{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T18:29:53Z","timestamp":1791224993593,"version":"4.1.0"},"reference-count":32,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100007219","name":"Natural Science Foundation of Shanghai","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007219","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013076","name":"National Major Science and Technology Projects of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013076","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Colloids and Surfaces B: Biointerfaces"],"published-print":{"date-parts":[[2020,5]]},"DOI":"10.1016\/j.colsurfb.2020.110882","type":"journal-article","created":{"date-parts":[[2020,2,18]],"date-time":"2020-02-18T19:45:40Z","timestamp":1582055140000},"page":"110882","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":29,"special_numbering":"C","title":["Study on the protection of dextran on erythrocytes during drug loading"],"prefix":"10.1016","volume":"189","author":[{"given":"Enge","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyi","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiumei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamal","family":"Zul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faisal","family":"Raza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2470-6828","authenticated-orcid":false,"given":"Jing","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingfeng","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.colsurfb.2020.110882_bib0005","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1016\/S0021-9290(03)00067-8","article-title":"Rheology of concentrated suspensions of deformable elastic particles such as human erythrocytes","volume":"36","author":"Rajinder","year":"2003","journal-title":"J. Biomech."},{"key":"10.1016\/j.colsurfb.2020.110882_bib0010","doi-asserted-by":"crossref","first-page":"863","DOI":"10.7150\/thno.11852","article-title":"Cell or cell membrane-based drug delivery systems","volume":"5","author":"Tan","year":"2015","journal-title":"Theranostics"},{"key":"10.1016\/j.colsurfb.2020.110882_bib0015","doi-asserted-by":"crossref","first-page":"3359","DOI":"10.1016\/0006-2952(83)90363-5","article-title":"Encapsulation of drugs in intact erythrocytes: an intravenous delivery system","volume":"32","author":"Pitt","year":"1983","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.colsurfb.2020.110882_bib0020","doi-asserted-by":"crossref","first-page":"1700270","DOI":"10.1002\/smtd.201700270","article-title":"Red blood cells for drug delivery","volume":"1","author":"Yan","year":"2017","journal-title":"Small Methods"},{"key":"10.1016\/j.colsurfb.2020.110882_bib0025","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1517\/17425247.2.2.311","article-title":"Erythrocyte-based drug delivery","volume":"2","author":"Rossi","year":"2005","journal-title":"Expert Opin. Drug Deliv."},{"key":"10.1016\/j.colsurfb.2020.110882_bib0030","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1002\/iub.478","article-title":"Drug delivery by red blood cells","volume":"63","author":"Biagiotti","year":"2011","journal-title":"IUBMB Life"},{"key":"10.1016\/j.colsurfb.2020.110882_bib0035","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.jconrel.2013.12.019","article-title":"Cell-penetrating peptides meditated encapsulation of protein therapeutics into intact red blood cells and its application","volume":"176","author":"He","year":"2014","journal-title":"J. Control. Release"},{"key":"10.1016\/j.colsurfb.2020.110882_bib0040","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.addr.2016.02.007","article-title":"Red blood cells: supercarriers for drugs, biologicals, and nanoparticles and inspiration for advanced delivery systems","volume":"106","author":"Villa","year":"2016","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.colsurfb.2020.110882_bib0045","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1248\/bpb.16.1118","article-title":"Hypoglycemic activity of polygonati rhizoma in normal and diabetic mice","volume":"16","author":"Kato","year":"1993","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.colsurfb.2020.110882_bib0050","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1002\/smll.200900919","article-title":"In vitro inhibition of fungal activity by macrophage-mediated sequestration and release of encapsulated amphotericin B nanosupension in red blood cells","volume":"6","author":"Staedtke","year":"2010","journal-title":"Small"},{"key":"10.1016\/j.colsurfb.2020.110882_bib0055","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/0304-4165(77)90332-4","article-title":"Effect of glutaraldehyde treatment on enzyme-loaded erythrocytes","volume":"496","author":"Deloach","year":"1977","journal-title":"Biochim. Biophys. Acta-Gen. Subj."},{"key":"10.1016\/j.colsurfb.2020.110882_bib0060","doi-asserted-by":"crossref","first-page":"15169","DOI":"10.1021\/la1023086","article-title":"Dilution technique to determine the hydrodynamic volume fraction of a vesicle suspension","volume":"26","author":"Seth","year":"2010","journal-title":"Langmuir"},{"key":"10.1016\/j.colsurfb.2020.110882_bib0065","first-page":"246","article-title":"The encapsulation of insulin in erythrocytes, J. Pharm","volume":"35","author":"Bird","year":"1983","journal-title":"Pharmacol."},{"key":"10.1016\/j.colsurfb.2020.110882_bib0070","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.bcmd.2004.06.004","article-title":"Factors associated with the performance of carrier erythrocytes obtained by hypotonic dialysis","volume":"33","author":"Mill\u00e1n","year":"2004","journal-title":"Blood Cells Mol. Dis."},{"key":"10.1016\/j.colsurfb.2020.110882_bib0075","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1081\/DDC-100102306","article-title":"Evaluation of hypotonic preswelling method for encapsulation of enalaprilat in intact human erythrocytes","volume":"26","author":"Tajerzadeh","year":"2000","journal-title":"Drug Dev. Ind. Pharm."},{"key":"10.1016\/j.colsurfb.2020.110882_bib0080","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.ijpharm.2007.04.001","article-title":"Preparation and in vitro evaluation of carrier erythrocytes for RES-targeted delivery of interferon-alpha 2b","volume":"341","author":"Hamidi","year":"2007","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.colsurfb.2020.110882_bib0085","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/0014-5793(88)80791-9","article-title":"Electroporation: high frequency of occurrence of a transient high-permeability state in erythrocytes and intact yeast","volume":"229","author":"Weaver","year":"1988","journal-title":"FEBS Lett."},{"key":"10.1016\/j.colsurfb.2020.110882_bib0090","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/S0302-4598(96)05062-3","article-title":"Theory of electroporation: a review","volume":"41","author":"Weaver","year":"1996","journal-title":"Bioelectrochem. Bioenerg."},{"key":"10.1016\/j.colsurfb.2020.110882_bib0095","doi-asserted-by":"crossref","first-page":"286","DOI":"10.3390\/pharmaceutics10040286","article-title":"Autologous red blood cell delivery of betamethasone phosphate sodium for long anti-Inflammation","volume":"10","author":"Zhang","year":"2018","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.colsurfb.2020.110882_bib0100","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1006\/cryo.1997.2038","article-title":"In vitro study of the protective effect of trehalose and dextran during freezing of human red blood cells in liquid nitrogen","volume":"35","author":"Pellerin-Mendes","year":"1997","journal-title":"Cryobiology"},{"key":"10.1016\/j.colsurfb.2020.110882_bib0105","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1080\/02652040802354707","article-title":"Influence of morphology and drug distribution on the release process of FITC-dextran-loaded microspheres prepared with different types of PLGA","volume":"26","author":"Cai","year":"2009","journal-title":"J. Microencapsul."},{"key":"10.1016\/j.colsurfb.2020.110882_bib0110","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/0005-2736(89)90081-3","article-title":"Low-pH association of proteins with the membranes of intact red blood cells. I. Exogenous glycophorin and the CD4 molecule","volume":"981","author":"Arvinte","year":"1989","journal-title":"Biochim. Biophys. Acta-Biomembr."},{"key":"10.1016\/j.colsurfb.2020.110882_bib0115","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.ijpharm.2006.10.036","article-title":"Effect of WOW process parameters on morphology and burst release of FITC-dextran loaded PLGA microspheres","volume":"334","author":"Mao","year":"2007","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.colsurfb.2020.110882_bib0120","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1007\/s12975-010-0049-x","article-title":"High and low molecular weight fluorescein isothiocyanate (FITC)-dextrans to assess blood-brain barrier disruption: technical considerations","volume":"2","author":"Hoffmann","year":"2011","journal-title":"Transl. Stroke Res."},{"key":"10.1016\/j.colsurfb.2020.110882_bib0125","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1007\/s00249-017-1255-1","article-title":"Simulation of the osmosis-based drug encapsulation in erythrocytes","volume":"47","author":"Ge","year":"2018","journal-title":"Eur. Biophys. J. Biophys. Lett."},{"key":"10.1016\/j.colsurfb.2020.110882_bib0130","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.ijpharm.2016.12.011","article-title":"Ex vivo encapsulation of dexamethasone sodium phosphate into human autologous erythrocytes using fully automated biomedical equipment","volume":"517","author":"Mambrini","year":"2017","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.colsurfb.2020.110882_bib0135","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1111\/j.1537-2995.2009.02095.x","article-title":"Red blood cell volume can be independently determined in vitro using sheep and human red blood cells labeled at different densities of biotin","volume":"49","author":"Mock","year":"2009","journal-title":"Transfusion"},{"key":"10.1016\/j.colsurfb.2020.110882_bib0140","doi-asserted-by":"crossref","first-page":"3327","DOI":"10.1073\/pnas.86.9.3327","article-title":"Reversible sodium pump defect and swelling in the diabetic rat erythrocyte: effects on filterability and implications for microangiopathy","volume":"86","author":"Kowluru","year":"1989","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.colsurfb.2020.110882_bib0145","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1042\/cs0980283","article-title":"Effects of proinsulin C-peptide on nitric oxide, microvascular blood flow and erythrocyte Na+, K+-ATPase activity in diabetes mellitus type I","volume":"98","author":"Forst","year":"2000","journal-title":"Clin. Sci."},{"key":"10.1016\/j.colsurfb.2020.110882_bib0150","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/0014-5793(89)80741-0","article-title":"Dextran protection of erythrocytes from low-pH-induced hemolysis","volume":"250","author":"Cudd","year":"1989","journal-title":"FEBS Lett."},{"key":"10.1016\/j.colsurfb.2020.110882_bib0155","doi-asserted-by":"crossref","first-page":"2207","DOI":"10.4049\/jimmunol.148.7.2207","article-title":"Exposure of phosphatidylserine on the surface of apoptotic lymphocytes triggers specific recognition and removal by macrophages","volume":"148","author":"Fadok","year":"1992","journal-title":"J. Immunol."},{"key":"10.1016\/j.colsurfb.2020.110882_bib0160","doi-asserted-by":"crossref","first-page":"2001","DOI":"10.1016\/S0024-3205(01)00991-2","article-title":"Mouse erythrocytes as carriers for coencapsulated alcohol and aldehyde dehydrogenase obtained by electroporation - in vivo survival rate in circulation, organ distribution and ethanol degradation","volume":"68","author":"Lizano","year":"2001","journal-title":"Life Sci."}],"container-title":["Colloids and Surfaces B: Biointerfaces"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0927776520301120?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0927776520301120?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T10:48:59Z","timestamp":1760525339000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0927776520301120"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5]]},"references-count":32,"alternative-id":["S0927776520301120"],"URL":"https:\/\/doi.org\/10.1016\/j.colsurfb.2020.110882","relation":{},"ISSN":["0927-7765"],"issn-type":[{"value":"0927-7765","type":"print"}],"subject":[],"published":{"date-parts":[[2020,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Study on the protection of dextran on erythrocytes during drug loading","name":"articletitle","label":"Article Title"},{"value":"Colloids and Surfaces B: Biointerfaces","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.colsurfb.2020.110882","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"110882"}}