{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T12:01:06Z","timestamp":1768564866389,"version":"3.49.0"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T00:00:00Z","timestamp":1548979200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T00:00:00Z","timestamp":1548979200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001412","name":"Council of Scientific and Industrial Research, India","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001412","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Colloids and Surfaces B: Biointerfaces"],"published-print":{"date-parts":[[2019,2]]},"DOI":"10.1016\/j.colsurfb.2018.11.053","type":"journal-article","created":{"date-parts":[[2018,11,22]],"date-time":"2018-11-22T05:44:11Z","timestamp":1542865451000},"page":"501-510","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"C","title":["Lipid and TPGS based novel core-shell type nanocapsular sustained release system of methotrexate for intravenous application"],"prefix":"10.1016","volume":"174","author":[{"given":"Sameer S.","family":"Katiyar","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Varun","family":"Kushwah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chander Parkash","family":"Dora","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0636-6674","authenticated-orcid":false,"given":"Sanyog","family":"Jain","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.colsurfb.2018.11.053_bib0005","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.jconrel.2014.05.029","article-title":"Sustained-release from nanocarriers: a review","volume":"193","author":"Natarajan","year":"2014","journal-title":"J. Control. Release"},{"issue":"1","key":"10.1016\/j.colsurfb.2018.11.053_bib0010","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.addr.2012.09.037","article-title":"Liposomal drug delivery systems: from concept to clinical applications","volume":"65","author":"Allen","year":"2013","journal-title":"Adv. Drug. Deliv. Rev."},{"issue":"9","key":"10.1016\/j.colsurfb.2018.11.053_bib0015","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.2217\/nnm.11.52","article-title":"Methotrexate-loaded SLNs prepared by coacervation technique: in vitro cytotoxicity and in vivo pharmacokinetics and biodistribution","volume":"6","author":"Battaglia","year":"2011","journal-title":"Nanomedicine"},{"issue":"12","key":"10.1016\/j.colsurfb.2018.11.053_bib0020","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1038\/nnano.2007.387","article-title":"Nanocarriers as an emerging platform for cancer therapy","volume":"2","author":"Peer","year":"2007","journal-title":"Nat. Nanotechnol."},{"issue":"22","key":"10.1016\/j.colsurfb.2018.11.053_bib0025","doi-asserted-by":"crossref","first-page":"2576","DOI":"10.1002\/smll.201001122","article-title":"Self\u2010Assembled Core\u2013Shell vascular\u2010targeted nanocapsules for temporal antivasculature and anticancer activities","volume":"6","author":"Wang","year":"2010","journal-title":"Small"},{"issue":"2","key":"10.1016\/j.colsurfb.2018.11.053_bib0030","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/S0168-3659(98)00116-3","article-title":"PLGA nanoparticles prepared by nanoprecipitation: drug loading and release studies of a water soluble drug","volume":"57","author":"Govender","year":"1999","journal-title":"J. Control. Release"},{"issue":"1","key":"10.1016\/j.colsurfb.2018.11.053_bib0035","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.ijpharm.2008.08.022","article-title":"Nanostructure of liquid crystalline matrix determines in vitro sustained release and in vivo oral absorption kinetics for hydrophilic model drugs","volume":"365","author":"Lee","year":"2009","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.colsurfb.2018.11.053_bib0040","series-title":"Preparation and Characterization of Poly (D, L-Lactide)(PLA) and Poly (D, L-Lactide)-Poly (Ethylene Glycol)(PLA-PEG) Nanocapsules Containing Antitumoral Agent Methotrexate, Macromol. Sym.","first-page":"228","author":"de Faria","year":"2005"},{"issue":"1","key":"10.1016\/j.colsurfb.2018.11.053_bib0045","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1021\/mp700086j","article-title":"Methotrexate loaded polyether-copolyester dendrimers for the treatment of gliomas: enhanced efficacy and intratumoral transport capability","volume":"5","author":"Dhanikula","year":"2008","journal-title":"Mol. Pharm."},{"issue":"10","key":"10.1016\/j.colsurfb.2018.11.053_bib0050","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.2217\/nnm.11.53","article-title":"Synthesis, pharmacoscintigraphic evaluation and antitumor efficacy of methotrexate-loaded, folate-conjugated, stealth albumin nanoparticles","volume":"6","author":"Jain","year":"2011","journal-title":"Nanomedicine"},{"issue":"4","key":"10.1016\/j.colsurfb.2018.11.053_bib0055","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1208\/s12249-011-9695-x","article-title":"Methotrexate-loaded chitosan-and glycolchitosan-based nanoparticles: a promising strategy for the administration of the anticancer drug to brain tumors","volume":"12","author":"Trapani","year":"2011","journal-title":"AAPS Pharmscitech."},{"issue":"5539","key":"10.1016\/j.colsurfb.2018.11.053_bib0060","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1136\/bmj.1.5539.553-b","article-title":"Methotrexate in cancer","volume":"1","author":"Boulter","year":"1967","journal-title":"Brit. Med. J."},{"issue":"1-2","key":"10.1016\/j.colsurfb.2018.11.053_bib0065","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.ijpharm.2017.07.060","article-title":"Improved metabolic stability and therapeutic efficacy of a novel molecular gemcitabine phospholipid complex","volume":"530","author":"Dora","year":"2017","journal-title":"Int. J. Pharm."},{"issue":"1-2","key":"10.1016\/j.colsurfb.2018.11.053_bib0070","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ijpharm.2017.09.071","article-title":"Improved oral bioavailability and therapeutic efficacy of erlotinib through molecular complexation with phospholipid","volume":"534","author":"Dora","year":"2017","journal-title":"Int. J. Pharm."},{"issue":"7","key":"10.1016\/j.colsurfb.2018.11.053_bib0075","doi-asserted-by":"crossref","first-page":"2608","DOI":"10.3109\/10717544.2015.1039667","article-title":"Co-delivery of rapamycin-and piperine-loaded polymeric nanoparticles for breast cancer treatment","volume":"23","author":"Katiyar","year":"2016","journal-title":"Drug. Deliv."},{"issue":"9","key":"10.1016\/j.colsurfb.2018.11.053_bib0080","doi-asserted-by":"crossref","first-page":"2542","DOI":"10.1021\/mp300320d","article-title":"Gelatin coated hybrid lipid nanoparticles for oral delivery of amphotericin B","volume":"9","author":"Jain","year":"2012","journal-title":"Mol. Pharm."},{"issue":"2","key":"10.1016\/j.colsurfb.2018.11.053_bib0085","first-page":"161","article-title":"Scanning electron microscope studies of red cell morphology","volume":"22","author":"Longster","year":"1972","journal-title":"Vox Sang."},{"issue":"5","key":"10.1016\/j.colsurfb.2018.11.053_bib0090","doi-asserted-by":"crossref","first-page":"1629","DOI":"10.1016\/j.nano.2018.04.009","article-title":"Co-delivery of docetaxel and gemcitabine using PEGylated self-assembled stealth nanoparticles for improved breast cancer therapy","volume":"14","author":"Kushwah","year":"2018","journal-title":"Nanomed.: Nanotechnol. Biol. Med."},{"key":"10.1016\/j.colsurfb.2018.11.053_bib0095","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.carbpol.2015.10.080","article-title":"Potential of erlotinib cyclodextrin nanosponge complex to enhance solubility, dissolution rate, in vitro cytotoxicity and oral bioavailability","volume":"137","author":"Dora","year":"2016","journal-title":"Carbohydr. Polym."},{"issue":"11","key":"10.1016\/j.colsurfb.2018.11.053_bib0100","doi-asserted-by":"crossref","first-page":"3871","DOI":"10.1021\/acs.molpharmaceut.5b00281","article-title":"Enhanced antitumor efficacy and reduced toxicity of docetaxel loaded estradiol functionalized stealth polymeric nanoparticles","volume":"12","author":"Jain","year":"2015","journal-title":"Mol. Pharm."},{"issue":"1","key":"10.1016\/j.colsurfb.2018.11.053_bib0105","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/1743-8977-7-22","article-title":"Nanomaterial cytotoxicity is composition, size, and cell type dependent","volume":"7","author":"Sohaebuddin","year":"2010","journal-title":"Part. Fibre Toxicol."},{"issue":"2","key":"10.1016\/j.colsurfb.2018.11.053_bib0110","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/j.biomaterials.2010.09.037","article-title":"The effect of the oral administration of polymeric nanoparticles on the efficacy and toxicity of tamoxifen","volume":"32","author":"Jain","year":"2011","journal-title":"Biomaterials"},{"issue":"10","key":"10.1016\/j.colsurfb.2018.11.053_bib0115","doi-asserted-by":"crossref","first-page":"4357","DOI":"10.1073\/pnas.91.10.4357","article-title":"Hepatocyte growth factor prevents acute renal failure and accelerates renal regeneration in mice","volume":"91","author":"Kawaida","year":"1994","journal-title":"Proc. Nat. Acad. Sci."},{"issue":"1-2","key":"10.1016\/j.colsurfb.2018.11.053_bib0120","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.ijpharm.2018.03.021","article-title":"\u03b5-Poly-l-Lysine\/plasmid DNA nanoplexes for efficient gene delivery in vivo","volume":"542","author":"Mandal","year":"2018","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.colsurfb.2018.11.053_bib0125","first-page":"173","article-title":"The hematoxylin and eosin, theory & practice of histological techniques., Churchill Livingstone of Elevier","volume":"7","author":"Bancroft","year":"2013","journal-title":"Philadelphia"},{"issue":"16","key":"10.1016\/j.colsurfb.2018.11.053_bib0130","doi-asserted-by":"crossref","first-page":"4058","DOI":"10.1016\/j.biomaterials.2011.02.022","article-title":"Formulation of docetaxel by folic acid-conjugated d-\u03b1-tocopheryl polyethylene glycol succinate 2000 (vitamin E TPGS 2k) micelles for targeted and synergistic chemotherapy","volume":"32","author":"Mi","year":"2011","journal-title":"Biomaterials"},{"issue":"13","key":"10.1016\/j.colsurfb.2018.11.053_bib0135","doi-asserted-by":"crossref","first-page":"3657","DOI":"10.1016\/j.biomaterials.2010.01.065","article-title":"Effects of particle size and surface charge on cellular uptake and biodistribution of polymeric nanoparticles","volume":"31","author":"He","year":"2010","journal-title":"Biomaterials"},{"issue":"6","key":"10.1016\/j.colsurfb.2018.11.053_bib0140","doi-asserted-by":"crossref","first-page":"2705","DOI":"10.1016\/j.ejmech.2010.01.069","article-title":"Synthesis of novel dendrimers having aspartate grafts and their ability to enhance the aqueous solubility of model drugs","volume":"45","author":"Ouyang","year":"2010","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.colsurfb.2018.11.053_bib0145","series-title":"Response Surface Methodology: Process and Product Optimization Using Designed Experiments","first-page":"1","author":"Myers","year":"2016"},{"issue":"15","key":"10.1016\/j.colsurfb.2018.11.053_bib0150","doi-asserted-by":"crossref","first-page":"1688","DOI":"10.1016\/j.addr.2006.09.017","article-title":"Freeze-drying of nanoparticles: formulation, process and storage considerations","volume":"58","author":"Abdelwahed","year":"2006","journal-title":"Adv. Drug Deliv. Rev."},{"issue":"1","key":"10.1016\/j.colsurfb.2018.11.053_bib0155","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1038\/nm0102-81","article-title":"Nanocapsules: lipid-coated aggregates of cisplatin with high cytotoxicity","volume":"8","author":"Burger","year":"2002","journal-title":"Nat. Med."},{"issue":"1","key":"10.1016\/j.colsurfb.2018.11.053_bib0160","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/S0304-4157(00)00012-5","article-title":"Surface active drugs: self-association and interaction with membranes and surfactants. Physicochemical and biological aspects","volume":"1508","author":"Schreier","year":"2000","journal-title":"BBA-Biomem."},{"issue":"10","key":"10.1016\/j.colsurfb.2018.11.053_bib0165","doi-asserted-by":"crossref","first-page":"1550","DOI":"10.1023\/A:1015000503629","article-title":"Inhibition of P-glycoprotein by D-\u03b1-tocopheryl polyethylene glycol 1000 succinate (TPGS)","volume":"16","author":"Dintaman","year":"1999","journal-title":"Pharm. Res."},{"issue":"5","key":"10.1016\/j.colsurfb.2018.11.053_bib0170","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1007\/s10495-009-0452-5","article-title":"Regulation of apoptosis-associated lysosomal membrane permeabilization","volume":"15","author":"Johansson","year":"2010","journal-title":"Apoptosis"},{"issue":"50","key":"10.1016\/j.colsurfb.2018.11.053_bib0175","doi-asserted-by":"crossref","first-page":"6434","DOI":"10.1038\/onc.2008.310","article-title":"Lysosomal membrane permeabilization in cell death","volume":"27","author":"Boya","year":"2008","journal-title":"Oncogene"}],"updated-by":[{"DOI":"10.1016\/j.colsurfb.2020.111330","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000}}],"container-title":["Colloids and Surfaces B: Biointerfaces"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S092777651830835X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S092777651830835X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T10:37:49Z","timestamp":1760524669000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S092777651830835X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2]]},"references-count":35,"alternative-id":["S092777651830835X"],"URL":"https:\/\/doi.org\/10.1016\/j.colsurfb.2018.11.053","relation":{},"ISSN":["0927-7765"],"issn-type":[{"value":"0927-7765","type":"print"}],"subject":[],"published":{"date-parts":[[2019,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Lipid and TPGS based novel core-shell type nanocapsular sustained release system of methotrexate for intravenous application","name":"articletitle","label":"Article Title"},{"value":"Colloids and Surfaces B: Biointerfaces","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.colsurfb.2018.11.053","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}