{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T05:37:22Z","timestamp":1790141842037,"version":"4.0.1"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,11,1]],"date-time":"2019-11-01T00:00:00Z","timestamp":1572566400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,11,1]],"date-time":"2019-11-01T00:00:00Z","timestamp":1572566400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["MOST105-2221-E-002-209-MY3"],"award-info":[{"award-number":["MOST105-2221-E-002-209-MY3"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["NSC102-2923-E-002-005-MY3"],"award-info":[{"award-number":["NSC102-2923-E-002-005-MY3"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Colloids and Surfaces B: Biointerfaces"],"published-print":{"date-parts":[[2019,11]]},"DOI":"10.1016\/j.colsurfb.2019.110461","type":"journal-article","created":{"date-parts":[[2019,8,26]],"date-time":"2019-08-26T11:30:13Z","timestamp":1566819013000},"page":"110461","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"special_numbering":"C","title":["Role of molecular weight and hydrophobicity of amphiphilic tri-block copolymers in temperature-dependent co-micellization process and drug solubility"],"prefix":"10.1016","volume":"183","author":[{"given":"Chin-Fen","family":"Lee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ching-Hsun","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7638-2066","authenticated-orcid":false,"given":"Tsang-Lang","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pratap","family":"Bahadur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Jen","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.colsurfb.2019.110461_bib0005","doi-asserted-by":"crossref","first-page":"717","DOI":"10.3109\/10837450.2013.823994","article-title":"Adoption of polymeric micelles to enhance the oral bioavailability of dexibuprofen: formulation, in-vitro evaluation and in-vivo pharmacokinetic study in healthy human volunteers","volume":"19","author":"Abdelbary","year":"2014","journal-title":"Pharm. Dev. Technol."},{"key":"10.1016\/j.colsurfb.2019.110461_bib0010","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1007\/s10637-010-9399-1","article-title":"A phase 2 study of SP1049C, doxorubicin in P-glycoprotein-targeting pluronics, in patients with advanced adenocarcinoma of the esophagus and gastroesophageal junction","volume":"29","author":"Valle","year":"2011","journal-title":"Invest. New Drugs"},{"key":"10.1016\/j.colsurfb.2019.110461_bib0015","doi-asserted-by":"crossref","first-page":"8613","DOI":"10.1016\/j.biomaterials.2012.08.007","article-title":"Co-delivery of paclitaxel and survivin shRNA by pluronic P85-PEI\/TPGS complex nanoparticles to overcome drug resistance in lung cancer","volume":"33","author":"Shen","year":"2012","journal-title":"Biomaterials"},{"key":"10.1016\/j.colsurfb.2019.110461_bib0020","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1016\/j.colsurfb.2018.12.031","article-title":"PEG-coated vesicles from Pluronic\/lipid mixtures for the carrying of photoactive erythrosine derivatives","volume":"175","author":"de Freitas","year":"2019","journal-title":"Colloids Surf. B. Biointerfaces"},{"key":"10.1016\/j.colsurfb.2019.110461_bib0025","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.colsurfb.2018.05.013","article-title":"Bulk and dispersed aqueous behaviour of an endogenous lipid, selachyl alcohol: effect of Tween 80 and Pluronic F127 on nanostructure","volume":"169","author":"Younus","year":"2018","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"10.1016\/j.colsurfb.2019.110461_bib0030","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.colsurfb.2018.03.001","article-title":"Pluronic\u00ae-bile salt mixed micelles","volume":"166","author":"Patel","year":"2018","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"10.1016\/j.colsurfb.2019.110461_bib0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.colsurfb.2013.03.043","article-title":"A new hydrate form of diflunisal precipitated from a microemulsion system","volume":"109","author":"Sung","year":"2013","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"10.1016\/j.colsurfb.2019.110461_bib0040","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.jcis.2018.02.076","article-title":"Self-assembled and pH-sensitive mixed micelles as an intracellular doxorubicin delivery system","volume":"523","author":"Jafarzadeh-Holagh","year":"2018","journal-title":"J. Colloid Interface Sci."},{"key":"10.1016\/j.colsurfb.2019.110461_bib0045","doi-asserted-by":"crossref","first-page":"2606","DOI":"10.1021\/la962033r","article-title":"Diode-array UV spectrometric evidence for cooperative interactions in binary mixtures of pluronics F77, F87, and F127","volume":"13","author":"Gaisford","year":"1997","journal-title":"Langmuir"},{"key":"10.1016\/j.colsurfb.2019.110461_bib0050","doi-asserted-by":"crossref","first-page":"3109","DOI":"10.1021\/la9812525","article-title":"Self-assembly of mixed amphiphilic triblock copolymers in aqueous solution","volume":"15","author":"Liu","year":"1999","journal-title":"Langmuir"},{"key":"10.1016\/j.colsurfb.2019.110461_bib0055","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1080\/02652048.2018.1441916","article-title":"Development and characterization of morin hydrate-loaded micellar nanocarriers for the effective management of Alzheimer\u2019s disease","volume":"35","author":"Singh","year":"2018","journal-title":"J. Microencapsulation"},{"key":"10.1016\/j.colsurfb.2019.110461_bib0060","doi-asserted-by":"crossref","first-page":"105","DOI":"10.3390\/polym10010105","article-title":"Synergistic effect of binary mixed-Pluronic systems on temperature dependent self-assembly process and drug solubility","volume":"10","author":"Lee","year":"2018","journal-title":"Polymers"},{"key":"10.1016\/j.colsurfb.2019.110461_bib0065","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.jcis.2008.09.054","article-title":"Structure, rheology and shear alignment of Pluronic block copolymer mixtures","volume":"329","author":"Newby","year":"2009","journal-title":"J. Colloid Interface Sci."},{"key":"10.1016\/j.colsurfb.2019.110461_bib0070","article-title":"Adding vitamin E-TPGS to the formulation of Genexol-PM: specially mixed micelles improve drug-loading ability and cytotoxicity against multidrug-resistant tumors significantly","volume":"10","author":"Fan","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.colsurfb.2019.110461_bib0075","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1002\/jbm.b.33824","article-title":"Co\u2010micellized Pluronic mixture with thermo\u2010sensitivity and residence stability as an injectable tissue adhesion barrier hydrogel","volume":"106","author":"Oh","year":"2018","journal-title":"J. Biomed. Mater. Res. B Appl. Biomater."},{"key":"10.1016\/j.colsurfb.2019.110461_bib0080","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/j.ijpharm.2013.01.043","article-title":"Nanostructured fluids from pluronic\u00ae mixtures","volume":"454","author":"Zhang","year":"2013","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.colsurfb.2019.110461_bib0085","doi-asserted-by":"crossref","first-page":"5284","DOI":"10.1016\/j.polymer.2014.08.031","article-title":"Micellization and gelation of PEO-PPO-PEO binary mixture with non-identical PPO block lengths in aqueous solution","volume":"55","author":"Pragatheeswaran","year":"2014","journal-title":"Polymer"},{"key":"10.1016\/j.colsurfb.2019.110461_bib0090","doi-asserted-by":"crossref","first-page":"2606","DOI":"10.1021\/la962033r","article-title":"Diode-array UV spectrometric evidence for cooperative interactions in binary mixtures of pluronics F77, F87, and F127","volume":"13","author":"Gaisford","year":"1997","journal-title":"Langmuir"},{"key":"10.1016\/j.colsurfb.2019.110461_bib0095","doi-asserted-by":"crossref","first-page":"9229","DOI":"10.1021\/la701157j","article-title":"Micellization and gelation of mixed copolymers P123 and F127 in aqueous solution","volume":"23","author":"Chaibundit","year":"2007","journal-title":"Langmuir"},{"key":"10.1016\/j.colsurfb.2019.110461_bib0100","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.jconrel.2003.11.003","article-title":"The effects of Pluronic block copolymers on the aggregation state of nystatin","volume":"95","author":"Croy","year":"2004","journal-title":"J. Control. Release"},{"key":"10.1016\/j.colsurfb.2019.110461_bib0105","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/0168-3659(92)90199-2","article-title":"A new class of drug carriers: micelles of poly (oxyethylene)-poly (oxypropylene) block copolymers as microcontainers for drug targeting from blood in brain","volume":"22","author":"Kabanov","year":"1992","journal-title":"J. Control. Release"},{"key":"10.1016\/j.colsurfb.2019.110461_bib0110","doi-asserted-by":"crossref","first-page":"8426","DOI":"10.1021\/la049514s","article-title":"Single-step synthesis and stabilization of metal nanoparticles in aqueous Pluronic block copolymer solutions at ambient temperature","volume":"20","author":"Sakai","year":"2004","journal-title":"Langmuir"},{"key":"10.1016\/j.colsurfb.2019.110461_bib0115","doi-asserted-by":"crossref","DOI":"10.1063\/1.3578183","article-title":"Microviscoelasticity of soft repulsive sphere dispersions: tracer particle microrheology of triblock copolymer micellar liquids and soft crystals","volume":"134","author":"Tanner","year":"2011","journal-title":"J. Chem. Phys."},{"key":"10.1016\/j.colsurfb.2019.110461_bib0120","doi-asserted-by":"crossref","first-page":"1687","DOI":"10.1007\/s00396-010-2308-5","article-title":"Study of heat of micellization and phase separation for Pluronic aqueous solutions by using a high sensitivity differential scanning calorimetry","volume":"288","author":"Tsui","year":"2010","journal-title":"Colloid Polym. Sci."},{"key":"10.1016\/j.colsurfb.2019.110461_bib0125","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.colsurfa.2016.08.070","article-title":"The origin of anomalous positive heat capacity change upon micellization of Pluronic triblock copolymer F108 in aqueous solutions: effect of PEO-PPO diblock impurities","volume":"509","author":"Hsu","year":"2016","journal-title":"Colloids Surf. A Physicochem. Eng. Asp."},{"key":"10.1016\/j.colsurfb.2019.110461_bib0130","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1107\/S0021889809043271","article-title":"A small\/wide-angle X-ray scattering instrument for structural characterization of air\u2013liquid interfaces, thin films and bulk specimens","volume":"43","author":"Jeng","year":"2010","journal-title":"J. Appl. Crystallogr."},{"key":"10.1016\/j.colsurfb.2019.110461_bib0135","doi-asserted-by":"crossref","first-page":"2237","DOI":"10.1039\/C4SM02886D","article-title":"A time-resolved study on the interaction of oppositely charged bicelles\u2013implications on the charged lipid exchange kinetics","volume":"11","author":"Yang","year":"2015","journal-title":"Soft Matter"},{"key":"10.1016\/j.colsurfb.2019.110461_bib0140","doi-asserted-by":"crossref","first-page":"13858","DOI":"10.1021\/la803272y","article-title":"Novel behavior of heat of micellization of Pluronics F68 and F88 in aqueous solutions","volume":"24","author":"Tsui","year":"2008","journal-title":"Langmuir"},{"key":"10.1016\/j.colsurfb.2019.110461_bib0145","doi-asserted-by":"crossref","first-page":"3403","DOI":"10.1007\/s00396-015-3662-0","article-title":"Effect of alcohols on the heat of micellization of Pluronic F88 aqueous solutions","volume":"293","author":"Hsu","year":"2015","journal-title":"Colloid Polym. Sci."},{"key":"10.1016\/j.colsurfb.2019.110461_bib0150","doi-asserted-by":"crossref","first-page":"3306","DOI":"10.1063\/1.461926","article-title":"A neutron scattering study of the structure of a bimodal colloidal crystal","volume":"96","author":"Bartlett","year":"1992","journal-title":"J. Chem. Phys."},{"key":"10.1016\/j.colsurfb.2019.110461_bib0155","doi-asserted-by":"crossref","first-page":"11318","DOI":"10.1021\/jp200212g","article-title":"Structure of micelles of a nonionic block copolymer determined by SANS and SAXS","volume":"115","author":"Manet","year":"2011","journal-title":"J. Phys. Chem. B"},{"key":"10.1016\/j.colsurfb.2019.110461_bib0160","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1007\/s12043-008-0212-z","article-title":"Small angle neutron scattering study of doxorubicin-surfactant complexes encapsulated in block copolymer micelles","volume":"71","author":"Bhattacharjee","year":"2008","journal-title":"Pramana"},{"key":"10.1016\/j.colsurfb.2019.110461_bib0165","doi-asserted-by":"crossref","first-page":"11545","DOI":"10.1021\/jp303185m","article-title":"Effect of temperature, cosolvent, and added drug on pluronic\u2013flurbiprofen micellization","volume":"116","author":"Alexander","year":"2012","journal-title":"J. Phys. Chem. B"},{"key":"10.1016\/j.colsurfb.2019.110461_bib0170","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1063\/1.1724075","article-title":"The intrinsic viscosity of polymer solutions","volume":"14","author":"Debye","year":"1946","journal-title":"J. Chem. Phys."},{"key":"10.1016\/j.colsurfb.2019.110461_bib0175","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.msea.2010.08.060","article-title":"Effects of molecular weight, temperature and salt on the self assembly of triblock copolymer solutions","volume":"528","author":"Fan","year":"2010","journal-title":"Mater. Sci. Eng. A"},{"key":"10.1016\/j.colsurfb.2019.110461_bib0180","doi-asserted-by":"crossref","first-page":"2236","DOI":"10.1021\/ma971253o","article-title":"Small-angle neutron scattering analysis of the structure and interaction of triblock copolymer micelles in aqueous solution","volume":"31","author":"Liu","year":"1998","journal-title":"Macromolecules"},{"key":"10.1016\/j.colsurfb.2019.110461_bib0185","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S0927-7757(99)00514-2","article-title":"Salt induced micellization and micelle structures of\u2019PEO\/PPO\/PEO block copolymers in aqueous solution","volume":"173","author":"Jain","year":"2000","journal-title":"Colloids Surf. A Physicochem. Eng. Asp."},{"key":"10.1016\/j.colsurfb.2019.110461_bib0190","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1007\/s10953-004-1051-2","article-title":"Temperature dependence of solubility for ibuprofen in some organic and aqueous solvents","volume":"33","author":"Garz\u00f3n","year":"2004","journal-title":"J. Solution Chem."}],"container-title":["Colloids and Surfaces B: Biointerfaces"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0927776519306058?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0927776519306058?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T23:21:07Z","timestamp":1777591267000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0927776519306058"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11]]},"references-count":38,"alternative-id":["S0927776519306058"],"URL":"https:\/\/doi.org\/10.1016\/j.colsurfb.2019.110461","relation":{},"ISSN":["0927-7765"],"issn-type":[{"value":"0927-7765","type":"print"}],"subject":[],"published":{"date-parts":[[2019,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Role of molecular weight and hydrophobicity of amphiphilic tri-block copolymers in temperature-dependent co-micellization process and drug solubility","name":"articletitle","label":"Article Title"},{"value":"Colloids and Surfaces B: Biointerfaces","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.colsurfb.2019.110461","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"110461"}}