{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T18:52:49Z","timestamp":1793731969654,"version":"4.6.1"},"reference-count":48,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Colloids and Surfaces B: Biointerfaces"],"published-print":{"date-parts":[[2021,10]]},"DOI":"10.1016\/j.colsurfb.2021.111930","type":"journal-article","created":{"date-parts":[[2021,6,17]],"date-time":"2021-06-17T01:21:32Z","timestamp":1623892892000},"page":"111930","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"special_numbering":"C","title":["Spectroscopic and docking studies of the interaction mechanisms of xylitol with \u03b1-casein and \u03ba-casein"],"prefix":"10.1016","volume":"206","author":[{"given":"Fanhua","family":"Kong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuejia","family":"An","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinlong","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenghan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boyuan","family":"Guan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiqing","family":"Yue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.colsurfb.2021.111930_bib0005","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1016\/j.foodres.2003.09.003","article-title":"Impact of sorbitol on the thermostability and heat-induced gelation of bovine serum albumin","volume":"36","author":"Baier","year":"2003","journal-title":"Food Res. Int."},{"key":"10.1016\/j.colsurfb.2021.111930_bib0010","doi-asserted-by":"crossref","first-page":"2055","DOI":"10.1007\/s00217-017-2916-0","article-title":"Mitigation role of erythritol and xylitol in the formation of 3-mo nochloropropane-1, 2-diol and its esters in glycerol and shortbread model systems","volume":"243","author":"Sadowska-Rociek","year":"2017","journal-title":"Eur. Food Res. Technol."},{"key":"10.1016\/j.colsurfb.2021.111930_bib0015","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1016\/j.foodhyd.2007.09.007","article-title":"Impact of cosolvents (polyols) on globular protein functionality: ultrasonic velocity, density, surface tension and solubility study","volume":"22","author":"Chanasattru","year":"2008","journal-title":"Food Hydrocoll."},{"key":"10.1016\/j.colsurfb.2021.111930_bib0020","doi-asserted-by":"crossref","first-page":"57","DOI":"10.17221\/35\/2016-CJFS","article-title":"Effect of cosolvents (polyols) on structural and foaming properties of soy protein isolate","volume":"35","author":"Pan","year":"2017","journal-title":"Czech J. Food Sci."},{"key":"10.1016\/j.colsurfb.2021.111930_bib0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2020.126804","article-title":"Interaction of xylitol with whey proteins: multi-spectroscopic techniques and docking studies","volume":"326","author":"Kong","year":"2020","journal-title":"Food Chem."},{"key":"10.1016\/j.colsurfb.2021.111930_bib0030","doi-asserted-by":"crossref","first-page":"2265","DOI":"10.1039\/C0SM00806K","article-title":"On the structural models of bovine casein micelles-review and possible improvements","volume":"7","author":"Dalgleish","year":"2011","journal-title":"Soft Matter"},{"key":"10.1016\/j.colsurfb.2021.111930_bib0035","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1016\/j.foodchem.2011.11.019","article-title":"Heating of milk alters the binding of curcumin to casein micelles: a fluorescence spectroscopy study","volume":"132","author":"Yazdi","year":"2012","journal-title":"Food Chem."},{"key":"10.1016\/j.colsurfb.2021.111930_bib0040","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1146\/annurev-food-022811-101214","article-title":"The structure of the casein micelle of milk and its changes during processing","volume":"3","author":"Dalgleish","year":"2012","journal-title":"Annu. Rev. Food Sci. Technol."},{"key":"10.1016\/j.colsurfb.2021.111930_bib0045","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/j.foodchem.2015.12.035","article-title":"Interactions of milk alpha- and beta-casein with malvidin-3-o-glucoside and their effects on the stability of grape skin anthocyanin extracts","volume":"199","author":"He","year":"2016","journal-title":"Food Chem."},{"key":"10.1016\/j.colsurfb.2021.111930_bib0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.saa.2020.118824","article-title":"Characteristics of the interaction mechanisms of xylitol with \u03b2-lactoglobulin and \u03b2-casein: a multi-spectral method and docking study","volume":"243","author":"Kong","year":"2020","journal-title":"Spectroc. Acta Pt. A-Molec. Biomolec. Spectr."},{"key":"10.1016\/j.colsurfb.2021.111930_bib0055","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.foodchem.2018.01.143","article-title":"Spectroscopic and docking studies on the interaction between caseins and \u03b2-carotene","volume":"255","author":"Allahdad","year":"2018","journal-title":"Food Chem."},{"key":"10.1016\/j.colsurfb.2021.111930_bib0060","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1016\/j.foodchem.2012.10.144","article-title":"Binding of vitamin a with milk \u03b1- and \u03b2-caseins","volume":"138","author":"Bourassa","year":"2013","journal-title":"Food Chem."},{"key":"10.1016\/j.colsurfb.2021.111930_bib0065","article-title":"Spectroscopic studies of the interaction between isolated polyphenols from coffee and the milk proteins","volume":"20","author":"El-Messery","year":"2020","journal-title":"J. Surf. Interfaces Mater."},{"key":"10.1016\/j.colsurfb.2021.111930_bib0070","doi-asserted-by":"crossref","first-page":"18","DOI":"10.3168\/jds.2017-13105","article-title":"Complexes of lutein with bovine and caprine caseins and their impact on lutein chemical stability in emulsion systems: effect of arabinogalactan","volume":"101","author":"Mora-Gutierrez","year":"2017","journal-title":"J. Dairy Sci."},{"key":"10.1016\/j.colsurfb.2021.111930_bib0075","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.foodchem.2018.01.091","article-title":"Combined spectroscopic, molecular docking and quantum mechanics study of \u03b2-casein and p-coumaric acid interactions following thermal treatment","volume":"252","author":"Kaur","year":"2018","journal-title":"Food Chem."},{"key":"10.1016\/j.colsurfb.2021.111930_bib0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.lwt.2019.108434","article-title":"Protective effects of \u03b1-casein or \u03b2-casein on the stability and antioxidant capacity of blueberry anthocyanins and their interaction mechanism","volume":"115","author":"Lang","year":"2019","journal-title":"LWT-Food Sci. Technol."},{"key":"10.1016\/j.colsurfb.2021.111930_bib0085","article-title":"Effects of \u03b1-casein and \u03b2-casein on the stability, antioxidant activity and bioaccessibility of blueberry anthocyanins with an in vitro simulated digestion","volume":"334","author":"Lang","year":"2020","journal-title":"Food Chem."},{"key":"10.1016\/j.colsurfb.2021.111930_bib0090","doi-asserted-by":"crossref","first-page":"2686","DOI":"10.1080\/10942912.2016.1247857","article-title":"A combination of spectroscopic and molecular docking techniques to study interaction of bis (indolyl) methane with bovine milk \u03b1-casein","volume":"20","author":"Dezhampanah","year":"2016","journal-title":"Int. J. Food Prop."},{"key":"10.1016\/j.colsurfb.2021.111930_bib0095","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1021\/jf505584m","article-title":"Novel insights into the inhibitory mechanism of kaempferol on xanthine oxidase","volume":"63","author":"Wang","year":"2015","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.colsurfb.2021.111930_bib0100","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.foodhyd.2018.06.011","article-title":"Analysis of the interaction mechanism of Anthocyanins (Aronia melanocarpa Elliot) with \u03b2-casein","volume":"84","author":"Wei","year":"2018","journal-title":"Food Hydrocoll."},{"key":"10.1016\/j.colsurfb.2021.111930_bib0105","doi-asserted-by":"crossref","first-page":"14018","DOI":"10.1021\/jp408578m","article-title":"Binding interactions of \u03b2-conglycinin and glycinin with vitamin b12","volume":"117","author":"Zhang","year":"2013","journal-title":"J. Phys. Chem. B"},{"key":"10.1016\/j.colsurfb.2021.111930_bib0110","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1016\/j.dyepig.2006.04.010","article-title":"Spectroscopic investigations on the mechanism of interaction of bioactive dye with bovine serum albumin","volume":"74","author":"Shaikh","year":"2007","journal-title":"Dyes Pigm."},{"key":"10.1016\/j.colsurfb.2021.111930_bib0115","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/j.foodres.2019.05.021","article-title":"Protective effects of bovine serum albumin on blueberry anthocyanins under illumination conditions and their mechanism analysis","volume":"122","author":"Lang","year":"2019","journal-title":"Food Res. Int."},{"key":"10.1016\/j.colsurfb.2021.111930_bib0120","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1016\/j.ijbiomac.2017.07.119","article-title":"Spectrofluorimetric and molecular docking studies on the interaction of cyanidin-3-o-glucoside with whey protein, \u03b2-lactoglobulin","volume":"105","author":"Cheng","year":"2017","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.colsurfb.2021.111930_bib0125","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/j.jphotobiol.2017.06.037","article-title":"Characterizing the binding interaction of fungicide boscalid with bovine serum albumin (BSA): a spectroscopic study in combination with molecular docking approach","volume":"173","author":"Lou","year":"2017","journal-title":"J. Photochem. Photobiol. B-Biol."},{"key":"10.1016\/j.colsurfb.2021.111930_bib0130","series-title":"Principle of Fluorescence Spectroscopy","first-page":"237","author":"Lakowicz","year":"1999"},{"key":"10.1016\/j.colsurfb.2021.111930_bib0135","doi-asserted-by":"crossref","DOI":"10.1016\/j.idairyj.2020.104841","article-title":"The effect of non-covalent interactions of xylitol with whey protein and casein on structure and functionality of protein","volume":"111","author":"Kong","year":"2020","journal-title":"Int. Dairy J."},{"key":"10.1016\/j.colsurfb.2021.111930_bib0140","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.jphotobiol.2016.09.025","article-title":"Binding interaction of ramipril with bovine serum albumin (BSA): insights from multi-spectroscopy and molecular docking methods","volume":"164","author":"Shi","year":"2016","journal-title":"J. Photochem. Photobiol. B-Biol."},{"key":"10.1016\/j.colsurfb.2021.111930_bib0145","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.jphotobiol.2017.05.039","article-title":"Probing the binding reaction of cytarabine to human serum albumin using multispectroscopic techniques with the aid of molecular docking","volume":"173","author":"Xu","year":"2017","journal-title":"J. Photochem. Photobiol. B-Biol."},{"key":"10.1016\/j.colsurfb.2021.111930_bib0150","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.foodhyd.2014.02.023","article-title":"\u03b2-Lactoglobulin\u2013naringenin complexes: nano-vehicles for the delivery of a hydrophobic nutraceutical","volume":"40","author":"Shpigelman","year":"2014","journal-title":"Food Hydrocoll."},{"key":"10.1016\/j.colsurfb.2021.111930_bib0155","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.colsurfb.2014.11.023","article-title":"Binding of glutathione and melatonin to human serum albumin: a comparative study","volume":"125","author":"Li","year":"2015","journal-title":"Colloid Surf. B Biointerfaces."},{"key":"10.1016\/j.colsurfb.2021.111930_bib0160","doi-asserted-by":"crossref","first-page":"1880","DOI":"10.1021\/jf2050262","article-title":"Binding between bixin and whey protein at pH 7.4 studied by spectroscopy and isothermal titration calorimetry","volume":"60","author":"Zhang","year":"2012","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.colsurfb.2021.111930_bib0165","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.foodchem.2018.10.057","article-title":"Binding of \u03b2-carotene to whey proteins: multi-spectroscopic techniques and docking studies","volume":"277","author":"Allahdad","year":"2018","journal-title":"Food Chem."},{"key":"10.1016\/j.colsurfb.2021.111930_bib0170","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.jpha.2016.05.009","article-title":"Binding interaction of phosphorus heterocycles with bovine serum albumin: a biochemical study","volume":"7","author":"Roy","year":"2017","journal-title":"J. Pharm. Anal."},{"key":"10.1016\/j.colsurfb.2021.111930_bib0175","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.foodres.2019.02.042","article-title":"New insights into the binding mechanism between osthole and \u03b2-lactoglobulin: spectroscopic, chemometrics and docking studies","volume":"120","author":"Wang","year":"2019","journal-title":"Food Res. Int."},{"key":"10.1016\/j.colsurfb.2021.111930_bib0180","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.foodchem.2015.03.128","article-title":"Fluorescence quenching study of resveratrol binding to zein and gliadin: towards a more rational approach to resveratrol encapsulation using water-insoluble proteins","volume":"185","author":"Joye","year":"2015","journal-title":"Food Chem."},{"key":"10.1016\/j.colsurfb.2021.111930_bib0185","doi-asserted-by":"crossref","first-page":"1572","DOI":"10.1016\/j.ijbiomac.2017.04.051","article-title":"Binding of erucic acid with human serum albumin using a spectroscopic and molecular docking study","volume":"105","author":"Rabbani","year":"2017","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.colsurfb.2021.111930_bib0190","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.jpba.2012.04.012","article-title":"Combined fluorescence spectroscopy and molecular modeling studies on the interaction between harmalol and human serum albumin","volume":"67-68","author":"Hemmateenejad","year":"2012","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.colsurfb.2021.111930_bib0195","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1016\/j.jff.2014.12.012","article-title":"Analysis of binding interaction of genistein and kaempferol with bovine \u03b1-lactalbumin","volume":"12","author":"Mohammadi","year":"2015","journal-title":"J. Funct. Food"},{"key":"10.1016\/j.colsurfb.2021.111930_bib0200","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.jphotobiol.2015.01.006","article-title":"Interaction of L-arginine with \u03ba-casein and its effect on amyloid fibril formation by the protein: multi-spectroscopic approaches","volume":"143","author":"Chen","year":"2015","journal-title":"J. Photochem. Photobiol. B-Biol."},{"key":"10.1016\/j.colsurfb.2021.111930_bib0205","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1016\/j.foodchem.2016.10.136","article-title":"Myricetin inhibits the generation of superoxide anion by reduced form of xanthine oxidase","volume":"221","author":"Zhang","year":"2017","journal-title":"Food Chem."},{"key":"10.1016\/j.colsurfb.2021.111930_bib0210","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.foodhyd.2016.09.027","article-title":"Formation of nanocomplexes comprising whey proteins and fucoxanthin: characterization, spectroscopic analysis, and molecular docking","volume":"63","author":"Zhu","year":"2017","journal-title":"Food Hydrocoll."},{"key":"10.1016\/j.colsurfb.2021.111930_bib0215","doi-asserted-by":"crossref","first-page":"6813","DOI":"10.1021\/jf500705s","article-title":"Separation and identification of anthocyanin extracted from mulberry fruit and the pigment binding properties toward human serum albumin","volume":"62","author":"Sheng","year":"2014","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.colsurfb.2021.111930_bib0220","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1002\/bio.2704","article-title":"Combined multispectroscopic and molecular docking investigation on the interaction between delphinidin-3-O-glucoside and bovine serum albumin","volume":"30","author":"Zuo","year":"2014","journal-title":"Luminescence"},{"key":"10.1016\/j.colsurfb.2021.111930_bib0225","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.foodchem.2018.06.015","article-title":"The effect of non-covalent interaction of chlorogenic acid with whey protein and casein on physicochemical and radical-scavenging activity of in vitro protein digests","volume":"268","author":"Jiang","year":"2018","journal-title":"Food Chem."},{"key":"10.1016\/j.colsurfb.2021.111930_bib0230","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1021\/jp3114557","article-title":"Binding sites of resveratrol, genistein, and curcumin with milk \u03b1- and \u03b2-caseins","volume":"117","author":"Bourassa","year":"2013","journal-title":"J. Phys. Chem. B"},{"key":"10.1016\/j.colsurfb.2021.111930_bib0235","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2020.128145","article-title":"Protein-polyphenol functional ingredients: the foaming properties of lactoferrin are enhanced by forming complexes with procyanidin","volume":"339","author":"Li","year":"2021","journal-title":"Food Chem."},{"key":"10.1016\/j.colsurfb.2021.111930_bib0240","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1080\/07391102.2012.742461","article-title":"Probing the binding sites of resveratrol, genistein, and curcumin with milk beta-lactoglobulin","volume":"31","author":"Kanakis","year":"2013","journal-title":"J. Biomol. Struct. Dyn."}],"container-title":["Colloids and Surfaces B: Biointerfaces"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S092777652100374X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S092777652100374X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T11:00:18Z","timestamp":1760526018000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S092777652100374X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10]]},"references-count":48,"alternative-id":["S092777652100374X"],"URL":"https:\/\/doi.org\/10.1016\/j.colsurfb.2021.111930","relation":{},"ISSN":["0927-7765"],"issn-type":[{"value":"0927-7765","type":"print"}],"subject":[],"published":{"date-parts":[[2021,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Spectroscopic and docking studies of the interaction mechanisms of xylitol with \u03b1-casein and \u03ba-casein","name":"articletitle","label":"Article Title"},{"value":"Colloids and Surfaces B: Biointerfaces","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.colsurfb.2021.111930","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"111930"}}