{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T07:36:07Z","timestamp":1790840167984,"version":"4.1.0"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82272452"],"award-info":[{"award-number":["82272452"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012476","name":"Fundamental Research Funds for Central Universities of the Central South University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012476","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016104","name":"Key Project of Research and Development Plan of Hunan Province","doi-asserted-by":"publisher","award":["2020SK2008,2021GK2012"],"award-info":[{"award-number":["2020SK2008,2021GK2012"]}],"id":[{"id":"10.13039\/100016104","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004735","name":"Hunan Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["2021JJ40929"],"award-info":[{"award-number":["2021JJ40929"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004735","name":"Hunan Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["2022JJ40754"],"award-info":[{"award-number":["2022JJ40754"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Colloids and Surfaces B: Biointerfaces"],"published-print":{"date-parts":[[2023,10]]},"DOI":"10.1016\/j.colsurfb.2023.113506","type":"journal-article","created":{"date-parts":[[2023,8,7]],"date-time":"2023-08-07T11:40:45Z","timestamp":1691408445000},"page":"113506","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"special_numbering":"C","title":["The bio-functionalized membrane loaded with Ta\/WH nanoparticles promote bone regeneration through neurovascular coupling"],"prefix":"10.1016","volume":"230","author":[{"given":"Kai","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongkun","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiangyu","family":"Nan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenbin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengfei","family":"Lei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yihe","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.colsurfb.2023.113506_bib1","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1097\/BOT.0000000000001420","article-title":"Autograft, allograft, and bone graft substitutes: clinical evidence and indications for use in the setting of orthopaedic trauma surgery","volume":"33","author":"Baldwin","year":"2019","journal-title":"J. Orthop. Trauma"},{"issue":"3","key":"10.1016\/j.colsurfb.2023.113506_bib2","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1038\/nbt.2816","article-title":"Mesenchymal stem cells: immune evasive, not immune privileged","volume":"32","author":"Ankrum","year":"2014","journal-title":"Nat. Biotechnol."},{"issue":"7625","key":"10.1016\/j.colsurfb.2023.113506_bib3","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1038\/nature19815","article-title":"Allogeneic transplantation of iPS cell-derived cardiomyocytes regenerates primate hearts","volume":"538","author":"Shiba","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.colsurfb.2023.113506_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2019.119617","article-title":"Electroactive composite scaffold with locally expressed osteoinductive factor for synergistic bone repair upon electrical stimulation","volume":"230","author":"Cui","year":"2020","journal-title":"Biomaterials"},{"issue":"1","key":"10.1016\/j.colsurfb.2023.113506_bib5","doi-asserted-by":"crossref","DOI":"10.1038\/natrevmats.2016.75","article-title":"Bioresponsive materials","volume":"2","author":"Lu","year":"2017","journal-title":"Nat. Rev. Mater."},{"key":"10.1016\/j.colsurfb.2023.113506_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2019.119536","article-title":"Progress in 3D bioprinting technology for tissue\/organ regenerative engineering","volume":"226","author":"Matai","year":"2020","journal-title":"Biomaterials"},{"key":"10.1016\/j.colsurfb.2023.113506_bib7","first-page":"137","article-title":"Cellulose-based composite scaffolds for bone tissue engineering and localized drug delivery","volume":"20","author":"Janmohammadi","year":"2023","journal-title":"Bioact. Mater."},{"issue":"2","key":"10.1016\/j.colsurfb.2023.113506_bib8","first-page":"163","article-title":"Development and challenges of cells- and materials-based tooth regeneration","volume":"3","author":"Fu","year":"2022","journal-title":"Eng. Regen."},{"issue":"1","key":"10.1016\/j.colsurfb.2023.113506_bib9","doi-asserted-by":"crossref","DOI":"10.1002\/SMMD.20220006","article-title":"Developing biomedical engineering technologies for reproductive medicine","volume":"1","author":"Zhu","year":"2022","journal-title":"Smart Med."},{"issue":"7802","key":"10.1016\/j.colsurfb.2023.113506_bib10","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1038\/s41586-020-2161-8","article-title":"Layered nanocomposites by shear-flow-induced alignment of nanosheets","volume":"580","author":"Zhao","year":"2020","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.colsurfb.2023.113506_bib11","doi-asserted-by":"crossref","DOI":"10.1002\/SMMD.20220012","article-title":"Bacterial infection microenvironment-responsive porous microspheres by microfluidics for promoting anti-infective therapy","volume":"1","author":"Gao","year":"2022","journal-title":"Smart Med."},{"key":"10.1016\/j.colsurfb.2023.113506_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.colsurfb.2021.111848","article-title":"The response of macrophages and their osteogenic potential modulated by micro\/nano-structured Ti surfaces","volume":"205","author":"Liu","year":"2021","journal-title":"Colloids Surf. B Biointerfaces"},{"issue":"6","key":"10.1016\/j.colsurfb.2023.113506_bib13","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.mattod.2013.06.005","article-title":"Biomimetic electrospun nanofibrous structures for tissue engineering","volume":"16","author":"Wang","year":"2013","journal-title":"Mater. Today"},{"key":"10.1016\/j.colsurfb.2023.113506_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2019.119555","article-title":"Hierarchical micro\/nanofibrous membranes of sustained releasing VEGF for periosteal regeneration","volume":"227","author":"Wu","year":"2020","journal-title":"Biomaterials"},{"key":"10.1016\/j.colsurfb.2023.113506_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.colsurfb.2022.112419","article-title":"Hydrostatic pressure stimulates the osteogenesis and angiogenesis of MSCs\/HUVECs co-culture on porous PLGA scaffolds","volume":"213","author":"Shen","year":"2022","journal-title":"Colloids Surf. B Biointerfaces"},{"issue":"21","key":"10.1016\/j.colsurfb.2023.113506_bib16","doi-asserted-by":"crossref","DOI":"10.1002\/adfm.202113390","article-title":"Gelatin-lysozyme nanofibrils electrospun patches with improved mechanical, antioxidant and bioresorbability properties for myocardial regeneration applications","volume":"32","author":"Carvalho","year":"2022","journal-title":"Adv. Funct. Mater."},{"issue":"36","key":"10.1016\/j.colsurfb.2023.113506_bib17","doi-asserted-by":"crossref","DOI":"10.1002\/smll.202106824","article-title":"Harnessing 4D printing bioscaffolds for advanced orthopedics","volume":"18","author":"Chen","year":"2022","journal-title":"Small"},{"issue":"43","key":"10.1016\/j.colsurfb.2023.113506_bib18","doi-asserted-by":"crossref","DOI":"10.1002\/adfm.202003717","article-title":"Inspired by nature: facile design of nanoclay-organic hydrogel bone sealant with multifunctional properties for robust bone regeneration","volume":"30","author":"Lee","year":"2020","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.colsurfb.2023.113506_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2021.121038","article-title":"Sequential activation of heterogeneous macrophage phenotypes is essential for biomaterials-induced bone regeneration","volume":"276","author":"Qiao","year":"2021","journal-title":"Biomaterials"},{"issue":"1","key":"10.1016\/j.colsurfb.2023.113506_bib20","doi-asserted-by":"crossref","first-page":"426","DOI":"10.7150\/thno.34126","article-title":"Type H blood vessels in bone modeling and remodeling","volume":"10","author":"Peng","year":"2020","journal-title":"Theranostics"},{"issue":"7492","key":"10.1016\/j.colsurfb.2023.113506_bib21","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1038\/nature13145","article-title":"Coupling of angiogenesis and osteogenesis by a specific vessel subtype in bone","volume":"507","author":"Kusumbe","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.colsurfb.2023.113506_bib22","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1016\/j.colsurfb.2018.04.060","article-title":"The effects of biomimetically conjugated VEGF on osteogenesis and angiogenesis of MSCs (human and rat) and HUVECs co-culture models","volume":"167","author":"L\u00fc","year":"2018","journal-title":"Colloids Surf. B Biointerfaces"},{"issue":"10","key":"10.1016\/j.colsurfb.2023.113506_bib23","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1038\/nm.4162","article-title":"Implant-derived magnesium induces local neuronal production of CGRP to improve bone-fracture healing in rats","volume":"22","author":"Zhang","year":"2016","journal-title":"Nat. Med."},{"issue":"11","key":"10.1016\/j.colsurfb.2023.113506_bib24","doi-asserted-by":"crossref","first-page":"1844","DOI":"10.1038\/s12276-022-00899-6","article-title":"Neurovascular coupling in bone regeneration","volume":"54","author":"Qin","year":"2022","journal-title":"Exp. Mol. Med."},{"issue":"7032","key":"10.1016\/j.colsurfb.2023.113506_bib25","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1038\/nature03398","article-title":"Leptin regulation of bone resorption by the sympathetic nervous system and CART","volume":"434","author":"Elefteriou","year":"2005","journal-title":"Nature"},{"issue":"8","key":"10.1016\/j.colsurfb.2023.113506_bib26","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1038\/nrd4337","article-title":"Semaphorins and plexins as therapeutic targets","volume":"13","author":"Worzfeld","year":"2014","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.colsurfb.2023.113506_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.compositesb.2022.110030","article-title":"Vascularization and neuralization of bioactive calcium magnesium phosphate\/hydrogels for wound healing","volume":"242","author":"Zhuang","year":"2022","journal-title":"Compos. Part B-Eng."},{"issue":"13","key":"10.1016\/j.colsurfb.2023.113506_bib28","doi-asserted-by":"crossref","DOI":"10.1002\/adfm.202109882","article-title":"Tissue-engineered bone functionalized with MoS2 nanosheets for enhanced repair of critical-size bone defect in rats","volume":"32","author":"Zhang","year":"2022","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.colsurfb.2023.113506_bib29","first-page":"257","article-title":"Microfluidic electrospray photo-crosslinkable \u03ba-Carrageenan microparticles for wound healing","volume":"2","author":"Luo","year":"2021","journal-title":"Eng. Regen."},{"key":"10.1016\/j.colsurfb.2023.113506_bib30","article-title":"Differential effect of tantalum nanoparticles versus tantalum micron particles on immune regulation","volume":"16","author":"Sun","year":"2022","journal-title":"Mater. Today Bio"},{"key":"10.1016\/j.colsurfb.2023.113506_bib31","article-title":"Micropatterned photothermal double-layer periosteum with angiogenesis-neurogenesis coupling effect for bone regeneration","volume":"18","author":"Li","year":"2023","journal-title":"Mater. Today Bio"},{"issue":"7","key":"10.1016\/j.colsurfb.2023.113506_bib32","doi-asserted-by":"crossref","first-page":"3321","DOI":"10.1021\/acsbiomaterials.1c00426","article-title":"Poly-epsilon-caprolactone\/Whitlockite Electrospun Bionic Membrane with an Osteogenic-Angiogenic Coupling Effect for Periosteal Regeneration","volume":"7","author":"Zhang","year":"2021","journal-title":"Acs Biomater. Sci. Eng."},{"issue":"17","key":"10.1016\/j.colsurfb.2023.113506_bib33","doi-asserted-by":"crossref","DOI":"10.3390\/ma14174857","article-title":"Resorbable Mg2+-containing phosphates for bone tissue repair","volume":"14","author":"Kazakova","year":"2021","journal-title":"Materials"},{"key":"10.1016\/j.colsurfb.2023.113506_bib34","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.biomaterials.2019.01.013","article-title":"Osteogenic magnesium incorporated into PLGA\/TCP porous scaffold by 3D printing for repairing challenging bone defect","volume":"197","author":"Lai","year":"2019","journal-title":"Biomaterials"},{"issue":"11","key":"10.1016\/j.colsurfb.2023.113506_bib35","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1038\/nm.3747","article-title":"Osteoclast progenitors promote bone vascularization and osteogenesis","volume":"20","author":"Kusumbe","year":"2014","journal-title":"Nat. Med."},{"issue":"6","key":"10.1016\/j.colsurfb.2023.113506_bib36","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1016\/j.biomaterials.2009.10.043","article-title":"The repair of large segmental bone defects in the rabbit with vascularized tissue engineered bone","volume":"31","author":"Zhou","year":"2010","journal-title":"Biomaterials"},{"issue":"6","key":"10.1016\/j.colsurfb.2023.113506_bib37","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202205336","article-title":"Nitric oxide-releasing bioinspired scaffold for exquisite regeneration of osteoporotic bone via regulation of homeostasis","volume":"10","author":"Lee","year":"2023","journal-title":"Adv. Sci."},{"key":"10.1016\/j.colsurfb.2023.113506_bib38","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.actbio.2022.09.023","article-title":"Neuro-bone tissue engineering: multiple potential translational strategies between nerve and bone","volume":"153","author":"Zhang","year":"2022","journal-title":"Acta Biomater."},{"key":"10.1016\/j.colsurfb.2023.113506_bib39","first-page":"206","article-title":"A multifunctional neuromodulation platform utilizing Schwann cell-derived exosomes orchestrates bone microenvironment via immunomodulation, angiogenesis and osteogenesis","volume":"23","author":"Hao","year":"2023","journal-title":"Bioact. Mater."},{"issue":"9","key":"10.1016\/j.colsurfb.2023.113506_bib40","doi-asserted-by":"crossref","DOI":"10.1002\/adfm.202109871","article-title":"Bioprinted constructs that mimic the ossification center microenvironment for targeted innervation in bone regeneration","volume":"32","author":"Li","year":"2022","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.colsurfb.2023.113506_bib41","first-page":"271","article-title":"Stratified-structural hydrogel incorporated with magnesium-ion-modified black phosphorus nanosheets for promoting neuro-vascularized bone regeneration","volume":"16","author":"Xu","year":"2022","journal-title":"Bioact. Mater."},{"issue":"15","key":"10.1016\/j.colsurfb.2023.113506_bib42","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202203099","article-title":"Multifunctional Scaffold for Osteoporotic Pathophysiological Microenvironment Improvement and Vascularized Bone Defect Regeneration","volume":"12","author":"Zhao","year":"2023","journal-title":"Adv. Healthc. Mater."},{"issue":"3","key":"10.1016\/j.colsurfb.2023.113506_bib43","doi-asserted-by":"crossref","first-page":"2086","DOI":"10.1021\/am405164f","article-title":"Well-coupled graphene and pd-based bimetallic nanocrystals nanocomposites for electrocatalytic oxygen reduction reaction","volume":"6","author":"Yin","year":"2014","journal-title":"ACS Appl. Mater. INTERFACES"}],"container-title":["Colloids and Surfaces B: Biointerfaces"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0927776523003843?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0927776523003843?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T16:12:11Z","timestamp":1778775131000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0927776523003843"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10]]},"references-count":43,"alternative-id":["S0927776523003843"],"URL":"https:\/\/doi.org\/10.1016\/j.colsurfb.2023.113506","relation":{},"ISSN":["0927-7765"],"issn-type":[{"value":"0927-7765","type":"print"}],"subject":[],"published":{"date-parts":[[2023,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The bio-functionalized membrane loaded with Ta\/WH nanoparticles promote bone regeneration through neurovascular coupling","name":"articletitle","label":"Article Title"},{"value":"Colloids and Surfaces B: Biointerfaces","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.colsurfb.2023.113506","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"113506"}}