{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T06:05:21Z","timestamp":1790834721441,"version":"4.1.0"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,10,1]],"date-time":"2017-10-01T00:00:00Z","timestamp":1506816000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100004837","name":"Ministerio de Ciencia e Innovaci\u00f3n","doi-asserted-by":"publisher","award":["MAT2011-29778-C02-01"],"award-info":[{"award-number":["MAT2011-29778-C02-01"]}],"id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004837","name":"Ministerio de Ciencia e Innovaci\u00f3n","doi-asserted-by":"publisher","award":["MAT2011-29778-C02-02"],"award-info":[{"award-number":["MAT2011-29778-C02-02"]}],"id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002809","name":"Generalitat de Catalunya","doi-asserted-by":"publisher","award":["FPU AP2008-01868"],"award-info":[{"award-number":["FPU AP2008-01868"]}],"id":[{"id":"10.13039\/501100002809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002809","name":"Generalitat de Catalunya","doi-asserted-by":"publisher","award":["SGR 1178"],"award-info":[{"award-number":["SGR 1178"]}],"id":[{"id":"10.13039\/501100002809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Colloids and Surfaces B: Biointerfaces"],"published-print":{"date-parts":[[2017,10]]},"DOI":"10.1016\/j.colsurfb.2017.07.045","type":"journal-article","created":{"date-parts":[[2017,7,19]],"date-time":"2017-07-19T15:30:05Z","timestamp":1500478205000},"page":"569-577","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"special_numbering":"C","title":["Differential neuronal and glial behavior on flat and micro patterned chitosan films"],"prefix":"10.1016","volume":"158","author":[{"given":"Marta","family":"Mattotti","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zaida","family":"Alvarez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Delgado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel A.","family":"Mateos-Timoneda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Conrado","family":"Aparicio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josep A.","family":"Planell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soledad","family":"Alc\u00e1ntara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth","family":"Engel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.colsurfb.2017.07.045_bib0005","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.carbpol.2008.11.002","article-title":"Chitins and chitosans for the repair of wounded skin, nerve, cartilage and bone","volume":"76","author":"Muzzarelli","year":"2009","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.colsurfb.2017.07.045_bib0010","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1163\/156856203769231628","article-title":"Studies on nerve cell affinity of biodegradable modified chitosan films","volume":"14","author":"Cheng","year":"2003","journal-title":"J. Biomater. Sci. Polym. Ed."},{"key":"10.1016\/j.colsurfb.2017.07.045_bib0015","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1002\/1097-4636(200011)52:2<285::AID-JBM7>3.0.CO;2-G","article-title":"Studies on nerve cell affinity of chitosan-derived materials","volume":"52","author":"Haipeng","year":"2000","journal-title":"J. Biomed. Mater. Res."},{"key":"10.1016\/j.colsurfb.2017.07.045_bib0020","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1089\/ten.tea.2007.0295","article-title":"Differentiation of postnatal neural stem cells into glia and functional neurons on laminin-coated polymeric substrates","volume":"14","author":"Mart\u00ednez-Ramos","year":"2008","journal-title":"Tissue Eng. Part A"},{"key":"10.1016\/j.colsurfb.2017.07.045_bib0025","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1039\/C4BM00215F","article-title":"Purine-crosslinked injectable chitosan sponges promote oligodendrocyte progenitor cells' attachment and differentiation","volume":"3","author":"Mekhail","year":"2015","journal-title":"Biomater. Sci."},{"key":"10.1016\/j.colsurfb.2017.07.045_bib0030","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1163\/156856203766652048","article-title":"Chitosan: potential use as a bioactive coating for orthopaedic and craniofacial\/dental implants","volume":"14","author":"Bumgardner","year":"2003","journal-title":"J. Biomater. Sci. Polym. Ed."},{"key":"10.1016\/j.colsurfb.2017.07.045_bib0035","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1111\/j.1525-1594.2004.00020.x","article-title":"Effects of a chitosan scaffold containing TGF-beta 1 encapsulated chitosan microspheres on in vitro chondrocyte culture","volume":"28","author":"Lee","year":"2004","journal-title":"Artif. Org."},{"key":"10.1016\/j.colsurfb.2017.07.045_bib0040","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1002\/jbm.a.31561","article-title":"Micro- and nanostructuring of freestanding, biodegradable, thin sheets of chitosan via soft lithography","volume":"85","author":"Fernandez","year":"2008","journal-title":"J. Biomed. Mater. Res. A"},{"key":"10.1016\/j.colsurfb.2017.07.045_bib0045","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1002\/jbm.a.31568","article-title":"Fabricate coaxial stacked nerve conduits through soft lithography and molding processes","volume":"85","author":"Wang","year":"2008","journal-title":"J. Biomed. Mater. Res. A"},{"key":"10.1016\/j.colsurfb.2017.07.045_bib0050","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1007\/s10544-007-9068-0","article-title":"Fabrication and evaluation of microgrooved polymers as peripheral nerve conduits","volume":"9","author":"Hsu","year":"2007","journal-title":"Biomed. Microdev."},{"key":"10.1016\/j.colsurfb.2017.07.045_bib0055","doi-asserted-by":"crossref","first-page":"045002","DOI":"10.1088\/1758-5082\/2\/4\/045002","article-title":"Effects of laminin blended with chitosan on axon guidance on patterned substrates","volume":"2","author":"Zhu","year":"2010","journal-title":"Biofabrication"},{"key":"10.1016\/j.colsurfb.2017.07.045_bib0060","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1177\/0885328210379928","article-title":"Differential adhesiveness and neurite-promoting activity for neural cells of chitosan, gelatin, and poly-L-lysine films","volume":"26","author":"Martin-Lopez","year":"2012","journal-title":"J. Biomater. Appl."},{"key":"10.1016\/j.colsurfb.2017.07.045_bib0065","doi-asserted-by":"crossref","first-page":"1684","DOI":"10.1021\/acs.biomac.6b00098","article-title":"Neuronal differentiation of induced pluripotent stem cells on surfactant templated chitosan hydrogels","volume":"17","author":"Worthington","year":"2016","journal-title":"Biomacromolecules"},{"key":"10.1016\/j.colsurfb.2017.07.045_bib0070","first-page":"197","article-title":"Don\u2019t fence me in: harnessing the beneficial roles of astrocytes for spinal cord repair","volume":"26","author":"White","year":"2008","journal-title":"Restor. Neurol. Neurosci."},{"key":"10.1016\/j.colsurfb.2017.07.045_bib0075","doi-asserted-by":"crossref","first-page":"4769","DOI":"10.1016\/j.biomaterials.2014.02.051","article-title":"Neurogenesis and vascularization of the damaged brain using a lactate-releasing biomimetic scaffold","volume":"35","author":"\u00c1lvarez","year":"2014","journal-title":"Biomaterials"},{"key":"10.1016\/j.colsurfb.2017.07.045_bib0080","doi-asserted-by":"crossref","first-page":"2221","DOI":"10.1016\/j.biomaterials.2012.12.001","article-title":"The effect of the composition of PLA films and lactate release on glial and neuronal maturation and the maintenance of the neuronal progenitor niche","volume":"34","author":"\u00c1lvarez","year":"2013","journal-title":"Biomaterials"},{"key":"10.1016\/j.colsurfb.2017.07.045_bib0085","doi-asserted-by":"crossref","first-page":"1759","DOI":"10.1016\/j.biomaterials.2011.10.086","article-title":"Inducing functional radial glia-like progenitors from cortical astrocyte cultures using micropatterned PMMA","volume":"33","author":"Mattotti","year":"2012","journal-title":"Biomaterials"},{"key":"10.1016\/j.colsurfb.2017.07.045_bib0090","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1017\/S1740925X0600010X","article-title":"Electric field-induced astrocyte alignment directs neurite outgrowth","volume":"2","author":"Alexander","year":"2006","journal-title":"Neuron Glia Biol."},{"key":"10.1016\/j.colsurfb.2017.07.045_bib0095","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1021\/bm034522t","article-title":"Protein adsorption modalities on polyelectrolyte multilayers","volume":"5","author":"Salloum","year":"2004","journal-title":"Biomacromolecules"},{"key":"10.1016\/j.colsurfb.2017.07.045_bib0100","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1016\/S0008-6215(03)00038-7","article-title":"Surface modification of chitosan films: effects of hydrophobicity on protein adsorption","volume":"338","author":"Tangpasuthadol","year":"2003","journal-title":"Carbohydr. Res."},{"key":"10.1016\/j.colsurfb.2017.07.045_bib0105","first-page":"932","article-title":"Relationship between antibacterial activity of chitosan and surface characteristics of cell wall","volume":"25","author":"Chung","year":"2004","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.colsurfb.2017.07.045_bib0110","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1242\/jeb.035162","article-title":"Chitosan produces potent neuroprotection and physiological recovery following traumatic spinal cord injury","volume":"213","author":"Cho","year":"2010","journal-title":"J. Exp. Biol."},{"key":"10.1016\/j.colsurfb.2017.07.045_bib0115","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1002\/term.1618","article-title":"Neuronal growth and differentiation on biodegradable membranes","volume":"9","author":"Morelli","year":"2015","journal-title":"J Tissue Eng. Regen. Med."},{"key":"10.1016\/j.colsurfb.2017.07.045_bib0120","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.bioelechem.2003.09.009","article-title":"Adhesion and proliferation of cells on new polymers modified biomaterials","volume":"62","author":"Lakard","year":"2004","journal-title":"Bioelectrochemistry"},{"key":"10.1016\/j.colsurfb.2017.07.045_bib0125","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1002\/jbm.a.31297","article-title":"Influence of the substrate\u2019s hydrophilicity on the in vitro Schwann cells viability","volume":"83","author":"Soria","year":"2007","journal-title":"J. Biomed. Mater. Res. A"},{"key":"10.1016\/j.colsurfb.2017.07.045_bib0130","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1002\/jbm.a.30803","article-title":"Survival and differentiation of embryonic neural explants on different biomaterials","volume":"79","author":"Soria","year":"2006","journal-title":"J. Biomed. Mater. Res. A"},{"key":"10.1016\/j.colsurfb.2017.07.045_bib0135","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1016\/j.biomaterials.2008.10.028","article-title":"In vitro behavior of neural stem cells in response to different chemical functional groups","volume":"30","author":"Ren","year":"2009","journal-title":"Biomaterials"},{"key":"10.1016\/j.colsurfb.2017.07.045_bib0140","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1002\/1097-4636(200009)53:5<592::AID-JBM20>3.0.CO;2-P","article-title":"Study of biodegradation behavior of chitosan-xanthan microspheres in simulated physiological media","volume":"53","author":"Chellat","year":"2000","journal-title":"J. Biomed. Mater. Res."},{"key":"10.1016\/j.colsurfb.2017.07.045_bib0145","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.prp.2010.10.008","article-title":"Hypoxia upregulates the expression of the O-linked N-acetylglucosamine containing epitope H in human ependymal cells","volume":"207","author":"Arvanitis","year":"2011","journal-title":"Pathol. Res. Pract."},{"key":"10.1016\/j.colsurfb.2017.07.045_bib0150","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/s004410100349","article-title":"Reactive astrocytes upregulate one or more gene products that are recognized by monoclonal antibody H","volume":"304","author":"Arvanitis","year":"2001","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.colsurfb.2017.07.045_bib0155","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1007\/s11010-006-9358-5","article-title":"Glucosamine-induced increase in Akt phosphorylation corresponds to increased endoplasmic reticulum stress in astroglial cells","volume":"298","author":"Matthews","year":"2007","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.colsurfb.2017.07.045_bib0160","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1002\/glia.440100306","article-title":"Oligodendrocytes produce low-molecular-weight glycoproteins containing N-acetyl-D-glucosamine in their golgi-apparatus","volume":"10","author":"Supler","year":"1994","journal-title":"Glia"},{"key":"10.1016\/j.colsurfb.2017.07.045_bib0165","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1038\/nrn2591","article-title":"The bright side of the glial scar in CNS repair","volume":"10","author":"Rolls","year":"2009","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.colsurfb.2017.07.045_bib0170","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/S0169-409X(01)00189-2","article-title":"Topical formulations and wound healing applications of chitosan","volume":"52","author":"Ueno","year":"2001","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.colsurfb.2017.07.045_bib0175","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.brainres.2007.03.016","article-title":"Transient microglial and prolonged astroglial upregulation of osteopontin following transient forebrain ischemia in rats","volume":"1151","author":"Choi","year":"2007","journal-title":"Brain Res."},{"key":"10.1016\/j.colsurfb.2017.07.045_bib0180","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1016\/j.ijbiomac.2011.02.011","article-title":"Chitooligosaccharide-mediated neuroprotection is associated with modulation of Hsps expression and reduction of MAPK phosphorylation","volume":"48","author":"Joodi","year":"2011","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.colsurfb.2017.07.045_bib0185","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/j.biomaterials.2006.08.044","article-title":"Polylysine-functionalised thermoresponsive chitosan hydrogel for neural tissue engineering","volume":"28","author":"Crompton","year":"2007","journal-title":"Biomaterials"},{"key":"10.1016\/j.colsurfb.2017.07.045_bib0190","doi-asserted-by":"crossref","first-page":"5406","DOI":"10.1002\/anie.200805179","article-title":"Engineering substrate topography at the micro- and nanoscale to control cell function","volume":"48","author":"Bettinger","year":"2009","journal-title":"Angew. Chem. Int. Ed. Engl."},{"key":"10.1016\/j.colsurfb.2017.07.045_bib0195","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/S0168-0102(02)00062-7","article-title":"Axon specification in hippocampal neurons","volume":"43","author":"Fukata","year":"2002","journal-title":"Neurosci. Res."},{"key":"10.1016\/j.colsurfb.2017.07.045_bib0200","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.jneumeth.2003.11.004","article-title":"Impact of micropatterned surfaces on neuronal polarity","volume":"134","author":"Vogt","year":"2004","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.colsurfb.2017.07.045_bib0205","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1098\/rsif.2006.0171","article-title":"Polarization of hippocampal neurons with competitive surface stimuli: contact guidance cues are preferred over chemical ligands","volume":"4","author":"Gomez","year":"2007","journal-title":"J. R. Soc. Interface"},{"key":"10.1016\/j.colsurfb.2017.07.045_bib0210","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1148\/radiol.2301021640","article-title":"Fiber tract-based atlas of human white matter anatomy","volume":"230","author":"Wakana","year":"2004","journal-title":"Radiology"},{"key":"10.1016\/j.colsurfb.2017.07.045_bib0215","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1163\/156856295X00698","article-title":"The influence of micro-topography on cellular response and the implications for silicone implants","volume":"7","author":"von Recum","year":"1995","journal-title":"J. Biomater. Sci. Polym. Ed."}],"container-title":["Colloids and Surfaces B: Biointerfaces"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0927776517304575?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0927776517304575?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,7,4]],"date-time":"2022-07-04T07:42:45Z","timestamp":1656920565000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0927776517304575"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10]]},"references-count":43,"alternative-id":["S0927776517304575"],"URL":"https:\/\/doi.org\/10.1016\/j.colsurfb.2017.07.045","relation":{},"ISSN":["0927-7765"],"issn-type":[{"value":"0927-7765","type":"print"}],"subject":[],"published":{"date-parts":[[2017,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Differential neuronal and glial behavior on flat and micro patterned chitosan films","name":"articletitle","label":"Article Title"},{"value":"Colloids and Surfaces B: Biointerfaces","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.colsurfb.2017.07.045","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}