{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T05:54:57Z","timestamp":1767851697918,"version":"3.49.0"},"reference-count":51,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Colloids and Surfaces B: Biointerfaces"],"published-print":{"date-parts":[[2024,9]]},"DOI":"10.1016\/j.colsurfb.2024.113985","type":"journal-article","created":{"date-parts":[[2024,5,25]],"date-time":"2024-05-25T16:10:12Z","timestamp":1716653412000},"page":"113985","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Self-assembled IR dye\/mitoxantrone loaded Porphysomes nanosystem for enhanced combinatorial chemo-photothermal cancer therapy"],"prefix":"10.1016","volume":"241","author":[{"given":"Monika","family":"Pebam","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sajmina","family":"Khatun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad Sadik","family":"Ali","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aditya","family":"Srivastava","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aravind Kumar","family":"Rengan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"124","key":"10.1016\/j.colsurfb.2024.113985_bib1","first-page":"13","article-title":"The lingering mysteries of metastatic recurrence in breast cancer","volume":"2020","author":"Riggio","year":"2020","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.colsurfb.2024.113985_bib2","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.jconrel.2017.05.011","article-title":"Chemotherapeutic drug-photothermal agent co-self-assembling nanoparticles for near-infrared fluorescence and photoacoustic dual-modal imaging-guided chemo-photothermal synergistic therapy","volume":"258","author":"Li","year":"2017","journal-title":"J. Control. Release"},{"key":"10.1016\/j.colsurfb.2024.113985_bib3","doi-asserted-by":"crossref","first-page":"48294","DOI":"10.1039\/C6RA07802H","article-title":"Recent trends in nano-based drug delivery systems for efficient delivery of phytochemicals in chemotherapy","volume":"6","author":"Subramanian","year":"2016","journal-title":"RSC Adv."},{"key":"10.1016\/j.colsurfb.2024.113985_bib4","doi-asserted-by":"crossref","first-page":"7312","DOI":"10.1021\/acsnano.8b03674","article-title":"Ultrasound triggered conversion of porphyrin\/camptothecin-fluoroxyuridine triad microbubbles into nanoparticles overcomes multidrug resistance in colorectal cancer","volume":"12","author":"Chen","year":"2018","journal-title":"ACS Nano"},{"key":"10.1016\/j.colsurfb.2024.113985_bib5","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1021\/ja409291g","article-title":"N -annulated perylene as an efficient electron donor for porphyrin-based dyes: enhanced light-harvesting ability and high-efficiency Co(II\/III)-based dye-sensitized solar cells","volume":"136","author":"Luo","year":"2014","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.colsurfb.2024.113985_bib6","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1021\/acsami.7b15583","article-title":"Zinc(II) metalated porphyrins as photothermogenic photosensitizers for cancer photodynamic\/photothermal synergistic therapy","volume":"10","author":"Ding","year":"2018","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.colsurfb.2024.113985_bib7","doi-asserted-by":"crossref","first-page":"55862","DOI":"10.1021\/acsami.1c17054","article-title":"In situ nanotransformable hydrogel for chemo-photothermal therapy of localized tumors and targeted therapy of highly metastatic tumors","volume":"13","author":"Baseeruddin Alvi","year":"2021","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.colsurfb.2024.113985_bib8","doi-asserted-by":"crossref","first-page":"1585","DOI":"10.1021\/acs.bioconjchem.9b00231","article-title":"Porphyrin-based nanomedicines for cancer treatment","volume":"30","author":"Xue","year":"2019","journal-title":"Bioconjug. Chem."},{"key":"10.1016\/j.colsurfb.2024.113985_bib9","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1021\/acsabm.8b00530","article-title":"Self-assembled porphyrin-based nanoparticles with enhanced near-infrared absorbance for fluorescence imaging and cancer photodynamic therapy","volume":"2","author":"Pan","year":"2019","journal-title":"ACS Appl. Bio Mater."},{"key":"10.1016\/j.colsurfb.2024.113985_bib10","doi-asserted-by":"crossref","first-page":"1585","DOI":"10.1021\/acs.bioconjchem.9b00231","article-title":"Porphyrin-based nanomedicines for cancer treatment","volume":"30","author":"Xue","year":"2019","journal-title":"Bioconjug. Chem."},{"key":"10.1016\/j.colsurfb.2024.113985_bib11","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1021\/acsabm.8b00530","article-title":"Self-assembled porphyrin-based nanoparticles with enhanced near-infrared absorbance for fluorescence imaging and cancer photodynamic therapy","volume":"2","author":"Pan","year":"2019","journal-title":"ACS Appl. Bio Mater."},{"key":"10.1016\/j.colsurfb.2024.113985_bib12","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1021\/acsbiomaterials.2c01539","article-title":"Self-assembled Aza-BODIPY and Iron(III) nanoparticles for photothermal-enhanced chemodynamic therapy in the NIR-II window","volume":"9","author":"Zhang","year":"2023","journal-title":"ACS Biomater. Sci. Eng."},{"key":"10.1016\/j.colsurfb.2024.113985_bib13","doi-asserted-by":"crossref","first-page":"6243","DOI":"10.1002\/smll.201602293","article-title":"A porphyrin-based conjugated polymer for highly efficient in vitro and in vivo photothermal therapy","volume":"12","author":"Guo","year":"2016","journal-title":"Small"},{"key":"10.1016\/j.colsurfb.2024.113985_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.jphotobiol.2020.111901","article-title":"NIR-dye based mucoadhesive nanosystem for photothermal therapy in breast cancer cells","volume":"208","author":"Jogdand","year":"2020","journal-title":"J. Photochem. Photobiol. B"},{"key":"10.1016\/j.colsurfb.2024.113985_bib15","doi-asserted-by":"crossref","unstructured":"H. Dai, Q. Shen, J. Shao, W. Wang, F. Gao, X. Dong, Small molecular NIR-II fluorophores for cancer phototheranostics, (n.d.). https:\/\/doi.org\/10.1016\/j.xinn.2021.100082.","DOI":"10.1016\/j.xinn.2021.100082"},{"key":"10.1016\/j.colsurfb.2024.113985_bib16","article-title":"DNA damage inducer mitoxantrone amplifies synergistic mild-photothermal chemotherapy for TNBC via decreasing heat shock protein 70 expression","volume":"10","author":"Chen","year":"2023","journal-title":"Adv. Sci."},{"key":"10.1016\/j.colsurfb.2024.113985_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.bea.2022.100040","article-title":"Glycol chitosan stabilized bimolecular nanoparticles for chemo photothermal killing of breast cancer cells","volume":"3","author":"Kaur","year":"2022","journal-title":"Biomed. Eng. Adv."},{"key":"10.1016\/j.colsurfb.2024.113985_bib18","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1021\/acsbiomaterials.1c01291","article-title":"Ultrathin nanosheet-supported Ag@Ag2O core-shell nanoparticles with vastly enhanced photothermal conversion efficiency for NIR-II-triggered photothermal therapy","volume":"8","author":"Li","year":"2022","journal-title":"ACS Biomater. Sci. Eng."},{"key":"10.1016\/j.colsurfb.2024.113985_bib19","doi-asserted-by":"crossref","unstructured":"S. Campbell, N. Smeets, Drug delivery: polymers in the development of controlled release systems, (2019) 1\u201329. https:\/\/doi.org\/10.1007\/978-3-319-92067-2_20-1.","DOI":"10.1007\/978-3-319-95987-0_20"},{"key":"10.1016\/j.colsurfb.2024.113985_bib20","article-title":"Accelerating diabetic wound healing by modulating the inflammatory environment using quercetin\u2013Rosemary oil lipid nanoemulsions with artificial intelligence-based wound closure analysis","volume":"7","author":"Ali","year":"2024","journal-title":"Adv. Ther. (Weinh. )"},{"key":"10.1016\/j.colsurfb.2024.113985_bib21","doi-asserted-by":"crossref","first-page":"6664","DOI":"10.1039\/D1FO00851J","article-title":"Quercetin nanoformulations: a promising strategy for tumor therapy","volume":"12","author":"Zang","year":"2021","journal-title":"Food Funct."},{"key":"10.1016\/j.colsurfb.2024.113985_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2023.144110","article-title":"Optoresponsive pheophorbide-silver based organometallic nanomaterials for high efficacy multimodal theranostics in Melanoma","volume":"470","author":"Mahadev Patil","year":"2023","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.colsurfb.2024.113985_bib23","doi-asserted-by":"crossref","DOI":"10.3390\/md16080277","article-title":"Green synthesis of gold nanoparticles using carrageenan oligosaccharide and their in vitro antitumor activity","volume":"16","author":"Chen","year":"2018","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.colsurfb.2024.113985_bib24","doi-asserted-by":"crossref","first-page":"2982","DOI":"10.1021\/acs.jmedchem.0c01399","article-title":"Cellular internalization and inhibition capacity of new anti-glioma peptide conjugates: physicochemical characterization and evaluation on various monolayer- A nd 3D-spheroid-based in vitro platforms","volume":"64","author":"Baranyai","year":"2021","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.colsurfb.2024.113985_bib25","doi-asserted-by":"crossref","first-page":"5333","DOI":"10.1021\/acsabm.2c00724","article-title":"Terminalia chebula polyphenol and near-infrared dye-loaded poly(lactic acid) nanoparticles for imaging and photothermal therapy of cancer cells","volume":"5","author":"Pebam","year":"2022","journal-title":"ACS Appl. Bio Mater."},{"key":"10.1016\/j.colsurfb.2024.113985_bib26","doi-asserted-by":"crossref","first-page":"2518","DOI":"10.1039\/D2BM01814D","article-title":"Camptothecin loaded casein nanosystem for tuning the therapeutic efficacy against highly metastatic triple-negative breast cancer cells \u2020","volume":"11","author":"Khatun","year":"2023","journal-title":"Biomater. Sci."},{"key":"10.1016\/j.colsurfb.2024.113985_bib27","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1021\/acsami.7b15583","article-title":"Zinc(II) metalated porphyrins as photothermogenic photosensitizers for cancer photodynamic\/photothermal synergistic therapy","volume":"10","author":"Ding","year":"2018","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.colsurfb.2024.113985_bib28","doi-asserted-by":"crossref","DOI":"10.1088\/1748-605X\/acf5b9","article-title":"PLGA nanoparticle loaded with antioxidants and photosensitizer for ROS shock mediated phototherapy of triple negative breast cancer","volume":"18","author":"Buddhiraju","year":"2023","journal-title":"Biomed. Mater."},{"key":"10.1016\/j.colsurfb.2024.113985_bib29","doi-asserted-by":"crossref","first-page":"3926","DOI":"10.1021\/acs.biomac.1c00744","article-title":"Self-assembled fluorosome-polydopamine complex for efficient tumor targeting and commingled photodynamic\/photothermal therapy of triple-negative breast cancer","volume":"22","author":"P.S","year":"2021","journal-title":"Biomacromolecules"},{"key":"10.1016\/j.colsurfb.2024.113985_bib30","doi-asserted-by":"crossref","first-page":"4947","DOI":"10.1039\/C7PY00559H","article-title":"Multicellular tumor spheroids: a relevant 3D model for the in vitro preclinical investigation of polymer nanomedicines","volume":"8","author":"Lazzari","year":"2017","journal-title":"Polym. Chem."},{"issue":"11","key":"10.1016\/j.colsurfb.2024.113985_bib31","first-page":"445","article-title":"Recent advances in multicellular tumor spheroid generation for drug screening","volume":"11","author":"Lee","year":"2021","journal-title":"Biosensors 2021"},{"key":"10.1016\/j.colsurfb.2024.113985_bib32","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.jconrel.2017.05.011","article-title":"Chemotherapeutic drug-photothermal agent co-self-assembling nanoparticles for near-infrared fluorescence and photoacoustic dual-modal imaging-guided chemo-photothermal synergistic therapy","volume":"258","author":"Li","year":"2017","journal-title":"J. Control. Release"},{"issue":"2023","key":"10.1016\/j.colsurfb.2024.113985_bib33","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1038\/s42255-023-00783-1","article-title":"Multifaceted mitochondria: moving mitochondrial science beyond function and dysfunction","volume":"5","author":"Monzel","year":"2023","journal-title":"Nat. Metab."},{"key":"10.1016\/j.colsurfb.2024.113985_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.pdpdt.2023.103872","article-title":"IR-775 - Hyptis loaded bioactive nanoparticles for enhanced phyto-photothermal therapy of breast cancer cells","volume":"44","author":"Pebam","year":"2023","journal-title":"Photodiagn. Photodyn. Ther."},{"key":"10.1016\/j.colsurfb.2024.113985_bib35","article-title":"Bioinspired gold coated phage nanosomes for anti-microbial and anti-cancer theranostics","volume":"23","author":"Yadav","year":"2023","journal-title":"Mater. Today Nano"},{"key":"10.1016\/j.colsurfb.2024.113985_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.jphotobiol.2020.111901","article-title":"NIR-dye based mucoadhesive nanosystem for photothermal therapy in breast cancer cells","volume":"208","author":"Jogdand","year":"2020","journal-title":"J. Photochem. Photobiol. B"},{"key":"10.1016\/j.colsurfb.2024.113985_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2021.108982","article-title":"A selective p53 activator and anticancer agent to improve colorectal cancer therapy","volume":"35","author":"Ramos","year":"2021","journal-title":"Cell Rep."},{"key":"10.1016\/j.colsurfb.2024.113985_bib38","doi-asserted-by":"crossref","first-page":"1852","DOI":"10.1038\/sj.onc.1204264","article-title":"Activation of the Fas pathway independently of Fas ligand during apoptosis induced by camptothecin in p53 mutant human colon carcinoma cells","volume":"20","author":"Shao","year":"2001","journal-title":"Oncogene"},{"issue":"1","key":"10.1016\/j.colsurfb.2024.113985_bib39","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1038\/s41598-020-64062-9","article-title":"Apoptotic and predictive factors by Bax, Caspases 3\/9, Bcl-2, p53 and Ki-67 in prostate cancer after 12 Gy single-dose","volume":"10","author":"Pisani","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.colsurfb.2024.113985_bib40","doi-asserted-by":"crossref","DOI":"10.1038\/s41419-020-2463-7","article-title":"Robust autoactivation for apoptosis by BAK but not BAX highlights BAK as an important therapeutic target","volume":"11","author":"Iyer","year":"2020","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.colsurfb.2024.113985_bib41","doi-asserted-by":"crossref","unstructured":"N.B. Bloch, T.E. Wales, M.S. Prew, H.R. Levy, J.R. Engen, L.D. Walensky, The conformational stability of pro-apoptotic BAX is dictated by discrete residues of the protein core, Nature Communications 2021 12:1 12 (2021) 1\u201312. https:\/\/doi.org\/10.1038\/s41467-021-25200-7.","DOI":"10.1038\/s41467-021-25200-7"},{"key":"10.1016\/j.colsurfb.2024.113985_bib42","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1007\/978-3-319-39406-0_4","article-title":"Apoptotic caspases in promoting cancer: implications from their roles in development and tissue homeostasis","volume":"930","author":"Dabrowska","year":"2016","journal-title":"Adv. Exp. Med Biol."},{"key":"10.1016\/j.colsurfb.2024.113985_bib43","doi-asserted-by":"crossref","unstructured":"C. Hounsell, Y. Fan, The Duality of Caspases in Cancer, as Told through the Fly, International Journal of Molecular Sciences 2021, Vol. 22, Page 8927 22 (2021) 8927. https:\/\/doi.org\/10.3390\/IJMS22168927.","DOI":"10.3390\/ijms22168927"},{"key":"10.1016\/j.colsurfb.2024.113985_bib44","doi-asserted-by":"crossref","first-page":"4281","DOI":"10.1038\/s41388-021-01852-z","article-title":"Shifting the paradigms for tumor suppression: lessons from the p53 field","volume":"40","author":"Barnoud","year":"2021","journal-title":"Oncogene"},{"issue":"1 8","key":"10.1016\/j.colsurfb.2024.113985_bib45","article-title":"Targeting p53 pathways: mechanisms, structures, and advances in therapy","volume":"8","author":"Wang","year":"2023","journal-title":"Signal Transduct. Target. Ther. 2023"},{"key":"10.1016\/j.colsurfb.2024.113985_bib46","doi-asserted-by":"crossref","first-page":"7860","DOI":"10.1523\/JNEUROSCI.19-18-07860.1999","article-title":"Bax-dependent caspase-3 activation is a key determinant in p53-induced apoptosis in neurons","volume":"19","author":"Cregan","year":"1999","journal-title":"J. Neurosci."},{"issue":"4","key":"10.1016\/j.colsurfb.2024.113985_bib47","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1038\/s12276-021-00590-2","article-title":"The p53-caspase-2 axis in the cell cycle and DNA damage response","volume":"53","author":"Lim","year":"2021","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.colsurfb.2024.113985_bib48","article-title":"Rapid recruitment of p53 to DNA damage sites directs DNA repair choice and integrity","volume":"119","author":"Wang","year":"2022","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"1","key":"10.1016\/j.colsurfb.2024.113985_bib49","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1038\/cdd.2017.169","article-title":"How does p53 induce apoptosis and how does this relate to p53-mediated tumour suppression?","volume":"25","author":"Aubrey","year":"2017","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.colsurfb.2024.113985_bib50","first-page":"415","article-title":"IR-783 inhibits breast cancer cell proliferation and migration by inducing mitochondrial fission","volume":"55","author":"Li","year":"2019","journal-title":"Int J. Oncol."},{"key":"10.1016\/j.colsurfb.2024.113985_bib51","doi-asserted-by":"crossref","first-page":"048","DOI":"10.1055\/s-0043-1768166","article-title":"The role of the matrix metalloproteinase-9 gene in tumor development and metastasis: a narrative review","volume":"10","author":"Kalali","year":"2023","journal-title":"Glob. Med. Genet."}],"container-title":["Colloids and Surfaces B: Biointerfaces"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0927776524002443?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0927776524002443?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,7,27]],"date-time":"2024-07-27T01:12:51Z","timestamp":1722042771000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0927776524002443"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9]]},"references-count":51,"alternative-id":["S0927776524002443"],"URL":"https:\/\/doi.org\/10.1016\/j.colsurfb.2024.113985","relation":{},"ISSN":["0927-7765"],"issn-type":[{"value":"0927-7765","type":"print"}],"subject":[],"published":{"date-parts":[[2024,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Self-assembled IR dye\/mitoxantrone loaded Porphysomes nanosystem for enhanced combinatorial chemo-photothermal cancer therapy","name":"articletitle","label":"Article Title"},{"value":"Colloids and Surfaces B: Biointerfaces","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.colsurfb.2024.113985","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"113985"}}