{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T11:29:53Z","timestamp":1793878193852,"version":"4.7.0"},"reference-count":68,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100009873","name":"Regione Autonoma della Sardegna","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009873","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Colloids and Surfaces B: Biointerfaces"],"published-print":{"date-parts":[[2021,3]]},"DOI":"10.1016\/j.colsurfb.2021.111564","type":"journal-article","created":{"date-parts":[[2021,1,8]],"date-time":"2021-01-08T20:47:25Z","timestamp":1610138845000},"page":"111564","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":40,"special_numbering":"C","title":["Tuning lipid structure by bile salts: Hexosomes for topical administration of catechin"],"prefix":"10.1016","volume":"199","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5788-6741","authenticated-orcid":false,"given":"Marco","family":"Fornasier","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa","family":"Pireddu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Del Giudice","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Sinico","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9420-2217","authenticated-orcid":false,"given":"Tommy","family":"Nylander","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin","family":"Schill\u00e9n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciano","family":"Galantini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio","family":"Murgia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.colsurfb.2021.111564_bib0005","doi-asserted-by":"crossref","first-page":"16989","DOI":"10.1039\/C9CP01953G","article-title":"Influence of polar co-solutes and salt on the hydration of lipid membranes","volume":"21","author":"Wolde-Kidan","year":"2019","journal-title":"Phys. Chem. Chem. Phys."},{"key":"10.1016\/j.colsurfb.2021.111564_bib0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2020.119398","article-title":"What\u2019s new in the field of phospholipid vesicular nanocarriers for skin drug delivery","volume":"583","author":"Lai","year":"2020","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.colsurfb.2021.111564_bib0015","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1517\/17425247.2011.574610","article-title":"Charged liposomes as carriers to enhance the permeation through the skin","volume":"8","author":"Gonz\u00e1lez-Rodr\u00edguez","year":"2011","journal-title":"Expert Opin. Drug Deliv."},{"key":"10.1016\/j.colsurfb.2021.111564_bib0020","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1159\/000501732","article-title":"Relevance of skin enzymes for rational drug design","volume":"32","author":"Pyo","year":"2019","journal-title":"Skin Pharmacol. Physiol."},{"key":"10.1016\/j.colsurfb.2021.111564_bib0025","doi-asserted-by":"crossref","first-page":"2131","DOI":"10.1038\/jid.2012.246","article-title":"Structure and function of the stratum corneum extracellular matrix","volume":"132","author":"Elias","year":"2012","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.colsurfb.2021.111564_bib0030","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.jcis.2016.06.054","article-title":"The effects of polar excipients transcutol and dexpanthenol on molecular mobility, permeability, and electrical impedance of the skin barrier","volume":"479","author":"Bj\u00f6rklund","year":"2016","journal-title":"J. Colloid Interface Sci."},{"key":"10.1016\/j.colsurfb.2021.111564_bib0035","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.jconrel.2016.04.030","article-title":"Chemical penetration enhancers in stratum corneum \u2013 relation between molecular effects and barrier function","volume":"232","author":"Pham","year":"2016","journal-title":"J. Control. Release"},{"key":"10.1016\/j.colsurfb.2021.111564_bib0040","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/j.colsurfb.2018.08.008","article-title":"3-hydroxycoumarin loaded vesicles for recombinant human tyrosinase inhibition in topical applications","volume":"171","author":"Schlich","year":"2018","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"10.1016\/j.colsurfb.2021.111564_bib0045","first-page":"S232","article-title":"Development and evaluation of azelaic acid based ethosomes for topical delivery for the treatment of acne, Indian","volume":"50","author":"Mistry","year":"2016","journal-title":"J. Pharm. Educ. Res."},{"key":"10.1016\/j.colsurfb.2021.111564_bib0050","doi-asserted-by":"crossref","first-page":"3135","DOI":"10.3109\/10717544.2016.1155244","article-title":"Novel elastic membrane vesicles (EMVs) and ethosomes-mediated effective topical delivery of aceclofenac: a new therapeutic approach for pain and inflammation","volume":"23","author":"Sharma","year":"2016","journal-title":"Drug Deliv."},{"key":"10.1016\/j.colsurfb.2021.111564_bib0055","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.ijpharm.2014.10.031","article-title":"Development of novel diolein-niosomes for cutaneous delivery of tretinoin: Influence of formulation and in vitro assessment","volume":"477","author":"Manca","year":"2014","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.colsurfb.2021.111564_bib0060","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1016\/j.msec.2016.07.043","article-title":"Formulation and optimization of niosomes for topical diacerein delivery using 3-factor, 3-level Box-Behnken design for the management of psoriasis","volume":"69","author":"Moghddam","year":"2016","journal-title":"Mater. Sci. Eng. C"},{"key":"10.1016\/j.colsurfb.2021.111564_bib0065","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.colsurfb.2011.05.041","article-title":"Niosomes vs microemulsions: new carriers for topical delivery of Capsaicin","volume":"87","author":"Tavano","year":"2011","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"10.1016\/j.colsurfb.2021.111564_bib0070","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1016\/j.lwt.2016.06.027","article-title":"Stabilization of natural canthaxanthin produced by Dietzia natronolimnaea HS-1 by encapsulation in niosomes","volume":"73","author":"Ravaghi","year":"2016","journal-title":"LWT - Food Sci. Technol."},{"key":"10.1016\/j.colsurfb.2021.111564_bib0075","first-page":"1525","article-title":"Theory of self-assembly of hydrocarbon amphiphiles into micelles and bilayers","volume":"72","author":"Israelachvili","year":"1976","journal-title":"J. Chem. Soc. Faraday Trans. 2 Mol. Chem. Phys"},{"key":"10.1016\/j.colsurfb.2021.111564_bib0080","doi-asserted-by":"crossref","first-page":"6964","DOI":"10.1021\/la970566+","article-title":"Submicron particles of reversed lipid phases in water stabilized by a nonionic amphiphilic polymer","volume":"13","author":"Gustafsson","year":"1997","journal-title":"Langmuir"},{"issue":"19","key":"10.1016\/j.colsurfb.2021.111564_bib0085","doi-asserted-by":"crossref","first-page":"3896","DOI":"10.1021\/jp984551b","article-title":"Imaging soft matter with the atomic force microscope: cubosomes and hexosomes","volume":"103","author":"Neto","year":"1999","journal-title":"J. Phys. Chem. B"},{"key":"10.1016\/j.colsurfb.2021.111564_bib0090","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.cocis.2020.03.006","article-title":"Recent advances of non-lamellar lyotropic liquid crystalline nanoparticles in nanomedicine","volume":"48","author":"Murgia","year":"2020","journal-title":"Curr. Opin. Colloid Interface Sci."},{"key":"10.1016\/j.colsurfb.2021.111564_bib0095","doi-asserted-by":"crossref","DOI":"10.1088\/1361-6528\/28\/5\/055102","article-title":"Cubosomes for in vivo fluorescence lifetime imaging","volume":"28","author":"Biffi","year":"2017","journal-title":"Nanotechnology"},{"key":"10.1016\/j.colsurfb.2021.111564_bib0100","doi-asserted-by":"crossref","first-page":"9566","DOI":"10.1021\/acs.langmuir.5b02101","article-title":"Docetaxel-loaded fluorescent liquid-crystalline nanoparticles for cancer theranostics","volume":"31","author":"Meli","year":"2015","journal-title":"Langmuir"},{"key":"10.1016\/j.colsurfb.2021.111564_bib0105","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/S0142-9612(99)00126-X","article-title":"The phase diagram of the monoolein\/water system: metastability and equilibrium aspects","volume":"21","author":"Qiu","year":"2000","journal-title":"Biomaterials"},{"key":"10.1016\/j.colsurfb.2021.111564_bib0110","doi-asserted-by":"crossref","first-page":"2958","DOI":"10.1002\/anie.201804067","article-title":"Cubosomes: the next generation of smart lipid nanoparticles?","volume":"58","author":"Barriga","year":"2019","journal-title":"Angew. Chemie - Int. Ed."},{"key":"10.1016\/j.colsurfb.2021.111564_bib0115","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.jcis.2020.07.038","article-title":"Cubosomes stabilized by a polyphosphoester-analog of Pluronic F127 with reduced cytotoxicity","volume":"580","author":"Fornasier","year":"2020","journal-title":"J. Colloid Interface Sci."},{"key":"10.1016\/j.colsurfb.2021.111564_bib0120","doi-asserted-by":"crossref","first-page":"6666","DOI":"10.1039\/C4SM01064G","article-title":"Novel RAFT amphiphilic brush copolymer steric stabilisers for cubosomes: poly(octadecyl acrylate)-block-poly(polyethylene glycol methyl ether acrylate)","volume":"10","author":"Chong","year":"2014","journal-title":"Soft Matter"},{"key":"10.1016\/j.colsurfb.2021.111564_bib0125","doi-asserted-by":"crossref","first-page":"2178","DOI":"10.1039\/C8SM02634C","article-title":"Interfacial properties of lipid sponge-like nanoparticles and the role of stabilizer on particle structure and surface interactions","volume":"15","author":"Valldeperas","year":"2019","journal-title":"Soft Matter"},{"key":"10.1016\/j.colsurfb.2021.111564_bib0130","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.jcis.2018.03.063","article-title":"Polymer-free cubosomes for simultaneous bioimaging and photodynamic action of photosensitizers in melanoma skin cancer cells","volume":"522","author":"Bazyli\u0144ska","year":"2018","journal-title":"J. Colloid Interface Sci."},{"key":"10.1016\/j.colsurfb.2021.111564_bib0135","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/j.jcis.2009.10.054","article-title":"Phase behavior of Phytantriol\/water bicontinuous cubic Pn3m cubosomes stabilized by Laponite disc-like particles","volume":"342","author":"Muller","year":"2010","journal-title":"J. Colloid Interface Sci."},{"key":"10.1016\/j.colsurfb.2021.111564_bib0140","doi-asserted-by":"crossref","first-page":"14757","DOI":"10.1021\/la203061f","article-title":"Revisiting \u03b2-casein as a stabilizer for lipid liquid crystalline nanostructured particles","volume":"27","author":"Zhai","year":"2011","journal-title":"Langmuir"},{"key":"10.1016\/j.colsurfb.2021.111564_bib0145","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1039\/C2SM27215F","article-title":"Physicochemical and rheological properties of a novel monoolein-based vesicle gel","volume":"9","author":"Angelico","year":"2013","journal-title":"Soft Matter"},{"issue":"5","key":"10.1016\/j.colsurfb.2021.111564_bib0150","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1002\/adhm.201200302","article-title":"Physicochemical, cytotoxic, and dermal release features of a novel cationic liposome nanocarrier","volume":"2","author":"Carboni","year":"2013","journal-title":"Adv. Healthc. Mater."},{"key":"10.1016\/j.colsurfb.2021.111564_bib0155","doi-asserted-by":"crossref","first-page":"12518","DOI":"10.1039\/C9CP01744E","article-title":"Block copolymers as bile salt sequestrants: intriguing structures formed in a mixture of an oppositely charged amphiphilic block copolymer and bile salt","volume":"21","author":"Schill\u00e9n","year":"2019","journal-title":"Phys. Chem. Chem. Phys."},{"key":"10.1016\/j.colsurfb.2021.111564_bib0160","doi-asserted-by":"crossref","first-page":"1504","DOI":"10.1039\/C6CP05665B","article-title":"Supramolecular assembly of a thermoresponsive steroidal surfactant with an oppositely charged thermoresponsive block copolymer","volume":"19","author":"Di Gregorio","year":"2017","journal-title":"Phys. Chem. Chem. Phys."},{"key":"10.1016\/j.colsurfb.2021.111564_bib0165","doi-asserted-by":"crossref","first-page":"13519","DOI":"10.1021\/acs.langmuir.5b03828","article-title":"Effects of bile salt sodium glycodeoxycholate on the self-assembly of PEO-PPO-PEO triblock copolymer P123 in aqueous solution","volume":"31","author":"Bayati","year":"2015","journal-title":"Langmuir"},{"key":"10.1016\/j.colsurfb.2021.111564_bib0170","doi-asserted-by":"crossref","first-page":"69313","DOI":"10.1039\/C6RA12514J","article-title":"Interaction between bile salt sodium glycodeoxycholate and PEO-PPO-PEO triblock copolymers in aqueous solution","volume":"6","author":"Bayati","year":"2016","journal-title":"RSC Adv."},{"key":"10.1016\/j.colsurfb.2021.111564_bib0175","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/j.jcis.2019.01.075","article-title":"A fluorescence study of the loading and time stability of doxorubicin in sodium cholate\/PEO-PPO-PEO triblock copolymer mixed micelles","volume":"540","author":"Tasca","year":"2019","journal-title":"J. Colloid Interface Sci."},{"key":"10.1016\/j.colsurfb.2021.111564_bib0180","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1016\/j.colsurfa.2016.05.096","article-title":"Complexes of PEO-PPO-PEO triblock copolymer P123 and bile salt sodium glycodeoxycholate in aqueous solution: a small angle X-ray and neutron scattering investigation","volume":"504","author":"Bayati","year":"2016","journal-title":"Colloids Surfaces A Physicochem. Eng. Asp."},{"key":"10.1016\/j.colsurfb.2021.111564_bib0185","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2020.119762","article-title":"Synergistic and antagonistic effects of non-ionic surfactants with bile salt + phospholipid mixed micelles on the solubility of poorly water-soluble drugs","volume":"588","author":"Clulow","year":"2020","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.colsurfb.2021.111564_bib0190","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.chemphyslip.2007.09.002","article-title":"Solubilization of sphingomyelin vesicles by addition of a bile salt","volume":"151","author":"C\u00e1rdenas","year":"2008","journal-title":"Chem. Phys. Lipids"},{"key":"10.1016\/j.colsurfb.2021.111564_bib0195","doi-asserted-by":"crossref","first-page":"5375","DOI":"10.1021\/bi015613i","article-title":"Molecular dynamics simulations of mixed micelles modeling human bile","volume":"41","author":"Marrink","year":"2002","journal-title":"Biochemistry"},{"key":"10.1016\/j.colsurfb.2021.111564_bib0200","doi-asserted-by":"crossref","first-page":"2292","DOI":"10.3390\/12102292","article-title":"Membranolytic activity of bile salts: influence of biological membrane properties and composition","volume":"12","author":"Garidel","year":"2007","journal-title":"Molecules"},{"key":"10.1016\/j.colsurfb.2021.111564_bib0205","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1080\/17425247.2016.1178233","article-title":"Bile acids and bile acid derivatives: use in drug delivery systems and as therapeutic agents","volume":"13","author":"Faustino","year":"2016","journal-title":"Expert Opin. Drug Deliv."},{"key":"10.1016\/j.colsurfb.2021.111564_bib0210","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.cocis.2015.08.004","article-title":"Bile salts and derivatives: rigid unconventional amphiphiles as dispersants, carriers and superstructure building blocks","volume":"20","author":"Galantini","year":"2015","journal-title":"Curr. Opin. Colloid Interface Sci."},{"key":"10.1016\/j.colsurfb.2021.111564_bib0215","doi-asserted-by":"crossref","first-page":"6803","DOI":"10.1021\/acs.langmuir.8b02657","article-title":"Bile salts: natural surfactants and precursors of a broad family of complex amphiphiles","volume":"35","author":"Di Gregorio","year":"2019","journal-title":"Langmuir"},{"issue":"11","key":"10.1016\/j.colsurfb.2021.111564_bib0220","doi-asserted-by":"crossref","first-page":"15748","DOI":"10.1021\/acsnano.0c06764","article-title":"Supracolloidal atomium","volume":"14","author":"Cautela","year":"2020","journal-title":"ACS Nano"},{"key":"10.1016\/j.colsurfb.2021.111564_bib0225","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/smll.201803215","article-title":"Sphere\u2013tubule superstructures through supramolecular and supracolloidal assembly pathways","volume":"14","author":"Cautela","year":"2018","journal-title":"Small"},{"key":"10.1016\/j.colsurfb.2021.111564_bib0230","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.ijpharm.2004.08.012","article-title":"Development of lidocaine gels for enhanced local anesthetic action","volume":"287","author":"Shin","year":"2004","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.colsurfb.2021.111564_bib0235","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.biomaterials.2004.02.020","article-title":"Effect of edge activators on the formation and transfection efficiency of ultradeformable liposomes","volume":"26","author":"Lee","year":"2005","journal-title":"Biomaterials"},{"issue":"3\u20134","key":"10.1016\/j.colsurfb.2021.111564_bib0240","article-title":"Transfersomes, liposomes and other lipid suspensions on the skin: permeation enhancement, vesicle penetration, and transdermal drug delivery","volume":"13","author":"Cevc","year":"1996","journal-title":"Crit. Rev. Ther. Drug Carrier Syst."},{"key":"10.1016\/j.colsurfb.2021.111564_bib0245","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.ijpharm.2010.06.034","article-title":"Role of edge activators and surface charge in developing ultradeformable vesicles with enhanced skin delivery","volume":"397","author":"El Zaafarany","year":"2010","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.colsurfb.2021.111564_bib0250","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.ijpharm.2004.02.024","article-title":"Interactions of surfactants (edge activators) and skin penetration enhancers with liposomes","volume":"276","author":"El Maghraby","year":"2004","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.colsurfb.2021.111564_bib0255","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1211\/jpp.58.2.0002","article-title":"Skin permeation of retinol in Tween 20-based deformable liposomes: in-vitro evaluation in human skin and keratinocyte models","volume":"58","author":"Oh","year":"2006","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.colsurfb.2021.111564_bib0260","doi-asserted-by":"crossref","first-page":"13626","DOI":"10.1021\/acs.langmuir.8b02343","article-title":"Bile salts caught in the act: from emulsification to nanostructural reorganization of lipid self-assemblies","volume":"34","author":"Sadeghpour","year":"2018","journal-title":"Langmuir"},{"key":"10.1016\/j.colsurfb.2021.111564_bib0265","doi-asserted-by":"crossref","first-page":"9377","DOI":"10.1021\/jf301787f","article-title":"Pharmacokinetics and blood-brain barrier penetration of (+)-Catechin and (-)-Epicatechin in rats by microdialysis sampling coupled to high-performance liquid chromatography with chemiluminescence detection","volume":"60","author":"Wu","year":"2012","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.colsurfb.2021.111564_bib0270","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.ejphar.2006.06.025","article-title":"Emerging role of polyphenolic compounds in the treatment of neurodegenerative diseases: a review of their intracellular targets","volume":"545","author":"Ramassamy","year":"2006","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.colsurfb.2021.111564_bib0275","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.colsurfb.2017.10.015","article-title":"Microemulsion formulation design and evaluation for hydrophobic compound: catechin topical application","volume":"161","author":"Lin","year":"2018","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"10.1016\/j.colsurfb.2021.111564_bib0280","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.jphotobiol.2016.03.026","article-title":"Enhancement of photoprotection potential of catechin loaded nanoemulsion gel against UVA induced oxidative stress","volume":"160","author":"Harwansh","year":"2016","journal-title":"J. Photochem. Photobiol. B, Biol."},{"key":"10.1016\/j.colsurfb.2021.111564_bib0285","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1124\/dmd.30.11.1246","article-title":"Contribution of presystemic hepatic extraction to the low oral bioavailability of green tea catechins in rats","volume":"30","author":"Cai","year":"2002","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.colsurfb.2021.111564_bib0290","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1080\/02652048.2017.1337248","article-title":"Catechin-loaded Eudragit microparticles for the management of diabetes: formulation, characterization and in vivo evaluation of antidiabetic efficacy","volume":"34","author":"Meena","year":"2017","journal-title":"J. Microencapsul."},{"key":"10.1016\/j.colsurfb.2021.111564_bib0295","doi-asserted-by":"crossref","first-page":"2157","DOI":"10.2147\/IJN.S59331","article-title":"Enhanced uptake and transport of (+)-catechin and (-)-epigallocatechin gallate in niosomal formulation by human intestinal caco-2 cells","volume":"9","author":"Song","year":"2014","journal-title":"Int. J. Nanomedicine"},{"key":"10.1016\/j.colsurfb.2021.111564_bib0300","doi-asserted-by":"crossref","first-page":"16536","DOI":"10.1021\/la303938k","article-title":"Nanoparticles with a bicontinuous cubic internal structure formed by cationic and non-ionic surfactants and an anionic polyelectrolyte","volume":"28","author":"Janiak","year":"2012","journal-title":"Langmuir"},{"key":"10.1016\/j.colsurfb.2021.111564_bib0305","doi-asserted-by":"crossref","first-page":"3004","DOI":"10.1039\/C0CP01539C","article-title":"Monoolein: a magic lipid?","volume":"13","author":"Kulkarni","year":"2011","journal-title":"Phys. Chem. Chem. Phys."},{"key":"10.1016\/j.colsurfb.2021.111564_bib0310","series-title":"Bile Salts","author":"de Buy Wenniger","year":"2013"},{"key":"10.1016\/j.colsurfb.2021.111564_bib0315","doi-asserted-by":"crossref","first-page":"3917","DOI":"10.1021\/la010224a","article-title":"Small-angle X-ray scattering and 13C NMR investigation on the internal structure of \u201ccubosomes","volume":"17","author":"Nakano","year":"2001","journal-title":"Langmuir"},{"key":"10.1016\/j.colsurfb.2021.111564_bib0320","doi-asserted-by":"crossref","first-page":"1558","DOI":"10.1039\/C6NJ03232J","article-title":"Theranostic hexosomes for cancer treatments: an in vitro study","volume":"41","author":"Meli","year":"2017","journal-title":"New J. Chem."},{"key":"10.1016\/j.colsurfb.2021.111564_bib0325","doi-asserted-by":"crossref","first-page":"23443","DOI":"10.1039\/C5RA01025J","article-title":"Solvatochromic fluorescent BODIPY derivative as imaging agent in camptothecin loaded hexosomes for possible theranostic applications","volume":"5","author":"Caltagirone","year":"2015","journal-title":"RSC Adv."},{"key":"10.1016\/j.colsurfb.2021.111564_bib0330","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.biomaterials.2005.05.097","article-title":"Topical delivery of low-molecular-weight heparin with surface-charged flexible liposomes","volume":"27","author":"Song","year":"2006","journal-title":"Biomaterials"},{"key":"10.1016\/j.colsurfb.2021.111564_bib0335","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.3109\/10717544.2014.976891","article-title":"Elastic liposome-based gel for topical delivery of 5-fluorouracil: in vitro and in vivo investigation","volume":"23","author":"Hussain","year":"2016","journal-title":"Drug Deliv."},{"key":"10.1016\/j.colsurfb.2021.111564_bib0340","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/j.ejps.2016.10.025","article-title":"Psoralen loaded liposomal nanocarriers for improved skin penetration and efficacy of topical PUVA in psoriasis","volume":"96","author":"Doppalapudi","year":"2017","journal-title":"Eur. J. Pharm. Sci."}],"container-title":["Colloids and Surfaces B: Biointerfaces"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0927776521000084?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0927776521000084?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T10:59:39Z","timestamp":1760525979000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0927776521000084"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3]]},"references-count":68,"alternative-id":["S0927776521000084"],"URL":"https:\/\/doi.org\/10.1016\/j.colsurfb.2021.111564","relation":{},"ISSN":["0927-7765"],"issn-type":[{"value":"0927-7765","type":"print"}],"subject":[],"published":{"date-parts":[[2021,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Tuning lipid structure by bile salts: Hexosomes for topical administration of catechin","name":"articletitle","label":"Article Title"},{"value":"Colloids and Surfaces B: Biointerfaces","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.colsurfb.2021.111564","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"111564"}}