{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T05:47:46Z","timestamp":1774504066878,"version":"3.50.1"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Colloids and Surfaces B: Biointerfaces"],"published-print":{"date-parts":[[2018,10]]},"DOI":"10.1016\/j.colsurfb.2018.06.059","type":"journal-article","created":{"date-parts":[[2018,6,28]],"date-time":"2018-06-28T15:32:39Z","timestamp":1530199959000},"page":"572-577","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["Fractal properties of biophysical models of pericellular brushes can be used to differentiate between cancerous and normal cervical epithelial cells"],"prefix":"10.1016","volume":"170","author":[{"given":"Juan de Dios","family":"Hern\u00e1ndez Vel\u00e1zquez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergio","family":"Mej\u00eda-Rosales","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Armando","family":"Gama Goicochea","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.colsurfb.2018.06.059_bib0005","series-title":"The Fractal Geometry of Nature","author":"Mandelbrot","year":"1983"},{"key":"10.1016\/j.colsurfb.2018.06.059_bib0010","first-page":"354","article-title":"Physiology in fractal dimension","volume":"75","author":"West","year":"1987","journal-title":"Am. Sci."},{"key":"10.1016\/j.colsurfb.2018.06.059_bib0015","first-page":"421","article-title":"Fractals in physiology and medicine","volume":"60","author":"Goldberger","year":"1987","journal-title":"Yale J. Biol. Med."},{"key":"10.1016\/j.colsurfb.2018.06.059_bib0020","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1109\/81.904882","article-title":"A comparison of waveform fractal dimension algorithms","volume":"48","author":"Esteller","year":"2001","journal-title":"IEEE T. Circuits Syst."},{"key":"10.1016\/j.colsurfb.2018.06.059_bib0025","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1007\/s00422-005-0561-3","article-title":"Linear correlation between fractal dimension of EEG Signal and handgrip force","volume":"93","author":"Liu","year":"2005","journal-title":"Biol. Cybern."},{"key":"10.1016\/j.colsurfb.2018.06.059_bib0030","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.rbmret.2005.02.001","article-title":"Analysis of cardiac health using fractal dimension and wavelet transformation","volume":"26","author":"Acharya","year":"2005","journal-title":"ITBM-RBM"},{"key":"10.1016\/j.colsurfb.2018.06.059_bib0035","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.bspc.2010.01.002","article-title":"Local fractal dimension based ECG arrhythmia classification","volume":"5","author":"Mishra","year":"2010","journal-title":"Biomed. Signal. Proces."},{"key":"10.1016\/j.colsurfb.2018.06.059_bib0040","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1002\/path.1711700412","article-title":"Quantitation od the renal arterial tree by fractal analysis","volume":"170","author":"Cross","year":"1993","journal-title":"J. Pathol."},{"key":"10.1016\/j.colsurfb.2018.06.059_bib0045","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1159\/000025742","article-title":"The fractal nature of myocardial blood flow emerges from a whole-organ model of arterial network","volume":"37","author":"Beard","year":"2000","journal-title":"J. Vasc. Res."},{"key":"10.1016\/j.colsurfb.2018.06.059_bib0050","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1006\/jtbi.2001.2367","article-title":"Fractal dimensions and multifractility in vascular branching","volume":"212","author":"Zamir","year":"2001","journal-title":"J. Theor. Biol."},{"issue":"194","key":"10.1016\/j.colsurfb.2018.06.059_bib0055","first-page":"e1","article-title":"Age-related rarefaction in the fractal dimension of retinal vessel","volume":"33","author":"Azemin","year":"2012","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.colsurfb.2018.06.059_bib0060","doi-asserted-by":"crossref","first-page":"2106","DOI":"10.1103\/PhysRevLett.67.2106","article-title":"Complex fractal dimension of the bronchial tree","volume":"67","author":"Shlesinger","year":"1991","journal-title":"Phys. Rev. Lett."},{"key":"10.1016\/j.colsurfb.2018.06.059_bib0065","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.compmedimag.2004.01.001","article-title":"A digital reference model of the human bronchial tree","volume":"28","author":"Schmidt","year":"2004","journal-title":"Comput. Med. Imag. Grap."},{"key":"10.1016\/j.colsurfb.2018.06.059_bib0070","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1054\/mehy.1997.0653","article-title":"Chaodynamic loss of complexity and self-similarity in cancer","volume":"52","author":"Sedivy","year":"1999","journal-title":"Med. Hypotheses"},{"key":"10.1016\/j.colsurfb.2018.06.059_bib0075","first-page":"3683","article-title":"Fractals and cancer","volume":"6","author":"Baish","year":"2000","journal-title":"Cancer Res."},{"key":"10.1016\/j.colsurfb.2018.06.059_bib0080","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1109\/4233.992163","article-title":"Fractal analysis in the detection of colonic cancer images","volume":"6","author":"Esgair","year":"2002","journal-title":"IEEE T. Inf. Technol. B"},{"key":"10.1016\/j.colsurfb.2018.06.059_bib0085","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1007\/s10278-006-0860-9","article-title":"Fractal analysis of contours of breast masses in mammograms","volume":"20","author":"Rangayyan","year":"2007","journal-title":"J. Digit. Imaging"},{"key":"10.1016\/j.colsurfb.2018.06.059_bib0090","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1016\/j.humpath.2007.10.001","article-title":"Relationship between tumor grade and computed architectural complexity in breast cancer specimens","volume":"39","author":"Tambasco","year":"2008","journal-title":"Hum. Pathol."},{"key":"10.1016\/j.colsurfb.2018.06.059_bib0095","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1016\/j.cpc.2008.12.011","article-title":"Computational cancer cells identification by fractal dimension analysis","volume":"180","author":"Timb\u00f3","year":"2009","journal-title":"Comput. Phys. Commun."},{"key":"10.1016\/j.colsurfb.2018.06.059_bib0100","doi-asserted-by":"crossref","DOI":"10.1103\/PhysRevLett.107.028101","article-title":"Cell surface as a fractal: Normal and cancerous cervical cells demonstrate different fractal behavior of surface adhesion maps at the nanoscale","volume":"107","author":"Dokukin","year":"2011","journal-title":"Phys. Rev. Lett."},{"key":"10.1016\/j.colsurfb.2018.06.059_bib0105","doi-asserted-by":"crossref","first-page":"1667","DOI":"10.1016\/j.nano.2015.04.012","article-title":"Towards early detection of cervical cancer: fractal dimension of AFM images of human cervical epithelial cells at different stages of progression to cancer","volume":"11","author":"Guz","year":"2015","journal-title":"Nanomed-Nanotechnol."},{"key":"10.1016\/j.colsurfb.2018.06.059_bib0110","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1556\/APH.14.2001.1-4.6","article-title":"Cancer detection on a cell-by-cell basis using a fractal dimension analysis","volume":"14","author":"Bauer","year":"2001","journal-title":"Acta Phys. Hung. N.S. Heavy Ion Phys."},{"key":"10.1016\/j.colsurfb.2018.06.059_bib0115","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1006\/gyno.2002.6842","article-title":"Fractal tumor growth of ovarian cancer: sonographic evaluation","volume":"87","author":"Kikuchi","year":"2002","journal-title":"Gynecol. Oncol."},{"key":"10.1016\/j.colsurfb.2018.06.059_bib0120","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1016\/j.physd.2007.09.016","article-title":"Fractal dimension of the choriocarcinoma cell invasion front","volume":"237","author":"Ahammer","year":"2008","journal-title":"Physica D"},{"key":"10.1016\/j.colsurfb.2018.06.059_bib0125","series-title":"Fractal Geometry in Biological Systems","first-page":"205","article-title":"Applications of fractal geometry in pathology","author":"Landini","year":"1996"},{"key":"10.1016\/j.colsurfb.2018.06.059_bib0130","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1038\/nnano.2009.77","article-title":"Atomic force microscopy detects differences in the surface brush of Normal and cancerous cells","volume":"4","author":"Iyer","year":"2009","journal-title":"Nat. Nanotechnol."},{"key":"10.1016\/j.colsurfb.2018.06.059_bib0135","doi-asserted-by":"crossref","DOI":"10.1088\/1367-2630\/16\/10\/105002","article-title":"The effect of neighboring cells on the stiffness of cancerous and Non-cancerous human mammary epithelial cells","volume":"16","author":"Guo","year":"2014","journal-title":"New J. Phys."},{"key":"10.1016\/j.colsurfb.2018.06.059_bib0140","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1186\/s11671-015-1174-y","article-title":"B: discrimination between cervical cancer cells and Normal cervical cells based on longitudinal elasticity using atomic force microscopy","volume":"10","author":"Zhao","year":"2015","journal-title":"Nanoscale Res. Lett."},{"key":"10.1016\/j.colsurfb.2018.06.059_bib0145","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1209\/0295-5075\/19\/3\/001","article-title":"Simulating microscopic hydrodynamic phenomena with dissipative particle dynamics","volume":"19","author":"Hoogerbrugge","year":"1992","journal-title":"Europhys. Lett."},{"key":"10.1016\/j.colsurfb.2018.06.059_bib0150","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1209\/0295-5075\/30\/4\/001","article-title":"Statistical mechanics of dissipative particle dynamics","volume":"4","author":"Espa\u00f1ol","year":"1995","journal-title":"Europhys. Lett."},{"key":"10.1016\/j.colsurfb.2018.06.059_bib0155","doi-asserted-by":"crossref","first-page":"13218","DOI":"10.1038\/srep13218","article-title":"Computer simulations of the mechanical response of brushes on the surface of cancerous epithelial cells","volume":"5","author":"Gama Goicochea","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.colsurfb.2018.06.059_bib0160","doi-asserted-by":"crossref","first-page":"5057","DOI":"10.1063\/1.458541","article-title":"Synamics of entangled linear polymer melts: a molecular-dynamics simulation","volume":"92","author":"Kremer","year":"1990","journal-title":"J. Chem. Phys."},{"key":"10.1016\/j.colsurfb.2018.06.059_bib0165","doi-asserted-by":"crossref","first-page":"5048","DOI":"10.1063\/1.1498463","article-title":"Equilibrium structure and lateral stress distribution of amphiphilic bilayers from dissipative particle dynamics simulations","volume":"10","author":"Shillcock","year":"2002","journal-title":"J. Chem. Phys."},{"key":"10.1016\/j.colsurfb.2018.06.059_bib0170","doi-asserted-by":"crossref","first-page":"1757","DOI":"10.1016\/S0032-3861(03)00023-5","article-title":"Mesoscopic simulation of Polymer\u2013Solvent phase separation: linear Chain behaviour and branching effects","volume":"44","author":"van Vliet","year":"2003","journal-title":"Polymer"},{"key":"10.1016\/j.colsurfb.2018.06.059_bib0175","first-page":"2357","article-title":"Dependence of thermodynamic properties of model systems on some dissipative particle dynamics parameters","volume":"105","author":"Gama Goicochea","year":"2007","journal-title":"Mol. Phys."},{"key":"10.1016\/j.colsurfb.2018.06.059_bib0180","doi-asserted-by":"crossref","first-page":"11656","DOI":"10.1021\/la701791h","article-title":"Adsorption and disjoining pressure isotherms of confined polymers using dissipative particle dynamics","volume":"23","author":"Gama Goicochea","year":"2007","journal-title":"Langmuir"},{"key":"10.1016\/j.colsurfb.2018.06.059_bib0185","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1103\/PhysRevLett.50.145","article-title":"Geometric implementation of hypercubic lattices with noninteger dimensionality by use of Low lacunarity fractal lattices","volume":"50","author":"Gefen","year":"1983","journal-title":"Phys. Rev. Lett."},{"key":"10.1016\/j.colsurfb.2018.06.059_bib0190","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1007\/BF00125351","article-title":"Lacunarity indices as measures of landscape texture","volume":"8","author":"Plotnick","year":"1993","journal-title":"Landsc. Ecol."},{"key":"10.1016\/j.colsurfb.2018.06.059_bib0195","doi-asserted-by":"crossref","first-page":"3552","DOI":"10.1103\/PhysRevA.44.3552","article-title":"Characterizing the lacunarity of random and deterministic fractal sets","volume":"44","author":"Allain","year":"1991","journal-title":"Phys. Rev. A"},{"key":"10.1016\/j.colsurfb.2018.06.059_bib0200","doi-asserted-by":"crossref","first-page":"3049","DOI":"10.2217\/fon.15.211","article-title":"Fractals: a possible New path to diagnose and cure cancer?","volume":"11","author":"Sokolv","year":"2015","journal-title":"Future Oncol."},{"key":"10.1016\/j.colsurfb.2018.06.059_bib0205","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/nmeth.2089","article-title":"NIH image to imageJ: 25 years of images analysis","volume":"9","author":"Schneider","year":"2012","journal-title":"Nat. Methods"},{"key":"10.1016\/j.colsurfb.2018.06.059_bib0210","doi-asserted-by":"crossref","DOI":"10.1088\/1367-2630\/17\/3\/033019","article-title":"Emergence of fractal geometry on the surface of human cervical epithelial cells during progression towards cancer","volume":"17","author":"Dokukin","year":"2015","journal-title":"New J. Phys."},{"key":"10.1016\/j.colsurfb.2018.06.059_bib0215","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1007\/s11242-015-0463-3","article-title":"Lacunarity of classical site percolation spanning clusters built on correlated square lattices","volume":"107","author":"Hidalgo-Olgu\u00edn","year":"2015","journal-title":"Transp. Porous Med."},{"key":"10.1016\/j.colsurfb.2018.06.059_bib0220","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.jtbi.2012.03.013","article-title":"Changes in fractal dimension and lacunarity as early markers of UV-induced apoptosis","volume":"303","author":"Pantic","year":"2012","journal-title":"J. Theor. Biol."},{"key":"10.1016\/j.colsurfb.2018.06.059_bib0225","series-title":"Polymer Brushes","first-page":"427","article-title":"Local Chain organization of switchable binary polymer brushes in selective solvents","author":"LeMieux","year":"2004"}],"container-title":["Colloids and Surfaces B: Biointerfaces"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0927776518304302?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0927776518304302?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T10:38:15Z","timestamp":1760524695000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0927776518304302"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10]]},"references-count":45,"alternative-id":["S0927776518304302"],"URL":"https:\/\/doi.org\/10.1016\/j.colsurfb.2018.06.059","relation":{},"ISSN":["0927-7765"],"issn-type":[{"value":"0927-7765","type":"print"}],"subject":[],"published":{"date-parts":[[2018,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Fractal properties of biophysical models of pericellular brushes can be used to differentiate between cancerous and normal cervical epithelial cells","name":"articletitle","label":"Article Title"},{"value":"Colloids and Surfaces B: Biointerfaces","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.colsurfb.2018.06.059","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}