{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T16:02:11Z","timestamp":1790179331988,"version":"4.1.0"},"reference-count":29,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Colloids and Surfaces B: Biointerfaces"],"published-print":{"date-parts":[[2018,1]]},"DOI":"10.1016\/j.colsurfb.2017.10.032","type":"journal-article","created":{"date-parts":[[2017,10,23]],"date-time":"2017-10-23T16:06:19Z","timestamp":1508774779000},"page":"228-235","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":43,"special_numbering":"C","title":["Mucus permeating self-emulsifying drug delivery systems (SEDDS): About the impact of mucolytic enzymes"],"prefix":"10.1016","volume":"161","author":[{"given":"Nuri Ari","family":"Efiana","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thi Nhu Quynh","family":"Phan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arko Jatmiko","family":"Wicaksono","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Bernkop- Schn\u00fcrch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10","key":"10.1016\/j.colsurfb.2017.10.032_bib0005","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1517\/17425247.2012.719870","article-title":"Potentials and challenges in self-nanoemulsifying drug delivery systems","volume":"9","author":"Khan","year":"2012","journal-title":"Expert Opin. Drug Deliv."},{"issue":"11","key":"10.1016\/j.colsurfb.2017.10.032_bib0010","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.1517\/17425247.2015.1068287","article-title":"Self-emulsifying drug delivery systems in oral (poly)peptide drug delivery","volume":"12","author":"Leonaviciute","year":"2015","journal-title":"Expert Opin. Drug Deliv."},{"issue":"3","key":"10.1016\/j.colsurfb.2017.10.032_bib0015","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1111\/bcpt.12342","article-title":"Mucus as a barrier to drug delivery \u2212Understanding and mimicking the barrier properties","volume":"116","author":"Boegh","year":"2015","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"issue":"5","key":"10.1016\/j.colsurfb.2017.10.032_bib0020","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.1021\/bm0609691","article-title":"Rheology of gastric mucin exhibits a pH-dependent sol-gel transition","volume":"8","author":"Celli","year":"2007","journal-title":"Biomacromolecules"},{"issue":"8","key":"10.1016\/j.colsurfb.2017.10.032_bib0025","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1136\/gut.13.8.666","article-title":"The structure and function of gastric mucus","volume":"13","author":"Allen","year":"1972","journal-title":"Gut"},{"issue":"1 Pt 2","key":"10.1016\/j.colsurfb.2017.10.032_bib0030","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/S0016-5085(85)80180-3","article-title":"Properties of gastric and duodenal mucus: effect of proteolysis, disulfide reduction, bile, acid, ethanol, and hypertonicity on mucus gel structure","volume":"88","author":"Bell","year":"1985","journal-title":"Gastroenterology"},{"issue":"1","key":"10.1016\/j.colsurfb.2017.10.032_bib0035","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1007\/s11051-012-1353-z","article-title":"Preparation and characterization of mucus-penetrating papain\/poly(acrylic acid) nanoparticles for oral drug delivery applications","volume":"15","author":"M\u00fcller","year":"2013","journal-title":"J. Nanoparticle Res."},{"issue":"3\u20134","key":"10.1016\/j.colsurfb.2017.10.032_bib0040","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.molcatb.2010.01.018","article-title":"Chemical modification of stem bromelain with anhydride groups to enhance its stability and catalytic activity","volume":"63","author":"Xue","year":"2010","journal-title":"J. Mol. Catal. B: Enzym."},{"issue":"2","key":"10.1016\/j.colsurfb.2017.10.032_bib0045","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1006\/abio.1993.1263","article-title":"Quantitative determination of chitosan and the percentage of free amino groups","volume":"211","author":"Curotto","year":"1993","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.colsurfb.2017.10.032_bib0050","doi-asserted-by":"crossref","first-page":"e146419","DOI":"10.1155\/2011\/146419","article-title":"Selective modification of chitosan to enable the formation of chitosan-DNA condensates by electron donator stabilization","volume":"2011","author":"Kador","year":"2011","journal-title":"Int. J. Carbohydr. Chem."},{"issue":"1\u20132","key":"10.1016\/j.colsurfb.2017.10.032_bib0055","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.ijpharm.2017.01.012","article-title":"Improved mucoadhesive properties of self-nanoemulsifying drug delivery systems (SNEDDS) by introducing acyl chitosan","volume":"519","author":"Efiana","year":"2017","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.colsurfb.2017.10.032_bib0060","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","article-title":"A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding","volume":"72","author":"Bradford","year":"1976","journal-title":"Anal. Biochem."},{"issue":"12","key":"10.1016\/j.colsurfb.2017.10.032_bib0065","doi-asserted-by":"crossref","first-page":"4406","DOI":"10.1002\/jps.23757","article-title":"Development and evaluation of a novel mucus diffusion test system approved by self-nanoemulsifying drug delivery systems","volume":"102","author":"Friedl","year":"2013","journal-title":"J. Pharm. Sci."},{"issue":"1","key":"10.1016\/j.colsurfb.2017.10.032_bib0070","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.ejpb.2013.12.012","article-title":"Development and in vivo evaluation of papain-functionalized nanoparticles: eur","volume":"87","author":"M\u00fcller","year":"2014","journal-title":"J. Pharm. Biopharm."},{"issue":"1\u20132","key":"10.1016\/j.colsurfb.2017.10.032_bib0075","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.ijpharm.2011.01.060","article-title":"Distribution of thiolated mucoadhesive nanoparticles on intestinal mucosa","volume":"408","author":"D\u00fcnnhaupt","year":"2011","journal-title":"Int. J. Pharm."},{"issue":"Pt A","key":"10.1016\/j.colsurfb.2017.10.032_bib0080","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.ejpb.2015.01.008","article-title":"Nanoparticles decorated with proteolytic enzymes, a promising strategy to overcome the mucus barrier","volume":"97","author":"Pereira de Sousa","year":"2015","journal-title":"Eur. J. Pharm. Biopharm."},{"issue":"24","key":"10.1016\/j.colsurfb.2017.10.032_bib0085","doi-asserted-by":"crossref","first-page":"2964","DOI":"10.1016\/j.tetlet.2009.03.220","article-title":"An improved method of amide synthesis using acyl chlorides","volume":"50","author":"Zhang","year":"2009","journal-title":"Tetrahedron Lett."},{"key":"10.1016\/j.colsurfb.2017.10.032_bib0090","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.aca.2015.05.004","article-title":"A review on enzyme and ultrasound: a controversial but fruitful relationship","volume":"889","author":"Delgado-Povedano","year":"2015","journal-title":"Anal. Chim. Acta"},{"issue":"2","key":"10.1016\/j.colsurfb.2017.10.032_bib0095","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1016\/j.carbpol.2013.08.017","article-title":"The effect of low-frequency ultrasound on the activity and efficiency of a commercial cellulase enzyme","volume":"98","author":"Szab\u00f3","year":"2013","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.colsurfb.2017.10.032_bib0100","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.fbp.2014.10.015","article-title":"Enzymolysis kinetics of garlic powder with single frequency countercurrent ultrasound pretreatment","volume":"95","author":"Huang","year":"2015","journal-title":"Food Bioprod. Process."},{"issue":"2","key":"10.1016\/j.colsurfb.2017.10.032_bib0105","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1021\/jf00038a005","article-title":"Inactivation of peroxidase, lipoxygenase, and polyphenol oxidase by manothermosonication","volume":"42","author":"Lopez","year":"1994","journal-title":"J. Agric. Food Chem."},{"issue":"6","key":"10.1016\/j.colsurfb.2017.10.032_bib0110","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1016\/j.sbi.2003.10.008","article-title":"The role of dynamics in allosteric regulation","volume":"13","author":"Kern","year":"2003","journal-title":"Curr. Opin. Struct. Biol."},{"issue":"1","key":"10.1016\/j.colsurfb.2017.10.032_bib0115","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/S0300-9084(98)80054-0","article-title":"Conformational dynamics and enzyme activity","volume":"80","author":"Yon","year":"1998","journal-title":"Biochimie"},{"key":"10.1016\/j.colsurfb.2017.10.032_bib0120","series-title":"Stem Bromelain - Ananas Comosus (Pineapple). [Online]","year":"2017"},{"key":"10.1016\/j.colsurfb.2017.10.032_bib0125","series-title":"Trypsin Precursor - Sus Scrofa (Pig). [Online]","year":"2017"},{"key":"10.1016\/j.colsurfb.2017.10.032_bib0130","series-title":"Papain Precursor - Carica Papaya (Papaya). [Online]","year":"2017"},{"issue":"04","key":"10.1016\/j.colsurfb.2017.10.032_bib0135","doi-asserted-by":"crossref","first-page":"1441013","DOI":"10.1142\/S179398441441013X","article-title":"Enzyme-Functionalized PLGA nanoparticles with enhanced mucus permeation rate","volume":"04","author":"Samaridou","year":"2014","journal-title":"Nano LIFE"},{"issue":"3","key":"10.1016\/j.colsurfb.2017.10.032_bib0140","doi-asserted-by":"crossref","first-page":"387","DOI":"10.2217\/nnm.13.26","article-title":"Development and in vitro evaluation of slippery nanoparticles for enhanced diffusion through native mucus","volume":"9","author":"Laffleur","year":"2014","journal-title":"Nanomed"},{"issue":"Pt A","key":"10.1016\/j.colsurfb.2017.10.032_bib0145","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.ejpb.2014.12.024","article-title":"Mucus permeating carriers: formulation and characterization of highly densely charged nanoparticles","volume":"97","author":"Pereira de Sousa","year":"2015","journal-title":"Eur. J. Pharm. Biopharm."}],"container-title":["Colloids and Surfaces B: Biointerfaces"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0927776517306835?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0927776517306835?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T10:33:03Z","timestamp":1760524383000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0927776517306835"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1]]},"references-count":29,"alternative-id":["S0927776517306835"],"URL":"https:\/\/doi.org\/10.1016\/j.colsurfb.2017.10.032","relation":{},"ISSN":["0927-7765"],"issn-type":[{"value":"0927-7765","type":"print"}],"subject":[],"published":{"date-parts":[[2018,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mucus permeating self-emulsifying drug delivery systems (SEDDS): About the impact of mucolytic enzymes","name":"articletitle","label":"Article Title"},{"value":"Colloids and Surfaces B: Biointerfaces","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.colsurfb.2017.10.032","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}