{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T19:07:05Z","timestamp":1787166425018,"version":"build-2736575974"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Colloids and Surfaces B: Biointerfaces"],"published-print":{"date-parts":[[2023,10]]},"DOI":"10.1016\/j.colsurfb.2023.113508","type":"journal-article","created":{"date-parts":[[2023,8,7]],"date-time":"2023-08-07T11:40:31Z","timestamp":1691408431000},"page":"113508","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Effective intracellular release of ibuprofen triggered by thermosensitive magnetic nanocarriers"],"prefix":"10.1016","volume":"230","author":[{"given":"Marcos E.","family":"Peralta","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julieta C.","family":"Parisi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel C.","family":"Castrogiovanni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sushilkumar A.","family":"Jadhav","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciano","family":"Carlos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriela N.","family":"Bosio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel O.","family":"M\u00e1rtire","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.colsurfb.2023.113508_bib1","doi-asserted-by":"crossref","DOI":"10.1186\/s12989-021-00433-y","article-title":"Silica-coated magnetic-nanoparticle-induced cytotoxicity is reduced in microglia by glutathione and citrate identified using integrated omics","volume":"18","author":"Shin","year":"2021","journal-title":"Part. Fibre Toxicol."},{"key":"10.1016\/j.colsurfb.2023.113508_bib2","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1038\/nmat3776","article-title":"Stimuli-responsive nanocarriers for drug delivery","volume":"12","author":"Mura","year":"2013","journal-title":"Nat. Mater."},{"key":"10.1016\/j.colsurfb.2023.113508_bib3","doi-asserted-by":"crossref","first-page":"4782","DOI":"10.1002\/smll.201601129","article-title":"Recent advances of using hybrid nanocarriers in remotely controlled therapeutic delivery","volume":"12","author":"Li","year":"2016","journal-title":"Small"},{"key":"10.1016\/j.colsurfb.2023.113508_bib4","doi-asserted-by":"crossref","DOI":"10.3390\/nano10050916","article-title":"Influence of the surface functionalization on the fate and performance of mesoporous silica nanoparticles","volume":"10","author":"Gisbert-Garzar\u00e1n","year":"2020","journal-title":"Nanomaterials"},{"key":"10.1016\/j.colsurfb.2023.113508_bib5","doi-asserted-by":"crossref","first-page":"14191","DOI":"10.1039\/C5NR02730F","article-title":"Smart multifunctional drug delivery towards anticancer therapy harmonized in mesoporous nanoparticles","volume":"7","author":"Baek","year":"2015","journal-title":"Nanoscale"},{"key":"10.1016\/j.colsurfb.2023.113508_bib6","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1021\/cm0011559","article-title":"A new property of MCM-41: drug delivery system","volume":"13","author":"Vallet-Regi","year":"2001","journal-title":"Chem. Mater."},{"key":"10.1016\/j.colsurfb.2023.113508_bib7","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.nano.2015.10.018","article-title":"Advances in silica based nanoparticles for targeted cancer therapy","volume":"12","author":"Yang","year":"2016","journal-title":"Nanomedicine"},{"key":"10.1016\/j.colsurfb.2023.113508_bib8","doi-asserted-by":"crossref","first-page":"1504","DOI":"10.1002\/adma.201104763","article-title":"Mesoporous silica nanoparticles: synthesis, biocompatibility and drug delivery","volume":"24","author":"Tang","year":"2012","journal-title":"Adv. Mater."},{"key":"10.1016\/j.colsurfb.2023.113508_bib9","doi-asserted-by":"crossref","DOI":"10.1002\/adfm.201902634","article-title":"Mesoporous silica nanoparticles for drug delivery","volume":"30","author":"Manzano","year":"2020","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.colsurfb.2023.113508_bib10","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1021\/acs.chemrev.5b00456","article-title":"Gated materials for on-command release of guest molecules","volume":"116","author":"Aznar","year":"2016","journal-title":"Chem. Rev."},{"key":"10.1016\/j.colsurfb.2023.113508_bib11","doi-asserted-by":"crossref","first-page":"2608","DOI":"10.1039\/D0BM01952F","article-title":"Photothermal therapy with silver nanoplates in HeLa cells studied by in situ fluorescence microscopy","volume":"9","author":"Rivas Aiello","year":"2021","journal-title":"Biomater. Sci."},{"key":"10.1016\/j.colsurfb.2023.113508_bib12","doi-asserted-by":"crossref","first-page":"13168","DOI":"10.1039\/C5NR03777H","article-title":"Magnetic field activated drug delivery using thermodegradable azo-functionalised PEG-coated core-shell mesoporous silica nanoparticles","volume":"7","author":"Saint-Cricq","year":"2015","journal-title":"Nanoscale"},{"key":"10.1016\/j.colsurfb.2023.113508_bib13","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1007\/s00396-009-2028-x","article-title":"Thermoresponsive copolymers: from fundamental studies to applications","volume":"287","author":"Liu","year":"2009","journal-title":"Colloid Polym. Sci."},{"key":"10.1016\/j.colsurfb.2023.113508_bib14","article-title":"Therapeutic potential of polymer-coated mesoporous silica nanoparticles","volume":"10","author":"Bansal","year":"2020","journal-title":"Appl. Sci."},{"key":"10.1016\/j.colsurfb.2023.113508_bib15","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.reactfunctpolym.2015.11.006","article-title":"Hybrid drug carriers with temperature-controlled on-off release: a simple and reliable synthesis of PNIPAM-functionalized mesoporous silica nanoparticles","volume":"98","author":"Brunella","year":"2016","journal-title":"React. Funct. Polym."},{"key":"10.1016\/j.colsurfb.2023.113508_bib16","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.jcis.2019.02.086","article-title":"Synthesis and in vitro testing of thermoresponsive polymer-grafted core-shell magnetic mesoporous silica nanoparticles for efficient controlled and targeted drug delivery","volume":"544","author":"Peralta","year":"2019","journal-title":"J. Colloid Interface Sci."},{"key":"10.1016\/j.colsurfb.2023.113508_bib17","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1016\/S1734-1140(13)71480-4","article-title":"Potential neuroprotective effect of ibuprofen, insights from the mice model of Parkinson\u2019s disease","volume":"65","author":"\u015awia\u0327tkiewicz","year":"2013","journal-title":"Pharmacol. Rep."},{"key":"10.1016\/j.colsurfb.2023.113508_bib18","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1038\/tpj.2010.55","article-title":"Changes in the gene expression profile of gastric cancer cells in response to ibuprofen: a gene pathway analysis","volume":"11","author":"Bonelli","year":"2011","journal-title":"Pharmacogenom. J."},{"key":"10.1016\/j.colsurfb.2023.113508_bib19","doi-asserted-by":"crossref","first-page":"35","DOI":"10.3892\/ijo.2013.2148","article-title":"S(+)-ibuprofen destabilizes MYC\/MYCN and AKT, increases p53 expression, and induces unfolded protein response and favorable phenotype in neuroblastoma cell lines","volume":"44","author":"Ikegaki","year":"2014","journal-title":"Int J. Oncol."},{"key":"10.1016\/j.colsurfb.2023.113508_bib20","doi-asserted-by":"crossref","first-page":"4881","DOI":"10.1021\/acs.chemrev.8b00626","article-title":"Reactive oxygen species (ROS)-based nanomedicine","volume":"119","author":"Yang","year":"2019","journal-title":"Chem. Rev."},{"key":"10.1016\/j.colsurfb.2023.113508_bib21","doi-asserted-by":"crossref","DOI":"10.1038\/cddiscovery.2017.7","article-title":"Malathion increases apoptotic cell death by inducing lysosomal membrane permeabilization in N2a neuroblastoma cells: a model for neurodegeneration in Alzheimer\u2019s disease","volume":"3","author":"Venkatesan","year":"2017","journal-title":"Cell Death Discov."},{"key":"10.1016\/j.colsurfb.2023.113508_bib22","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2020.566026","article-title":"Cytoprotective and neurotrophic effects of octadecaneuropeptide (ODN) in in vitro and in vivo models of neurodegenerative diseases","volume":"11","author":"Masmoudi-Kouki","year":"2020","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.colsurfb.2023.113508_bib23","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1111\/jnc.13618","article-title":"Cellular models for Parkinson\u2019s disease","author":"Falkenburger","year":"2016","journal-title":"J. Neurochem"},{"issue":"3","key":"10.1016\/j.colsurfb.2023.113508_bib24","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1016\/j.chemosphere.2006.06.030","article-title":"Inhibition of mitochondrial bioenergetics by carbaryl is only evident for higher concentrations \u2013 Relevance for carbaryl toxicity mechanisms","volume":"66","author":"Antonio","year":"2007","journal-title":"Chemosphere"},{"key":"10.1016\/j.colsurfb.2023.113508_bib25","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1016\/j.chemosphere.2006.06.030","article-title":"Inhibition of mitochondrial bioenergetics by carbaryl is only evident for higher concentrations \u2013 relevance for carbaryl toxicity mechanisms","volume":"66","author":"Moreno","year":"2007","journal-title":"Chemosphere"},{"key":"10.1016\/j.colsurfb.2023.113508_bib26","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1007\/978-1-4939-2074-7_5","article-title":"Culture and functional characterization of human hepatoma HepG2 cells","author":"Donato","year":"2015","journal-title":"Protoc. In Vitro Hepatocyte Res."},{"key":"10.1016\/j.colsurfb.2023.113508_bib27","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1039\/b707313e","article-title":"Measuring the lifetime of singlet oxygen in a single cell: addressing the issue of cell viability","volume":"6","author":"Hatz","year":"2007","journal-title":"Photochem. Photobiol. Sci."},{"key":"10.1016\/j.colsurfb.2023.113508_bib28","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.saa.2018.01.027","article-title":"Imidazole and beta-carotene photoprotection against photodynamic therapy evaluated by synchrotron infrared microscopy","volume":"195","author":"Bosio","year":"2018","journal-title":"Spectrochim. Acta A Mol. Biomol. Spectrosc."},{"key":"10.1016\/j.colsurfb.2023.113508_bib29","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-09406-8","article-title":"Ibuprofen and ketoprofen potentiate UVA-induced cell death by a photosensitization process","volume":"7","author":"Bignon","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.colsurfb.2023.113508_bib30","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1016\/j.tiv.2015.02.011","article-title":"The utility of HepG2 cells to identify direct mitochondrial dysfunction in the absence of cell death","volume":"29","author":"Kamalian","year":"2015","journal-title":"Toxicol. Vitr."}],"container-title":["Colloids and Surfaces B: Biointerfaces"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0927776523003867?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0927776523003867?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T11:21:57Z","timestamp":1760527317000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0927776523003867"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10]]},"references-count":30,"alternative-id":["S0927776523003867"],"URL":"https:\/\/doi.org\/10.1016\/j.colsurfb.2023.113508","relation":{},"ISSN":["0927-7765"],"issn-type":[{"value":"0927-7765","type":"print"}],"subject":[],"published":{"date-parts":[[2023,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effective intracellular release of ibuprofen triggered by thermosensitive magnetic nanocarriers","name":"articletitle","label":"Article Title"},{"value":"Colloids and Surfaces B: Biointerfaces","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.colsurfb.2023.113508","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"113508"}}