{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T18:21:20Z","timestamp":1774549280124,"version":"3.50.1"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Colloids and Surfaces B: Biointerfaces"],"published-print":{"date-parts":[[2022,12]]},"DOI":"10.1016\/j.colsurfb.2022.112864","type":"journal-article","created":{"date-parts":[[2022,9,21]],"date-time":"2022-09-21T05:08:35Z","timestamp":1663736915000},"page":"112864","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["Glycyrrhetinic acid modified chlorambucil prodrug for hepatocellular carcinoma treatment based on DNA replication and tumor microenvironment"],"prefix":"10.1016","volume":"220","author":[{"given":"Lihong","family":"Sang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Faxing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiajia","family":"Jia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pingtian","family":"Ding","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ting","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dongkai","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.colsurfb.2022.112864_bib1","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1002\/hep.1840150532","article-title":"Hepatocellular carcinoma: recent progress[J]","volume":"15","author":"Okuda","year":"1992","journal-title":"Hepatology"},{"key":"10.1016\/j.colsurfb.2022.112864_bib2","doi-asserted-by":"crossref","first-page":"2181","DOI":"10.1002\/1097-0142(19930401)71:7<2181::AID-CNCR2820710703>3.0.CO;2-3","article-title":"A comparative study of hepaticresection and transcatheter arterial embolization for the treatment of primary hepatocellular carcinoma[J]","volume":"71","author":"Kanematsu","year":"1993","journal-title":"Cancer"},{"key":"10.1016\/j.colsurfb.2022.112864_bib3","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1084\/jem.193.6.727","article-title":"Colony-stimulating factor 1 promotes progression of mammary tumors to malignancy[J]","volume":"193","author":"Lin","year":"2001","journal-title":"J. Exp. Med."},{"issue":"4","key":"10.1016\/j.colsurfb.2022.112864_bib4","doi-asserted-by":"crossref","first-page":"52","DOI":"10.3109\/10428194.2015.1085528","article-title":"Systematic review of the recent evidence for the efficacy and safety of chlorambucil in the treatment of B-cell malignancies[J]","volume":"57","author":"Lepretre","year":"2016","journal-title":"Leuk. Lymphoma"},{"issue":"4","key":"10.1016\/j.colsurfb.2022.112864_bib5","first-page":"1","article-title":"Chlorambuci for the treatment of patients with chronic lymphocytic leukemia-a systematic review and meta-analysis of randomized trials[J]","volume":"57","author":"Vidal","year":"2016","journal-title":"Leuk. Lymphoma"},{"issue":"1\u20132","key":"10.1016\/j.colsurfb.2022.112864_bib6","first-page":"85","article-title":"Chlorambucil-inducedd pulmonary disease:a case report and review of the literature[J]","volume":"77","author":"Khong","year":"1998","journal-title":"Ann. Hepatol."},{"issue":"1\u20132","key":"10.1016\/j.colsurfb.2022.112864_bib7","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/0027-5107(96)00020-6","article-title":"DNA adducts from chemotherapeutic agents[J]","volume":"355","author":"Lawley","year":"1996","journal-title":"Mutat. Res."},{"issue":"2","key":"10.1016\/j.colsurfb.2022.112864_bib8","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1615\/CritRevImmunol.v28.i2.20","article-title":"Immune-potentiating effects of the chemotherapeutic drug cyclophosphamide [J]","volume":"28","author":"Brode","year":"2008","journal-title":"Crit. Rev. Immunol."},{"issue":"2","key":"10.1016\/j.colsurfb.2022.112864_bib9","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.jdermsci.2005.02.002","article-title":"Cyclophosphamide decreases the number, percentage and the function of CD25+ CD4+ regulatory T cells, which suppress induction of contact hypersensitivity [J]","volume":"39","author":"Ikezawa","year":"2005","journal-title":"J. Dermatol. Sci."},{"issue":"4","key":"10.1016\/j.colsurfb.2022.112864_bib10","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1007\/s10555-014-9529-x","article-title":"Emerging roles of regulatory T cells in tumour progression and metastasis [J]","volume":"33","author":"Halvorsen","year":"2014","journal-title":"Cancer Metastas. Rev."},{"issue":"7","key":"10.1016\/j.colsurfb.2022.112864_bib11","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/j.jmst.2016.05.001","article-title":"Folic acid functionalized vertically aligned carbon nanotube (FA-VACNT) electrodes for cancer sensing applications[J]","volume":"32","author":"Zanganeh","year":"2016","journal-title":"J. Mater. Sci. Technol."},{"issue":"5","key":"10.1016\/j.colsurfb.2022.112864_bib12","doi-asserted-by":"crossref","first-page":"467","DOI":"10.3109\/1061186X.2012.685475","article-title":"The anti-tumor performance of docetaxel liposomes surface-modified with glycyrrhetinic acid[J]","volume":"20","author":"Li","year":"2012","journal-title":"Drug Target."},{"issue":"17","key":"10.1016\/j.colsurfb.2022.112864_bib13","doi-asserted-by":"crossref","first-page":"4748","DOI":"10.1016\/j.biomaterials.2010.02.042","article-title":"Glycyrrhetinic acid-modified chitosan\/polyethylene glycol nano-particles for liver-targeted delivery[J]","volume":"31","author":"Tian","year":"2010","journal-title":"Biomaterials"},{"issue":"8","key":"10.1016\/j.colsurfb.2022.112864_bib14","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1016\/S0305-4179(96)00053-8","article-title":"In vitro induetion of anti-type 2 T cells by glycyrrhizin [J]","volume":"22","author":"Nakajima","year":"1996","journal-title":"Burns"},{"issue":"3","key":"10.1016\/j.colsurfb.2022.112864_bib15","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1111\/j.1440-1746.1997.tb00416.x","article-title":"Effects of glycyrrhizin on inmmte-inediated cytotoxicity [J]","volume":"12","author":"Yoshikawa","year":"1997","journal-title":"Gastroenterol. Hepatol."},{"key":"10.1016\/j.colsurfb.2022.112864_bib16","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1111\/j.1348-0421.1982.tb00207.x","article-title":"Interferon induction by glycyrrhizin and glycyrrhetinic acid in mice [J]","volume":"26","author":"Abe","year":"1982","journal-title":"Microbiol. Immunol."},{"issue":"13","key":"10.1016\/j.colsurfb.2022.112864_bib17","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1016\/j.intimp.2004.07.023","article-title":"Glycyrrhizin and related compounds down-regulate production of inflammatory chemokines IL-8 and eotaxin 1 in a human lung fibroblast cell line[J]","volume":"4","author":"Matsui","year":"2004","journal-title":"Int. Immunopharmacol."},{"issue":"11","key":"10.1016\/j.colsurfb.2022.112864_bib18","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1016\/j.phymed.2013.04.008","article-title":"18 beta-glycyrrhetinic acid induces immunological adjuvant activity of Th1 against Candida albicans surface mannan extract[J]","volume":"20","author":"Kim","year":"2013","journal-title":"Phytomedicine"},{"issue":"8","key":"10.1016\/j.colsurfb.2022.112864_bib19","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1038\/nrm3629","article-title":"Control of cell cycle transcription during G1 and S phases[J]","volume":"14","author":"Bertoli","year":"2013","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.colsurfb.2022.112864_bib20","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.dnarep.2016.04.008","article-title":"Multiple functions of P21 in cell cycle, apoptosis and transcriptional regulation after DNA damage[J]","volume":"42","author":"Karimian","year":"2016","journal-title":"DNA Repair"},{"issue":"4","key":"10.1016\/j.colsurfb.2022.112864_bib21","first-page":"180","article-title":"MPF-based meiotic cell cycle control: half a century of lessons from starfish oocytes[J]","volume":"94","author":"Kishimoto","year":"2018","journal-title":"Phys. Biol."},{"issue":"12","key":"10.1016\/j.colsurfb.2022.112864_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.tranon.2020.100871","article-title":"The interaction mechanism between autophagy and apoptosis in colon cancer[J]","volume":"13","author":"Xie","year":"2020","journal-title":"Transl. Oncol."},{"issue":"4","key":"10.1016\/j.colsurfb.2022.112864_bib23","first-page":"88","article-title":"Involvement of Mfn2, Bcl2\/Bax signaling andmitochondrial viability in the potential protective effect of Royal jelly against mitochondria-mediated ovarian apoptosis by cisplatin in rats[J]","volume":"23","author":"Hashem","year":"2020","journal-title":"Iran. J. Basic Med. Sci."},{"key":"10.1016\/j.colsurfb.2022.112864_bib24","first-page":"9","article-title":"Recent advances in targeting CD8+T cell immunity for more effective cancer immunotherpy[J]","author":"Durgeau","year":"2018","journal-title":"Front. Immunol."},{"issue":"1","key":"10.1016\/j.colsurfb.2022.112864_bib25","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1097\/PAI.0b013e3181b6a741","article-title":"A high number of CD8+T cells infiltrated in NSCLC tissues in associated with a favorable prognosis[J]","volume":"18","author":"Zhuang","year":"2010","journal-title":"Appl. Immunohistochem. Mol. Morphol."},{"key":"10.1016\/j.colsurfb.2022.112864_bib26","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S0065-230X(10)07003-X","article-title":"Regulatory T cells in cancer[J]","volume":"107","author":"Mougiakakos","year":"2010","journal-title":"Adv. Cancer Res."},{"issue":"1","key":"10.1016\/j.colsurfb.2022.112864_bib27","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.lungcan.2011.06.002","article-title":"Prognostic potential of Foxp3 expression in non-small cell lung cancer cells combined with turn or-infiltrating regulatory T cells[J]","volume":"75","author":"Tao","year":"2012","journal-title":"Lung Cancer"},{"issue":"5","key":"10.1016\/j.colsurfb.2022.112864_bib28","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1097\/JTO.0b013e3181d60fd7","article-title":"Tumor-infiltrating Foxp3 regulatory T cells are correlated with cyclooxygenase-2 expression and are associated with recurrence in resected non-small cell lung cancer[J]","volume":"5","author":"Shimizu","year":"2010","journal-title":"J. Thorac. Oncol."},{"key":"10.1016\/j.colsurfb.2022.112864_bib29","first-page":"59","article-title":"Effects of rice bran polysaccharide on CD4+T cells and CD8+ T cells in chickens[J]","volume":"4","author":"Li","year":"2009","journal-title":"China Anim. Husb. Vet. Med."},{"issue":"11","key":"10.1016\/j.colsurfb.2022.112864_bib30","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1016\/j.phymed.2013.04.008","article-title":"18 beta-glycyrrhetinic acid induces immunological adjuvant activity of Th1 against Candida albicans surface mannan extract[J]","volume":"20","author":"Kim","year":"2013","journal-title":"Phytomedicine"}],"container-title":["Colloids and Surfaces B: Biointerfaces"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0927776522005471?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0927776522005471?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T11:19:54Z","timestamp":1760527194000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0927776522005471"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12]]},"references-count":30,"alternative-id":["S0927776522005471"],"URL":"https:\/\/doi.org\/10.1016\/j.colsurfb.2022.112864","relation":{},"ISSN":["0927-7765"],"issn-type":[{"value":"0927-7765","type":"print"}],"subject":[],"published":{"date-parts":[[2022,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Glycyrrhetinic acid modified chlorambucil prodrug for hepatocellular carcinoma treatment based on DNA replication and tumor microenvironment","name":"articletitle","label":"Article Title"},{"value":"Colloids and Surfaces B: Biointerfaces","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.colsurfb.2022.112864","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"112864"}}