{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T20:47:19Z","timestamp":1790628439969,"version":"4.1.0"},"reference-count":61,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100006769","name":"Russian Science Foundation","doi-asserted-by":"publisher","award":["21-74-20019"],"award-info":[{"award-number":["21-74-20019"]}],"id":[{"id":"10.13039\/501100006769","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Colloids and Surfaces B: Biointerfaces"],"published-print":{"date-parts":[[2024,5]]},"DOI":"10.1016\/j.colsurfb.2024.113854","type":"journal-article","created":{"date-parts":[[2024,3,16]],"date-time":"2024-03-16T07:08:56Z","timestamp":1710572936000},"page":"113854","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"special_numbering":"C","title":["Carrageenan films as promising mucoadhesive ocular drug delivery systems"],"prefix":"10.1016","volume":"237","author":[{"given":"Aleksandra V.","family":"Volod\u2019ko","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elvira Yu.","family":"Son","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valery P.","family":"Glazunov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viktoriya N.","family":"Davydova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elga I.","family":"Alexander-Sinkler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Svetlana A.","family":"Aleksandrova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miralda I.","family":"Blinova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irina M.","family":"Yermak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.colsurfb.2024.113854_bib1","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.4155\/tde.14.75","article-title":"Advances in ophthalmic drug delivery","volume":"5","author":"Morrison","year":"2014","journal-title":"Ther. Deliv."},{"key":"10.1016\/j.colsurfb.2024.113854_bib2","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1081\/DDC-120003445","article-title":"Ocular preparations: the formulation approach","volume":"28","author":"Pal Kaur","year":"2002","journal-title":"Drug Dev. Ind. Pharm."},{"key":"10.1016\/j.colsurfb.2024.113854_bib3","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.jconrel.2018.06.031","article-title":"Polymer-based carriers for ophthalmic drug delivery","volume":"285","author":"Imperiale","year":"2018","journal-title":"J. Control. Release"},{"key":"10.1016\/j.colsurfb.2024.113854_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2020.116764","article-title":"Thermo- and pH-sensitive glycosaminoglycans derivatives obtained by controlled grafting of poly(N-isopropylacrylamide)","volume":"248","author":"Pilipenko","year":"2020","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.colsurfb.2024.113854_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2019.118734","article-title":"Novel in situ gelling ophthalmic drug delivery system based on gellan gum and hydroxyethylcellulose: innovative rheological characterization, in vitro and in vivo evidence of a sustained precorneal retention time","volume":"574","author":"Destruel","year":"2020","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.colsurfb.2024.113854_bib6","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.jddst.2018.10.034","article-title":"Development of polysaccharide-based mucoadhesive ophthalmic lubricating vehicles: the effect of different polymers on physicochemical properties and functionality","volume":"49","author":"Ra\u010di\u0107","year":"2019","journal-title":"J. Drug Deliv. Sci. Technol."},{"key":"10.1016\/j.colsurfb.2024.113854_bib7","doi-asserted-by":"crossref","first-page":"22","DOI":"10.3390\/pharmaceutics12010022","article-title":"Polysaccharides in ocular drug delivery","volume":"12","author":"Dubashynskaya","year":"2019","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.colsurfb.2024.113854_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2024.129496","article-title":"Matrix hyaluronic acid and bilayer poly-hydroxyethyl methacrylate-hyaluronic acid films as potential ocular drug delivery platforms","volume":"260","author":"Tighsazzadeh","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.colsurfb.2024.113854_bib9","doi-asserted-by":"crossref","first-page":"522","DOI":"10.3390\/md20080522","article-title":"Mucoadhesive marine polysaccharides","volume":"20","author":"Yermak","year":"2022","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.colsurfb.2024.113854_bib10","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1016\/j.ijbiomac.2019.10.005","article-title":"Mucoadhesive properties of sulphated polysaccharides carrageenans from red seaweed families Gigartinaceae and Tichocarpaceae","volume":"142","author":"Yermak","year":"2020","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.colsurfb.2024.113854_bib11","doi-asserted-by":"crossref","first-page":"244","DOI":"10.3109\/10408444.2013.861798","article-title":"Food additive carrageenan: Part II: a critical review of carrageenan in vivo safety studies","volume":"44","author":"Weiner","year":"2014","journal-title":"Crit. Rev. Toxicol."},{"key":"10.1016\/j.colsurfb.2024.113854_bib12","doi-asserted-by":"crossref","first-page":"435","DOI":"10.3390\/md18090435","article-title":"Carrageenans as broad-spectrum microbicides: current status and challenges","volume":"18","author":"Lee","year":"2020","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.colsurfb.2024.113854_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2021.117642","article-title":"Insight on structure-property relationships of carrageenan from marine red algal: a review","volume":"257","author":"Jiang","year":"2021","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.colsurfb.2024.113854_bib14","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/S0924-2244(02)00066-3","article-title":"1H and 13C high resolution NMR spectroscopy of carrageenans: application in research and industry","volume":"13","author":"van de Velde","year":"2002","journal-title":"Trends Food Sci. Technol."},{"key":"10.1016\/j.colsurfb.2024.113854_bib15","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1515\/botm.1994.37.2.163","article-title":"A modified system of nomenclature for red algal galactans","volume":"37","author":"Knutsen","year":"1994","journal-title":"Bot. Mar."},{"key":"10.1016\/j.colsurfb.2024.113854_bib16","first-page":"1814","article-title":"The carrageenan system of polysaccharides. Part I. the relation between the \u03ba- and \u03bb-components","author":"Rees","year":"1963","journal-title":"J. Chem. Soc."},{"key":"10.1016\/j.colsurfb.2024.113854_bib17","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1007\/s10811-007-9295-z","article-title":"Structure and properties of carrageenan-like polysaccharide from the red alga Tichocarpus crinitus (Gmel.) Rupr. (Rhodophyta, Tichocarpaceae)","volume":"20","author":"Barabanova","year":"2008","journal-title":"J. Appl. Phycol."},{"key":"10.1016\/j.colsurfb.2024.113854_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2019.115518","article-title":"Structural characteristics of carrageenans of red alga Mastocarpus pacificus from sea of Japan","volume":"229","author":"Kravchenko","year":"2020","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.colsurfb.2024.113854_bib19","doi-asserted-by":"crossref","first-page":"2601","DOI":"10.1007\/s10811-018-1435-0","article-title":"Effects of iota-carrageenan on ocular Chlamydia trachomatis infection in vitro and in vivo","volume":"30","author":"Inic-Kanada","year":"2018","journal-title":"J. Appl. Phycol."},{"key":"10.1016\/j.colsurfb.2024.113854_bib20","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.carbpol.2018.06.086","article-title":"Carrageenan based hydrogels for drug delivery, tissue engineering and wound healing","volume":"198","author":"Yegappan","year":"2018","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.colsurfb.2024.113854_bib21","doi-asserted-by":"crossref","first-page":"60386","DOI":"10.1039\/C5RA06858D","article-title":"Effect of carrageenan and potassium chloride on an in situ gelling ophthalmic drug delivery system based on methylcellulose","volume":"5","author":"Bhowmick","year":"2015","journal-title":"RSC Adv."},{"key":"10.1016\/j.colsurfb.2024.113854_bib22","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1080\/03639045.2017.1414232","article-title":"A novel ion-activated in situ gelling ophthalmic delivery system based on \u03ba-carrageenan for acyclovir","volume":"44","author":"Li","year":"2018","journal-title":"Drug Dev. Ind. Pharm."},{"key":"10.1016\/j.colsurfb.2024.113854_bib23","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/j.ejpb.2015.06.003","article-title":"In vitro and in vivo ocular safety and eye surface permanence determination by direct and Magnetic Resonance Imaging of ion-sensitive hydrogels based on gellan gum and kappa-carrageenan","volume":"94","author":"Fern\u00e1ndez-Ferreiro","year":"2015","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.colsurfb.2024.113854_bib24","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1016\/j.ijpharm.2017.06.060","article-title":"Cysteamine polysaccharide hydrogels: Study of extended ocular delivery and biopermanence time by PET imaging","volume":"528","author":"Luaces-Rodr\u00edguez","year":"2017","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.colsurfb.2024.113854_bib25","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/j.ejpb.2003.12.002","article-title":"Carrageenan\u2013gelatin mucoadhesive systems for ion-exchange based ophthalmic delivery: in vitro and preliminary in vivo studies","volume":"57","author":"Bonferoni","year":"2004","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.colsurfb.2024.113854_bib26","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/j.carbpol.2011.07.051","article-title":"Impact of magnetic nanofillers in the swelling and release properties of \u03ba-carrageenan hydrogel nanocomposites","volume":"87","author":"Daniel-da-Silva","year":"2012","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.colsurfb.2024.113854_bib27","doi-asserted-by":"crossref","first-page":"337","DOI":"10.3390\/md15110337","article-title":"Carrageenans-sulfated polysaccharides from red seaweeds as matrices for the inclusion of echinochrome","volume":"15","author":"Yermak","year":"2017","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.colsurfb.2024.113854_bib28","first-page":"1121929","article-title":"Composition comprising di-and trisodium salts of echinochrome for treating ocular conditions","volume":"3","author":"Elyakov","year":"2004","journal-title":"Eur. Pat."},{"key":"10.1016\/j.colsurfb.2024.113854_bib29","first-page":"34","article-title":"Histochrome, a new antioxidant, in the treatment of ocular diseases","volume":"115","author":"Egorov","year":"1999","journal-title":"Vestn. Oftalmol."},{"key":"10.1016\/j.colsurfb.2024.113854_bib30","first-page":"171","article-title":"Amelioration of endotoxin-induced uveitis treated with the sea urchin pigment echinochrome in rats","volume":"20","author":"Lennikov","year":"2014","journal-title":"Mol. Vis."},{"key":"10.1016\/j.colsurfb.2024.113854_bib31","doi-asserted-by":"crossref","first-page":"412","DOI":"10.3390\/md19080412","article-title":"Multifaceted clinical effects of echinochrome","volume":"19","author":"Kim","year":"2021","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.colsurfb.2024.113854_bib32","doi-asserted-by":"crossref","first-page":"11702","DOI":"10.3390\/ijms231911702","article-title":"The anti-inflammatory effect of carrageenan\/echinochrom complex at experimental endotoxemia","volume":"23","author":"Yermak","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.colsurfb.2024.113854_bib33","doi-asserted-by":"crossref","first-page":"15754","DOI":"10.3390\/ijms232415754","article-title":"Antiherpetic activity of carrageenan complex with echinochrome a and its liposomal form","volume":"23","author":"Krylova","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.colsurfb.2024.113854_bib34","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.1001\/jama.2013.280318","article-title":"Conjunctivitis: a systematic review of diagnosis and treatment","volume":"310","author":"Azari","year":"2013","journal-title":"JAMA"},{"key":"10.1016\/j.colsurfb.2024.113854_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2021.118479","article-title":"Carrageenan gel beads for echinochrome inclusion: influence of structural features of carrageenan","volume":"272","author":"Yermak","year":"2021","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.colsurfb.2024.113854_bib36","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2014\/861904","article-title":"Ophthalmic drug dosage forms: characterisation and research methods","volume":"2014","author":"Baranowski","year":"2014","journal-title":"Sci. World J."},{"key":"10.1016\/j.colsurfb.2024.113854_bib37","doi-asserted-by":"crossref","unstructured":"N.J. Kim, A. Harris, A. Elghouche, W. Gama, B. Siesky, Ocular Permeation Enhancers, 2016. \u3008https:\/\/doi.org\/10.1007\/978-3-319-29346-2_9\u3009.","DOI":"10.1007\/978-3-319-29346-2_9"},{"key":"10.1016\/j.colsurfb.2024.113854_bib38","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1002\/mabi.201000388","article-title":"Advances in mucoadhesion and mucoadhesive polymers","volume":"11","author":"Khutoryanskiy","year":"2011","journal-title":"Macromol. Biosci."},{"key":"10.1016\/j.colsurfb.2024.113854_bib39","series-title":"Sixt. Int. Seaweed Symp.","first-page":"555","article-title":"Chemical structure and gel properties of carrageenans from algae belonging to the Gigartinaceae and Tichocarpaceae, collected from the Russian Pacific coast","author":"Yermak","year":"1999"},{"key":"10.1016\/j.colsurfb.2024.113854_bib40","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1007\/s10811-007-9295-z","article-title":"Structure and properties of carrageenan-like polysaccharide from the red alga Tichocarpus crinitus (Gmel.) Rupr. (Rhodophyta, Tichocarpaceae)","volume":"20","author":"Barabanova","year":"2008","journal-title":"J. Appl. Phycol."},{"key":"10.1016\/j.colsurfb.2024.113854_bib41","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.carbpol.2013.04.063","article-title":"Polysaccharide structure of tetrasporic red seaweed Tichocarpus crinitus","volume":"98","author":"Byankina (Barabanova)","year":"2013","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.colsurfb.2024.113854_bib42","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/0144-8617(90)90067-3","article-title":"Role of the molecular weight on the mechanical properties of kappa carrageenan gels","volume":"12","author":"Rochas","year":"1990","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.colsurfb.2024.113854_bib43","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1002\/macp.1988.021890118","article-title":"Evaluation of the viscometric constants for chitosan","volume":"189","author":"Roberts","year":"1988","journal-title":"Die Makromol. Chem. Macromol. Chem. Phys."},{"key":"10.1016\/j.colsurfb.2024.113854_bib44","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.ijpharm.2019.05.059","article-title":"Development and evaluation of performance characteristics of timolol-loaded composite ocular films as potential delivery platforms for treatment of glaucoma","volume":"566","author":"Tighsazzadeh","year":"2019","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.colsurfb.2024.113854_bib45","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/S0022-1694(00)00184-0","article-title":"Development and application of a new sessile drop contact angle method to assess soil water repellency","volume":"231\u2013232","author":"Bachmann","year":"2000","journal-title":"J. Hydrol."},{"key":"10.1016\/j.colsurfb.2024.113854_bib46","first-page":"614","article-title":"An SV40-immortalized human corneal epithelial cell line and its characterization","volume":"36","author":"Araki-Sasaki","year":"1995","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.colsurfb.2024.113854_bib47","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0022-1759(83)90303-4","article-title":"Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays","volume":"65","author":"Mosmann","year":"1983","journal-title":"J. Immunol. Methods"},{"key":"10.1016\/j.colsurfb.2024.113854_bib48","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1023\/A:1008071925884","article-title":"Chemical structure and gel properties of carrageenans from algae belonging to the Gigartinaceae and Tichocarpaceae, collected from the Russian Pacific Coast","volume":"11","author":"Yermak","year":"1999","journal-title":"J. Appl. Phycol."},{"key":"10.1016\/j.colsurfb.2024.113854_bib49","doi-asserted-by":"crossref","first-page":"12905","DOI":"10.3390\/ijms222312905","article-title":"New insights into the structure of kappa\/beta-carrageenan: a novel potential inhibitor of HIV-1","volume":"22","author":"Yermak","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.colsurfb.2024.113854_bib50","doi-asserted-by":"crossref","first-page":"704","DOI":"10.3390\/md19120704","article-title":"Comparative analysis of the functional properties of films based on carrageenans, chitosan, and their polyelectrolyte complexes","volume":"19","author":"Volod\u2019ko","year":"2021","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.colsurfb.2024.113854_bib51","doi-asserted-by":"crossref","first-page":"2255","DOI":"10.1007\/s10792-022-02226-4","article-title":"Investigation of the effect of solution pH value on rabbit corneal stroma biomechanics","volume":"42","author":"Wang","year":"2022","journal-title":"Int. Ophthalmol."},{"key":"10.1016\/j.colsurfb.2024.113854_bib52","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1001\/archopht.1976.03910030405011","article-title":"Human tear pH","volume":"94","author":"Carney","year":"1976","journal-title":"Arch. Ophthalmol."},{"key":"10.1016\/j.colsurfb.2024.113854_bib53","first-page":"161","article-title":"pH Stability of ophthalmic solutions","volume":"75","author":"Garcia-Valldecabres","year":"2004","journal-title":"Optom. - J. Am. Optom. Assoc."},{"key":"10.1016\/j.colsurfb.2024.113854_bib54","series-title":"Drug Target. Stimuli Sensitive Drug Deliv. Syst.","first-page":"211","article-title":"Stimuli sensitive ocular drug delivery systems","author":"Otero-Espinar","year":"2018"},{"key":"10.1016\/j.colsurfb.2024.113854_bib55","doi-asserted-by":"crossref","first-page":"825","DOI":"10.3390\/app9050825","article-title":"Mucoadhesive hydrogel nanoparticles as smart biomedical drug delivery system","volume":"9","author":"Hanafy","year":"2019","journal-title":"Appl. Sci."},{"key":"10.1016\/j.colsurfb.2024.113854_bib56","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1016\/j.foodhyd.2007.05.013","article-title":"Structure and function of hybrid carrageenans","volume":"22","author":"van de Velde","year":"2008","journal-title":"Food Hydrocoll."},{"key":"10.1016\/j.colsurfb.2024.113854_bib57","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1007\/s10126-018-9842-4","article-title":"Carrageenans from Sarcothalia crispata and Gigartina skottsbergii: structural analysis and interpolyelectrolyte complex formation for drug controlled release","volume":"20","author":"Hughes","year":"2018","journal-title":"Mar. Biotechnol."},{"key":"10.1016\/j.colsurfb.2024.113854_bib58","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1016\/j.carbpol.2012.12.026","article-title":"Atomic force microscopy imaging of carrageenans from red algae of Gigartinaceae and Tichocarpaceae families","volume":"93","author":"Sokolova","year":"2013","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.colsurfb.2024.113854_bib59","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1201\/9781420027631.ch7","article-title":"Carrageenans: structural and conformational studies","author":"Stortz","year":"2005","journal-title":": Handb. Carbohydr. Eng."},{"key":"10.1016\/j.colsurfb.2024.113854_bib60","doi-asserted-by":"crossref","first-page":"1837","DOI":"10.1021\/bm800276d","article-title":"Why is chitosan mucoadhesive?","volume":"9","author":"Sogias","year":"2008","journal-title":"Biomacromolecules"},{"key":"10.1016\/j.colsurfb.2024.113854_bib61","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.colsurfb.2017.05.042","article-title":"The wettability and swelling of selected mucoadhesive polymers in simulated saliva and vaginal fluids","volume":"156","author":"Rojewska","year":"2017","journal-title":"Colloids Surf. B Biointerfaces"}],"container-title":["Colloids and Surfaces B: Biointerfaces"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0927776524001127?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0927776524001127?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,9,8]],"date-time":"2024-09-08T06:23:24Z","timestamp":1725776604000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0927776524001127"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5]]},"references-count":61,"alternative-id":["S0927776524001127"],"URL":"https:\/\/doi.org\/10.1016\/j.colsurfb.2024.113854","relation":{},"ISSN":["0927-7765"],"issn-type":[{"value":"0927-7765","type":"print"}],"subject":[],"published":{"date-parts":[[2024,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Carrageenan films as promising mucoadhesive ocular drug delivery systems","name":"articletitle","label":"Article Title"},{"value":"Colloids and Surfaces B: Biointerfaces","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.colsurfb.2024.113854","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"113854"}}