISSN":["0927-7765"],"issn-type":[{"value":"0927-7765","type":"print"}],"subject":[],"published":{"date-parts":[[2016,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Biopolymeric hydrogels \u2212 nanostructured TiO2 hybrid materials as potential injectable scaffolds for bone regeneration","name":"articletitle","label":"Article Title"},{"value":"Colloids and Surfaces B: Biointerfaces","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.colsurfb.2016.09.031","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}