{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T18:27:33Z","timestamp":1793039253437,"version":"4.5.0"},"reference-count":51,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Colloids and Surfaces B: Biointerfaces"],"published-print":{"date-parts":[[2023,2]]},"DOI":"10.1016\/j.colsurfb.2022.113065","type":"journal-article","created":{"date-parts":[[2022,11,30]],"date-time":"2022-11-30T11:19:13Z","timestamp":1669807153000},"page":"113065","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":38,"special_numbering":"C","title":["Intranasally administered thermosensitive gel for brain-targeted delivery of rhynchophylline to treat Parkinson\u2019s disease"],"prefix":"10.1016","volume":"222","author":[{"given":"Honglei","family":"Lin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lukuan","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingrui","family":"Lv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianrong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenyuan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingfei","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fulei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.colsurfb.2022.113065_bib1","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1038\/nrneurol.2017.188","article-title":"Blood-brain barrier breakdown in Alzheimer disease and other neurodegenerative disorders","volume":"14","author":"Sweeney","year":"2018","journal-title":"Nat. Rev. Neurol."},{"issue":"15","key":"10.1016\/j.colsurfb.2022.113065_bib2","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1056\/NEJM199710093371503","article-title":"Posteroventral medial pallidotomy in advanced Parkinson\u2019s disease","volume":"337","author":"Lang","year":"1997","journal-title":"N. Engl. J. Med."},{"issue":"127","key":"10.1016\/j.colsurfb.2022.113065_bib3","article-title":"The role of dopamine in action control: Insights from medication effects in Parkinson\u2019s disease","author":"Ruitenberg","year":"2021","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.colsurfb.2022.113065_bib4","first-page":"8","article-title":"Exploring the link between Parkinson's disease and type 2 diabetes mellitus in Drosophila","volume":"36","author":"Jos\u00e9","year":"2022","journal-title":"FASEB J. Off. Publ. Fed. Am. Soc. Exp. Biol."},{"key":"10.1016\/j.colsurfb.2022.113065_bib5","first-page":"3","article-title":"Colliding bodies optimization with machine learning based Parkinson\u2019s disease diagnosis","volume":"44","author":"Kumar Dutta","year":"2023","journal-title":"Comput. Syst. Sci. Eng."},{"key":"10.1016\/j.colsurfb.2022.113065_bib6","first-page":"11","article-title":"Rhynchophylline protects against the amyloid \u03b2-induced increase of spontaneous discharges in the hippocampal CA1 region of rats","volume":"40","author":"Hui","year":"2015","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.colsurfb.2022.113065_bib7","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s00401-018-1815-1","article-title":"Functional morphology of the blood-brain barrier in health and disease","volume":"135","author":"Liebner","year":"2018","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.colsurfb.2022.113065_bib8","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.tibtech.2018.01.006","article-title":"Nanotechnology-based strategies for siRNA brain delivery for disease therapy","volume":"36","author":"Zheng","year":"2018","journal-title":"Trends Biotechnol."},{"key":"10.1016\/j.colsurfb.2022.113065_bib9","first-page":"3","article-title":"Hypertonic saline downregulates endothelial cell-derived VEGF expression and reduces blood-brain barrier permeability induced by cerebral ischaemia via the VEGFR2\/eNOS pathway","volume":"44","author":"Qiaosheng","year":"2019","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.colsurfb.2022.113065_bib10","doi-asserted-by":"crossref","first-page":"4","DOI":"10.3171\/jns.2000.92.4.0599","article-title":"In vivo assessment of the window of barrier opening after osmotic blood-brain barrier disruption in humans","volume":"92","author":"Siegal","year":"2000","journal-title":"J. Neurosurg."},{"key":"10.1016\/j.colsurfb.2022.113065_bib11","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.jconrel.2017.06.023","article-title":"L-type amino acid transporter 1 utilizing prodrugs: how to achieveeffective brain delivery and low systemic exposure of drugs","volume":"261","author":"Puris","year":"2017","journal-title":"J. Control. Release"},{"key":"10.1016\/j.colsurfb.2022.113065_bib12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/10611860600612953","article-title":"Targeted brain delivery of AZT via transferrin anchored pegylated albumin nanoparticles","volume":"14","author":"Mishra","year":"2006","journal-title":"J. Drug Target."},{"key":"10.1016\/j.colsurfb.2022.113065_bib13","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/0896-6273(94)90351-4","article-title":"Globose basal cells are neuronal progenitors in the olfactory epithelium:a lineage analysis using a replication-incompetent retrovirus","volume":"13","author":"Caggiano","year":"1994","journal-title":"Neuron"},{"key":"10.1016\/j.colsurfb.2022.113065_bib14","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.jddst.2015.08.003","article-title":"Formulation and evaluation of thermoreversible mucoadhesive in-situ gel for intranasal delivery of naratriptan hydrochloride","volume":"29","author":"Shelke","year":"2015","journal-title":"J. Drug Deliv. Sci. Technol."},{"key":"10.1016\/j.colsurfb.2022.113065_bib15","doi-asserted-by":"crossref","DOI":"10.9734\/jpri\/2021\/v33i34B31853","article-title":"Brain targeting through intranasal route: an overview","author":"Anusha","year":"2021","journal-title":"J. Pharm. Res. Int."},{"key":"10.1016\/j.colsurfb.2022.113065_bib16","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/0896-6273(94)90351-4","article-title":"Globose basal cells are neuronal progenitors in the olfactory epithelium:a lineage analysis using a replication-incompetent retrovirus","volume":"13","author":"Caggiano","year":"1994","journal-title":"Neuron"},{"key":"10.1016\/j.colsurfb.2022.113065_bib17","first-page":"8","article-title":"In vitro and in vivo evaluation of an ionic sensitive in situ gel containing nanotransfersomes for aripiprazole nasal delivery","volume":"26","author":"Somayeh","year":"2021","journal-title":"Pharm. Dev. Technol."},{"key":"10.1016\/j.colsurfb.2022.113065_bib18","first-page":"7","article-title":"Development of a cyclodextrin-based mucoadhesive-thermosensitive in situ gel for clonazepam intranasal delivery","volume":"13","author":"Marzia","year":"2021","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.colsurfb.2022.113065_bib19","first-page":"335","article-title":"Nasal biocompatible powder of geraniol oil complexed with cyclodextrins for neurodegenerative diseases: physicochemical characterization and in vivo evidences of nose to brain delivery","author":"Truzzi","year":"2021","journal-title":"J. Control. Release Off. J. Control. Release Soc."},{"key":"10.1016\/j.colsurfb.2022.113065_bib20","first-page":"0","article-title":"Preparation and in vitro evaluation of thermosensitive and mucoadhesive hydrogels for intranasal delivery of phenobarbital sodium","volume":"0","author":"Mitra","year":"2021","journal-title":"Ther. Deliv."},{"key":"10.1016\/j.colsurfb.2022.113065_bib21","doi-asserted-by":"crossref","first-page":"2","DOI":"10.3390\/molecules22020246","article-title":"Poloxamer-based thermoreversible gel for topical delivery of emodin: influence of P407 and P188 on solubility of emodin and its application in cellular activity screening","volume":"22","author":"Ban","year":"2017","journal-title":"Molecules"},{"issue":"6","key":"10.1016\/j.colsurfb.2022.113065_bib22","first-page":"673","article-title":"In situ forming hydrogels based on chitosan for drug delivery and tissue regeneration","volume":"11","author":"Liu","year":"2016","journal-title":"Asian J. Pharm. Sci."},{"issue":"45","key":"10.1016\/j.colsurfb.2022.113065_bib23","doi-asserted-by":"crossref","first-page":"73280","DOI":"10.18632\/oncotarget.11789","article-title":"Thermo-sensitive composite hydrogels based on poloxamer 407 and alginate and their therapeutic effect in embolization in rabbit VX2 liver tumors","volume":"7","author":"Huang","year":"2016","journal-title":"Oncotarget"},{"issue":"1","key":"10.1016\/j.colsurfb.2022.113065_bib24","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/j.biopha.2017.10.023","article-title":"Effect of a combination of mometasone furoate, levofloxacin, and retinyl palmitate with an in situgel-forming nasal delivery system on nasal mucosa damage repair in an experimental rabbit model","volume":"96","author":"Aksoy","year":"2017","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.colsurfb.2022.113065_bib25","doi-asserted-by":"crossref","first-page":"2103","DOI":"10.1208\/s12249-018-1010-7","article-title":"Thermosensitive poloxamer 407\/poly (acrylic acid) hydrogels with potential application as injectable drug delivery system","volume":"19","author":"Boonlai","year":"2018","journal-title":"AAPS PharmSciTech"},{"key":"10.1016\/j.colsurfb.2022.113065_bib26","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1007\/s11595-020-2255-z","article-title":"Nanocomposite polymer hydrogels reinforced by carbon dots and hectorite clay","volume":"35","author":"Ma","year":"2020","journal-title":"J. Wuhan Univ. Technol. Mater. Sci. Ed."},{"key":"10.1016\/j.colsurfb.2022.113065_bib27","first-page":"222","article-title":"Degradation of thermoresponsive laponite\/PEG-b-PLGA nanocomposite hydrogels controlled by blending PEG-b-PLGA diblock copolymers with different PLGA molecular weights","author":"Maeda","year":"2021","journal-title":"Polym. Degrad. Stab."},{"key":"10.1016\/j.colsurfb.2022.113065_bib28","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1016\/j.jsps.2019.09.006","article-title":"Progesterone loaded thermosensitive hydrogel for vaginal application: formulation and in vitro comparison with commercial product","volume":"27","author":"Vel\u00e1zquez","year":"2019","journal-title":"Saudi Pharm. J."},{"key":"10.1016\/j.colsurfb.2022.113065_bib29","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.actbio.2020.04.028","article-title":"Poloxamer A versatile triblock copolymer for biomedical applications","volume":"110","author":"Zarrintaj","year":"2020","journal-title":"Acta Biomater."},{"key":"10.1016\/j.colsurfb.2022.113065_bib30","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.colsurfa.2018.05.012","article-title":"Effect of hydrophilically modified ibuprofen on thermoresponsive gelation of pluronic copolymer","volume":"553","author":"Wei","year":"2018","journal-title":"Colloids Surf. A Physicochem. Eng. Asp."},{"key":"10.1016\/j.colsurfb.2022.113065_bib31","first-page":"491","article-title":"New progress in the application of carbomer and polycarbofe in pharmacy","volume":"22","author":"Lu","year":"2002","journal-title":"Chin. J. Hosp. Pharm."},{"issue":"13\u201314","key":"10.1016\/j.colsurfb.2022.113065_bib32","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1016\/j.intimp.2009.09.010","article-title":"Anti-inflammatory effects of rhynchophylline and isorhynchophylline in mouse N9 microglial cells and the molecular mechanism","volume":"9","author":"Yuan","year":"2009","journal-title":"Int. Immunopharmacol."},{"issue":"2","key":"10.1016\/j.colsurfb.2022.113065_bib33","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1080\/03639045.2020.1717516","article-title":"Design and optimization of a child-friendly dispersible tablet containing isoniazid,pyrazinamide,and rifampicin for treating tuberculosis in pediatrics","volume":"46","author":"Javier","year":"2020","journal-title":"Drug Dev. Ind. Pharm."},{"key":"10.1016\/j.colsurfb.2022.113065_bib34","first-page":"417","article-title":"Influence of seven absorption enhancers on nasal mucosa-assessment of toxicity","volume":"36","author":"Zhao","year":"2004","journal-title":"J. Peking Univ."},{"issue":"1","key":"10.1016\/j.colsurfb.2022.113065_bib35","first-page":"59","article-title":"Impact of Lycium barbarum Polysaccharide and Danshensu on vascular endothelial growth factor in the process of retinal neovascularization of rabbit","volume":"6","author":"Tian","year":"2013","journal-title":"Int. J. Ophthalmol."},{"key":"10.1016\/j.colsurfb.2022.113065_bib36","first-page":"330","article-title":"Prediction effect of ethanol molecules on doxorubicin drug delivery using single-walled carbon nanotube carrier through POPC cell membrane","author":"Sina","year":"2021","journal-title":"J. Mol. Liq."},{"key":"10.1016\/j.colsurfb.2022.113065_bib37","first-page":"322","article-title":"Theorical investigation of adsorption mechanism of doxorubicin anticancer drug on the pristine and functionalized single-walled carbon nanotube surface as a drug delivery vehicle: a DFT study","author":"Sina","year":"2021","journal-title":"J. Mol. Liq."},{"key":"10.1016\/j.colsurfb.2022.113065_bib38","first-page":"101","article-title":"Investigate the importance of mechanical properties of SWCNT on Doxorubicin anti-cancer drug adsorption for medical application: a molecular dynamic study","author":"Karimzadeh","year":"2020","journal-title":"J. Mol. Graph. Model."},{"key":"10.1016\/j.colsurfb.2022.113065_bib39","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.actbio.2020.04.028","article-title":"Poloxamer A versatile triblock copolymer for biomedical applications","volume":"110","author":"Zarrintaj","year":"2020","journal-title":"Acta Biomater."},{"key":"10.1016\/j.colsurfb.2022.113065_bib40","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.colsurfa.2018.05.012","article-title":"Effect of hydrophilically modified ibuprofen on thermoresponsive gelation of pluronic copolymer","volume":"553","author":"Wei","year":"2018","journal-title":"Colloids Surf. A Physicochem Eng. Asp."},{"key":"10.1016\/j.colsurfb.2022.113065_bib41","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/j.eurpolymj.2015.05.014","article-title":"An overview of injectable polymeric hydrogels for tissue engineering","volume":"72","author":"Sivashanmugam","year":"2015","journal-title":"Eur. Polym. J."},{"key":"10.1016\/j.colsurfb.2022.113065_bib42","first-page":"14","article-title":"Formulation and evaluation of luliconazole microsponges loaded gel for topical delivery","volume":"11","author":"Sultan","year":"2021","journal-title":"Res. J. Pharm. Technol."},{"key":"10.1016\/j.colsurfb.2022.113065_bib43","unstructured":"Pharmaceutical Research, New Pharmaceutical Research Study Results Reported from Zhejiang University,\u00a0Biotech Week, 2013."},{"key":"10.1016\/j.colsurfb.2022.113065_bib44","first-page":"3","article-title":"Nasal mucus proteome and its involvement in allergic rhinitis","volume":"17","author":"Valentin","year":"2020","journal-title":"Expert Rev. Proteom."},{"issue":"1","key":"10.1016\/j.colsurfb.2022.113065_bib45","article-title":"Drug release behavior from in situ gelatinized thermosensitive nanogel aqueous dispersions","volume":"361","author":"Wang","year":"2008","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.colsurfb.2022.113065_bib46","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ijpharm.2008.03.029","article-title":"Intranasal nanoemulsion based brain targeting drug delivery system of risperidone","volume":"358","author":"Kumar","year":"2008","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.colsurfb.2022.113065_bib47","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0378-5173(03)00341-7","article-title":"Profiles of methotrexate in blood and CSF following intranasal and intravenous administration to rats","volume":"263","author":"Wang","year":"2003","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.colsurfb.2022.113065_bib48","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ncrna.2021.12.004","article-title":"Altered expression of miR-29a-3p and miR-34a-5p by specific inhibition of GSK3\u03b2 in the MPP+ treated SH-SY5Y Parkinson's model","volume":"7","author":"Morteza","year":"2022","journal-title":"Non-coding RNA Res."},{"key":"10.1016\/j.colsurfb.2022.113065_bib49","first-page":"1","article-title":"The protective effect of decoction of Rehmanniae via PI3K\/Akt\/mTOR pathway in MPP; -induced Parkinson's disease model cells","volume":"41","author":"Dajing","year":"2021","journal-title":"J. Recept. Signal Transduct."},{"key":"10.1016\/j.colsurfb.2022.113065_bib50","first-page":"1","article-title":"The effect of intra-striatal administration of GPR55 agonist (LPI) and antagonist (ML193) on sensorimotor and motor functions in a Parkinson's disease rat model","volume":"33","author":"Iman","year":"2020","journal-title":"Acta Neuropsychiatr."},{"issue":"1\u20132","key":"10.1016\/j.colsurfb.2022.113065_bib51","first-page":"105","article-title":"A panel of oxidative stress markers in Parkinson's disease","volume":"62","author":"Bolner","year":"2016","journal-title":"Clin. Lab."}],"container-title":["Colloids and Surfaces B: Biointerfaces"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0927776522007494?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0927776522007494?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T11:15:34Z","timestamp":1760526934000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0927776522007494"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2]]},"references-count":51,"alternative-id":["S0927776522007494"],"URL":"https:\/\/doi.org\/10.1016\/j.colsurfb.2022.113065","relation":{},"ISSN":["0927-7765"],"issn-type":[{"value":"0927-7765","type":"print"}],"subject":[],"published":{"date-parts":[[2023,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Intranasally administered thermosensitive gel for brain-targeted delivery of rhynchophylline to treat Parkinson\u2019s disease","name":"articletitle","label":"Article Title"},{"value":"Colloids and Surfaces B: Biointerfaces","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.colsurfb.2022.113065","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"113065"}}