{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T18:20:16Z","timestamp":1789496416194,"version":"build-2803163510"},"reference-count":106,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Colloids and Surfaces B: Biointerfaces"],"published-print":{"date-parts":[[2022,9]]},"DOI":"10.1016\/j.colsurfb.2022.112657","type":"journal-article","created":{"date-parts":[[2022,6,24]],"date-time":"2022-06-24T02:22:38Z","timestamp":1656037358000},"page":"112657","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":40,"special_numbering":"C","title":["Green self-assembled lactoferrin carboxymethyl cellulose nanogels for synergistic chemo\/herbal breast cancer therapy"],"prefix":"10.1016","volume":"217","author":[{"given":"Mai A.","family":"Atallah","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marwa A.","family":"Sallam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mona A.","family":"Abdelmoneem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"Teleb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kadria A.","family":"Elkhodairy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adnan A.","family":"Bekhit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asmaa F.","family":"Khafaga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed E.","family":"Noreldin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed O.","family":"Elzoghby","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sherine N.","family":"Khattab","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.colsurfb.2022.112657_bib1","doi-asserted-by":"crossref","first-page":"E359","DOI":"10.1002\/ijc.29210","article-title":"Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012","volume":"136","author":"Ferlay","year":"2015","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.colsurfb.2022.112657_bib2","doi-asserted-by":"crossref","first-page":"e625","DOI":"10.1016\/S1470-2045(14)70364-X","article-title":"Epidemiology, biology, and treatment of triple-negative breast cancer in women of African ancestry, The","volume":"15","author":"Brewster","year":"2014","journal-title":"Lancet Oncol."},{"key":"10.1016\/j.colsurfb.2022.112657_bib3","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202007426","article-title":"A multichannel Ca(2+) nanomodulator for multilevel mitochondrial destruction-mediated cancer therapy","volume":"33","author":"Zheng","year":"2021","journal-title":"Adv. Mater."},{"key":"10.1016\/j.colsurfb.2022.112657_bib4","doi-asserted-by":"crossref","first-page":"2088","DOI":"10.1021\/acs.nanolett.0c04778","article-title":"Ultrasound-augmented mitochondrial calcium ion overload by calcium nanomodulator to induce immunogenic cell death","volume":"21","author":"Zheng","year":"2021","journal-title":"Nano Lett."},{"key":"10.1016\/j.colsurfb.2022.112657_bib5","first-page":"1","article-title":"Calcium ion nanomodulators for mitochondria-targeted multimodal cancer therapy","volume":"17","author":"Zheng","year":"2022","journal-title":"Asian J. Pharm. Sci."},{"key":"10.1016\/j.colsurfb.2022.112657_bib6","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.scib.2020.07.013","article-title":"Polypeptide nanoformulation-induced immunogenic cell death and remission of immunosuppression for enhanced chemoimmunotherapy","volume":"66","author":"Feng","year":"2021","journal-title":"Sci. Bull."},{"key":"10.1016\/j.colsurfb.2022.112657_bib7","doi-asserted-by":"crossref","first-page":"261","DOI":"10.2217\/nnm-2021-0019","article-title":"Sequentially stimuli-responsive anticancer nanomedicines","volume":"16","author":"Wei","year":"2021","journal-title":"Nanomedicine"},{"key":"10.1016\/j.colsurfb.2022.112657_bib8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jconrel.2021.02.003","article-title":"X-ray-responsive polypeptide nanogel for concurrent chemoradiotherapy","volume":"332","author":"Wang","year":"2021","journal-title":"J. Control. Release"},{"key":"10.1016\/j.colsurfb.2022.112657_bib9","doi-asserted-by":"crossref","DOI":"10.1063\/5.0061530","article-title":"Smart transformable nanoparticles for enhanced tumor theranostics","volume":"8","author":"Chen","year":"2021","journal-title":"Appl. Phys. Rev."},{"key":"10.1016\/j.colsurfb.2022.112657_bib10","doi-asserted-by":"crossref","unstructured":"A. Elzoghby, Editorial (Thematic Issue: Nanocarriers Based on Natural Polymers as Platforms for Drug and Gene Delivery Applications), Current pharmaceutical design, 22 (2016) 3303\u20133304.","DOI":"10.2174\/1381612822999160511151612"},{"key":"10.1016\/j.colsurfb.2022.112657_bib11","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.2217\/nnm-2021-0086","article-title":"Celecoxib repurposing in cancer therapy: molecular mechanisms and nanomedicine-based delivery technologies","volume":"16","author":"Khafaga","year":"2021","journal-title":"Nanomedicine"},{"key":"10.1016\/j.colsurfb.2022.112657_bib12","doi-asserted-by":"crossref","first-page":"57","DOI":"10.15212\/bioi-2021-0016","article-title":"Challenges and opportunities of nanomedicines in clinical translation","volume":"2","author":"Zheng","year":"2021","journal-title":"BIO Integr."},{"key":"10.1016\/j.colsurfb.2022.112657_bib13","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1016\/j.arabjc.2017.07.010","article-title":"Curcumin-loaded layer-by-layer folic acid and casein coated carboxymethyl cellulose\/casein nanogels for treatment of skin cancer","volume":"13","author":"Priya","year":"2020","journal-title":"Arab. J. Chem."},{"key":"10.1016\/j.colsurfb.2022.112657_bib14","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/j.colsurfb.2014.12.024","article-title":"Green-step assembly of low density lipoprotein\/sodium carboxymethyl cellulose nanogels for facile loading and pH-dependent release of doxorubicin","volume":"126","author":"He","year":"2015","journal-title":"Coll. Surf. B Biointerfaces"},{"key":"10.1016\/j.colsurfb.2022.112657_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2020.120355","article-title":"Lactoferrin, a multi-functional glycoprotein: Active therapeutic, drug nanocarrier & targeting ligand","volume":"263","author":"Elzoghby","year":"2020","journal-title":"Biomaterials"},{"issue":"301","key":"10.1016\/j.colsurfb.2022.112657_bib16","first-page":"e301","article-title":"Lactoferrin: structure, function and applications","volume":"33","author":"Gonz\u00e1lez-Ch\u00e1vez","year":"2009","journal-title":"Int. J. Antimicrob. Agents"},{"key":"10.1016\/j.colsurfb.2022.112657_bib17","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1080\/17425247.2018.1505858","article-title":"Lactoferrin-decorated vs PEGylated zein nanospheres for combined aromatase inhibitor and herbal therapy of breast cancer","volume":"15","author":"El-Lakany","year":"2018","journal-title":"Expert Opin. Drug Deliv."},{"key":"10.1016\/j.colsurfb.2022.112657_bib18","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1186\/s12944-019-1075-7","article-title":"Emerging roles of low-density lipoprotein in the development and treatment of breast cancer","volume":"18","author":"Guan","year":"2019","journal-title":"Lipids Health Dis."},{"key":"10.1016\/j.colsurfb.2022.112657_bib19","article-title":"A comparitive study to evaluate the role of serum lipid levels in aetiology of carcinoma breast","volume":"9","author":"Kumar","year":"2015","journal-title":"J. Clin. Diagn. Res.: JCDR"},{"key":"10.1016\/j.colsurfb.2022.112657_bib20","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1111\/j.2042-7158.2011.01410.x","article-title":"Recombination adenovirus-mediated human lactoferrin cDNA inhibits the growth of human MCF-7 breast cancer cells","volume":"64","author":"Wang","year":"2012","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.colsurfb.2022.112657_bib21","doi-asserted-by":"crossref","first-page":"389S","DOI":"10.1080\/07315724.2001.10719173","article-title":"Antiinflammatory activities of lactoferrin","volume":"20","author":"Conneely","year":"2001","journal-title":"J. Am. Coll. Nutr."},{"key":"10.1016\/j.colsurfb.2022.112657_bib22","doi-asserted-by":"crossref","first-page":"188","DOI":"10.4103\/2277-9175.164010","article-title":"Cytoprotective and antioxidant effects of human lactoferrin against H2O2-induced oxidative stress in human umbilical vein endothelial cells","volume":"4","author":"Safaeian","year":"2015","journal-title":"Adv. Biomed. Res."},{"key":"10.1016\/j.colsurfb.2022.112657_bib23","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.carbpol.2006.01.013","article-title":"Semi-interpenetrating polymer network microspheres of gelatin and sodium carboxymethyl cellulose for controlled release of ketorolac tromethamine","volume":"65","author":"Rokhade","year":"2006","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.colsurfb.2022.112657_bib24","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1016\/j.clinthera.2005.09.010","article-title":"Pemetrexed: a multitargeted antifolate","volume":"27","author":"Rollins","year":"2005","journal-title":"Clin. Ther."},{"key":"10.1016\/j.colsurfb.2022.112657_bib25","doi-asserted-by":"crossref","first-page":"671","DOI":"10.2147\/CMAR.S150975","article-title":"Efficacy and safety of pemetrexed and nedaplatin followed by pemetrexed maintenance therapy in advanced lung adenocarcinoma","volume":"9","author":"Lin","year":"2017","journal-title":"Cancer Manag. Res."},{"key":"10.1016\/j.colsurfb.2022.112657_bib26","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1080\/10826068.2019.1692220","article-title":"Delivery of pemetrexed by magnetic nanoparticles: design, characterization, in vitro and in vivo assessment","volume":"50","author":"Ak","year":"2020","journal-title":"Prep. Biochem. Biotechnol."},{"key":"10.1016\/j.colsurfb.2022.112657_bib27","doi-asserted-by":"crossref","first-page":"2785","DOI":"10.2217\/nnm-2017-0247","article-title":"Shell-crosslinked zein nanocapsules for oral codelivery of exemestane and resveratrol in breast cancer therapy","volume":"12","author":"Elzoghby","year":"2017","journal-title":"Nanomedicine"},{"key":"10.1016\/j.colsurfb.2022.112657_bib28","first-page":"183","article-title":"Anticancer therapeutics: \u201cAddictive\u201d targets, multi-targeted drugs, new drug combinations","volume":"8","author":"Broxterman","year":"2005","journal-title":"Drug Resist. Update Rev. Comment. Antimicrob. Anticancer Chemother."},{"key":"10.1016\/j.colsurfb.2022.112657_bib29","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1007\/s12274-020-3124-y","article-title":"Self-targeting visualizable hyaluronate nanogel for synchronized intracellular release of doxorubicin and cisplatin in combating multidrug-resistant breast cancer","volume":"14","author":"Ma","year":"2021","journal-title":"Nano Res."},{"key":"10.1016\/j.colsurfb.2022.112657_bib30","doi-asserted-by":"crossref","DOI":"10.3390\/cancers12010048","article-title":"Honokiol: a review of its anticancer potential and mechanisms","volume":"12","author":"Ong","year":"2019","journal-title":"Cancers"},{"key":"10.1016\/j.colsurfb.2022.112657_bib31","doi-asserted-by":"crossref","first-page":"2621","DOI":"10.1016\/j.bmcl.2004.02.067","article-title":"Efficient synthesis and structure-activity relationship of honokiol, a neurotrophic biphenyl-type neolignan","volume":"14","author":"Esumi","year":"2004","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.colsurfb.2022.112657_bib32","first-page":"769","article-title":"Honokiol, a phytochemical from Magnolia spp., inhibits breast cancer cell migration by targeting nitric oxide and cyclooxygenase-2","volume":"38","author":"Singh","year":"2011","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.colsurfb.2022.112657_bib33","doi-asserted-by":"crossref","first-page":"R35","DOI":"10.1186\/bcr3128","article-title":"Honokiol activates AMP-activated protein kinase in breast cancer cells via an LKB1-dependent pathway and inhibits breast carcinogenesis","volume":"14","author":"Nagalingam","year":"2012","journal-title":"Breast Cancer Res. BCR"},{"issue":"2013","key":"10.1016\/j.colsurfb.2022.112657_bib34","article-title":"K-Oxyma: a strong acylation-promoting, 2-CTC resin-friendly coupling additive","author":"Cherkupally","year":"2013","journal-title":"Eur. J. Org. Chem."},{"key":"10.1016\/j.colsurfb.2022.112657_bib35","doi-asserted-by":"crossref","first-page":"3116","DOI":"10.1002\/ejoc.201500142","article-title":"EDC\u00b7HCl and potassium salts of oxyma and oxyma-B as superior coupling cocktails for peptide synthesis","volume":"2015","author":"Jad","year":"2015","journal-title":"Eur. J. Org. Chem."},{"key":"10.1016\/j.colsurfb.2022.112657_bib36","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1248\/cpb.58.501","article-title":"Sulfonate esters of 1-hydroxypyridin-2(1H)-one and ethyl 2-cyano-2-(hydroxyimino)acetate (oxyma) as effective peptide coupling reagents to replace 1-hydroxybenzotriazole and 1-hydroxy-7-azabenzotriazole","volume":"58","author":"Khattab","year":"2010","journal-title":"Chem. Pharm. Bull."},{"key":"10.1016\/j.colsurfb.2022.112657_bib37","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.1246\/bcsj.20100075","volume":"83","author":"Khattab","year":"2010","journal-title":"Bull. Chem. Soc. Jpn."},{"key":"10.1016\/j.colsurfb.2022.112657_bib38","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.carbpol.2016.09.038","article-title":"Dimethyl-\u03b2-cyclodextrin\/salazosulfapyridine inclusion complex-loaded chitosan nanoparticles for sustained release","volume":"156","author":"Tang","year":"2017","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.colsurfb.2022.112657_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.nantod.2019.100800","article-title":"Engineered nanomedicines with enhanced tumor penetration","volume":"29","author":"Ding","year":"2019","journal-title":"Nano Today"},{"key":"10.1016\/j.colsurfb.2022.112657_bib40","doi-asserted-by":"crossref","first-page":"3026","DOI":"10.1021\/acs.bioconjchem.8b00428","article-title":"Lactobionic\/folate dual-targeted amphiphilic maltodextrin-based micelles for targeted codelivery of sulfasalazine and resveratrol to hepatocellular carcinoma","volume":"29","author":"Anwar","year":"2018","journal-title":"Bioconjugate Chem."},{"key":"10.1016\/j.colsurfb.2022.112657_bib41","doi-asserted-by":"crossref","first-page":"4781","DOI":"10.2147\/IJN.S317409","article-title":"Potential privilege of maltodextrin-\u03b1-tocopherol nano-micelles in seizing tacrolimus renal toxicity, managing rheumatoid arthritis and accelerating bone regeneration","volume":"16","author":"Helal","year":"2021","journal-title":"Int. J. Nanomed."},{"key":"10.1016\/j.colsurfb.2022.112657_bib42","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1021\/acsbiomaterials.8b01374","article-title":"Inhalable dual-targeted hybrid lipid nanocore-protein shell composites for combined delivery of genistein and all-trans retinoic acid to lung cancer cells","volume":"6","author":"Kamel","year":"2020","journal-title":"ACS Biomater. Sci. Eng."},{"key":"10.1016\/j.colsurfb.2022.112657_bib43","doi-asserted-by":"crossref","DOI":"10.1016\/j.colsurfb.2020.110824","article-title":"Synthesis of lactoferrin mesoporous silica nanoparticles for pemetrexed\/ellagic acid synergistic breast cancer therapy","volume":"188","author":"Ali","year":"2020","journal-title":"Coll. Surf. B Biointerfaces"},{"key":"10.1016\/j.colsurfb.2022.112657_bib44","doi-asserted-by":"crossref","DOI":"10.1016\/j.colsurfb.2021.111694","article-title":"A novel \u2018smart\u2019 PNIPAM-based copolymer for breast cancer targeted therapy: synthesis, and characterization of dual pH\/temperature-responsive lactoferrin-targeted PNIPAM-co-AA","volume":"202","author":"Metawea","year":"2021","journal-title":"Coll. Surf. B Biointerfaces"},{"key":"10.1016\/j.colsurfb.2022.112657_bib45","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.jconrel.2018.08.026","article-title":"Dual-targeted casein micelles as green nanomedicine for synergistic phytotherapy of hepatocellular carcinoma","volume":"287","author":"Abdelmoneem","year":"2018","journal-title":"J. Control. Release"},{"key":"10.1016\/j.colsurfb.2022.112657_bib46","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2021.118941","article-title":"Self-assembled chitosan derived microparticles inhibit tumor angiogenesis and induce apoptosis in Ehrlich-ascites-tumor bearing mice","volume":"278","author":"Punarvasu","year":"2022","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.colsurfb.2022.112657_bib47","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.jep.2017.08.012","article-title":"Aqueous extract from pecan nut [Carya illinoinensis (Wangenh) C. Koch] shell show activity against breast cancer cell line MCF-7 and Ehrlich ascites tumor in Balb-C mice","volume":"211","author":"Hilbig","year":"2018","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.colsurfb.2022.112657_bib48","doi-asserted-by":"crossref","first-page":"1354","DOI":"10.1016\/j.foodhyd.2010.12.014","article-title":"Formation of protein nanoparticles by controlled heat treatment of lactoferrin: Factors affecting particle characteristics","volume":"25","author":"Bengoechea","year":"2011","journal-title":"Food Hydrocoll."},{"key":"10.1016\/j.colsurfb.2022.112657_bib49","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1002\/bip.20539","article-title":"Nanogels prepared by self-assembly of oppositely charged globular proteins","volume":"83","author":"Yu","year":"2006","journal-title":"Biopolymers"},{"key":"10.1016\/j.colsurfb.2022.112657_bib50","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.foodhyd.2015.02.039","article-title":"Cationized gelatin\/gum arabic polyelectrolyte complex: study of electrostatic interactions","volume":"49","author":"Sarika","year":"2015","journal-title":"Food Hydrocoll."},{"key":"10.1016\/j.colsurfb.2022.112657_bib51","doi-asserted-by":"crossref","first-page":"1882","DOI":"10.1021\/bm049786+","article-title":"Versatile and efficient formation of colloids of biopolymer-based polyelectrolyte complexes","volume":"5","author":"Schatz","year":"2004","journal-title":"Biomacromolecules"},{"key":"10.1016\/j.colsurfb.2022.112657_bib52","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/j.colsurfb.2013.08.012","article-title":"Ovalbumin-gum arabic interactions: effect of pH, temperature, salt, biopolymers ratio and total concentration","volume":"113","author":"Niu","year":"2014","journal-title":"Coll. Surf. B Biointerfaces"},{"key":"10.1016\/j.colsurfb.2022.112657_bib53","doi-asserted-by":"crossref","first-page":"2615","DOI":"10.1021\/jp309135m","article-title":"Influence of protein self-association on complex coacervation with polysaccharide: a monte carlo study","volume":"117","author":"Li","year":"2013","journal-title":"J. Phys. Chem. B"},{"key":"10.1016\/j.colsurfb.2022.112657_bib54","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodhyd.2016.01.010","article-title":"Low density lipoprotein\/pectin complex nanogels as potential oral delivery vehicles for curcumin","volume":"57","author":"Zhou","year":"2016","journal-title":"Food Hydrocoll."},{"key":"10.1016\/j.colsurfb.2022.112657_bib55","doi-asserted-by":"crossref","first-page":"9827","DOI":"10.1021\/la1001013","article-title":"Fabrication and morphological characterization of biopolymer particles formed by electrostatic complexation of heat treated lactoferrin and anionic polysaccharides","volume":"26","author":"Peinado","year":"2010","journal-title":"Langmuir ACS J. Surf. Colloids"},{"key":"10.1016\/j.colsurfb.2022.112657_bib56","doi-asserted-by":"crossref","first-page":"5720","DOI":"10.1021\/acs.jafc.7b01848","article-title":"Biocompatible polyelectrolyte complex nanoparticles from lactoferrin and pectin as potential vehicles for antioxidative curcumin","volume":"65","author":"Yan","year":"2017","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.colsurfb.2022.112657_bib57","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.colsurfb.2014.12.051","article-title":"Construction of pH-sensitive lysozyme\/pectin nanogel for tumor methotrexate delivery","volume":"126","author":"Lin","year":"2015","journal-title":"Coll. Surf. B Biointerfaces"},{"key":"10.1016\/j.colsurfb.2022.112657_bib58","doi-asserted-by":"crossref","first-page":"7515","DOI":"10.1021\/jp2013557","article-title":"Assembly of bioactive peptide\u2013chitosan nanocomplexes","volume":"115","author":"Hu","year":"2011","journal-title":"J. Phys. Chem. B"},{"key":"10.1016\/j.colsurfb.2022.112657_bib59","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.ijpharm.2015.03.043","article-title":"Casein\/pectin nanocomplexes as potential oral delivery vehicles","volume":"486","author":"Luo","year":"2015","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.colsurfb.2022.112657_bib60","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.cis.2010.10.001","article-title":"Protein\/polysaccharide complexes and coacervates in food systems","volume":"167","author":"Schmitt","year":"2010","journal-title":"Adv. Colloid Interface Sci."},{"key":"10.1016\/j.colsurfb.2022.112657_bib61","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.ejpb.2009.04.004","article-title":"Characterization and superficial transformations on mini-matrices made of interpolymer complexes of chitosan and carboxymethylcellulose during in vitro clarithromycin release","volume":"73","author":"G\u00f3mez-Burgaz","year":"2009","journal-title":"Eur. J. Pharm. Biopharm. Off. J. Arb. Pharm. Verfahr. e. V."},{"key":"10.1016\/j.colsurfb.2022.112657_bib62","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1080\/10408390902841529","article-title":"Structural design principles for delivery of bioactive components in nutraceuticals and functional foods","volume":"49","author":"McClements","year":"2009","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"10.1016\/j.colsurfb.2022.112657_bib63","doi-asserted-by":"crossref","first-page":"3964","DOI":"10.1021\/jf980266d","article-title":"Thermal denaturation of human lactoferrin and its effect on the ability to bind iron","volume":"46","author":"Mata","year":"1998","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.colsurfb.2022.112657_bib64","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.cis.2010.10.006","article-title":"Recent progress in biopolymer nanoparticle and microparticle formation by heat-treating electrostatic protein-polysaccharide complexes","volume":"167","author":"Jones","year":"2011","journal-title":"Adv. Colloid Interface Sci."},{"key":"10.1016\/j.colsurfb.2022.112657_bib65","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/S0924-2244(00)89083-4","article-title":"Recent advances in the understanding of egg white protein functionality","volume":"6","author":"Mine","year":"1995","journal-title":"Trends Food Sci. Technol."},{"key":"10.1016\/j.colsurfb.2022.112657_bib66","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1016\/j.ijpharm.2012.10.022","article-title":"Nanogels fabricated by lysozyme and sodium carboxymethyl cellulose for 5-fluorouracil controlled release","volume":"441","author":"Zhu","year":"2013","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.colsurfb.2022.112657_bib67","doi-asserted-by":"crossref","first-page":"2252","DOI":"10.3762\/bjoc.13.222","article-title":"Structural diversity in the host-guest complexes of the antifolate pemetrexed with native cyclodextrins: gas phase, solution and solid state studies","volume":"13","author":"Ceborska","year":"2017","journal-title":"Beilstein J. Org. Chem."},{"key":"10.1016\/j.colsurfb.2022.112657_bib68","doi-asserted-by":"crossref","first-page":"72","DOI":"10.4103\/0975-7406.67003","article-title":"Cyclodextrins in delivery systems: applications","volume":"2","author":"Tiwari","year":"2010","journal-title":"J. Pharm. bioallied Sci."},{"key":"10.1016\/j.colsurfb.2022.112657_bib69","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1023\/A:1014520830813","article-title":"The driving forces in the inclusion complexation of cyclodextrins","volume":"42","author":"Liu","year":"2002","journal-title":"J. Incl. Phenom."},{"key":"10.1016\/j.colsurfb.2022.112657_bib70","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.ijpharm.2013.06.050","article-title":"Study on formability of solid nanosuspensions during nanodispersion and solidification: I. Novel role of stabilizer\/drug property","volume":"454","author":"Yue","year":"2013","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.colsurfb.2022.112657_bib71","first-page":"1651","article-title":"Physicochemical characterization and dissolution properties of binary systems of pyrimethamine and 2-hydroxypropyl--cyclodextrin","volume":"8","author":"Onyeji","year":"2009","journal-title":"Afr. J. Biotechnol."},{"key":"10.1016\/j.colsurfb.2022.112657_bib72","doi-asserted-by":"crossref","first-page":"449","DOI":"10.3746\/pnf.2020.25.4.449","article-title":"Study of flavonoid\/hydroxypropyl-\u03b2-cyclodextrin inclusion complexes by UV-Vis, FT-IR, DSC, and X-ray diffraction analysis","volume":"25","author":"Kim","year":"2020","journal-title":"Prev. Nutr. Food Sci."},{"key":"10.1016\/j.colsurfb.2022.112657_bib73","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1016\/j.carbpol.2010.08.027","article-title":"Polysaccharides as stabilizers for the synthesis of magnetic nanoparticles","volume":"83","author":"Chang","year":"2011","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.colsurfb.2022.112657_bib74","doi-asserted-by":"crossref","first-page":"10004","DOI":"10.3390\/molecules200610004","article-title":"Synthesis and physicochemical characterization of the impurities of pemetrexed disodium, an anticancer drug","volume":"20","author":"Michalak","year":"2015","journal-title":"Molecules"},{"key":"10.1016\/j.colsurfb.2022.112657_bib75","doi-asserted-by":"crossref","first-page":"5469","DOI":"10.2147\/IJN.S178416","article-title":"Preparation of honokiol nanoparticles by liquid antisolvent precipitation technique, characterization, pharmacokinetics, and evaluation of inhibitory effect on HepG2 cells","volume":"13","author":"Wu","year":"2018","journal-title":"Int. J. Nanomed."},{"key":"10.1016\/j.colsurfb.2022.112657_bib76","series-title":"Dosage Form Design Considerations","first-page":"179","article-title":"Chapter 6 - Influence of drug properties and routes of drug administration on the design of controlled release system","author":"Indurkhya","year":"2018"},{"key":"10.1016\/j.colsurfb.2022.112657_bib77","doi-asserted-by":"crossref","first-page":"4271","DOI":"10.1016\/S0032-3861(00)00768-0","article-title":"Thermal and dynamic mechanical analysis of PVA\/MC blend hydrogels","volume":"42","author":"Park","year":"2001","journal-title":"Polymer"},{"key":"10.1016\/j.colsurfb.2022.112657_bib78","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/j.ejps.2007.08.010","article-title":"Comparative drug release studies of two cationic drugs from pH-responsive nanogels","volume":"32","author":"Tan","year":"2007","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.colsurfb.2022.112657_bib79","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1016\/j.jconrel.2012.05.038","article-title":"Design and characterization of a novel amphiphilic chitosan nanocapsule-based thermo-gelling biogel with sustained in vivo release of the hydrophilic anti-epilepsy drug ethosuximide","volume":"161","author":"Hsiao","year":"2012","journal-title":"J. Control. Release: Off. J. Control. Release Soc."},{"key":"10.1016\/j.colsurfb.2022.112657_bib80","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.jconrel.2015.02.008","article-title":"Hyaluronic acid nanogels with enzyme-sensitive cross-linking group for drug delivery","volume":"205","author":"Yang","year":"2015","journal-title":"J. Control. Release Off. J. Control. Release Soc."},{"key":"10.1016\/j.colsurfb.2022.112657_bib81","doi-asserted-by":"crossref","DOI":"10.1016\/j.msec.2020.111422","article-title":"Lactoferrin-dual drug nanoconjugate: synergistic anti-tumor efficacy of docetaxel and the NF-\u03baB inhibitor celastrol","volume":"118","author":"Abdelmoneem","year":"2021","journal-title":"Mater. Sci. Eng. C"},{"key":"10.1016\/j.colsurfb.2022.112657_bib82","doi-asserted-by":"crossref","DOI":"10.3389\/fchem.2022.847573","article-title":"Methotrexate-lactoferrin targeted exemestane cubosomes for synergistic breast cancer therapy","volume":"10","author":"Mokhtar","year":"2022","journal-title":"Front. Chem."},{"key":"10.1016\/j.colsurfb.2022.112657_bib83","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.jconrel.2014.05.025","article-title":"Anticancer polymeric nanomedicine bearing synergistic drug combination is superior to a mixture of individually-conjugated drugs","volume":"187","author":"Markovsky","year":"2014","journal-title":"J. Control. Release Off. J. Control. Release Soc."},{"key":"10.1016\/j.colsurfb.2022.112657_bib84","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.ejpb.2020.08.004","article-title":"Combination of magnetic targeting with synergistic inhibition of NF-\u03baB and glutathione via micellar drug nanomedicine enhances its anti-tumor efficacy","volume":"155","author":"Elhasany","year":"2020","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.colsurfb.2022.112657_bib85","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1042\/BST0350056","article-title":"Designing polymer conjugates as lysosomotropic nanomedicines","volume":"35","author":"Duncan","year":"2007","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.colsurfb.2022.112657_bib86","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.1021\/bc800500a","article-title":"Proteolysis: a biological process adapted in drug delivery, therapy, and imaging","volume":"20","author":"Law","year":"2009","journal-title":"Bioconjug. Chem."},{"key":"10.1016\/j.colsurfb.2022.112657_bib87","article-title":"Maltodextrin-\u03b1-tocopherol conjugates of vitamin E: Influence of degree of derivatization on physicochemical properties and biological evaluation","volume":"60","author":"Helal","year":"2020","journal-title":"J. Drug Deliv. Sci. Technol."},{"key":"10.1016\/j.colsurfb.2022.112657_bib88","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.ijpharm.2005.06.025","article-title":"Adsorption kinetics of plasma proteins on solid lipid nanoparticles for drug targeting","volume":"302","author":"G\u00f6ppert","year":"2005","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.colsurfb.2022.112657_bib89","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.colsurfb.2017.01.038","article-title":"Honokiol nanomicellar formulation produced increased oral bioavailability and anticancer effects in triple negative breast cancer (TNBC)","volume":"153","author":"Godugu","year":"2017","journal-title":"Coll. Surf. B Biointerfaces"},{"key":"10.1016\/j.colsurfb.2022.112657_bib90","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2020.116325","article-title":"Targeted delivery of honokiol by zein\/hyaluronic acid core-shell nanoparticles to suppress breast cancer growth and metastasis","volume":"240","author":"Zhang","year":"2020","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.colsurfb.2022.112657_bib91","doi-asserted-by":"crossref","first-page":"95","DOI":"10.4274\/tjps.07078","article-title":"Assessment of cytotoxicity profiles of different phytochemicals: comparison of neutral red and MTT assays in different cells in different time periods","volume":"14","author":"Bacanli","year":"2017","journal-title":"Turk. J. Pharm. Sci."},{"key":"10.1016\/j.colsurfb.2022.112657_bib92","doi-asserted-by":"crossref","first-page":"1894","DOI":"10.1111\/jcmm.13474","article-title":"Honokiol inhibits in vitro and in vivo growth of oral squamous cell carcinoma through induction of apoptosis, cell cycle arrest and autophagy","volume":"22","author":"Huang","year":"2018","journal-title":"J. Cell Mol. Med."},{"key":"10.1016\/j.colsurfb.2022.112657_bib93","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.2147\/IJN.S150237","article-title":"Development of liposomal pemetrexed for enhanced therapy against multidrug resistance mediated by ABCC5 in breast cancer","volume":"13","author":"Bai","year":"2018","journal-title":"Int. J. Nanomed."},{"key":"10.1016\/j.colsurfb.2022.112657_bib94","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/S0022-2143(98)90018-X","article-title":"Drug combinations: from laboratory to practice","volume":"132","author":"Chou","year":"1998","journal-title":"J. Lab. Clin. Med."},{"key":"10.1016\/j.colsurfb.2022.112657_bib95","doi-asserted-by":"crossref","first-page":"6438","DOI":"10.1016\/S0021-9258(17)39978-7","article-title":"A simple generalized equation for the analysis of multiple inhibitions of Michaelis-Menten kinetic systems","volume":"252","author":"Chou","year":"1977","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.colsurfb.2022.112657_bib96","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/s12951-019-0445-7","article-title":"Combining hydrophilic chemotherapy and hydrophobic phytotherapy via tumor-targeted albumin-QDs nano-hybrids: covalent coupling and phospholipid complexation approaches","volume":"17","author":"Zayed","year":"2019","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.colsurfb.2022.112657_bib97","doi-asserted-by":"crossref","DOI":"10.1016\/j.colsurfb.2020.110997","article-title":"Co-administration of tretinoin enhances the anti-cancer efficacy of etoposide via tumor-targeted green nano-micelles","volume":"192","author":"Gaber","year":"2020","journal-title":"Coll. Surf. B Biointerfaces"},{"key":"10.1016\/j.colsurfb.2022.112657_bib98","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.ejmech.2015.04.056","article-title":"Exploring quercetin and luteolin derivatives as antiangiogenic agents","volume":"97","author":"Ravishankar","year":"2015","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.colsurfb.2022.112657_bib99","doi-asserted-by":"crossref","first-page":"481","DOI":"10.2217\/nnm-2017-0301","article-title":"Phytosomal bilayer-enveloped casein micelles for codelivery of monascus yellow pigments and resveratrol to breast cancer","volume":"13","author":"El-Far","year":"2018","journal-title":"Nanomedicine"},{"key":"10.1016\/j.colsurfb.2022.112657_bib100","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.2147\/IJN.S241428","article-title":"Design, formulation and in vivo evaluation of novel honokiol-loaded PEGylated PLGA nanocapsules for treatment of breast cancer","volume":"15","author":"Haggag","year":"2020","journal-title":"Int J. Nanomed."},{"key":"10.1016\/j.colsurfb.2022.112657_bib101","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/S0002-9343(99)00259-4","article-title":"Apoptosis: definition, mechanisms, and relevance to disease","volume":"107","author":"Saikumar","year":"1999","journal-title":"Am. J. Med."},{"key":"10.1016\/j.colsurfb.2022.112657_bib102","first-page":"13","article-title":"Caspase-3 activation is a critical determinant of genotoxic stress-induced apoptosis","volume":"414","author":"Mazumder","year":"2008","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.colsurfb.2022.112657_bib103","first-page":"738","article-title":"Caspase 3 in breast cancer","volume":"9","author":"O\u2019Donovan","year":"2003","journal-title":"Clin. Cancer Res. Off. J. Am. Assoc. Cancer Res."},{"key":"10.1016\/j.colsurfb.2022.112657_bib104","doi-asserted-by":"crossref","first-page":"2411","DOI":"10.3892\/or.2015.3830","article-title":"Pemetrexed induces apoptosis in malignant mesothelioma and lung cancer cells through activation of reactive oxygen species and inhibition of sirtuin 1","volume":"33","author":"Hwang","year":"2015","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.colsurfb.2022.112657_bib105","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1002\/jso.21936","article-title":"Honokiol produces anti-neoplastic effects on melanoma cells in vitro","volume":"104","author":"Mannal","year":"2011","journal-title":"J. Surg. Oncol."},{"key":"10.1016\/j.colsurfb.2022.112657_bib106","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.2217\/nnm-2018-0006","article-title":"Folate conjugated vs PEGylated phytosomal casein nanocarriers for codelivery of fungal- and herbal-derived anticancer drugs","volume":"13","author":"El-Far","year":"2018","journal-title":"Nanomedicine"}],"container-title":["Colloids and Surfaces B: Biointerfaces"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S092777652200340X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S092777652200340X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T11:18:50Z","timestamp":1760527130000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S092777652200340X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9]]},"references-count":106,"alternative-id":["S092777652200340X"],"URL":"https:\/\/doi.org\/10.1016\/j.colsurfb.2022.112657","relation":{},"ISSN":["0927-7765"],"issn-type":[{"value":"0927-7765","type":"print"}],"subject":[],"published":{"date-parts":[[2022,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Green self-assembled lactoferrin carboxymethyl cellulose nanogels for synergistic chemo\/herbal breast cancer therapy","name":"articletitle","label":"Article Title"},{"value":"Colloids and Surfaces B: Biointerfaces","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.colsurfb.2022.112657","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"112657"}}