{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T17:12:36Z","timestamp":1792429956336,"version":"4.5.0"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Colloids and Surfaces B: Biointerfaces"],"published-print":{"date-parts":[[2022,12]]},"DOI":"10.1016\/j.colsurfb.2022.112858","type":"journal-article","created":{"date-parts":[[2022,9,22]],"date-time":"2022-09-22T12:46:54Z","timestamp":1663850814000},"page":"112858","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"special_numbering":"C","title":["Construction of a double-responsive modified guar gum nanoparticles and its application in oral insulin administration"],"prefix":"10.1016","volume":"220","author":[{"given":"Mingze","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxin","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiapeng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuanxi","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinpeng","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenfeng","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Runcai","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan-Qing","family":"Guan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.colsurfb.2022.112858_bib1","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1016\/S0140-6736(13)62219-9","article-title":"The many faces of diabetes: a disease with increasing heterogeneity","volume":"383","author":"Tuomi","year":"2014","journal-title":"Lancet"},{"key":"10.1016\/j.colsurfb.2022.112858_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.diabres.2021.108972","article-title":"Reprint of: classification of diabetes mellitus","author":"Adler","year":"2021","journal-title":"Diabetes Res. Clin. Pract."},{"key":"10.1016\/j.colsurfb.2022.112858_bib3","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.diabres.2013.11.002","article-title":"Global estimates of diabetes prevalence for 2013 and projections for 2035","volume":"103","author":"Guariguata","year":"2014","journal-title":"Diabetes Res. Clin. Pract."},{"key":"10.1016\/j.colsurfb.2022.112858_bib4","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/S0140-6736(13)60591-7","article-title":"Type 1 diabetes","volume":"383","author":"Atkinson","year":"2014","journal-title":"Lancet"},{"key":"10.1016\/j.colsurfb.2022.112858_bib5","doi-asserted-by":"crossref","first-page":"689","DOI":"10.4239\/wjd.v5.i5.689","article-title":"Advances in management of type 1 diabetes mellitus","volume":"5","author":"Aathira","year":"2014","journal-title":"World J. Diabetes"},{"key":"10.1016\/j.colsurfb.2022.112858_bib6","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.2337\/diacare.26.4.1321","article-title":"Both continuous subcutaneous insulin infusion and a multiple daily insulin injection regimen with glargine as basal insulin are equally better than traditional multiple daily insulin injection treatment","volume":"26","author":"Lepore","year":"2003","journal-title":"Diabetes Care"},{"key":"10.1016\/j.colsurfb.2022.112858_bib7","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1038\/s41573-019-0053-0","article-title":"Advances in oral peptide therapeutics","volume":"19","author":"Drucker","year":"2020","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.colsurfb.2022.112858_bib8","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1177\/1932296817691303","article-title":"Oral insulin delivery in a physiologic context: review","volume":"11","author":"Arbit","year":"2017","journal-title":"J. Diabetes Sci. Technol."},{"key":"10.1016\/j.colsurfb.2022.112858_bib9","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.apsb.2018.06.005","article-title":"Adapting liposomes for oral drug delivery","volume":"9","author":"He","year":"2019","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.colsurfb.2022.112858_bib10","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.jconrel.2017.09.003","article-title":"Potential of insulin nanoparticle formulations for oral delivery and diabetes treatment","volume":"264","author":"Wong","year":"2017","journal-title":"J. Control. Release"},{"key":"10.1016\/j.colsurfb.2022.112858_bib11","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.1016\/j.biotechadv.2015.02.010","article-title":"Polymer-based nanoparticles for oral insulin delivery: revisited approaches","volume":"33","author":"Fonte","year":"2015","journal-title":"Biotechnol. Adv."},{"key":"10.1016\/j.colsurfb.2022.112858_bib12","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1016\/j.drudis.2012.03.019","article-title":"An overview of natural polymers for oral insulin delivery","volume":"17","author":"Sonia","year":"2012","journal-title":"Drug Discov. Today"},{"key":"10.1016\/j.colsurfb.2022.112858_bib13","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.carbpol.2020.117504","article-title":"The role of polysaccharides from natural resources to design oral insulin micro- and nanoparticles intended for the treatment of Diabetes mellitus: a review","volume":"256","author":"Meneguin","year":"2021","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.colsurfb.2022.112858_bib14","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.carbpol.2019.115210","article-title":"Polysaccharides constructed hydrogels as vehicles for proteins and peptides. A review","volume":"225","author":"Dragan","year":"2019","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.colsurfb.2022.112858_bib15","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1016\/j.ijbiomac.2021.03.087","article-title":"Recent advances in guar gum based drug delivery systems and their administrative routes","volume":"181","author":"Verma","year":"2021","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.colsurfb.2022.112858_bib16","doi-asserted-by":"crossref","first-page":"4281","DOI":"10.1021\/acs.biomac.7b01322","article-title":"Preparation and characterization of hypoglycemic nanoparticles for oral insulin delivery","volume":"18","author":"Zhang","year":"2017","journal-title":"Biomacromolecules"},{"key":"10.1016\/j.colsurfb.2022.112858_bib17","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.carbpol.2020.116617","article-title":"Carboxymethyl beta-cyclodextrin grafted carboxymethyl chitosan hydrogel-based microparticles for oral insulin delivery","volume":"246","author":"Yang","year":"2020","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.colsurfb.2022.112858_bib18","doi-asserted-by":"crossref","first-page":"21","DOI":"10.3390\/molecules22101707","article-title":"Electrostatic self-assembled chitosan-pectin nano- and microparticles for insulin delivery","volume":"22","author":"Maciel","year":"2017","journal-title":"Molecules"},{"key":"10.1016\/j.colsurfb.2022.112858_bib19","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1016\/j.carbpol.2018.07.053","article-title":"Guar gum and its composites as potential materials for diverse applications: a review","volume":"199","author":"Sharma","year":"2018","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.colsurfb.2022.112858_bib20","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1007\/s13197-011-0522-x","article-title":"Guar gum: processing, properties and food applications\u2013a review","volume":"51","author":"Mudgil","year":"2014","journal-title":"J. Food Sci. Technol."},{"key":"10.1016\/j.colsurfb.2022.112858_bib21","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.ijbiomac.2011.04.022","article-title":"Prospective of guar gum and its derivatives as controlled drug delivery systems","volume":"49","author":"Prabaharan","year":"2011","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.colsurfb.2022.112858_bib22","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/07388550601166458","article-title":"Microbial biosynthesis of polyglutamic acid biopolymer and applications in the biopharmaceutical, biomedical and food industries","volume":"27","author":"Buescher","year":"2007","journal-title":"Crit. Rev. Biotechnol."},{"key":"10.1016\/j.colsurfb.2022.112858_bib23","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1099\/mic.0.081448-0","article-title":"Poly-gamma-glutamic acid: production, properties and applications","volume":"161","author":"Ogunleye","year":"2015","journal-title":"Microbiology"},{"key":"10.1016\/j.colsurfb.2022.112858_bib24","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1136\/postgradmedj-2015-133281","article-title":"Pathophysiology of type 1 and type 2 diabetes mellitus: a 90-year perspective","volume":"92","author":"Zaccardi","year":"2016","journal-title":"Postgrad. Med. J."},{"key":"10.1016\/j.colsurfb.2022.112858_bib25","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/nrd4477","article-title":"Managing diabetes with nanomedicine: challenges and opportunities","volume":"14","author":"Veiseh","year":"2015","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.colsurfb.2022.112858_bib26","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1016\/j.ijbiomac.2012.03.009","article-title":"Structure and antioxidant activities of sulfated guar gum: homogeneous reaction using DMAP\/DCC catalyst","volume":"50","author":"Wang","year":"2012","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.colsurfb.2022.112858_bib27","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1016\/j.ijbiomac.2018.09.080","article-title":"Synthesis of chemically crosslinked pullulan\/gelatin-based extracellular matrix-mimetic gels","volume":"122","author":"Han","year":"2019","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.colsurfb.2022.112858_bib28","doi-asserted-by":"crossref","first-page":"7451","DOI":"10.1039\/C8TB02113A","article-title":"Preparation and characterization of layer-by-layer hypoglycemic nanoparticles with pH-sensitivity for oral insulin delivery","volume":"6","author":"Zhang","year":"2018","journal-title":"J. Mater. Chem. B"},{"key":"10.1016\/j.colsurfb.2022.112858_bib29","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.colsurfb.2020.111203","article-title":"Folate targeted PEGylated liposomes for the oral delivery of insulin: in vitro and in vivo studies","volume":"194","author":"Yazdi","year":"2020","journal-title":"Colloid Surf. B-Biointerfaces"},{"key":"10.1016\/j.colsurfb.2022.112858_bib30","doi-asserted-by":"crossref","first-page":"2692","DOI":"10.1021\/acs.bioconjchem.7b00571","article-title":"Facile formation of gold-nanoparticle-loaded gamma-polyglutamic acid nanogels for tumor computed tomography imaging","volume":"28","author":"Zhu","year":"2017","journal-title":"Bioconjug. Chem."},{"key":"10.1016\/j.colsurfb.2022.112858_bib31","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.molliq.2018.08.136","article-title":"Chitosan-Guar gum blend silver nanoparticle bionanocomposite with potential for catalytic degradation of dyes and catalytic reduction of nitrophenol","volume":"271","author":"Vanaamudan","year":"2018","journal-title":"J. Mol. Liq."},{"key":"10.1016\/j.colsurfb.2022.112858_bib32","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.carbpol.2006.02.008","article-title":"Characterization of insulin-loaded alginate nanoparticles produced by ionotropic pre-gelation through DSC and FTIR studies","volume":"66","author":"Sarmento","year":"2006","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.colsurfb.2022.112858_bib33","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.bios.2006.01.008","article-title":"Concanavalin A for in vivo glucose sensing: a biotoxicity review","volume":"22","author":"Ballerstadt","year":"2006","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.colsurfb.2022.112858_bib34","doi-asserted-by":"crossref","first-page":"S25","DOI":"10.1089\/dia.2017.0035","article-title":"Continuous glucose monitoring: a review of recent studies demonstrating improved glycemic outcomes","volume":"19","author":"Rodbard","year":"2017","journal-title":"Diabetes Technol. Ther."},{"key":"10.1016\/j.colsurfb.2022.112858_bib35","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1111\/j.1476-5381.2012.01911.x","article-title":"The use of animal models in diabetes research","volume":"166","author":"King","year":"2012","journal-title":"Br. J. Pharm."},{"key":"10.1016\/j.colsurfb.2022.112858_bib36","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1038\/nrd.2015.36","article-title":"Pursuit of a perfect insulin","volume":"15","author":"Zaykov","year":"2016","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.colsurfb.2022.112858_bib37","first-page":"17","article-title":"Type 1 diabetes mellitus","volume":"3","author":"Katsarou","year":"2017","journal-title":"Nat. Rev. Dis. Prim."},{"key":"10.1016\/j.colsurfb.2022.112858_bib38","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1007\/s11892-017-0892-1","article-title":"Biopsychosocial aspects of weight management in type 1 diabetes: a review and next steps","volume":"17","author":"Driscoll","year":"2017","journal-title":"Curr. Diabetes Rep."},{"key":"10.1016\/j.colsurfb.2022.112858_bib39","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/j.cmet.2014.02.009","article-title":"The ratio of macronutrients, not caloric intake, dictates cardiometabolic health, aging, and longevity in ad libitum-fed mice","volume":"19","author":"Solon-Biet","year":"2014","journal-title":"Cell Metab."},{"key":"10.1016\/j.colsurfb.2022.112858_bib40","doi-asserted-by":"crossref","first-page":"17391","DOI":"10.1073\/pnas.1008025107","article-title":"Leptin therapy improves insulin-deficient type 1 diabetes by CNS-dependent mechanisms in mice","volume":"107","author":"Fujikawa","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.colsurfb.2022.112858_bib41","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1126\/science.1114397","article-title":"Toxic potential of materials at the nanolevel","volume":"311","author":"Nel","year":"2006","journal-title":"Science"},{"key":"10.1016\/j.colsurfb.2022.112858_bib42","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1258\/la.2010.010090","article-title":"Single dose streptozotocin-induced diabetes: considerations for study design in islet transplantation models","volume":"45","author":"Deeds","year":"2011","journal-title":"Lab. Anim."},{"key":"10.1016\/j.colsurfb.2022.112858_bib43","doi-asserted-by":"crossref","first-page":"2133","DOI":"10.1152\/physrev.00063.2017","article-title":"Mechanisms of insulin action and insulin resistance","volume":"98","author":"Petersen","year":"2018","journal-title":"Physiol. Rev."}],"container-title":["Colloids and Surfaces B: Biointerfaces"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0927776522005410?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0927776522005410?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T11:11:25Z","timestamp":1760526685000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0927776522005410"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12]]},"references-count":43,"alternative-id":["S0927776522005410"],"URL":"https:\/\/doi.org\/10.1016\/j.colsurfb.2022.112858","relation":{},"ISSN":["0927-7765"],"issn-type":[{"value":"0927-7765","type":"print"}],"subject":[],"published":{"date-parts":[[2022,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Construction of a double-responsive modified guar gum nanoparticles and its application in oral insulin administration","name":"articletitle","label":"Article Title"},{"value":"Colloids and Surfaces B: Biointerfaces","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.colsurfb.2022.112858","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"112858"}}