{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T11:30:08Z","timestamp":1780054208945,"version":"3.54.0"},"reference-count":58,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Tehran University of Medical Sciences","award":["97-02-33-29338"],"award-info":[{"award-number":["97-02-33-29338"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Colloids and Surfaces B: Biointerfaces"],"published-print":{"date-parts":[[2019,6]]},"DOI":"10.1016\/j.colsurfb.2019.01.027","type":"journal-article","created":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T17:34:32Z","timestamp":1551461672000},"page":"307-316","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":46,"special_numbering":"C","title":["Erythropoietin-loaded solid lipid nanoparticles: Preparation, optimization, and in vivo evaluation"],"prefix":"10.1016","volume":"178","author":[{"given":"Tahereh","family":"Dara","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alireza","family":"Vatanara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohsen","family":"Nabi Meybodi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Molood Alsadat","family":"Vakilinezhad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soroor Sadegh","family":"Malvajerd","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faezeh","family":"Vakhshiteh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Azam","family":"Shamsian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Sharifzadeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hooman","family":"Kaghazian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Hossein","family":"Mosaddegh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.colsurfb.2019.01.027_bib0005","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.bej.2012.07.007","article-title":"Production and characterization of novel chitosan nanoparticles for controlled release of rHu-erythropoietin","volume":"68","author":"Bulmer","year":"2012","journal-title":"Biochem. Eng. J."},{"key":"10.1016\/j.colsurfb.2019.01.027_bib0010","doi-asserted-by":"crossref","first-page":"650","DOI":"10.3109\/02652048.2012.680507","article-title":"Novel erythropoietin-loaded nanoparticles with prolonged in vivo response","volume":"29","author":"Fayed","year":"2012","journal-title":"J. Microencapsulation"},{"key":"10.1016\/j.colsurfb.2019.01.027_bib0015","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.brainres.2015.05.031","article-title":"Erythropoietin attenuates Alzheimer-like memory impairments and pathological changes induced by amyloid \u03b242 in mice","volume":"1618","author":"Li","year":"2015","journal-title":"Brain Res."},{"key":"10.1016\/j.colsurfb.2019.01.027_bib0020","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1080\/02652040601058533","article-title":"The preparation of sustained release erythropoietin microparticle","volume":"24","author":"Yeh","year":"2007","journal-title":"J. Microencapsulation"},{"key":"10.1016\/j.colsurfb.2019.01.027_bib0025","doi-asserted-by":"crossref","first-page":"4282","DOI":"10.3390\/ijms12074282","article-title":"Preparation and characterization of catalase-loaded solid lipid nanoparticles protecting enzyme against proteolysis","volume":"12","author":"Qi","year":"2011","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.colsurfb.2019.01.027_bib0030","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1016\/j.addr.2003.12.002","article-title":"Solid lipid nanoparticles for parenteral drug delivery","volume":"56","author":"Wissing","year":"2004","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.colsurfb.2019.01.027_bib0035","doi-asserted-by":"crossref","first-page":"S15","DOI":"10.1185\/030079906X159588","article-title":"Pleiotropic effects of erythropoietin in neuronal and vascular systems","volume":"22","author":"Boogaerts","year":"2006","journal-title":"Curr. Med. Res. Opin."},{"key":"10.1016\/j.colsurfb.2019.01.027_bib0040","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.jconrel.2014.10.023","article-title":"Investigation of protein distribution in solid lipid particles and its impact on protein release using coherent anti-stokes Raman scattering microscopy","volume":"197","author":"Christophersen","year":"2015","journal-title":"J. Controlled Release"},{"key":"10.1016\/j.colsurfb.2019.01.027_bib0045","doi-asserted-by":"crossref","first-page":"245","DOI":"10.15171\/apb.2018.029","article-title":"Application of response surface method for preparation, optimization, and characterization of nicotinamide loaded solid lipid nanoparticles","volume":"8","author":"Vakilinezhad","year":"2018","journal-title":"Adv. Pharma. Bull."},{"key":"10.1016\/j.colsurfb.2019.01.027_bib0050","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1208\/s12249-009-9197-2","article-title":"Diazepam-loaded solid lipid nanoparticles: design and characterization","volume":"10","author":"Abdelbary","year":"2009","journal-title":"AAPS Pharmscitech"},{"key":"10.1016\/j.colsurfb.2019.01.027_bib0055","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.ejps.2012.07.006","article-title":"Development and optimization of baicalin-loaded solid lipid nanoparticles prepared by coacervation method using central composite design","volume":"47","author":"Hao","year":"2012","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.colsurfb.2019.01.027_bib0060","first-page":"683","article-title":"Development and optimization of solid lipid nanoparticle formulation for ophthalmic delivery of chloramphenicol using a Box-Behnken design","volume":"6","author":"Hao","year":"2011","journal-title":"Int. J. Nanomed."},{"key":"10.1016\/j.colsurfb.2019.01.027_bib0065","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/j.colsurfb.2015.09.040","article-title":"Enhanced anti-hyperproliferative activity of human thymidylate synthase inhibitor peptide by solid lipid nanoparticle delivery","volume":"136","author":"Sacchetti","year":"2015","journal-title":"Colloids Surf. B: Biointerfaces"},{"key":"10.1016\/j.colsurfb.2019.01.027_bib0070","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1248\/cpb.58.650","article-title":"Formulation and evaluation of solid lipid nanoparticles of a water soluble drug: zidovudine","volume":"58","author":"Singh","year":"2010","journal-title":"Chem. Pharm. Bull."},{"key":"10.1016\/j.colsurfb.2019.01.027_bib0075","doi-asserted-by":"crossref","first-page":"724","DOI":"10.3109\/10837450.2015.1116563","article-title":"The effect of freeze-dried antibody concentrations on its stability in the presence of trehalose and hydroxypropyl-\u03b2-cyclodextrin: a Box\u2013Behnken statistical design","volume":"22","author":"Faghihi","year":"2017","journal-title":"Pharma. Dev. Technol."},{"key":"10.1016\/j.colsurfb.2019.01.027_bib0080","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.ijpharm.2015.12.063","article-title":"Preparation and in vivo evaluation of insulin-loaded biodegradable nanoparticles prepared from diblock copolymers of PLGA and PEG","volume":"499","author":"Haggag","year":"2016","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.colsurfb.2019.01.027_bib0085","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.ijpharm.2008.01.008","article-title":"Solid lipid nanoparticles for pulmonary delivery of insulin","volume":"356","author":"Liu","year":"2008","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.colsurfb.2019.01.027_bib0090","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S0939-6411(96)00017-3","article-title":"Microencapsulation of rh-erythropoietin, using biodegradable poly (D, L-lactide-co-glycolide): protein stability and the effects of stabilizing excipients","volume":"43","author":"Morlock","year":"1997","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.colsurfb.2019.01.027_bib0095","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1038\/227680a0","article-title":"Cleavage of structural proteins during the assembly of the head of bacteriophage T4","volume":"227","author":"Laemmli","year":"1970","journal-title":"Nature"},{"key":"10.1016\/j.colsurfb.2019.01.027_bib0100","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/S0927-7765(02)00053-X","article-title":"Design of lipid nanoparticles for the oral delivery of hydrophilic macromolecules","volume":"27","author":"Garc\u0131a-Fuentes","year":"2003","journal-title":"Colloids Surf. B: Biointerfaces"},{"key":"10.1016\/j.colsurfb.2019.01.027_bib0105","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1016\/j.colsurfb.2013.06.013","article-title":"The effective encapsulation of a hydrophobic lipid-insoluble drug in solid lipid nanoparticles using a modified double emulsion solvent evaporation method","volume":"112","author":"Nabi-Meibodi","year":"2013","journal-title":"Colloids Surf. B: Biointerfaces"},{"key":"10.1016\/j.colsurfb.2019.01.027_bib0110","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.jddst.2016.06.012","article-title":"Brain delivery of baclofen as a hydrophilic drug by nanolipid carriers: characteristics and pharmacokinetics evaluation","volume":"37","author":"Ghasemian","year":"2017","journal-title":"J. Drug Delivery Sci. Technol."},{"key":"10.1016\/j.colsurfb.2019.01.027_bib0115","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/S1773-2247(13)50034-7","article-title":"Optimized double emulsion-solvent evaporation process for production of solid lipid nanoparticles containing baclofene as a lipid insoluble drug","volume":"23","author":"Nabi-Meibodi","year":"2013","journal-title":"J. Drug Delivery Sci. Technol."},{"key":"10.1016\/j.colsurfb.2019.01.027_bib0120","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.ijpharm.2011.12.037","article-title":"Loading hydrophilic drug in solid lipid media as nanoparticles: statistical modeling of entrapment efficiency and particle size","volume":"424","author":"Ghadiri","year":"2012","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.colsurfb.2019.01.027_bib0125","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1111\/jphp.12737","article-title":"Encapsulation of ritonavir in solid lipid nanoparticles: in\u2010vitro anti\u2010HIV\u20101 activity using lentiviral particles","volume":"69","author":"Javan","year":"2017","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.colsurfb.2019.01.027_bib0130","article-title":"Brain delivery of curcumin using solid lipid nanoparticles and nanostructured lipid carriers: preparation, optimization, and pharmacokinetic evaluation","author":"Sadegh Malvajerd","year":"2018","journal-title":"ACS Chem. Neurosci."},{"key":"10.1016\/j.colsurfb.2019.01.027_bib0135","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1016\/j.colsurfb.2010.07.029","article-title":"Design and ocular tolerance of flurbiprofen loaded ultrasound-engineered NLC","volume":"81","author":"Gonzalez-Mira","year":"2010","journal-title":"Colloids Surf. B: Biointerfaces"},{"key":"10.1016\/j.colsurfb.2019.01.027_bib0140","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.jconrel.2008.06.011","article-title":"Formulating erythropoietin-loaded sustained-release PLGA microspheres without protein aggregation","volume":"130","author":"Geng","year":"2008","journal-title":"J. Controlled Release"},{"key":"10.1016\/j.colsurfb.2019.01.027_bib0145","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/S0168-3659(99)00008-5","article-title":"Biodegradable recombinant human erythropoietin loaded microspheres prepared from linear and star-branched block copolymers: influence of encapsulation technique and polymer composition on particle characteristics","volume":"59","author":"Pistel","year":"1999","journal-title":"J. Controlled Release"},{"key":"10.1016\/j.colsurfb.2019.01.027_bib0150","doi-asserted-by":"crossref","first-page":"2663","DOI":"10.5012\/bkcs.2013.34.9.2663","article-title":"Analysis of the structure and stability of erythropoietin by pH and temperature changes using various LC\/MS","volume":"34","author":"Chang","year":"2013","journal-title":"Bull. Korean Chem. Soc."},{"key":"10.1016\/j.colsurfb.2019.01.027_bib0155","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0022-1759(83)90303-4","article-title":"Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays","volume":"65","author":"Mosmann","year":"1983","journal-title":"J. Immunol. Methods"},{"key":"10.1016\/j.colsurfb.2019.01.027_bib0160","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.pbb.2014.12.011","article-title":"Erythropoietin improves synaptic plasticity and memory deficits by decrease of the neurotransmitter release probability in the rat model of Alzheimer\u2019s disease","volume":"130","author":"Tazangi","year":"2015","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.colsurfb.2019.01.027_bib0165","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1271\/bbb.65.1321","article-title":"Kinetic and thermodynamic analysis of thermal unfolding of recombinant erythropoietin","volume":"65","author":"Arakawa","year":"2001","journal-title":"Biosci. Biotechnol. Biochem."},{"key":"10.1016\/j.colsurfb.2019.01.027_bib0170","volume":"vol.121","author":"Hyseni","year":"2015"},{"key":"10.1016\/j.colsurfb.2019.01.027_bib0175","doi-asserted-by":"crossref","first-page":"474","DOI":"10.3109\/21691401.2016.1173046","article-title":"Application of quality-by-design approach to optimize diallyl disulfide-loaded solid lipid nanoparticles","volume":"45","author":"Talluri","year":"2017","journal-title":"Artif. Cells Nanomed. Biotechnol."},{"key":"10.1016\/j.colsurfb.2019.01.027_bib0180","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1016\/j.addr.2007.04.007","article-title":"Solid lipid nanoparticles as a drug delivery system for peptides and proteins","volume":"59","author":"Almeida","year":"2007","journal-title":"Adv. Drug Delivery Rev."},{"key":"10.1016\/j.colsurfb.2019.01.027_bib0185","first-page":"80","article-title":"Solid lipid nanoparticles: a review","volume":"2","author":"Ekambaram","year":"2012","journal-title":"Sci. Rev. Chem. Commun."},{"key":"10.1016\/j.colsurfb.2019.01.027_bib0190","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.steroids.2015.05.012","article-title":"Design, characterization and skin permeating potential of Fluocinolone acetonide loaded nanostructured lipid carriers for topical treatment of psoriasis","volume":"101","author":"Pradhan","year":"2015","journal-title":"Steroids"},{"key":"10.1016\/j.colsurfb.2019.01.027_bib0195","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.colsurfa.2009.11.006","article-title":"Optimization of nanostructured lipid carriers for lutein delivery","volume":"353","author":"Liu","year":"2010","journal-title":"Colloids Surf. A: Physicochem. Eng. Aspects"},{"key":"10.1016\/j.colsurfb.2019.01.027_bib0200","doi-asserted-by":"crossref","first-page":"590","DOI":"10.3109\/02652048.2014.898707","article-title":"Physico-chemical characterisation, cytotoxic activity, and biocompatibility studies of tamoxifen-loaded solid lipid nanoparticles prepared via a temperature-modulated solidification method","volume":"31","author":"Lakkadwala","year":"2014","journal-title":"J. Microencapsulation"},{"key":"10.1016\/j.colsurfb.2019.01.027_bib0205","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.jcis.2009.03.012","article-title":"Effect of surfactant surface coverage on formation of solid lipid nanoparticles (SLN)","volume":"334","author":"Helgason","year":"2009","journal-title":"J. Colloid Interface Sci."},{"key":"10.1016\/j.colsurfb.2019.01.027_bib0210","first-page":"1912","article-title":"Development, optimization and evaluation of surfactant-based pulmonary nanolipid carrier system of paclitaxel for the management of drug resistance lung cancer using Box-Behnken design","volume":"23","author":"Kaur","year":"2016","journal-title":"Drug delivery"},{"key":"10.1016\/j.colsurfb.2019.01.027_bib0215","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1007\/s11051-008-9402-3","article-title":"Optimization of \u03b2-carotene loaded solid lipid nanoparticles preparation using a high shear homogenization technique","volume":"11","author":"Triplett","year":"2009","journal-title":"J. Nanopart. Res."},{"key":"10.1016\/j.colsurfb.2019.01.027_bib0220","first-page":"7","article-title":"Preparation, characterization and rheological properties of vitamin E enriched nanoemulsion","volume":"27","author":"Sharif","year":"2017","journal-title":"Pak. J. Food Sci."},{"key":"10.1016\/j.colsurfb.2019.01.027_bib0225","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.ejps.2017.01.026","article-title":"Formulation and optimization of doxorubicin loaded polymeric nanoparticles using Box-Behnken design: ex-vivo stability and in-vitro activity","volume":"100","author":"Shaikh","year":"2017","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.colsurfb.2019.01.027_bib0230","series-title":"Excipients That Facilitate Amorphous Drug Stabilization, Excipient Applications in Formulation Design and Drug Delivery","first-page":"463","author":"Wei","year":"2015"},{"key":"10.1016\/j.colsurfb.2019.01.027_bib0235","series-title":"Methods and Compositions for Pulmonary Delivery of Insulin, Google Patents","author":"Patton","year":"2009"},{"key":"10.1016\/j.colsurfb.2019.01.027_bib0240","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.ijpharm.2016.09.033","article-title":"Comparison of different in vitro release methods used to investigate nanocarriers intended for dermal application","volume":"513","author":"Balzus","year":"2016","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.colsurfb.2019.01.027_bib0245","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1007\/s11095-005-5356-7","article-title":"Interaction of polysorbate 80 with erythropoietin: a case study in protein\u2013surfactant interactions","volume":"22","author":"Villalobos","year":"2005","journal-title":"Pharm. Res."},{"key":"10.1016\/j.colsurfb.2019.01.027_bib0250","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/S0939-6411(98)00012-5","article-title":"Recombinant human erythropoietin (rhEPO) loaded poly (lactide-co-glycolide) microspheres: influence of the encapsulation technique and polymer purity on microsphere characteristics","volume":"45","author":"Bittner","year":"1998","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.colsurfb.2019.01.027_bib0255","doi-asserted-by":"crossref","first-page":"167","DOI":"10.18433\/J3D59T","article-title":"Kinetic analysis of drug release from nanoparticles","volume":"11","author":"Barzegar-Jalali","year":"2008","journal-title":"J. Pharm. Pharm. Sci."},{"key":"10.1016\/j.colsurfb.2019.01.027_bib0260","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ejpb.2014.02.005","article-title":"Nanotoxicology applied to solid lipid nanoparticles and nanostructured lipid carriers\u2013a systematic review of in vitro data","volume":"87","author":"Doktorovova","year":"2014","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.colsurfb.2019.01.027_bib0265","doi-asserted-by":"crossref","DOI":"10.1055\/s-0036-1571560","article-title":"Epicardial erythropoietin hydrogel improves cardiac functions and accelerates rapid proliferation and tissue transformation in the intracardiac mesenchyme after myocardial infarction","volume":"64","author":"Klopsch","year":"2016","journal-title":"Thoracic Cardiovasc. Surgeon"},{"key":"10.1016\/j.colsurfb.2019.01.027_bib0270","article-title":"To investigate the in-vitro effect of erythropoietin on cell lines using MTT assay","volume":"300","author":"Hanif","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.colsurfb.2019.01.027_bib0275","first-page":"45","article-title":"Cellular uptake of coumarin-6 as a model drug loaded in solid lipid nanoparticles","volume":"62","author":"Rivolta","year":"2011","journal-title":"J. Physiol. Pharmacol."},{"key":"10.1016\/j.colsurfb.2019.01.027_bib0280","doi-asserted-by":"crossref","first-page":"116","DOI":"10.3390\/molecules21010116","article-title":"Skin delivery and in vitro biological evaluation of trans-resveratrol-loaded solid lipid nanoparticles for skin disorder therapies","volume":"21","author":"Rigon","year":"2016","journal-title":"Molecules"},{"key":"10.1016\/j.colsurfb.2019.01.027_bib0285","first-page":"541","article-title":"Erythropoietin and platelet production","volume":"84","author":"Beguin","year":"1999","journal-title":"Haematologica"},{"key":"10.1016\/j.colsurfb.2019.01.027_bib0290","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1002\/(SICI)1099-1263(200001\/02)20:1<25::AID-JAT624>3.0.CO;2-7","article-title":"Effects of phenylhydrazine or phlebotomy on peripheral blood, bone marrow and erythropoietin in Wistar rats","volume":"20","author":"Criswell","year":"2000","journal-title":"J. Appl. Toxicol. Int. J."}],"container-title":["Colloids and Surfaces B: Biointerfaces"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0927776519300268?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0927776519300268?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,5,20]],"date-time":"2019-05-20T03:40:04Z","timestamp":1558323604000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0927776519300268"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6]]},"references-count":58,"alternative-id":["S0927776519300268"],"URL":"https:\/\/doi.org\/10.1016\/j.colsurfb.2019.01.027","relation":{},"ISSN":["0927-7765"],"issn-type":[{"value":"0927-7765","type":"print"}],"subject":[],"published":{"date-parts":[[2019,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Erythropoietin-loaded solid lipid nanoparticles: Preparation, optimization, and in vivo evaluation","name":"articletitle","label":"Article Title"},{"value":"Colloids and Surfaces B: Biointerfaces","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.colsurfb.2019.01.027","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}