{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T10:56:05Z","timestamp":1780656965570,"version":"3.54.1"},"reference-count":54,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100007904","name":"Texas A and M University","doi-asserted-by":"publisher","award":["247099"],"award-info":[{"award-number":["247099"]}],"id":[{"id":"10.13039\/100007904","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007904","name":"Texas A and M University","doi-asserted-by":"publisher","award":["R15CA213103"],"award-info":[{"award-number":["R15CA213103"]}],"id":[{"id":"10.13039\/100007904","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["247099"],"award-info":[{"award-number":["247099"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["R15CA213103"],"award-info":[{"award-number":["R15CA213103"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["247099"],"award-info":[{"award-number":["247099"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R15CA213103"],"award-info":[{"award-number":["R15CA213103"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["247099"],"award-info":[{"award-number":["247099"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["R15CA213103"],"award-info":[{"award-number":["R15CA213103"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004586","name":"Funda\u00e7\u00e3o Carlos Chagas Filho de Amparo \u00e0 Pesquisa do Estado do Rio de Janeiro","doi-asserted-by":"publisher","award":["247099"],"award-info":[{"award-number":["247099"]}],"id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004586","name":"Funda\u00e7\u00e3o Carlos Chagas Filho de Amparo \u00e0 Pesquisa do Estado do Rio de Janeiro","doi-asserted-by":"publisher","award":["R15CA213103"],"award-info":[{"award-number":["R15CA213103"]}],"id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["247099"],"award-info":[{"award-number":["247099"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["R15CA213103"],"award-info":[{"award-number":["R15CA213103"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Colloids and Surfaces B: Biointerfaces"],"published-print":{"date-parts":[[2021,10]]},"DOI":"10.1016\/j.colsurfb.2021.111952","type":"journal-article","created":{"date-parts":[[2021,6,29]],"date-time":"2021-06-29T00:23:28Z","timestamp":1624926208000},"page":"111952","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"special_numbering":"C","title":["Rheumatoid arthritis treatment using hydroxychloroquine and methotrexate co-loaded nanomicelles: In vivo results"],"prefix":"10.1016","volume":"206","author":[{"given":"Tais Monteiro","family":"Magne","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward","family":"Helal-Neto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9414-3103","authenticated-orcid":false,"given":"Luana Barbosa","family":"Correa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciana Magalh\u00e3es","family":"Rebelo Alencar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7724-9491","authenticated-orcid":false,"given":"Sara","family":"Gemini Piperni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Surtaj H.","family":"Iram","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2059-6548","authenticated-orcid":false,"given":"Prapanna","family":"Bhattarai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4047-1726","authenticated-orcid":false,"given":"Lin","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"Ricci-Junior","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3065-0541","authenticated-orcid":false,"given":"Maria das Gra\u00e7as Muller","family":"de Oliveira Henriques","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9612-0063","authenticated-orcid":false,"given":"Elaine Cruz","family":"Rosas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7221-6404","authenticated-orcid":false,"given":"Ralph","family":"Santos-Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.colsurfb.2021.111952_bib0005","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1016\/j.nano.2015.12.365","article-title":"Folate-targeted nanoparticles for rheumatoid arthritis therapy","volume":"12","author":"Nogueira","year":"2016","journal-title":"Nanomed. Nanotechnol., Biol. Med."},{"key":"10.1016\/j.colsurfb.2021.111952_bib0010","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1080\/08923973.2018.1434793","article-title":"Experimental animal models for rheumatoid arthritis","volume":"40","author":"Choudhary","year":"2018","journal-title":"Immunopharmacol. Immunotoxicol."},{"key":"10.1016\/j.colsurfb.2021.111952_bib0015","doi-asserted-by":"crossref","first-page":"18001","DOI":"10.1038\/nrdp.2018.1","article-title":"Rheumatoid arthritis","volume":"4","author":"Smolen","year":"2018","journal-title":"Nat Rev Dis Prim."},{"key":"10.1016\/j.colsurfb.2021.111952_bib0020","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1166\/jbn.2020.2966","article-title":"Engineered high-loaded mixed-monoclonal antibodies (adalimumab, rituximab and trastuzumab) polymeric nanoparticle for rheumatoid arthritis treatment: a proof of concept","volume":"16","author":"He","year":"2021","journal-title":"J. Biomed. Nanotechnol."},{"key":"10.1016\/j.colsurfb.2021.111952_bib0025","first-page":"519","article-title":"One year in review 2019: novelties in the treatment of rheumatoid arthritis","volume":"37","author":"Silvagni","year":"2019","journal-title":"Clin. Exp. Rheumatol."},{"key":"10.1016\/j.colsurfb.2021.111952_bib0030","doi-asserted-by":"crossref","DOI":"10.3390\/nano8010042","article-title":"Lipid-based nanoparticles as a potential delivery approach in the treatment of rheumatoid arthritis","volume":"8","author":"Chuang","year":"2018","journal-title":"Nanomaterials."},{"key":"10.1016\/j.colsurfb.2021.111952_bib0035","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.jconrel.2019.01.015","article-title":"Dexamethasone palmitate nanoparticles: an efficient treatment for rheumatoid arthritis","volume":"296","author":"Lorscheider","year":"2019","journal-title":"J. Control. Release"},{"key":"10.1016\/j.colsurfb.2021.111952_bib0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2019.119730","article-title":"Reactive oxygen species-responsive dexamethasone-loaded nanoparticles for targeted treatment of rheumatoid arthritis via suppressing the iRhom2\/TNF-\u03b1\/BAFF signaling pathway","volume":"232","author":"Ni","year":"2020","journal-title":"Biomaterials."},{"key":"10.1016\/j.colsurfb.2021.111952_bib0045","doi-asserted-by":"crossref","DOI":"10.1016\/j.colsurfb.2020.110814","article-title":"Lycopene used as anti-inflammatory nanodrug for the treatment of rheumathoid arthritis: animal assay, pharmacokinetics, ABC transporter and tissue deposition","volume":"188","author":"Moia","year":"2020","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"10.1016\/j.colsurfb.2021.111952_bib0050","doi-asserted-by":"crossref","first-page":"1552","DOI":"10.1007\/s13346-020-00821-5","article-title":"Development, characterization, and anti-leishmanial activity of topical amphotericin B nanoemulsions","volume":"10","author":"dos Santos Matos","year":"2020","journal-title":"Drug Deliv. Transl. Res."},{"key":"10.1016\/j.colsurfb.2021.111952_bib0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.jphotobiol.2020.112010","article-title":"Development, characterization and photobiological activity of nanoemulsion containing zinc phthalocyanine for oral infections treatment","volume":"211","author":"Schuenck-Rodrigues","year":"2020","journal-title":"J. Photochem. Photobiol. B, Biol."},{"issue":"2016","key":"10.1016\/j.colsurfb.2021.111952_bib0060","first-page":"1","article-title":"American college of rheumatology guideline for the treatment of rheumatoid arthritis","volume":"68","author":"Singh","year":"2015","journal-title":"Arthritis Rheumatol."},{"key":"10.1016\/j.colsurfb.2021.111952_bib0065","doi-asserted-by":"crossref","first-page":"S685","DOI":"10.1136\/annrheumdis-2019-216655","article-title":"EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs: 2019 update","volume":"79","author":"Smolen","year":"2020","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.colsurfb.2021.111952_bib0070","first-page":"2077","article-title":"Combination therapy with methotrexate and hydroxychloroquine for rheumatoid arthritis increases exposure to methotrexate","volume":"29","author":"Carmichael","year":"2002","journal-title":"J. Rheumatol."},{"key":"10.1016\/j.colsurfb.2021.111952_bib0075","doi-asserted-by":"crossref","first-page":"36642","DOI":"10.1021\/acsami.7b12233","article-title":"Improving tumor specificity and anticancer activity of dasatinib by dual-targeted polymeric micelles","volume":"9","author":"Yao","year":"2017","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.colsurfb.2021.111952_bib0080","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.nano.2019.03.012","article-title":"Tumor-targeted drug delivery and sensitization by MMP2-responsive polymeric micelles","volume":"19","author":"Yao","year":"2019","journal-title":"Nanomed. Nanotechnol., Biol. Med."},{"key":"10.1016\/j.colsurfb.2021.111952_bib0085","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1016\/j.ijpharm.2012.02.028","article-title":"Folic acid-functionalized human serum albumin nanocapsules for targeted drug delivery to chronically activated macrophages","volume":"427","author":"Rollett","year":"2012","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.colsurfb.2021.111952_bib0090","first-page":"1","article-title":"Therapeutic surfactant-stripped frozen micelles","volume":"7","author":"Zhang","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.colsurfb.2021.111952_bib0095","doi-asserted-by":"crossref","first-page":"939","DOI":"10.2147\/IJN.S130696","article-title":"Redox-sensitive micelles composed of disulfide-linked pluronic-linoleic acid for enhanced anticancer efficiency of brusatol","volume":"13","author":"Zhang","year":"2018","journal-title":"Int. J. Nanomedicine"},{"key":"10.1016\/j.colsurfb.2021.111952_bib0100","first-page":"1","article-title":"Development and characterization of lecithin-based self-assembling mixed polymeric micellar (saMPMs) drug delivery systems for curcumin","volume":"6","author":"Chen","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.colsurfb.2021.111952_bib0105","doi-asserted-by":"crossref","first-page":"17028","DOI":"10.1039\/C3RA47370H","article-title":"Polymeric micelles as drug delivery vehicles","volume":"4","author":"Ahmad","year":"2014","journal-title":"RSC Adv."},{"key":"10.1016\/j.colsurfb.2021.111952_bib0110","first-page":"1","article-title":"Recent advances in nanomicelles delivery systems","volume":"11","author":"Tawfik","year":"2021","journal-title":"Nanomaterials"},{"key":"10.1016\/j.colsurfb.2021.111952_bib0115","doi-asserted-by":"crossref","first-page":"4350","DOI":"10.1021\/la304836e","article-title":"Encapsulation of hydrophobic drugs in pluronic F127 micelles: effects of drug hydrophobicity, solution temperature, and pH","volume":"29","author":"Basak","year":"2013","journal-title":"Langmuir."},{"key":"10.1016\/j.colsurfb.2021.111952_bib0120","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2019.118460","article-title":"Optimization of composition and obtainment parameters of biocompatible nanoemulsions intended for intraductal administration of piplartine (piperlongumine) and mammary tissue targeting","volume":"567","author":"Carvalho","year":"2019","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.colsurfb.2021.111952_bib0125","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.molliq.2017.01.065","article-title":"Systematic characterization of Pluronic\u00ae micelles and their application for solubilization and in vitro release of some hydrophobic anticancer drugs","volume":"230","author":"Raval","year":"2017","journal-title":"J. Mol. Liq."},{"key":"10.1016\/j.colsurfb.2021.111952_bib0130","article-title":"Electro-responsive brain-targeting mixed micelles based on Pluronic F127 and D-\u03b1-tocopherol polyethylene glycol succinate\u2013ferrocene","volume":"601","author":"ying Meng","year":"2020","journal-title":"Colloids Surfaces A Physicochem. Eng. Asp."},{"key":"10.1016\/j.colsurfb.2021.111952_bib0135","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1007\/s13205-014-0214-0","article-title":"Nanoemulsion: an advanced mode of drug delivery system","volume":"5","author":"Jaiswal","year":"2015","journal-title":"3 Biotech"},{"key":"10.1016\/j.colsurfb.2021.111952_bib0140","doi-asserted-by":"crossref","first-page":"6469","DOI":"10.2147\/IJN.S89364","article-title":"Enhancement of encapsulation efficiency of nanoemulsion-containing aripiprazole for the treatment of schizophrenia using mixture experimental design","volume":"10","author":"Masoumi","year":"2015","journal-title":"Int. J. Nanomed."},{"key":"10.1016\/j.colsurfb.2021.111952_bib0145","doi-asserted-by":"crossref","first-page":"S137","DOI":"10.1016\/j.matpr.2018.08.055","article-title":"Development and characterization of aerosol nanoemulsion system encapsulating low water soluble quercetin for lung cancer treatment","author":"Arbain","year":"2018","journal-title":"Mater. Today Proc."},{"key":"10.1016\/j.colsurfb.2021.111952_bib0150","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.ejps.2018.10.001","article-title":"Development of a safety and efficacy nanoemulsion delivery system encapsulated gambogic acid for acute myeloid leukemia in vitro and in vivo","volume":"125","author":"Feng","year":"2018","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.colsurfb.2021.111952_bib0155","article-title":"Nanoemulsion preconcentrate of a pentacyclic triterpene for improved oral efficacy: Formulation design and in-vivo antimalarial activity","volume":"57","author":"Jyotshna","year":"2020","journal-title":"J. Drug Deliv. Sci. Technol."},{"key":"10.1016\/j.colsurfb.2021.111952_bib0160","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics10020057","article-title":"Impact of particle size and polydispersity index on the clinical applications of lipidic nanocarrier systems","volume":"10","author":"Danaei","year":"2018","journal-title":"Pharmaceutics."},{"key":"10.1016\/j.colsurfb.2021.111952_bib0165","article-title":"Nanotechnology for microfluidics","author":"Jiang","year":"2019","journal-title":"wiley"},{"key":"10.1016\/j.colsurfb.2021.111952_bib0170","doi-asserted-by":"crossref","first-page":"5577","DOI":"10.2147\/IJN.S36111","article-title":"The role of surface charge in cellular uptake and cytotoxicity of medical nanoparticles","volume":"7","author":"Fr\u00f6hlich","year":"2012","journal-title":"Int. J. Nanomed."},{"key":"10.1016\/j.colsurfb.2021.111952_bib0175","doi-asserted-by":"crossref","first-page":"485","DOI":"10.2217\/nnm.10.10","article-title":"Nanomicellar formulations for sustained drug delivery: strategies and underlying principles","volume":"5","author":"Trivedi","year":"2010","journal-title":"Nanomedicine"},{"key":"10.1016\/j.colsurfb.2021.111952_bib0180","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/B978-0-12-819811-7.00011-4","article-title":"Polymeric micelle-based drug delivery systems for tuberculosis treatment","author":"Gorain","year":"2020","journal-title":"Nanotechnol. Based Approaches Tuberc. Treat."},{"key":"10.1016\/j.colsurfb.2021.111952_bib0185","doi-asserted-by":"crossref","first-page":"3488","DOI":"10.1039\/C7TB00701A","article-title":"Switchable release nano-reservoirs for co-delivery of drugs via a facile micelle-hydrogel composite","volume":"5","author":"Patel","year":"2017","journal-title":"J. Mater. Chem. B."},{"key":"10.1016\/j.colsurfb.2021.111952_bib0190","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.1016\/j.xphs.2016.01.016","article-title":"Development and evaluation of a novel drug delivery: Pluronics\/SDS mixed micelle loaded with myricetin in vitro and in vivo","volume":"105","author":"Wang","year":"2016","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.colsurfb.2021.111952_bib0195","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1016\/j.colsurfb.2011.08.002","article-title":"Mixed micelle formation with hydrophobic and hydrophilic pluronic block copolymers: Implications for controlled and targeted drug delivery","volume":"88","author":"Kulthe","year":"2011","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"10.1016\/j.colsurfb.2021.111952_bib0200","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/j.ejps.2009.04.004","article-title":"Quantifying drug release from PLGA nanoparticulates","volume":"37","author":"Corrigan","year":"2009","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.colsurfb.2021.111952_bib0205","doi-asserted-by":"crossref","DOI":"10.2174\/1381612823666170601105439","article-title":"Methotrexate in the treatment of psoriasis and rheumatoid arthritis: mechanistic insights, current issues and novel delivery approaches","volume":"23","author":"Rajitha","year":"2017","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.colsurfb.2021.111952_bib0210","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.jbspin.2018.07.004","article-title":"Methotrexate mechanism in treatment of rheumatoid arthritis","volume":"86","author":"Friedman","year":"2019","journal-title":"Jt. Bone Spine."},{"key":"10.1016\/j.colsurfb.2021.111952_bib0215","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1002\/1529-0131(200107)44:7<1515::AID-ART273>3.0.CO;2-7","article-title":"Effect of folic or folinic acid supplementation on the toxicity and efficacy of methotrexate in rheumatoid arthritis: A forty-eight-week, multicenter, randomized, double-blind, placebo-controlled study","volume":"44","author":"Van Ede","year":"2001","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.colsurfb.2021.111952_bib0220","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.1001\/jama.2018.13103","article-title":"Diagnosis and management of rheumatoid arthritis: a review","volume":"320","author":"Aletaha","year":"2018","journal-title":"JAMA."},{"key":"10.1016\/j.colsurfb.2021.111952_bib0225","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1016\/j.ejmech.2018.09.027","article-title":"Side effects of methotrexate therapy for rheumatoid arthritis: A systematic review","volume":"158","author":"Wang","year":"2018","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.colsurfb.2021.111952_bib0230","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1038\/s41584-020-0372-x","article-title":"Mechanisms of action of hydroxychloroquine and chloroquine: implications for rheumatology","volume":"16","author":"Schrezenmeier","year":"2020","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.colsurfb.2021.111952_bib0235","first-page":"131","article-title":"The effects of methotrexate and hydroxychloroquine combination therapy vs methotrexate monotherapy in early rheumatoid arthritis patients","volume":"58","author":"Schapink","year":"2019","journal-title":"Rheumatol. (United Kingdom)."},{"key":"10.1016\/j.colsurfb.2021.111952_bib0240","doi-asserted-by":"crossref","DOI":"10.1186\/s13000-015-0447-1","article-title":"MDR-1 and MRP-1 activity in peripheral blood leukocytes of rheumatoid arthritis patients","volume":"10","author":"Micsik","year":"2015","journal-title":"Diagn. Pathol."},{"key":"10.1016\/j.colsurfb.2021.111952_bib0245","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.1136\/ard.2005.049189","article-title":"Down regulation of multidrug resistance protein-1 expression in patients with early rheumatoid arthritis exposed to methotrexate as a first disease-modifying antirheumatic drug","volume":"65","author":"Hider","year":"2006","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.colsurfb.2021.111952_bib0250","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1007\/s11010-007-9430-9","article-title":"The metabolic changes caused by dexamethasone in the adjuvant-induced arthritic rat","volume":"302","author":"Caparroz-Assef","year":"2007","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.colsurfb.2021.111952_bib0255","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.biopha.2017.07.101","article-title":"Berberine ameliorates methotrexate-induced liver injury by activating Nrf2\/HO-1 pathway and PPAR\u03b3, and suppressing oxidative stress and apoptosis in rats","volume":"94","author":"Mahmoud","year":"2017","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.colsurfb.2021.111952_bib0260","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1002\/art.1780200314","article-title":"Antigen\u2010induced arthritis in mice","volume":"20","author":"Brackertz","year":"1977","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.colsurfb.2021.111952_bib0265","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1038\/s41584-019-0243-5","article-title":"Systemic effects of IL-17 in inflammatory arthritis","volume":"15","author":"Beringer","year":"2019","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.colsurfb.2021.111952_bib0270","doi-asserted-by":"crossref","DOI":"10.1007\/s11095-020-02827-7","article-title":"Interactions of tofacitinib and dexamethasone on lymphocyte proliferation","volume":"37","author":"Yu","year":"2020","journal-title":"Pharm. Res."}],"container-title":["Colloids and Surfaces B: Biointerfaces"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0927776521003969?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0927776521003969?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T11:05:00Z","timestamp":1760526300000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0927776521003969"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10]]},"references-count":54,"alternative-id":["S0927776521003969"],"URL":"https:\/\/doi.org\/10.1016\/j.colsurfb.2021.111952","relation":{},"ISSN":["0927-7765"],"issn-type":[{"value":"0927-7765","type":"print"}],"subject":[],"published":{"date-parts":[[2021,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Rheumatoid arthritis treatment using hydroxychloroquine and methotrexate co-loaded nanomicelles: In vivo results","name":"articletitle","label":"Article Title"},{"value":"Colloids and Surfaces B: Biointerfaces","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.colsurfb.2021.111952","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"111952"}}