{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T02:56:55Z","timestamp":1791428215509,"version":"4.3.3"},"reference-count":51,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2016YFC1100300"],"award-info":[{"award-number":["2016YFC1100300"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100016346","name":"The Second Hospital of Tianjin Medical University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100016346","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019065","name":"Tianjin Science and Technology Program","doi-asserted-by":"publisher","award":["19KPXMRC00020"],"award-info":[{"award-number":["19KPXMRC00020"]}],"id":[{"id":"10.13039\/501100019065","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Colloids and Surfaces B: Biointerfaces"],"published-print":{"date-parts":[[2022,10]]},"DOI":"10.1016\/j.colsurfb.2022.112719","type":"journal-article","created":{"date-parts":[[2022,7,27]],"date-time":"2022-07-27T11:42:00Z","timestamp":1658922120000},"page":"112719","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"special_numbering":"C","title":["Enhanced anti-microbial activity and osseointegration of Ta\/Cu co-implanted polyetheretherketone"],"prefix":"10.1016","volume":"218","author":[{"given":"Rongxin","family":"Wan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojuan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Lei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoying","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiqing","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanqing","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.colsurfb.2022.112719_bib1","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.jpor.2015.10.001","article-title":"Applications of polyetheretherketone (PEEK) in oral implantology and prosthodontics","volume":"60","author":"Snb","year":"2016","journal-title":"J. Prosthodont. Res."},{"issue":"4","key":"10.1016\/j.colsurfb.2022.112719_bib2","doi-asserted-by":"crossref","first-page":"5426","DOI":"10.3390\/ijms15045426","article-title":"Current strategies to improve the bioactivity of PEEK","volume":"15","author":"Ma","year":"2014","journal-title":"Int. J. Mol. Sci."},{"issue":"12","key":"10.1016\/j.colsurfb.2022.112719_bib3","doi-asserted-by":"crossref","first-page":"3717","DOI":"10.1016\/j.biomaterials.2013.12.056","article-title":"Osseointegration of machined, injection moulded and oxygen plasma modified PEEK implants in a sheep model","volume":"35","author":"Poulsson","year":"2014","journal-title":"Biomaterials"},{"issue":"1","key":"10.1016\/j.colsurfb.2022.112719_bib4","doi-asserted-by":"crossref","DOI":"10.18063\/ijb.v8i1.438","article-title":"Static compressive behavior and material failure mechanism of trabecular tantalum scaffolds fabricated by laser powder bed fusion-based additive manufacturing","volume":"8","author":"Yang","year":"2022","journal-title":"Int. J. Bioprinting"},{"issue":"10","key":"10.1016\/j.colsurfb.2022.112719_bib5","doi-asserted-by":"crossref","DOI":"10.3390\/ma14102647","article-title":"The clinical application of porous tantalum and its new development for bone tissue engineering","volume":"14","author":"Huang","year":"2021","journal-title":"Materials"},{"key":"10.1016\/j.colsurfb.2022.112719_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.msec.2020.111112","article-title":"Tantalum-coated polylactic acid fibrous membranes for guided bone regeneration","volume":"115","author":"Hwang","year":"2020","journal-title":"Mater. Sci. Eng. C -Mater. Biol. Appl."},{"key":"10.1016\/j.colsurfb.2022.112719_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.colsurfb.2021.112055","article-title":"Tantalum and its derivatives in orthopedic and dental implants: Osteogenesis and antibacterial properties","volume":"208","author":"Wang","year":"2021","journal-title":"Colloids Surf. B-Biointerfaces"},{"issue":"73","key":"10.1016\/j.colsurfb.2022.112719_bib8","doi-asserted-by":"crossref","first-page":"46472","DOI":"10.1039\/C7RA08036K","article-title":"Enhanced osteointegration of tantalum-modified titanium implants with micro\/nano-topography","volume":"7","author":"Shi","year":"2017","journal-title":"RSC Adv."},{"key":"10.1016\/j.colsurfb.2022.112719_bib9","doi-asserted-by":"crossref","first-page":"725","DOI":"10.2147\/IJN.S286643","article-title":"Nanostructured coating of non-crystalline tantalum pentoxide on polyetheretherketone enhances RBMS Cells\/HGE cells adhesion","volume":"Volume 16","author":"Pang","year":"2021","journal-title":"Int. J. Nanomed."},{"key":"10.1016\/j.colsurfb.2022.112719_bib10","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.colsurfb.2018.10.081","article-title":"Influences of tantalum pentoxide and surface coarsening on surface roughness, hydrophilicity, surface energy, protein adsorption and cell responses to PEEK based biocomposite","volume":"174","author":"Mei","year":"2019","journal-title":"Colloids Surf. B-Biointerfaces"},{"issue":"4","key":"10.1016\/j.colsurfb.2022.112719_bib11","first-page":"928","article-title":"Implantable PEKK\/tantalum microparticles composite with improved surface performances for regulating cell behaviors,promoting bone formation and osseointegration","volume":"6","author":"Hu","year":"2021","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.colsurfb.2022.112719_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioadv.2022.212736","article-title":"Simultaneous incorporation of gallium oxide and tantalum microparticles into micro-arc oxidation coating of titanium possessing antibacterial effect and stimulating cellular response","volume":"135","author":"Wang","year":"2022","journal-title":"Biomater. Adv."},{"key":"10.1016\/j.colsurfb.2022.112719_bib13","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.msec.2019.03.091","article-title":"Tantalum nanoparticles reinforced polyetheretherketone shows enhanced bone formation","volume":"101","author":"Zhu","year":"2019","journal-title":"Mater. Sci. Eng. C: Mater. Biol. Appl."},{"issue":"1","key":"10.1016\/j.colsurfb.2022.112719_bib14","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1080\/09205063.2021.1974812","article-title":"Comparison of surface properties, cell behaviors, bone regeneration and osseointegration between nano tantalum\/PEEK composite and nano silicon nitride\/PEEK composite","volume":"33","author":"Hu","year":"2022","journal-title":"J. Biomater. Sci. -Polym. Ed."},{"issue":"1","key":"10.1016\/j.colsurfb.2022.112719_bib15","doi-asserted-by":"crossref","DOI":"10.1186\/s12951-020-00594-6","article-title":"Preparation of antibacterial and osteoconductive 3D-printed PLGA\/Cu(I)@ZIF-8 nanocomposite scaffolds for infected bone repair","volume":"18","author":"Zou","year":"2020","journal-title":"J. Nanobiotechnol."},{"issue":"2","key":"10.1016\/j.colsurfb.2022.112719_bib16","doi-asserted-by":"crossref","DOI":"10.1002\/mabi.201900271","article-title":"Surface modification strategies to improve the osseointegration of poly(etheretherketone) and its composites","volume":"20","author":"Buck","year":"2020","journal-title":"Macromol. Biosci."},{"issue":"4","key":"10.1016\/j.colsurfb.2022.112719_bib17","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1016\/j.bioactmat.2020.09.017","article-title":"Biological applications of copper-containing materials","volume":"6","author":"Wang","year":"2021","journal-title":"Bioactive Mater."},{"issue":"2","key":"10.1016\/j.colsurfb.2022.112719_bib18","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1002\/jbm.b.34405","article-title":"Antibacterial activity of copper-bearing 316L stainless steel for the prevention of implant-related infection","volume":"108","author":"Zhuang","year":"2020","journal-title":"J. Biomed. Mater. Res. Part B: Appl. Biomater."},{"issue":"23","key":"10.1016\/j.colsurfb.2022.112719_bib19","doi-asserted-by":"crossref","DOI":"10.3390\/ma12234017","article-title":"Development of antibacterial Ti-Cux alloys for dental applications: effects of ageing for alloys with up to 10\u2009wt% Cu","volume":"12","author":"Fowler","year":"2019","journal-title":"Materials"},{"issue":"4","key":"10.1016\/j.colsurfb.2022.112719_bib20","first-page":"659","article-title":"The anti-bacterial activity of titanium-copper sintered alloy against Porphyromonas gingivalis in vitro, Dental","volume":"35","author":"Bai","year":"2016","journal-title":"Mater. J."},{"issue":"2","key":"10.1016\/j.colsurfb.2022.112719_bib21","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1177\/0885328212441957","article-title":"Effectiveness of antibacterial copper additives in silicone implants","volume":"28","author":"Gosau","year":"2013","journal-title":"J. Biomater. Appl."},{"key":"10.1016\/j.colsurfb.2022.112719_bib22","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.colsurfb.2018.06.020","article-title":"The Cu-containing TiO 2 coatings with modulatory effects on macrophage polarization and bactericidal capacity prepared by micro-arc oxidation on titanium substrates","volume":"170","author":"Qha","year":"2018","journal-title":"Colloids Surf. B: Biointerfaces"},{"key":"10.1016\/j.colsurfb.2022.112719_bib23","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.biomaterials.2019.04.008","article-title":"A surface-engineered polyetheretherketone biomaterial implant with direct and immunoregulatory antibacterial activity against methicillin-resistant Staphylococcus aureus","volume":"208","author":"Wei","year":"2019","journal-title":"Biomaterials"},{"key":"10.1016\/j.colsurfb.2022.112719_bib24","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1093\/rb\/rbu007","article-title":"Advances in the surface modification techniques of bone-related implants for last 10 years","volume":"1","author":"Zhi-Ye","year":"2014","journal-title":"Regen. Biomater."},{"issue":"25","key":"10.1016\/j.colsurfb.2022.112719_bib25","doi-asserted-by":"crossref","first-page":"6882","DOI":"10.1016\/j.biomaterials.2014.04.101","article-title":"Stimulation of bone growth following zinc incorporation into biomaterials","volume":"35","author":"Qiao","year":"2014","journal-title":"Biomaterials"},{"key":"10.1016\/j.colsurfb.2022.112719_bib26","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.colsurfb.2014.02.019","article-title":"Enhanced osteoblast responses to poly ether ether ketone surface modified by water plasma immersion ion implantation","volume":"117","author":"Wang","year":"2014","journal-title":"Colloids Surf. B Biointerfaces"},{"issue":"3\u20134","key":"10.1016\/j.colsurfb.2022.112719_bib27","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/S0266-3538(02)00230-0","article-title":"Mechanical properties of injection molded hydroxyapatite-polyetheretherketone biocomposites","volume":"63","author":"Bakar","year":"2003","journal-title":"Compos. Sci. Technol."},{"issue":"2","key":"10.1016\/j.colsurfb.2022.112719_bib28","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/0169-4332(94)00538-9","article-title":"AES and XPS study of thin RF-sputtered Ta 2 O 5 layers","volume":"84","author":"Atanassova","year":"1995","journal-title":"Appl. Surf. Sci."},{"key":"10.1016\/j.colsurfb.2022.112719_bib29","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1016\/j.molliq.2016.06.028","article-title":"Fabrication of novel shape Cu and Cu\/Cu2O nanoparticles modified electrode for the determination of dopamine and paracetamol","volume":"221","author":"Devaraj","year":"2016","journal-title":"J. Mol. Liq."},{"issue":"1","key":"10.1016\/j.colsurfb.2022.112719_bib30","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1111\/cid.12274","article-title":"Foreign body reaction to biomaterials: on mechanisms for buildup and breakdown of osseointegration","volume":"18","author":"Trindade","year":"2016","journal-title":"Clin. Implant Dent. Relat. Res."},{"issue":"4","key":"10.1016\/j.colsurfb.2022.112719_bib31","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1016\/j.nano.2017.01.011","article-title":"Layer-by-layer self-assembled multilayers on PEEK implants improve osseointegration in an osteoporosis rabbit model","volume":"13","author":"Liu","year":"2017","journal-title":"Nanomed. -Nanotechnol. Biol. Med."},{"issue":"12","key":"10.1016\/j.colsurfb.2022.112719_bib32","doi-asserted-by":"crossref","first-page":"4447","DOI":"10.1016\/j.actbio.2012.07.038","article-title":"Anti-infective and osteointegration properties of silicon nitride, poly(ether ether ketone), and titanium implants","volume":"8","author":"Webster","year":"2012","journal-title":"Acta Biomater."},{"issue":"4","key":"10.1016\/j.colsurfb.2022.112719_bib33","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/0263-4368(95)94023-R","article-title":"Tantalum and its alloys","volume":"13","author":"Cardonne","year":"1995","journal-title":"Int. J. Refract. Met. Hard Mater."},{"issue":"23\u201324","key":"10.1016\/j.colsurfb.2022.112719_bib34","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1089\/ten.tea.2017.0048","article-title":"Roughness and hydrophilicity as osteogenic biomimetic surface properties","volume":"23","author":"Boyan","year":"2017","journal-title":"Tissue Eng. Part A"},{"issue":"1","key":"10.1016\/j.colsurfb.2022.112719_bib35","doi-asserted-by":"crossref","DOI":"10.1116\/1.4935853","article-title":"Physicochemical properties of copper important for its antibacterial activity and development of a unified model","volume":"11","author":"Hans","year":"2015","journal-title":"Biointerphases"},{"issue":"10","key":"10.1016\/j.colsurfb.2022.112719_bib36","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.3390\/ma10101115","article-title":"Surface modification of polymer substrates for biomedical applications","volume":"10","author":"Nedela","year":"2017","journal-title":"Materials"},{"issue":"1","key":"10.1016\/j.colsurfb.2022.112719_bib37","first-page":"231","article-title":"The effects of plasma immersion ion implantation and deposition (PIII&D) process voltages on the morphology, phase formation and E. coli adhesion of Ag coatings obtained on the surface of Ti6Al4V orthopedic implant material in nitrogen plasma","volume":"32","author":"Gencer","year":"2017","journal-title":"J. Fac. Eng. Archit. Gazi Univ."},{"key":"10.1016\/j.colsurfb.2022.112719_bib38","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.colsurfb.2016.02.056","article-title":"Enhanced osteogenic activity of poly ether ether ketone using calcium plasma immersion ion implantation","volume":"142","author":"Lu","year":"2016","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"10.1016\/j.colsurfb.2022.112719_bib39","doi-asserted-by":"crossref","first-page":"5831","DOI":"10.2147\/IJN.S328767","article-title":"Emerging trends in nanomaterials for antibacterial applications","volume":"16","author":"Yougbare","year":"2021","journal-title":"Int. J. Nanomed."},{"issue":"3","key":"10.1016\/j.colsurfb.2022.112719_bib40","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.carbpol.2008.07.039","article-title":"Antibacterial activity of chitosan tripolyphosphate nanoparticles loaded with various metal ions","volume":"75","author":"Du","year":"2009","journal-title":"Carbohydr. Polym."},{"issue":"5","key":"10.1016\/j.colsurfb.2022.112719_bib41","doi-asserted-by":"crossref","DOI":"10.3390\/nano12050805","article-title":"Application of copper nanoparticles in dentistry","volume":"12","author":"Xu","year":"2022","journal-title":"Nanomaterials"},{"key":"10.1016\/j.colsurfb.2022.112719_bib42","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.biomaterials.2019.04.008","article-title":"A surface-engineered polyetheretherketone biomaterial implant with direct and immunoregulatory antibacterial activity against methicillin-resistant Staphylococcus aureus","volume":"208","author":"Liu","year":"2019","journal-title":"Biomaterials"},{"key":"10.1016\/j.colsurfb.2022.112719_bib43","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.actbio.2019.09.030","article-title":"Activating macrophages for enhanced osteogenic and bactericidal performance by Cu ion release from micro\/nano-topographical coating on a titanium substrate","volume":"100","author":"Huang","year":"2019","journal-title":"Acta Biomater."},{"issue":"7","key":"10.1016\/j.colsurfb.2022.112719_bib44","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1097\/00005131-200608000-00005","article-title":"Bacterial adherence to tantalum versus commonly used orthopedic metallic implant materials","volume":"20","author":"Schildhauer","year":"2006","journal-title":"J. Orthop. Trauma"},{"issue":"3","key":"10.1016\/j.colsurfb.2022.112719_bib45","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1002\/jbm.a.35953","article-title":"Bacterial and mammalian cells adhesion to tantalum-decorated micro-\/nano-structured titanium","volume":"105","author":"Zhu","year":"2017","journal-title":"J. Biomed. Mater. Res. Part A"},{"issue":"2019","key":"10.1016\/j.colsurfb.2022.112719_bib46","doi-asserted-by":"crossref","first-page":"8693","DOI":"10.2147\/IJN.S218640","article-title":"Ta-coated titanium surface with superior bacteriostasis and osseointegration","volume":"14","author":"Zhang","year":"2019","journal-title":"Int. J. Nanomed."},{"issue":"1","key":"10.1016\/j.colsurfb.2022.112719_bib47","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1302\/0301-620X.97B1.34236","article-title":"Is tantalum protective against infection in revision total hip arthroplasty?","volume":"97B","author":"Tokarski","year":"2015","journal-title":"Bone Jt. J."},{"issue":"4","key":"10.1016\/j.colsurfb.2022.112719_bib48","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1097\/00002281-200307000-00004","article-title":"Molecular and cellular biology of new bone formation: insights into the ankylosis of ankylosing spondylitis","volume":"15","author":"Zhang","year":"2003","journal-title":"Curr. Opin. Rheumatol."},{"issue":"2","key":"10.1016\/j.colsurfb.2022.112719_bib49","doi-asserted-by":"crossref","DOI":"10.3390\/biomimetics7020074","article-title":"Biomimetic implant surfaces and their role in biological integration-a concise review","volume":"7","author":"Cruz","year":"2022","journal-title":"Biomimetics"},{"issue":"2020","key":"10.1016\/j.colsurfb.2022.112719_bib50","article-title":"From the performance to the essence: the biological mechanisms of how tantalum contributes to osteogenesis","author":"Qian","year":"2020","journal-title":"Biomed. Res. Int."},{"issue":"6","key":"10.1016\/j.colsurfb.2022.112719_bib51","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1177\/0885328217739456","article-title":"Transplantation of copper-doped calcium polyphosphate scaffolds combined with copper (II) preconditioned bone marrow mesenchymal stem cells for bone defect repair","volume":"32","author":"Li","year":"2018","journal-title":"J. Biomater. Appl."}],"container-title":["Colloids and Surfaces B: Biointerfaces"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0927776522004027?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0927776522004027?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T11:11:23Z","timestamp":1760526683000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0927776522004027"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10]]},"references-count":51,"alternative-id":["S0927776522004027"],"URL":"https:\/\/doi.org\/10.1016\/j.colsurfb.2022.112719","relation":{},"ISSN":["0927-7765"],"issn-type":[{"value":"0927-7765","type":"print"}],"subject":[],"published":{"date-parts":[[2022,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Enhanced anti-microbial activity and osseointegration of Ta\/Cu co-implanted polyetheretherketone","name":"articletitle","label":"Article Title"},{"value":"Colloids and Surfaces B: Biointerfaces","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.colsurfb.2022.112719","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"112719"}}