{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T04:06:29Z","timestamp":1779163589007,"version":"3.51.4"},"reference-count":100,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Colloids and Surfaces B: Biointerfaces"],"published-print":{"date-parts":[[2020,9]]},"DOI":"10.1016\/j.colsurfb.2020.111046","type":"journal-article","created":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T10:54:23Z","timestamp":1588330463000},"page":"111046","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":39,"special_numbering":"C","title":["Influence of formulation variables on miconazole nitrate\u2013loaded lipid based nanocarrier for topical delivery"],"prefix":"10.1016","volume":"193","author":[{"given":"Passant M.","family":"Al-Maghrabi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"El-Sayed","family":"Khafagy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mamdouh M.","family":"Ghorab","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7714-2267","authenticated-orcid":false,"given":"Shadeed","family":"Gad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.colsurfb.2020.111046_bib0005","doi-asserted-by":"crossref","first-page":"109","DOI":"10.4155\/tde.10.16","article-title":"Challenges and opportunities in dermal\/transdermal delivery","volume":"1","author":"Paudel","year":"2010","journal-title":"Ther. Deliv."},{"key":"10.1016\/j.colsurfb.2020.111046_bib0010","first-page":"1","article-title":"QbD Approach in the formulation and evaluation of Miconazole Nitrate loaded ethosomal cream-o-gel","volume":"8","author":"Mulani","year":"2017","journal-title":"Int. Res. J. Pharm. Sci."},{"key":"10.1016\/j.colsurfb.2020.111046_bib0015","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.ijpharm.2010.06.020","article-title":"Miconazole nanosuspensions: influence of formulation variables on particle size reduction and physical stability","volume":"396","author":"Cerdeira","year":"2010","journal-title":"Int. J. Pharm."},{"issue":"165\u2013170","key":"10.1016\/j.colsurfb.2020.111046_bib0020","first-page":"172","article-title":"Antimycotic agents in oral candidosis: an overview: 2. Treatment of oral candidosis","volume":"27","author":"Ellepola","year":"2000","journal-title":"Dent. Update"},{"key":"10.1016\/j.colsurfb.2020.111046_bib0025","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.powtec.2010.02.035","article-title":"Effect of lipid nanoparticles containing fatty alcohols having different chain length on the ex vivo skin permeability of Econazole nitrate","volume":"201","author":"Sanna","year":"2010","journal-title":"Powder Technol."},{"key":"10.1016\/j.colsurfb.2020.111046_bib0030","doi-asserted-by":"crossref","first-page":"473","DOI":"10.3109\/10837450.2014.882939","article-title":"Quality by design approach for formulation, evaluation and statistical optimization of diclofenac-loaded ethosomes via transdermal route","volume":"20","author":"Jain","year":"2015","journal-title":"Pharm. Dev. Technol."},{"key":"10.1016\/j.colsurfb.2020.111046_bib0035","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/j.xphs.2016.10.001","article-title":"Recent advances in lipid-based vesicles and particulate carriers for topical and transdermal application","volume":"106","author":"Jain","year":"2017","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.colsurfb.2020.111046_bib0040","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1002\/jps.20666","article-title":"Deep percutaneous penetration into muscles and joints","volume":"95","author":"Lee","year":"2006","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.colsurfb.2020.111046_bib0045","first-page":"48","article-title":"Preparation and in vitro evaluation of miconazole nitrate-loaded topical liposomes","volume":"26","author":"Agarwal","year":"2002","journal-title":"Pharm Tech."},{"key":"10.1016\/j.colsurfb.2020.111046_bib0050","article-title":"Comparative studies on skin permeation of miconazole using different novel carriers","volume":"1","author":"Singh","year":"2010","journal-title":"Int. J. Pharm. Sci. Res."},{"key":"10.1016\/j.colsurfb.2020.111046_bib0055","first-page":"48","article-title":"Preparation and in vitro evaluation of miconazole nitrate\u2013loaded topical liposomes","volume":"5","author":"Sawant","year":"2005","journal-title":"Drug Del Tech"},{"key":"10.1016\/j.colsurfb.2020.111046_bib0060","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.ijpharm.2007.05.065","article-title":"Positively charged microemulsions for topical application","volume":"346","author":"Peira","year":"2008","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.colsurfb.2020.111046_bib0065","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/S0939-6411(00)00087-4","article-title":"Solid lipid nanoparticles (SLN) for controlled drug delivery - a review of the state of the art","volume":"50","author":"Muller","year":"2000","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.colsurfb.2020.111046_bib0070","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1093\/toxsci\/kft179","article-title":"Accumulated polymer degradation products as effector molecules in cytotoxicity of polymeric nanoparticles","volume":"136","author":"Singh","year":"2013","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.colsurfb.2020.111046_bib0075","doi-asserted-by":"crossref","first-page":"374","DOI":"10.2340\/00015555-0874","article-title":"Ethosome formulations of known contact allergens can increase their sensitizing capacity","volume":"90","author":"Madsen","year":"2010","journal-title":"Acta Derm. Venereol."},{"key":"10.1016\/j.colsurfb.2020.111046_bib0080","doi-asserted-by":"crossref","first-page":"349","DOI":"10.4103\/0250-474X.57282","article-title":"Solid lipid nanoparticles: a modern formulation approach in drug delivery system","volume":"71","author":"Mukherjee","year":"2009","journal-title":"Indian J. Pharm. Sci."},{"key":"10.1016\/j.colsurfb.2020.111046_bib0085","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1007\/s11239-016-1440-6","article-title":"Encapsulation of eptifibatide in RGD-modified nanoliposomes improves platelet aggregation inhibitory activity","volume":"43","author":"Bardania","year":"2017","journal-title":"J. Thromb. Thrombolysis"},{"key":"10.1016\/j.colsurfb.2020.111046_bib0090","doi-asserted-by":"crossref","first-page":"33","DOI":"10.15171\/ijb.1399","article-title":"Optimization of RGD-modified nano-liposomes encapsulating eptifibatide","volume":"14","author":"Bardania","year":"2016","journal-title":"Iran. J. Biotechnol."},{"key":"10.1016\/j.colsurfb.2020.111046_bib0095","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1016\/j.colsurfb.2017.11.023","article-title":"Formulation and anti-neurotoxic activity of baicalein-incorporating neutral nanoliposome","volume":"161","author":"Aliakbari","year":"2018","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"10.1016\/j.colsurfb.2020.111046_bib0100","doi-asserted-by":"crossref","first-page":"1","DOI":"10.21859\/ijb.2008","article-title":"RGD-modified nano-liposomes encapsulated eptifibatide with proper hemocompatibility and cytotoxicity effect","volume":"17","author":"Bardania","year":"2019","journal-title":"Iran. J. Biotechnol."},{"key":"10.1016\/j.colsurfb.2020.111046_bib0105","doi-asserted-by":"crossref","first-page":"9174","DOI":"10.1039\/C8NR00632F","article-title":"The potential of zwitterionic nanoliposomes against neurotoxic alpha-synuclein aggregates in Parkinson\u2019s Disease","volume":"10","author":"Aliakbari","year":"2018","journal-title":"Nanoscale"},{"key":"10.1016\/j.colsurfb.2020.111046_bib0110","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1208\/s12249-012-9783-6","article-title":"Propylene glycol liposomes as a topical delivery system for miconazole nitrate: comparison with conventional liposomes","volume":"13","author":"Elmoslemany","year":"2012","journal-title":"AAPS PharmSciTech"},{"key":"10.1016\/j.colsurfb.2020.111046_bib0115","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.ijpharm.2007.05.065","article-title":"Positively charged microemulsions for topical application","volume":"346","author":"Peira","year":"2008","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.colsurfb.2020.111046_bib0120","first-page":"354","article-title":"Ethosomes: a review","volume":"4","author":"Aggarwal","year":"2016","journal-title":"Int J Pharm Med Res"},{"key":"10.1016\/j.colsurfb.2020.111046_bib0125","first-page":"138","article-title":"Microemulsions: a novel drug carrier system","volume":"20","author":"Katiyar","year":"2013","journal-title":"Int. J. Pharm. Sci. Rev. Res."},{"key":"10.1016\/j.colsurfb.2020.111046_bib0130","article-title":"A review on microemulsion a promising optimising technique used as a novel drug delivery system","volume":"9","author":"Chaudhary","year":"2018","journal-title":"Int. Res. J. Pharm. Pharmacol."},{"key":"10.1016\/j.colsurfb.2020.111046_bib0135","doi-asserted-by":"crossref","first-page":"585","DOI":"10.2174\/092986710790416290","article-title":"Development of nanoparticles for antimicrobial drug delivery","volume":"17","author":"Zhang","year":"2010","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.colsurfb.2020.111046_bib0140","doi-asserted-by":"crossref","first-page":"60","DOI":"10.4103\/2230-973X.133047","article-title":"Development and evaluation of solid lipid nanoparticles of mometasone furoate for topical delivery","volume":"4","author":"Madan","year":"2014","journal-title":"Int. J. Pharm. Investig."},{"key":"10.1016\/j.colsurfb.2020.111046_bib0145","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.ejps.2006.04.016","article-title":"Formulation of poorly water-soluble drugs for oral administration: physicochemical and physiological issues and the lipid formulation classification system","volume":"29","author":"Pouton","year":"2006","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.colsurfb.2020.111046_bib0150","doi-asserted-by":"crossref","first-page":"441","DOI":"10.2147\/IJN.S100625","article-title":"Miconazole-loaded solid lipid nanoparticles: formulation and evaluation of a novel formula with high bioavailability and antifungal activity","volume":"11","author":"Aljaeid","year":"2016","journal-title":"Int. J. Nanomedicine"},{"key":"10.1016\/j.colsurfb.2020.111046_bib0155","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1208\/s12249-009-9199-0","article-title":"Preparation and evaluation of miconazole nitrate-loaded solid lipid nanoparticles for topical delivery","volume":"10","author":"Bhalekar","year":"2009","journal-title":"AAPS PharmSciTech"},{"key":"10.1016\/j.colsurfb.2020.111046_bib0160","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S0939-6411(97)00150-1","article-title":"Solid lipid nanoparticles (SLN) for controlled drug delivery--drug release and release mechanism","volume":"45","author":"zur Muhlen","year":"1998","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.colsurfb.2020.111046_bib0165","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.ejps.2009.02.021","article-title":"Amphotericin B-entrapping lipid nanoparticles and their in vitro and in vivo characteristics","volume":"37","author":"Jung","year":"2009","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.colsurfb.2020.111046_bib0170","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/j.msec.2012.09.007","article-title":"Clotrimazole nanoparticle gel for mucosal administration","volume":"33","author":"Esposito","year":"2013","journal-title":"Mater. Sci. Eng. C Mater. Biol. Appl."},{"key":"10.1016\/j.colsurfb.2020.111046_bib0175","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/S0939-6411(03)00040-7","article-title":"The influence of solid lipid nanoparticles on skin hydration and viscoelasticity-in vivo study","volume":"56","author":"Wissing","year":"2003","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.colsurfb.2020.111046_bib0180","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/S0168-3659(99)00223-0","article-title":"Vitamin A-loaded solid lipid nanoparticles for topical use: drug release properties","volume":"66","author":"Jenning","year":"2000","journal-title":"J. Control. Release"},{"key":"10.1016\/j.colsurfb.2020.111046_bib0185","first-page":"313","article-title":"Investigations on the occlusive properties of solid lipid nanoparticles (SLN)","volume":"52","author":"Wissing","year":"2001","journal-title":"J. Cosmet. Sci."},{"key":"10.1016\/j.colsurfb.2020.111046_bib0190","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.ijpharm.2004.02.032","article-title":"Development of a controlled release formulation based on SLN and NLC for topical clotrimazole delivery","volume":"278","author":"Souto","year":"2004","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.colsurfb.2020.111046_bib0195","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.jconrel.2008.02.011","article-title":"Influence of oil content on physicochemical properties and skin distribution of Nile red-loaded NLC","volume":"128","author":"Teeranachaideekul","year":"2008","journal-title":"J. Control. Release"},{"key":"10.1016\/j.colsurfb.2020.111046_bib0200","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1080\/02652040500162436","article-title":"SLN and NLC for topical delivery of ketoconazole","volume":"22","author":"Souto","year":"2005","journal-title":"J. Microencapsul."},{"key":"10.1016\/j.colsurfb.2020.111046_bib0205","doi-asserted-by":"crossref","first-page":"207","DOI":"10.2174\/157016311796799062","article-title":"20 years of lipid nanoparticles (SLN and NLC): present state of development and industrial applications","volume":"8","author":"Muller","year":"2011","journal-title":"Curr. Drug Discov. Technol."},{"key":"10.1016\/j.colsurfb.2020.111046_bib0210","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1080\/10717544.2017.1413444","article-title":"Fluconazole-loaded solid lipid nanoparticles topical gel for treatment of pityriasis versicolor: formulation and clinical study","volume":"25","author":"El-Housiny","year":"2018","journal-title":"Drug Deliv."},{"key":"10.1016\/j.colsurfb.2020.111046_bib0215","doi-asserted-by":"crossref","first-page":"735","DOI":"10.3109\/02652048.2010.517854","article-title":"Chitosan-associated SLN: in vitro and ex vivo characterization of cyclosporine A loaded ophthalmic systems","volume":"27","author":"Sandri","year":"2010","journal-title":"J. Microencapsul."},{"key":"10.1016\/j.colsurfb.2020.111046_bib0220","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1016\/j.colsurfb.2013.05.041","article-title":"Miconazole-loaded nanostructured lipid carriers (NLC) for local delivery to the oral mucosa: improving antifungal activity","volume":"111","author":"Mendes","year":"2013","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"10.1016\/j.colsurfb.2020.111046_bib0225","first-page":"156","article-title":"UV spectrophotometric method development and validation for quantitative estimation of miconazole nitrate (MIC)","volume":"5","author":"Savale","year":"2017","journal-title":"AJPAMC"},{"key":"10.1016\/j.colsurfb.2020.111046_bib0230","doi-asserted-by":"crossref","first-page":"443","DOI":"10.3109\/10717544.2010.483252","article-title":"Design and development of solid lipid nanoparticles for topical delivery of an anti-fungal agent","volume":"17","author":"Jain","year":"2010","journal-title":"Drug Deliv."},{"key":"10.1016\/j.colsurfb.2020.111046_bib0235","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1208\/s12249-012-9908-y","article-title":"Nanolipidgel for enhanced skin deposition and improved antifungal activity","volume":"14","author":"Wavikar","year":"2013","journal-title":"AAPS PharmSciTech"},{"key":"10.1016\/j.colsurfb.2020.111046_bib0240","doi-asserted-by":"crossref","first-page":"7","DOI":"10.3390\/pharmaceutics9030033","article-title":"Transdermal permeation of drugs in various animal species","volume":"9","author":"Todo","year":"2017","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.colsurfb.2020.111046_bib0245","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/jat.3004","article-title":"Animal models for percutaneous absorption","volume":"35","author":"Jung","year":"2015","journal-title":"J. Appl. Toxicol."},{"key":"10.1016\/j.colsurfb.2020.111046_bib0250","doi-asserted-by":"crossref","first-page":"26","DOI":"10.2174\/1871523017666181115104159","article-title":"Development of betamethasone dipropionate-loaded nanostructured lipid carriers for topical and transdermal delivery","volume":"18","author":"Hanna","year":"2018","journal-title":"Antiinflamm. Antiallergy Agents Med. Chem."},{"key":"10.1016\/j.colsurfb.2020.111046_bib0255","doi-asserted-by":"crossref","first-page":"642","DOI":"10.3109\/10717544.2014.933284","article-title":"Nanoemulsion gel-based topical delivery of an antifungal drug: in vitro activity and in vivo evaluation","volume":"23","author":"Hussain","year":"2016","journal-title":"Drug Deliv."},{"key":"10.1016\/j.colsurfb.2020.111046_bib0260","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/S0022-3565(25)08751-8","article-title":"Methods for the study of irritation and toxicity of substances applied topically to the skin and mucous membranes","volume":"82","author":"Draize","year":"1944","journal-title":"J. Phamacol. Exp. Ther."},{"key":"10.1016\/j.colsurfb.2020.111046_bib0265","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ijpharm.2017.05.029","article-title":"Sertaconazole nitrate loaded nanovesicular systems for targeting skin fungal infection: in-vitro, ex-vivo and in-vivo evaluation","volume":"527","author":"Abdellatif","year":"2017","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.colsurfb.2020.111046_bib0270","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1016\/j.chemphyslip.2012.01.006","article-title":"Development, characterization and in vivo assessment of effective lipidic nanoparticles for dermal delivery of fluconazole against cutaneous candidiasis","volume":"165","author":"Gupta","year":"2012","journal-title":"Chem. Phys. Lipids"},{"key":"10.1016\/j.colsurfb.2020.111046_bib0275","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1080\/02681219480000471","article-title":"A novel model of cutaneous candidiasis produced in prednisolone-treated guinea-pigs","volume":"32","author":"Maebashi","year":"1994","journal-title":"J. Med. Vet. Mycol."},{"key":"10.1016\/j.colsurfb.2020.111046_bib0280","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1080\/03639040802325893","article-title":"Physically cross-linked polyvinyl alcohol for the topical delivery of fluconazole","volume":"35","author":"Abdel-Mottaleb","year":"2009","journal-title":"Drug Dev. Ind. Pharm."},{"key":"10.1016\/j.colsurfb.2020.111046_bib0285","first-page":"683","article-title":"Assessment of anti-dermatophytic activity of zincoderma GM cream inexperimental Tinea pedis in wistar rats","volume":"5","author":"Satyam","year":"2015","journal-title":"Int J Pharm Chem Biol Sci"},{"key":"10.1016\/j.colsurfb.2020.111046_bib0290","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/S0378-5173(00)00378-1","article-title":"Characterisation of a novel solid lipid nanoparticle carrier system based on binary mixtures of liquid and solid lipids","volume":"199","author":"Jenning","year":"2000","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.colsurfb.2020.111046_bib0295","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1080\/03639045.2017.1371739","article-title":"Effect of semicrystalline polymers on self-emulsifying solid dispersions of nateglinide: in vitro and in vivo evaluation","volume":"44","author":"Swain","year":"2018","journal-title":"Drug Dev. Ind. Pharm."},{"key":"10.1016\/j.colsurfb.2020.111046_bib0300","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/pharmaceutics10030074","article-title":"Pharmaceutical dispersion techniques for dissolution and bioavailability enhancement of poorly water-soluble drugs","volume":"10","author":"Zhang","year":"2018","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.colsurfb.2020.111046_bib0305","first-page":"102","article-title":"Gelucire: A versatile polymer for modified release drug delivery system","volume":"4","author":"Panigrahi","year":"2018","journal-title":"FJPS"},{"key":"10.1016\/j.colsurfb.2020.111046_bib0310","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1208\/s12249-009-9197-2","article-title":"Diazepam-loaded solid lipid nanoparticles: design and characterization","volume":"10","author":"Abdelbary","year":"2009","journal-title":"AAPS PharmSciTech"},{"key":"10.1016\/j.colsurfb.2020.111046_bib0315","doi-asserted-by":"crossref","first-page":"143","DOI":"10.15171\/apb.2016.021","article-title":"The impact of variables on particle size of solid lipid nanoparticles and nanostructured lipid carriers; a comparative literature review","volume":"6","author":"Azhar Shekoufeh Bahari","year":"2016","journal-title":"Adv. Pharm. Bull."},{"key":"10.1016\/j.colsurfb.2020.111046_bib0320","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.ejps.2012.05.010","article-title":"Are nanostructured lipid carriers (NLCs) better than solid lipid nanoparticles (SLNs): development, characterizations and comparative evaluations of clotrimazole-loaded SLNs and NLCs?","volume":"47","author":"Das","year":"2012","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.colsurfb.2020.111046_bib0325","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.jddst.2017.02.001","article-title":"Enhancing bioavailability and controlling the release of glibenclamide from optimized solid lipid nanoparticles","volume":"38","author":"Elbahwy","year":"2017","journal-title":"J. Drug Deliv. Sci. Technol."},{"key":"10.1016\/j.colsurfb.2020.111046_bib0330","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.ejps.2013.03.013","article-title":"Development of solid lipid nanoparticles based controlled release system for topical delivery of terbinafine hydrochloride","volume":"49","author":"Vaghasiya","year":"2013","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.colsurfb.2020.111046_bib0335","doi-asserted-by":"crossref","first-page":"304","DOI":"10.3109\/10837450.2013.778872","article-title":"Nanostructured lipid carriers (NLCs) versus solid lipid nanoparticles (SLNs) for topical delivery of meloxicam","volume":"19","author":"Khalil","year":"2014","journal-title":"Pharm. Dev. Technol."},{"key":"10.1016\/j.colsurfb.2020.111046_bib0340","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2012\/750891","article-title":"Current state-of-Art and new trends on lipid nanoparticles (SLN and NLC) for oral drug delivery","volume":"2012","author":"Severino","year":"2012","journal-title":"J. Drug Deliv."},{"key":"10.1016\/j.colsurfb.2020.111046_bib0345","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/S0168-3659(97)00046-1","article-title":"Physicochemical characterization of lipid nanoparticles and evaluation of their drug loading capacity and sustained release potential","volume":"48","author":"Westesen","year":"1997","journal-title":"J. Control. Release"},{"key":"10.1016\/j.colsurfb.2020.111046_bib0350","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1080\/02652040010000361","article-title":"Encapsulation of retinoids in solid lipid nanoparticles (SLN)","volume":"18","author":"Jenning","year":"2001","journal-title":"J. Microencapsul."},{"key":"10.1016\/j.colsurfb.2020.111046_bib0355","first-page":"4409","article-title":"Development of terbinafine solid lipid nanoparticles as a topical delivery system","volume":"7","author":"Chen","year":"2012","journal-title":"Int. J. Nanomedicine"},{"key":"10.1016\/j.colsurfb.2020.111046_bib0360","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.ejpb.2010.10.011","article-title":"Novel sugar esters proniosomes for transdermal delivery of vinpocetine: preclinical and clinical studies","volume":"77","author":"El-Laithy","year":"2011","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.colsurfb.2020.111046_bib0365","doi-asserted-by":"crossref","first-page":"203","DOI":"10.3109\/08982104.2013.788025","article-title":"Design and optimization of surfactant-based nanovesicles for ocular delivery of Clotrimazole","volume":"23","author":"Basha","year":"2013","journal-title":"J. Liposome Res."},{"key":"10.1016\/j.colsurfb.2020.111046_bib0370","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/j.ijpharm.2018.07.014","article-title":"A novel nasal almotriptan loaded solid lipid nanoparticles in mucoadhesive in situ gel formulation for brain targeting: preparation, characterization and in vivo evaluation","volume":"548","author":"Youssef","year":"2018","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.colsurfb.2020.111046_bib0375","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/S0378-5173(02)00315-0","article-title":"Size-dependency of nanoparticle-mediated gene transfection: studies with fractionated nanoparticles","volume":"244","author":"Prabha","year":"2002","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.colsurfb.2020.111046_bib0380","first-page":"513","article-title":"Chitosan \u2013sodium alginate nanoparticles as submicroscopic reservoirs for ocular delivery: formulation, optimization and in vitro chacterization","volume":"68","author":"Motwani","year":"2008","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.colsurfb.2020.111046_bib0385","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/pharmaceutics10010026","article-title":"Design, optimization and characterization of a transfersomal gel using miconazole nitrate for the treatment of candida skin infections","volume":"10","author":"Qushawy","year":"2018","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.colsurfb.2020.111046_bib0390","first-page":"51","article-title":"Solid state compatibility studies of miconazole using thermal and spectroscopic methods","volume":"5","author":"Gupta","year":"2015","journal-title":"Adv. Anal. Chem."},{"key":"10.1016\/j.colsurfb.2020.111046_bib0395","doi-asserted-by":"crossref","first-page":"1895","DOI":"10.3109\/03639045.2012.670641","article-title":"Proliposome powders for enhanced intestinal absorption and bioavailability of raloxifene hydrochloride: effect of surface charge","volume":"39","author":"Velpula","year":"2013","journal-title":"Drug Dev. Ind. Pharm."},{"key":"10.1016\/j.colsurfb.2020.111046_bib0400","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.ejpb.2010.05.003","article-title":"Non-destructive methods of characterization of risperidone solid lipid nanoparticles","volume":"76","author":"Rahman","year":"2010","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.colsurfb.2020.111046_bib0405","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1002\/jps.2600770512","article-title":"Effect of vehicle amphiphilicity on the dissolution and bioavailability of a poorly water-soluble drug from solid dispersions","volume":"77","author":"Serajuddin","year":"1988","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.colsurfb.2020.111046_bib0410","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.3109\/03639048909043661","article-title":"Oral sustained release dosage forms comparison between matrices and reservoir devices","volume":"15","author":"Barochez","year":"1989","journal-title":"Drug Dev. Ind. Pharm."},{"key":"10.1016\/j.colsurfb.2020.111046_bib0415","doi-asserted-by":"crossref","first-page":"791","DOI":"10.3109\/03639045.2012.709251","article-title":"Gelucire 44\/14 based immediate release formulations for poorly water-soluble drugs","volume":"39","author":"Da Fonseca Antunes","year":"2013","journal-title":"Drug Dev. Ind. Pharm."},{"key":"10.1016\/j.colsurfb.2020.111046_bib0420","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.ijpharm.2014.08.003","article-title":"In vivo pharmacokinetics and biodistribution of resveratrol-loaded solid lipid nanoparticles for brain delivery","volume":"474","author":"Jose","year":"2014","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.colsurfb.2020.111046_bib0425","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/j.ijbiomac.2013.10.004","article-title":"Methotrexate-loaded chitosan nanogels as\u2019 Trojan Horses\u2019 for drug delivery to brain: preparation and in vitro\/in vivo characterization","volume":"62","author":"Azadi","year":"2013","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.colsurfb.2020.111046_bib0430","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.ejpb.2017.04.007","article-title":"Microwave-assisted microemulsion technique for production of miconazole nitrate- and econazole nitrate-loaded solid lipid nanoparticles","volume":"117","author":"Shah","year":"2017","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.colsurfb.2020.111046_bib0435","first-page":"1","article-title":"Evaluation of the DDSolver software applications","volume":"2014","author":"Zuo","year":"2014","journal-title":"Biomed Res. Int."},{"key":"10.1016\/j.colsurfb.2020.111046_bib0440","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1007\/s11095-016-2062-6","article-title":"Preparation, physicochemical characterization and anti-fungal evaluation of nystatin-loaded PLGA-glucosamine nanoparticles","volume":"34","author":"Mohammadi","year":"2017","journal-title":"Pharm. Res."},{"key":"10.1016\/j.colsurfb.2020.111046_bib0445","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/j.colsurfb.2011.07.036","article-title":"Formulation design, preparation and physicochemical characterizations of solid lipid nanoparticles containing a hydrophobic drug: effects of process variables","volume":"88","author":"Das","year":"2011","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"10.1016\/j.colsurfb.2020.111046_bib0450","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1046\/j.1467-2494.2001.00087.x","article-title":"A novel sunscreen system based on tocopherol acetate incorporated into solid lipid nanoparticles","volume":"23","author":"Wissing","year":"2001","journal-title":"Int. J. Cosmet. Sci."},{"key":"10.1016\/j.colsurfb.2020.111046_bib0455","first-page":"783","article-title":"Solid lipid nanoparticles (SLN)--a novel carrier for UV blockers","volume":"56","author":"Wissing","year":"2001","journal-title":"Pharmazie"},{"key":"10.1016\/j.colsurfb.2020.111046_bib0460","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1208\/pt070491","article-title":"Development and evaluation of topical formulation containing solid lipid nanoparticles of vitamin A","volume":"7","author":"Pople","year":"2006","journal-title":"AAPS PharmSciTech"},{"key":"10.1016\/j.colsurfb.2020.111046_bib0465","first-page":"46","article-title":"Design and evaluation of miconazole nitrate loaded nanostructured lipid carriers (NLC) for improving the antifungal therapy","volume":"3","author":"Sanap","year":"2013","journal-title":"J Appl Pharm"},{"key":"10.1016\/j.colsurfb.2020.111046_bib0470","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/S0939-6411(03)00040-7","article-title":"The influence of solid lipid nanoparticles on skin hydration and viscoelasticity--in vivo study","volume":"56","author":"Wissing","year":"2003","journal-title":"Eur. J. Pharm. Biopharm."},{"issue":"1","key":"10.1016\/j.colsurfb.2020.111046_bib0475","article-title":"Lipid vesicles and nanoparticle for non-invasive topical and transdermal drug delivery","volume":"26","author":"Shabbir","year":"2020","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.colsurfb.2020.111046_bib0480","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1211\/jpp.59.8.0002","article-title":"Solid lipid nanoparticles (SLN) as carriers for the topical delivery of econazole nitrate: in-vitro characterization, ex-vivo and in-vivo studies","volume":"59","author":"Sanna","year":"2007","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.colsurfb.2020.111046_bib0485","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2019\/2834941","article-title":"Lipid nano- and microparticles: an overview of patent-related research","volume":"2019","author":"Battaglia","year":"2019","journal-title":"J. Nanomater."},{"key":"10.1016\/j.colsurfb.2020.111046_bib0490","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/S0169-409X(02)00118-7","article-title":"Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) in cosmetic and dermatological preparations","volume":"54","author":"Muller","year":"2002","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.colsurfb.2020.111046_bib0495","first-page":"1578","article-title":"Miconazole nitrate microemulsion: preparation, characterization and evaluation for enhancement of antifungal activity","volume":"37","author":"Syed","year":"2018","journal-title":"Lat. Am. J. Pharm."},{"key":"10.1016\/j.colsurfb.2020.111046_bib0500","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1007\/s10856-015-5487-2","article-title":"Skin targeted lipid vesicles as novel nano-carrier of ketoconazole: characterization, in vitro and in vivo evaluation","volume":"26","author":"Guo","year":"2015","journal-title":"J. Mater. Sci. Mater. Med."}],"container-title":["Colloids and Surfaces B: Biointerfaces"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0927776520302769?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0927776520302769?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T10:52:21Z","timestamp":1760525541000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0927776520302769"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9]]},"references-count":100,"alternative-id":["S0927776520302769"],"URL":"https:\/\/doi.org\/10.1016\/j.colsurfb.2020.111046","relation":{},"ISSN":["0927-7765"],"issn-type":[{"value":"0927-7765","type":"print"}],"subject":[],"published":{"date-parts":[[2020,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Influence of formulation variables on miconazole nitrate\u2013loaded lipid based nanocarrier for topical delivery","name":"articletitle","label":"Article Title"},{"value":"Colloids and Surfaces B: Biointerfaces","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.colsurfb.2020.111046","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"111046"}}